Clinical trials: Heart Failure NYHA Class II, active
Heart Failure, Heart Failure NYHA Class II
Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure
The purpose of BENEFIT-HF is to demonstrate the safety and effectiveness of Baroreflex Activation Therapy (BAT) with the Barostim System in participants with heart failure, defined as NYHA Functional Class II or III, LVEF < 50%…
- Conditions
- Heart Failure, Heart Failure NYHA Class II, Heart Failure NYHA Class III
- Trial name
- BENEFIT-HF (NCT07232030)
- Testing
- Barostim System, Usual care medical management
- Where
- 20 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- CVRx, Inc.
Heart Failure and Preserved Ejection Fraction, Heart Failure New York Heart Association Class III
PrEcision Pacing in HFpEF: the PEP-HFpEF Trial
The PEP-HFpEF study is a prospective, single-center mechanistic study evaluating personalized heart rate pacing (myPACE) in patients with heart failure with preserved ejection fraction (HFpEF) and existing cardiac physiologic…
- Conditions
- Heart Failure and Preserved Ejection Fraction, Heart Failure New York Heart Association Class III, Heart Failure New York Heart Association (NYHA) Class II
- Trial name
- NCT07864558
- Testing
- Individualized myPACE pacemaker programming
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Tufts Medical Center
Heart Failure, NYHA Class III Heart Failure
NORM-HF Pivotal Study
This is an international, multi-center, prospective, randomized, open-label blinded endpoint study designed to demonstrate that use of the FIRE1 NORM™ System in the management of New York Heart Association Class II/III HF…
- Conditions
- Heart Failure, NYHA Class III Heart Failure, NYHA Class II Heart Failure
- Trial name
- NORM-HF (NCT07574593)
- Testing
- IVC Sensor
- Where
- 25 sites in United States
- Volunteers
- 800 people
- Sponsor
- Foundry Innovation & Research 1, Limited (FIRE1)
Heart Failure, NYHA Class II Heart Failure
Dietary Tracking in Heart Failure
Emerging evidence links ultra processed foods (UPFs) to adverse cardiovascular outcomes. UPFs are often high in sodium, unhealthy fats and added sugars, while being low in essential nutrients and fiber.
- Conditions
- Heart Failure, NYHA Class II Heart Failure, NYHA Class III Heart Failure
- Trial name
- DOTTIE (NCT07649148)
- Testing
- Limiting Ultraprocessed Food (UPF) in Diet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Heart Failure With Reduced Ejection Fraction, Heart Failure NYHA Class II
Yoga Based Cardiac Rehabilitation in Heart Failure Failure
The clinical study compares the benefits of yoga based rehabilitation programme versus an educational package during recovery of patients with heart failure.
- Conditions
- Heart Failure With Reduced Ejection Fraction, Heart Failure NYHA Class II, Heart Failure NYHA Class III
- Trial name
- Yoga-CaRe HF (NCT07817589)
- Testing
- Yoga-CaRe HF, Health Education
- Where
- 16 sites in India
- Volunteers
- 3,500 people
- Sponsor
- Centre for Chronic Disease Control, India
Heart Failure, Heart Failure NYHA Class IV
Association Between the Sit-To-Stand Test and the Prognosis of Patients With Heart Failure
Introduction: Heart failure (HF), among cardiovascular diseases, is the disease that has been increasing its incidence and prevalence the most in recent years in the world population, due to the aging of the population.
- Conditions
- Heart Failure, Heart Failure NYHA Class IV, Heart Failure; With Decompensation, Heart Failure NYHA Class III
- Trial name
- NCT07045649
- Testing
- 1-minute sit-to-stand test
- Where
- Brazil
- Volunteers
- 68 people
- Sponsor
- Centro Universitário Augusto Motta
Heart Failure NYHA Class II, Heart Failure NYHA Class III
CardioMEMS HF System Real-World Evidence Post-Approval Study
The purpose of this post-approval study (PAS) is to evaluate the long-term safety and effectiveness of the CardioMEMS™ HF System using real-world evidence (RWE) methods.
- Trial name
- NCT06306573
- Testing
- CardioMEMS HF System
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Abbott Medical Devices
Heart Failure NYHA Class II, Heart Failure NYHA Class III
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
This is a prospective, multi-center, open label, randomized control clinical trial evaluating the safety and efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2…
- Conditions
- Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure
- Trial name
- NCT05934487
- Testing
- Cordella™ Pulmonary Artery Sensor System
- Where
- 48 sites in United States, Belgium and 1 more
- Volunteers
- 1,750 people
- Sponsor
- Endotronix, Inc.
