Clinical trials: Heart Failure Systolic
Heart Failure, Systolic, Iron Deficiency
Intravenous Iron in paTients With Heart failURe and Reduced Ejection fracTion (HFREF) pLus Iron dEficiency
Effects of ferric carboxymaltose single HD (1000 mg) infusion upon FGF23 in patients with isolated HFREF compared to patients with HFREF+CKD (all pts with iron deficiency).
- Trial name
- Iron Turtle (NCT03079518)
- Testing
- Ferric Carboxymaltose, blood withdrawal
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- RWTH Aachen University
Chronic Systolic Heart Failure
Renal Artery Denervation in Chronic Heart Failure Study
The REACH study, is a prospective, double-blinded, randomised, controlled study of the safety and effectiveness of renal denervation in subjects with chronic systolic heart failure.
- Trial name
- REACH (NCT01639378)
- Testing
- Renal Denervation
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- Imperial College London
Heart Failure, Ischemic Heart Disease
Acute Effect of Strength Training on Blood Pressure in Cardiac Patients
Moderate and heavy strength training exercise and the acute blood pressure rise in cardiac patient, how high?
- Conditions
- Heart Failure, Ischemic Heart Disease, Heart Transplant Recipients
- Trial name
- NCT01912248
- Testing
- strength training
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Christian Dall
Atrial Fibrillation (AF), Heart Failure and Reduced Ejection Fraction
Wearable Device-Assisted Remote Management to Improve Prognosis in Patients With Acute Heart Failure Complicated by Atrial Fibrillation: WARM-HF Trial (Stage 2)
With the advancement of wearable technology, continuous non-invasive monitoring of vital signs, arrhythmia burden, and physical status has become increasingly feasible.
- Trial name
- NCT07687862
- Testing
- wearable device based remote management (GDMT titration for HF, rhythm control and anticoagulation management for AF)
- Volunteers
- 818 people
- Sponsor
- Beijing Anzhen Hospital
Heart Failure
RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure
BRITISH is a UK multicentre trial of patients who have been diagnosed with heart failure due to Non-Ischemic Cardiomyopathy (NICM, or heart failure that is not caused by blocked heart arteries.
- Trial name
- BRITISH (NCT05568069)
- Testing
- Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronisation Therapy Defibrillator (CRTD)
- Where
- 47 sites in United Kingdom
- Volunteers
- 2,504 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Heart Failure and Reduced Ejection Fraction, NYHA Class III Heart Failure
Propensity-Matched Study of Cardiac Contractility Modulation Therapy in Heart Failure
The purpose of this prospective, multi-center, propensity-matched coverage with evidence development (CED) study is to assess the impact of cardiac contractility modulation (CCM) on mortality and heart failure hospitalizations in…
- Trial name
- BRIGHTEN-HF (NCT07209098)
- Testing
- Cardiac Contractility Modulation (CCM)
- Where
- United States
- Volunteers
- 4,200 people
- Sponsor
- Impulse Dynamics
Diet, Sodium-Restricted, Heart Failure, Systolic
Effect of Sodium Intake on Brain Natriuretic Peptide Levels in Patients With Heart Failure
The SODA-HF trial is a randomized, double-blind, controlled trial to evaluate the effect of moderate to severe sodium restriction on brain natriuretic peptide in patients with heart failure and reduced ejection fraction (less…
- Conditions
- Diet, Sodium-Restricted, Heart Failure, Systolic, Natriuretic Peptide, Brain, Clinical Trial
- Trial name
- SODA-HF (NCT03351283)
- Testing
- Severe sodium restriction, Moderate sodium restriction
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Instituto Mexicano del Seguro Social
Psoriasis, Cardiovascular Diseases
Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis
In a prospective cohort study (n = 1.000), the investigators aim to investigate the correlation between cardiac biomarkers and advanced echocardiography and determine whether these are prognostic markers of heart disease in…
- Conditions
- Psoriasis, Cardiovascular Diseases, Cardiovascular Risk Factor, Cardiovascular Pathology
- Trial name
- PSOCADIA (NCT04950218)
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Herlev and Gentofte Hospital
Heart Failure, Systolic
Mechanistic Clinical Trial of Advanced Imaging for CRT
This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.
