Clinical trials: Heart Failure Patients
Cardiac Failure, Systolic Heart Failure
Ferric Carboximaltose on Intra-myocardial Iron Load in Patients With Heart Failure
In general, anemia is associated with a greater presence of HF symptoms, worsening NYHA functional class, higher rate of hospitalization for heart failure, and reduced survival.
- Conditions
- Cardiac Failure, Systolic Heart Failure, Heart Failure, Systolic
- Trial name
- IronHeart (NCT03871699)
- Testing
- Ferric carboxymaltose
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital Moinhos de Vento
Nutrition, Heart Failure
Nutritional Orientations and Adherence, Nutritional Status, Clinical and Life Quality Parameters of Heart Failure (HF) Patients
The nutritional systematic orientations in outpatients with heart failure throughout 1 year in comparison to conventional treatment is estimated to lead to higher nutritional treatment adherence and improved nutritional status…
- Trial name
- NCT00957814
- Testing
- Nutritional education
- Volunteers
- 46 people
- Sponsor
- Federal University of Rio Grande do Sul
CHF
Effects of Remote Monitoring of Patients With Heart Failure Based on Smartphone Application
CHF is a most wild-spread and prognostically poor outcome most of cardiovascular and other disease. Despite of significant progress in treatment of CHF for the last years, death from this pathology stayed very high, reaching 60%…
- Trial name
- ERICA-HF (NCT04591964)
- Testing
- mobile application "M-Cardio" based on android
- Where
- Kyrgyzstan
- Volunteers
- 300 people
- Sponsor
- National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Heart Failure, Chronic Kidney Diseases
Creating A Cardiorenal Multidisciplinary Team for Management HF and CKD Patients
Several drugs have been labeled as guideline-directed-medical therapies (GDMT) to improve overall health outcomes and slow the progression of disease in patients with heart failure (HF).
- Trial name
- NCT05531214
- Testing
- Multidisciplinary Care Coordination Team
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- George Washington University
Chronic Heart Failure (CHF), Iron Deficiency
Evaluation on Performance and Oxydative Stress in Patient With Iron deficIency and Stable Heart Failure Study
ERADAL-HF is a double blinded, multi-centre, prospective, randomized, three arm study, enrolled ambulatory patients with chronic heart failure [New York Heart Association (NYHA) class II/III], with iron deficiency [defined as…
- Trial name
- ERADAL-HF (NCT04225728)
- Testing
- Iron Sucrose IV, Ferric polymaltose hydroxide complex IM, Saline solution
- Where
- Cameroon
- Volunteers
- 45 people
- Sponsor
- CN NGANOU-GNINDJIO, MD, MSc
Heart Failure
Medication Adherence Telemonitoring to Reduce Heart Failure Readmissions
The overall purpose of this project is to determine the feasibility of conducting a large scale randomized clinical trial that compares remote monitoring of adherence to loop diuretics using a wireless electronic pillcap with…
- Trial name
- TEAM-HF (NCT02378571)
- Testing
- Medication adherence telemonitoring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Columbia University
Depression, Stage B Heart Failure
The Light Heart Study: Daily Light Box Use for Depressive Symptoms in Patients With Stage B Heart Failure
The Light-Heart study is a randomized, double-blind, controlled trial investigating the effects of bright white light (BWL) therapy on depressive symptoms, quality of life, and functioning in patients with Stage B heart failure.
- Trial name
- Light-Heart (NCT02691000)
- Testing
- LiteBook
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Acute Heart Failure
Efficacy and Safety of corticoSTEROids Added to Standard Therapy in Patients With Acute Heart Failure (STERO-AHF)
STERO-AHF is a pilot, prospective, multicenter, randomized, open-label, controlled study aimed to evaluate the diuretic efficacy and early clinical benefit of corticosteroid therapy administered for 7 days, in addition to…
- Trial name
- STERO-AHF (NCT05809011)
- Testing
- Dexamethasone, Prednisone
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Heart Failure
Evaluation of Clinical and Genetic Modifiers of Long-term Survival in Heart Failure
The purpose of this study is to evaluate the beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade in patients with chronic heart failure.
- Trial name
- NCT03461107
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Tongji Hospital
Acute Heart Failure, Acute Decompensation of Chronic Heart Failure
Tezosentan in Acute Heart Failure
The randomized patients with acute heart failure will be stratified based on the presence or absence of a Swan-Ganz catheter and assigned to receive either tezosentan 5 mg/h for the first 30 minutes and 1 mg/h thereafter or…
- Conditions
- Acute Heart Failure, Acute Decompensation of Chronic Heart Failure, New Onset of Heart Failure
- Trial name
- VERITAS 1 (NCT00525707)
- Testing
- tezosentan
- Where
- 35 sites in United States, Austria and 8 more
- Volunteers
- 735 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Atrial Fibrillation, End Stage Renal Disease
Trial to Evaluate Anticoagulation Therapy in Hemodialysis Patients With Atrial Fibrillation
This is a prospective, randomized, open-label, blinded end-point evaluation trial. The patient population consists of patients on hemodialysis who have atrial fibrillation (AF) and end-stage renal disease (ESRD) .