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Early Metabolic Adaptations to SGLT2 Inhibition in Heart Failure
The goal of this observational study is to learn about SGLT2 inhibition medications in patients with symptomatic heart failure who are clinically prescribed FDA-approved SGLT2 inhibitors.
- Conditions
- Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure
- Trial name
- EMAS-HF (NCT05885607)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Heart Failure, Heart Failure NYHA Class I
Promoting Well-being and Health in Heart Failure
The focus of this study is to test the efficacy of a 12-week, phone-delivered Positive Psychology-Motivational Interviewing (PP-MI) intervention, with additional twice weekly PP and health behavior text messages for a total of 24…
- Conditions
- Heart Failure, Heart Failure NYHA Class I, Heart Failure NYHA Class II, Heart Failure NYHA Class III
- Trial name
- NCT04829617
- Testing
- PP-MI Intervention, MI-alone Intervention
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Massachusetts General Hospital
Heart Failure, Heart Failure NYHA Class II
Heart Failure Management for Patient With CIED Remotely Monitored
This randomized, controlled, open-label, parallel, multicenter clinical study evaluates the efficacy of SmartSignalHF compared with heart failure (HF) remote monitoring (RM) standard of care in implanted patients with heart…
- Conditions
- Heart Failure, Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure With Reduced Ejection Fraction (HFrEF)
- Trial name
- PROACT-HF (NCT07247032)
- Testing
- SmartSignalHF, HF RM standard of care
- Where
- France
- Volunteers
- 1,132 people
- Sponsor
- Implicity
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Optimization of STAR
The aim of this study is optimize the STAR (SympTom mAnagement self-caRe) intervention to support patients with HF in staying healthy, and particularly in self-monitoring and managing symptoms.
- Trial name
- STAR (NCT07065578)
- Testing
- STAR condition 1, STAR condition 2, STAR condition 3
- Volunteers
- 320 people
- Sponsor
- UMC Utrecht
Heart Failure New York Heart Association (NYHA) Class II, Heart Failure New York Heart Association (NYHA) Class III
Exercise Intervention in Patients With Heart Failure With Preserved and Reduced Ejection Fraction
The objective of this study is to assess by what physiological mechanisms patients with heart failure benefit from exercise. Effects of an exercise intervention will be assessed for both central (heart and lungs) and peripheral…
- Trial name
- NCT05255172
- Testing
- Supervised Exercise
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Region Skane
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Baduanjin-eight-silken-movement With Self-efficacy Building for Patients With Chronic Heart Failure (BESMILE-HF Study)
Chronic heart failure (CHF) is a major and growing public health problem and poses economic burden on the society. There is a need for a safe, equipment-free, low-cost, and easily implemented exercise-based cardiac rehabilitation…
- Conditions
- Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure
- Trial name
- BESMILE-HF (NCT03180320)
- Testing
- BESMILE-HF program, Usual medications
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Heart Failure NYHA Class II, Heart Failure NYHA Class III
Comprehensive Hybrid Cardiac Rehabilitation Trial on Heart Failure
CO-CREATION-HF aims to evaluate the effectiveness of a comprehensive and hybrid cardiac rehabilitation model compared to supervised exercise alone.
- Trial name
- COCREATIONHF (NCT06313684)
- Testing
- Comprehensive Initial Assessment, Continuous evaluation, Interval Exercise
- Where
- 4 sites in Chile
- Volunteers
- 152 people
- Sponsor
- Universidad de La Frontera
Vascular Disease, Cardiovascular
A Preventive, Multidisciplinary Primary Care Intervention Organized Around a Therapeutic Garden: Acceptability to Patients Suffering from Cardio-neurovascular Pathology and to Those Involved in the Action.
A preventive, multidisciplinary primary care intervention organized around a therapeutic garden: Acceptability to patients suffering from cardio-neurovascular pathology and to those involved in the action.
- Conditions
- Vascular Disease, Cardiovascular, Atrial Fibrillation (AF), Heart Failure NYHA Class II
- Trial name
- ArTERRE (NCT06646601)
- Testing
- Intervention of prevention
- Where
- France
- Volunteers
- 157 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Ischemic Heart Disease, Ischemic Cardiomyopathy
Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery
Ischemic heart disease (IHD) leads the global mortality statistics. Atherosclerotic plaques in coronary arteries hallmark IHD, drive hypoxia, and may rupture to result in myocardial infarction (MI) and death of contractile…
- Conditions
- Ischemic Heart Disease, Ischemic Cardiomyopathy, Heart Failure, Systolic, Heart Failure NYHA Class III
- Trial name
- AAMS2 (NCT05632432)
- Testing
- Epicardial AAMs-patch transplantation, RNA-stabilized whole blood sampling, Plasma sampling
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Hospital District of Helsinki and Uusimaa