- Trial name
- NCT03398369
- Testing
- CMR/CTA Guidance for CRT
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Virginia
Congestive Heart Failure
REGISTRY EVALUATION OF VITAL INFORMATION FOR VADs IN AMBULATORY LIFE
REVIVAL will establish a prospective, observational, multicenter patient cohort in ambulatory patients with chronic, advanced, systolic heart failure that will provide a greater understanding of their clinical trajectory (rates…
- Trial name
- REVIVAL (NCT01369407)
- Testing
- No Intervention
- Where
- 21 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Michigan
Diastolic Heart Failure
If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure
The purpose of this study is to investigate whether the medicine ivabradine, a novel drug which slows the heart rate has a favourable effect on patients with diastolic heart failure.
- Trial name
- NCT00757055
- Testing
- Ivabradine
- Where
- Ireland
- Sponsor
- St Vincent's University Hospital, Ireland
Heart Failure, Atrial Fibrillation
Digoxin Versus Ivabradine in Heart Failure With Preserved Systolic Function
This is an investigator-started study. The trial is coded as no. GC\&PJ-Dig-Iva2009-2012. The authors have no conflict of interest and there was no financial sponsoring The study was planned according to the Good Clinical Quality…
- Trial name
- DIGvsIVA (NCT01796093)
- Testing
- Digoxin and ivabradine
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Cocco, Giuseppe, M.D.
Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
Researchers are looking for a better way to treat children who have heart failure with left ventricular systolic dysfunction (LVSD).
- Trial name
- FIORE (NCT07188805)
- Testing
- Finerenone (Kerendia, BAY94-8862)
- Where
- 133 sites in United States, Argentina and 21 more
- Volunteers
- 111 people
- Sponsor
- Bayer
Heart Failure, Congestive, Sleep Apnea Syndromes
Effects of Adaptive Servoventilation in Patients With Systolic Heart Failure and Sleep-Disordered Breathing
Prospective, follow-up registry of heart failure patients with or without sleep-disordered breathing (SDB). To test the hypothesis that treatment of nocturnal central sleep apnea with Cheyne-Stokes respiration by adaptive…
- Conditions
- Heart Failure, Congestive, Sleep Apnea Syndromes, Adaptive Servoventilation
- Trial name
- NCT01657188
- Testing
- Cheyne-Stokes respiration by adaptive servoventilation
- Where
- Germany
- Volunteers
- 550 people
- Sponsor
- Ruhr University of Bochum
Heart Failure, Systolic, Renal Disease, End Stage
Interleukin-1 Blockade for the Treatment of Heart Failure in Patients With Advanced Chronic Kidney Disease
Interleukin-1 blockade for the treatment of heart failure in patients with advanced chronic kidney disease (End-stage renal disease and Heart fAilure - Anakinra Remodeling Trial) is a Phase 2, single-arm trial designed to…
- Conditions
- Heart Failure, Systolic, Renal Disease, End Stage, Chronic Kidney Diseases
- Trial name
- E-HART (NCT03062176)
- Testing
- Anakinra
- Sponsor
- Virginia Commonwealth University
Heart Failure, Systolic
TRANSFORM Heart Failure with Reduced Ejection Fraction
The goal of the TRANSFORM-HFrEF trial will be to study the current guideline-directed medical therapy (GDMT) landscape for HFrEF and determine effective methods and models of increasing adherence to GDMT and improving Quality of…
- Trial name
- TRANSFORMHFrEF (NCT04872959)
- Testing
- HealthReveal
- Sponsor
- Massachusetts General Hospital