Clinical trials: Heart Failure Congestive
Chronic Kidney Diseases, Heart Failure With Preserved Ejection Fraction
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease
The goal of this study is to better understand the effects of a sodium-glucose transport protein 2 inhibitor, dapagliflozin, added on to standard of care on heart and lung function and circulating metabolites (substances created…
- Conditions
- Chronic Kidney Diseases, Heart Failure With Preserved Ejection Fraction, Kidney Diseases, Heart Failure
- Trial name
- NCT05719714
- Testing
- Dapagliflozin 10 MG [Farxiga]
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Northwestern University
Sleep Apnea, Heart Failure
Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure
Sleep Apnea (SA) is a disorder that causes pauses in breathing during sleep that expose the heart to oxygen deprivation. It is common in patients with heart failure (HF) where it is associated with increased risk of…
- Trial name
- ADVENT-HF (NCT01128816)
- Testing
- Adaptive Servo Ventilation
- Where
- 49 sites in United States, Brazil and 7 more
- Volunteers
- 732 people
- Sponsor
- Toronto Rehabilitation Institute
Heart Failure, Ventricular Assist Device
Influence of Telemonitoring on the Management of LVAD-patients
The current study aims to investigate whether telemedical monitoring in patients with terminal heart failure and an implanted left ventricular assist device (LVAD) has an influence on LVAD-associated complications…
- Conditions
- Heart Failure, Ventricular Assist Device, Telemedicine
- Trial name
- NCT04613401
- Testing
- questionnaire (observational study)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital, Essen
Heart Failure
Influence of Edoxaban on Coagulability and Thrombin Generation: An in Vitro Study Focusing on Thrombelastography
The influence of different doses of edoxaban on physical characteristics of the clot and thrombin generation kinetics in blood samples will be studied by in vitro spiking of blood samples collected from patients treated for heart…
- Trial name
- NCT02448901
- Testing
- Edoxaban
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Myocarditis, Heart Failure
ARrhythmias in MYocarditis
Myocarditis promotes the occurrence of serious cardiac arrhythmias and conduction disorders which may lead to sudden cardiac death, the need for catheter ablation of arrhythmia or implantation of a cardioverter-defibrillator or…
- Conditions
- Myocarditis, Heart Failure, Endomyocardial Biopsy, Arrythmia
- Trial name
- ARMY (NCT03801681)
- Testing
- ECG holter monitoring
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Heart Failure, Diastolic, Hypertension
Renal Denervation in Patients With Heart Failure With Normal LV Ejection Fraction
It is a randomized prospective controlled study of transcatheter renal denervation in patients with Heart Failure With Normal LV Ejection Fraction.
- Trial name
- NCT02115230
- Testing
- Renal denervation + medical therapy
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- InCor Heart Institute
Duchenne Muscular Dystrophy (DMD)
Sodium/Glucose Cotransporter-2 Inhibitors (SGLT2i) Therapy in Duchenne Cardiomyopathy
This is a pharmacokinetic study (PK Study) to better understand empagliflozin dosing in pediatric Duchenne muscular dystrophy patients.
- Trial name
- CHERISH (NCT07172971)
- Testing
- SGLT-2 inhibitor, SGLT2 inhibitor
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Heart Failure
Is There a Benefit to Optimize Heart Failure (HF) Treatment in Aged Over 80 Year's Old Patients?
The purpose of this study is to determine if there is an interest to optimize HF (heart failure) management in patients over 80 years old.
- Trial name
- HF 80 (NCT01437371)
- Testing
- - Angiotensin conversing enzyme inhibitors: enalapril, captopril, lisinopril, ramipril, trandolapril.
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Clermont-Ferrand
Heart Failure
The Effects of a High Fat and Low Carbohydrate Diet on Clinical Status in Patients With Heart Failure
The aim of the present study was to evaluate the effects of a high fat, low carbohydrate (CHO) diet on clinical status during 60 days of follow-up in patients with stable heart failure (HF).
- Trial name
- NCT02150798
- Testing
- High fat and low carbohydrate diet, Control diet
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Heart Failure With Preserved Ejection Fraction
The PeriCut Catheter System Early Feasibility Study (REIMAGINE-HFpEF)
The PeriCut early feasibility study will evaluate the safety and feasibility of successfully performing a minimally invasive pericardiotomy in patients with heart failure with preserved ejection fraction using the PeriCut…
- Trial name
- REIMAGINE-HF (NCT06702501)
- Testing
- PeriCut Catheter System performs minimally invasive pericardiotomy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Heart Failure Solutions, Inc.