- Trial name
- RENAL-AF (NCT02942407)
- Testing
- apixaban, warfarin
- Where
- 58 sites in United States
- Volunteers
- 154 people
- Sponsor
- Christopher Granger, MD
Bradyarrhythmia, Atrioventricular Block
PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial
PROTECT-SYNC study is a multicenter, randomized, controlled trial. A total of 7 medical centers across Republic of Korea will enroll 450 patients during 2 years of enrollment period, and followed for 2 years of follow-up period.
- Conditions
- Bradyarrhythmia, Atrioventricular Block, Left Bundle Branch Area Pacing
- Trial name
- NCT05585411
- Testing
- Left bundle branch area pacing, Right ventricular pacing
- Where
- 8 sites in South Korea
- Volunteers
- 450 people
- Sponsor
- Yonsei University
Depression, Heart Failure
Personalized Treatments for Depressive Symptoms in Patients With Advanced Heart Failure
We are doing this study to help patients, caregivers, and providers make decisions about how best to manage depressive symptoms in advanced heart failure.
- Trial name
- NCT03688100
- Testing
- Behavioral Activation Therapy, Medication Management
- Where
- United States
- Volunteers
- 494 people
- Sponsor
- Cedars-Sinai Medical Center
Left Ventricular Ejection Fraction Less Then or Equal to 50percent
Left Bundle Branch Area Pacing in Heart Failure Patients With Ejection Fraction Below Normal
While cardiac resynchronization therapy remains the mainstay for advanced HF, it is not always feasible due to unfavorable anatomy of coronary sinus or pacing characteristics.
- Trial name
- NCT06148571
- Testing
- left bundle branch area pacing
- Where
- South Korea
- Volunteers
- 142 people
- Sponsor
- Seoul National University Hospital
Chronic Heart Failure
Hospital-Community-Family-Care Management Platform for Chronic Heart Failure
The purpose of this study is to determine whether the Hospital-Community-Family-Care Management Platform for Chronic Heart Failure reduces the mortality, readmission rates and costs of the subjects with CHF.
- Trial name
- HCF-CMP-CHF (NCT02029287)
- Testing
- Hospital-Community-Family-Care Management Platform Online, Subjects with CHF via conventional clinic visit according to the latest relevant guidelines
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xiang Gu
Infection, Hypervolemia
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the…
- Conditions
- Infection, Hypervolemia, Hypovolemia, Septic Shock
- Trial name
- PIVA (NCT03736421)
- Testing
- Peripheral Intravenous Analysis (PIVA), Non-invasive fluid response measure, Passive leg raise (PLR)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Heart Failure
Impact of Exercise Training on Exercise Capacity in Patients With Severe Chronic Heart Failure
Patients with heart failure are limited in their exercise capacity due to skeletal muscle alteration and an impairment of peripheral perfusion.
- Trial name
- NCT00176384
- Testing
- Aerobic endurance exercise training (ergometer)
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University of Leipzig
Heart Failure, Systolic, Pulmonary Disease
Robotic-assisted Exercise Training in Heart Failure
Background: Regular physical activity is an evidence-based adjuvant therapy of chronic heart failure or chronic lung diseases. Structured exercise training is safe, increases exercise capacity and quality of life, relieves…
- Trial name
- NCT04839133
- Testing
- MyoSuitFeasibility
- Where
- 2 sites in Germany
- Volunteers
- 30 people
- Sponsor
- German Heart Institute
Acute Decompensated Heart Failure (ADHF)
The Effect of Dapagliflozin on Patients With Cardiomyopathy
This randomized controlled trial evaluates the efficacy and tolerability of early initiation of dapagliflozin in adult patients hospitalized with acute heart failure (AHF).
- Trial name
- Dapagliflozin (NCT07076615)
- Testing
- Dapagliflozin (DAPA), Diuretic
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- May Mohamed Abdalla
Strength Training Effects, HFrEF - Heart Failure With Reduced Ejection Fraction
Eccentric Muscle Training in Cardiac Rehabilitation
The goal of this interventional study is to assess the training effects in a training schedule in which eccentric overload training and eccentric cycle training are used.
- Trial name
- NCT07636343
- Testing
- eccentric bike training, eccentric overload training, aerobic treadmill training
- Where
- Belgium
- Volunteers
- 3 people
- Sponsor
- University Hospital, Antwerp