Clinical trials: Heart Failure NYHA Class II
Heart Failure
QUantum Genomics Incremental Dosing in Heart Failure - QUID-HF
Heart Failure (HF) a common clinical condition characterized by either by a heart that does not pump sufficiently or becomes stiff. A variety of mechanisms contribute to progressive cardiac remodeling and dysfunction.
- Trial name
- QUID-HF (NCT02780180)
- Testing
- QGC001
- Where
- 23 sites in Czechia, France and 6 more
- Volunteers
- 23 people
- Sponsor
- Quantum Genomics SA
Heart Failure NYHA Class II, Heart Failure NYHA Class III
CardioMEMS HF System Real-World Evidence Post-Approval Study
The purpose of this post-approval study (PAS) is to evaluate the long-term safety and effectiveness of the CardioMEMS™ HF System using real-world evidence (RWE) methods.
- Trial name
- NCT06306573
- Testing
- CardioMEMS HF System
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Heart Failure With Reduced Ejection Fraction
Gender-Based Differences in Heart Failure Hospitalizations Among Patients With Heart Failure Treated With Spironolactone
Aldosterone antagonists or mineralocorticoid receptor antagonists (MRAs) are used as therapeutic agents for the management of HF with reduced ejection fraction (HFrEF).
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure NYHA Class II, Heart Failure NYHA Class III
- Trial name
- NCT06641284
- Testing
- Spironolactone
- Where
- Saudi Arabia
- Volunteers
- 509 people
- Sponsor
- Ahmad Abdullah Salawi
Heart Failure, Heart Failure NYHA Class II
Heart Failure Management for Patient With CIED Remotely Monitored
This randomized, controlled, open-label, parallel, multicenter clinical study evaluates the efficacy of SmartSignalHF compared with heart failure (HF) remote monitoring (RM) standard of care in implanted patients with heart…
- Conditions
- Heart Failure, Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure With Reduced Ejection Fraction (HFrEF)
- Trial name
- PROACT-HF (NCT07247032)
- Testing
- SmartSignalHF, HF RM standard of care
- Where
- France
- Volunteers
- 1,132 people
- Sponsor
- Implicity
Chronic Illness, NYHA Class II-IV Heart Failure
Addressing Pain Through Navigator-Led Palliative Care Optimized for Heart Failure (ADAPT-HF)
Using the MOST framework, factorial pilot design, and an iterative, community-based process, the purpose of this study is to pilot test to further develop and refine a palliative care (PC) intervention addressing pain of Black…
- Trial name
- ADAPT HF (NCT06270875)
- Testing
- ADAPT HF
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Heart Failure NYHA Class II, Heart Failure NYHA Class III
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2…
- Conditions
- Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure
- Trial name
- NCT05934487
- Testing
- Cordella™ Pulmonary Artery Sensor System
- Where
- 48 sites in United States, Belgium and 1 more
- Volunteers
- 1,750 people
- Sponsor
- Endotronix, Inc.
Heart Failure NYHA Class II, Heart Failure NYHA Class III
A Study to Improve Physician-Youth Communication and Medical Decision Making
The goal of this study is improving patient-centered communication for young people with advanced heart disease.
- Conditions
- Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
- Trial name
- CHATT (NCT05835063)
- Testing
- We Chatt communication tool, Usual/standard care
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Michigan
Heart Failure, NYHA Class II Heart Failure
Dietary Tracking in Heart Failure
Emerging evidence links ultra processed foods (UPFs) to adverse cardiovascular outcomes. UPFs are often high in sodium, unhealthy fats and added sugars, while being low in essential nutrients and fiber.
- Conditions
- Heart Failure, NYHA Class II Heart Failure, NYHA Class III Heart Failure
- Trial name
- DOTTIE (NCT07649148)
- Testing
- Limiting Ultraprocessed Food (UPF) in Diet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Heart Failure, Congestive
Resynchronization/Defibrillation for Ambulatory Heart Failure Trial
Congestive heart failure (CHF) is a common health problem that leads to frequent hospitalizations and an increased death rate. In spite of advances in drug therapy, it remains a significant public health problem.
- Trial name
- RAFT (NCT00251251)
- Testing
- Optimal Medical Therapy plus ICD, Optimal Medical Therapy plus CRT/ICD
- Where
- 33 sites in Australia, Belgium and 5 more
- Volunteers
- 1,798 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Congestive Heart Failure
Safety and Efficacy Study of Once and Twice Daily Doses of MCC-135 in Subjects With Congestive Heart Failure.
The purpose of this study is to determine the effect of two different doses of MCC-135, once daily (QD) or twice daily (BID), on the disease state and the quality of life in subjects with congestive heart failure.
- Trial name
- NCT00050076
- Testing
- MCC-135
- Where
- 53 sites in United States
- Volunteers
- 204 people
- Sponsor
- Takeda
Congestive Heart Failure
Add-on Aliskiren Treatment in Patients With Chronic Congestive Heart Failure
Aliskiren is a potent direct renin inhibitor and has been recently shown to have favorable neurohumoral effects in patients with heart failure (HF) Objective：To study the effects of add-on aliskiren treatment in patients with HF…
- Trial name
- NCT01040494
- Testing
- Aliskiren
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Rehabilitation With CHF; NYHA Class I or II
Baduanjin Exercise for Patients With Chronic Heart Failure on Phase II Cardiac Rehabilitation
Chronic heart failure (CHF) is the end stage of various kinds of cardiovascular diseases with high mortality. After a long period of medical treatment or surgical treatment, patients suffered great pain physically and mentally.
- Trial name
- BEPCR (NCT03229681)
- Testing
- Baduanjin exercise, Routine rehabilitation group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Chronic Heart Failure, Coronary Heart Disease (CHD)
Real-World Effectiveness and Costs of Yiqi Fumai Lyophilized Injection in Coronary Heart Disease-Related Chronic Heart Failure
This two-center retrospective cohort study will use de-identified electronic health records from June 1, 2021 through June 1, 2026 to compare patients with coronary heart disease-related chronic left ventricular dysfunction or…
- Trial name
- NCT07841275
- Testing
- Yiqi Fumai Lyophilized Injection
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- China Academy of Chinese Medical Sciences
Heart Failure With Reduced Ejection Fraction, Heart Failure NYHA Class II
Yoga Based Cardiac Rehabilitation in Heart Failure Failure
The clinical study compares the benefits of yoga based rehabilitation programme versus an educational package during recovery of patients with heart failure.
- Conditions
- Heart Failure With Reduced Ejection Fraction, Heart Failure NYHA Class II, Heart Failure NYHA Class III
- Trial name
- Yoga-CaRe HF (NCT07817589)
- Testing
- Yoga-CaRe HF, Health Education
- Where
- 16 sites in India
- Volunteers
- 3,500 people
- Sponsor
- Centre for Chronic Disease Control, India
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Optimization of STAR
The aim of this study is optimize the STAR (SympTom mAnagement self-caRe) intervention to support patients with HF in staying healthy, and particularly in self-monitoring and managing symptoms.
- Trial name
- STAR (NCT07065578)
- Testing
- STAR condition 1, STAR condition 2, STAR condition 3
- Volunteers
- 320 people
- Sponsor
- UMC Utrecht
Heart Failure NYHA Class II
The Effect of Chan-Chuang Qigong on Fatigue, Exercise Capacity and Quality of Lifpatients With Heart Failure
This study aimed to investigate the impact of Chan-Chuang Qigong on fatigue, exercise capacity, quality of life, and heart function in heart failure patients.
- Trial name
- NCT06521281
- Testing
- Chan-Chuang qigong
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- Chia-Lin Hsieh
Congestive Heart Failure
A Study Investigating the Safety, Tolerability, and Pharmacokinetics of MTP-131 in Subjects With Congestive Heart Failure
This is a Phase 1, single-center, randomized, double-blind, single ascending dose, placebo-controlled study, in subjects aged 45-80 years with stable mild to moderate heart failure due to left ventricular systolic dysfunction, to…
- Trial name
- NCT02388464
- Testing
- MTP-131
- Where
- Bulgaria
- Volunteers
- 36 people
- Sponsor
- Stealth BioTherapeutics Inc.
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Biomarker Study: Heart Failure Patients at Risk
In order to determine if NfL can be a prognostic biomarker for VCID, participants will undergo a baseline evaluation consisting of neuropsychological testing and a blood draw with a 12-month follow-up consisting of…
- Conditions
- Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
- Trial name
- NCT05336175
- Testing
- Angiotensin 1-7, Saline solution
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Arizona
Heart Failure NYHA Class I, Heart Failure NYHA Class II
Future Patient - Telerehabilitation of Heart Failure Patients
The idea behind the Future Patient research project is to develop a telerehabilitation program and tools for patients with heart failure.
- Conditions
- Heart Failure NYHA Class I, Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
- Trial name
- NCT03388918
- Testing
- Telerehabilitation
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Aalborg University
Heart Failure, Heart Failure NYHA Class IV
Association Between the Sit-To-Stand Test and the Prognosis of Patients With Heart Failure
Introduction: Heart failure (HF), among cardiovascular diseases, is the disease that has been increasing its incidence and prevalence the most in recent years in the world population, due to the aging of the population.
- Conditions
- Heart Failure, Heart Failure NYHA Class IV, Heart Failure; With Decompensation, Heart Failure NYHA Class III
- Trial name
- NCT07045649
- Testing
- 1-minute sit-to-stand test
- Where
- Brazil
- Volunteers
- 68 people
- Sponsor
- Centro Universitário Augusto Motta