End Stage Renal Disease, Cardio-Renal Syndrome
Cardio-Renal Registry
Cardiovascular disease is the leading cause of morbidity and mortality among patients with chronic kidney disease (CKD). Even after adjustment for known cardiovascular risk factors, including diabetes and hypertension, mortality…
- Conditions
- End Stage Renal Disease, Cardio-Renal Syndrome, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- BHCRR (NCT06521801)
- Testing
- Observation
- Where
- United Kingdom
- Volunteers
- 60,000 people
- Sponsor
- Queen Mary University of London
Heart Failure With Left Ventricular Ejection Fraction Greater Than or Equal to 40 Per Cent, Healthy Volunteers
A Study to Compare How Much of the Study Treatment Finerenone Gets Into the Blood When the Same Amount is Taken in One and in Two Tablets of Different Strengths in Healthy Male Participants
In this bioequivalence study, healthy male participants took the study treatment finerenone in the form of one and two tablets of different strengths by mouth.
- Trial name
- NCT07116512
- Testing
- Finerenone (BAY94-8862): intervention A, Finerenone (BAY94-8862): intervention B
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bayer
Type 2 Diabetes Mellitus, Cardiovascular Diseases
Soluble TREM-1 in Diabetes-Associated Cardiovascular Complications
Cardiovascular disease is the leading cause of illness and death among individuals with type 2 diabetes mellitus (T2DM). Chronic low-grade inflammation contributes significantly to blood vessel damage, atherosclerosis, and…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Diseases, Coronary Artery Disease, Heart Failure
- Trial name
- NCT07847112
- Volunteers
- 85 people
- Sponsor
- Assiut University
Heart Failure
RADIATE-HF - Efficacy and Safety of Cardiac Radiation in Advanced Heart Failure
The RADIATE-HF study is a prospective, interventional, single-center, open-label, non-randomized study conducted at the Rennes University Hospital.
- Trial name
- RADIATE-HF (NCT07770230)
- Testing
- Low-dose cardiac radiation therapy (5 Gy)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Rennes University Hospital
Heart Failure With Reduced Ejection Fraction
Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score
The purpose of this trial is to better understand how the beta-blocker metoprolol works in people with Heart Failure with Reduced Ejection Fraction (HFrEF) according to participants genetics.
- Trial name
- NCT07490067
- Testing
- Metoprolol Succinate, Beta-Blocker Polygenic Score, Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Heart Failure, Cardiovascular Risk Factor
Feasibility of the Implementation of Tools for Heart Failure Risk Prediction
The purpose of this study is to gather information to develop a heart failure screening and prevention program.
- Trial name
- FIT-HF (NCT04684264)
- Testing
- Heart Failure Prevention Clinic
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Northwestern University
Acute Heart Failure
Acute Heart Failure - COngestion Repeated Evaluation (AHF-CORE)
The AHF-CORE study is a prospective, non-randomized, multicenter regional study. The main objective of the AHF-CORE study is to identify congestion markers (clinical, biological and ultrasound) at the beginning and at the end of…
- Trial name
- AHF-CORE (NCT03327532)
- Testing
- Clinical examination centered on congestion, Cardio-pulmonary and peritoneal ultrasound, Blood sample retrieved for biological assessment and biobanking
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Central Hospital, Nancy, France
Chronic Obstructive Pulmonary Disease, Heart Failure
Multidimensional Approach for COPD and High Complexity
The MACH Study trial will examine the impact on high complexity COPD patients of a multidimensional approach (moderate-intensity physical activity program and clinic-therapeutic re-evaluation of the participants)
- Conditions
- Chronic Obstructive Pulmonary Disease, Heart Failure, Chronic Disease
- Trial name
- MACH (NCT04986332)
- Testing
- Physical activity program, Global therapeutic remodeling
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Heart Failure, Heart Failure With Preserved Ejection Fraction
Empagliflozin on the Function of Left Atrium in Heart Failure With Mildly Reduced or Preserved Ejection Fraction
The number of heart failure with mildly reduced or preserved ejection fraction gradually increases. SGLT2-i has been shown to reduce the risk of hospitalization for heart failure and cardiovascular death among patients with…
- Conditions
- Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction
- Trial name
- NCT05600387
- Testing
- Empagliflozin 10 MG
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhijun Sun
Acute Coronary Syndrome, Heart Failure
Impact of COVID19 Outbreak in Cardiac Acute Care
This registry will evaluate the impact of the COVID19 outbreak on Cardiac patients admitted in the Intensive Care Unit of the Pitie-Salpetriere Hospital in Paris, France
- Conditions
- Acute Coronary Syndrome, Heart Failure, COVID
- Trial name
- CCU-COVID19 (NCT04344912)
- Testing
- Data collection
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris