Clinical trials: Heart Failure With Preserved Ejection Fraction (HFPEF)
HFpEF - Heart Failure With Preserved Ejection Fraction
HEART Camp Connect -Promoting Exercise in Adults With Heart Failure With Preserved Ejection Fraction
The goal of this study is to learn more about patients with heart failure with preserved ejection fraction (HFpEF) and exercise.
- Trial name
- NCT05784753
- Testing
- HEART Camp, HEART Camp Connect
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Heart Failure With Preserved Ejection Fraction, Iron Deficiencies
The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life
This study will address whether the additional use of Ferric Derisomaltose on top of standard care will improve exercise capacity and quality of life in patients with acute heart failure and iron deficiency.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Iron Deficiencies, Acute Heart Failure
- Trial name
- COREVIVE-HFpEF (NCT05991128)
- Testing
- Ferric derisomaltose
- Where
- China
- Volunteers
- 170 people
- Sponsor
- China-Japan Friendship Hospital
Symptomatic Heart Failure With Preserved Ejection Fraction (HFpEF)
AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
This is a Phase 2 dose-finding study in adult participants with symptomatic HFpEF.
- Trial name
- AMBER-HFpEF (NCT06793371)
- Testing
- CK-4021586 (150 mg, 300 mg, 450 mg, and 600 mg)
- Where
- 26 sites in United States
- Volunteers
- 60 people
- Sponsor
- Cytokinetics
COPD (Chronic Obstructive Pulmonary Disease), Heart Failure With Preserved Ejection Fraction (HFpEF; Diagnosis)
Heart Failure With Preserved Ejection Fraction in Patients With Сhronic Obstructive Pulmonary Disease: Clinical Course and Prognosis
Study aim is comparison of heart failire with preserved ejection fraction (HFpEF) detection rate in patients with Сhronic Obstructive Pulmonary Disease (COPD) and the clinical course and prognosis in patients with COPD depending…
- Trial name
- HIPSTER (NCT07375433)
- Testing
- Echocardiography, Spirometry, Body plethysmography
- Where
- 2 sites in Russia
- Volunteers
- 200 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Obesity (BMI>30), Heart Failure With Preserved Ejection Fraction (HFPEF)
Pilot Study of Endoscopic Sleeve Gastroplasty for Obese Patients With Heart Failure and Preserved Ejection Fraction
This is a small research study to see whether losing weight with a minimally invasive weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can help improve symptoms of a type of heart failure called HFpEF in adults…
- Trial name
- NCT07798219
- Testing
- Endoscopic sleeve gastroplasty (ESG)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Heart Failure With Preserved Ejection Fraction
Cilostazol for HFpEF
Determine if cilostazol improves symptoms and NTproBNP levels (heart failure blood marker) in heart failure with preserved ejection fraction (HFpEF) - a prevalent syndrome without targeted evidence-based treatment.
- Trial name
- NCT05126836
- Testing
- Cilostazol 100Mg Tab
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Minnesota
Heart Failure, Diastolic (HFpEF)
Effect of Short-term Oxygen During CPET in HFpEF
In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients…
- Trial name
- NCT04157660
- Testing
- Oxygen application
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University of Zurich
Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2
Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction: Metabolic Effects. (KETO-HFpEF-Metabolic)
Heart failure (HF) is among the most common causes of death in patients with type 2 diabetes (T2D). Ketones, 3-hydroxybutyrate (3-OHB), have shown to have beneficial effects in patients with hearth failure with reduced ejection…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2, Ketonemia
- Trial name
- NCT05159570
- Testing
- Ketone ester
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Heart Failure With Preserved Ejection Fraction (HFpEF)
DETERMINE-preserved - Dapagliflozin Effect on Exercise Capacity Using a 6-minute Walk Test in Patients With Heart Failure With Preserved Ejection Fraction
International, Multicentre, Parallel-group, Randomised, Double-blind, Placebo-controlled, Phase III Study Evaluating the effect of Dapagliflozin on Exercise Capacity in Heart Failure Patients with Preserved Ejection Fraction…
- Trial name
- NCT03877224
- Testing
- Dapagliflozin
- Where
- 101 sites in United States, Argentina and 10 more
- Volunteers
- 504 people
- Sponsor
- AstraZeneca
Atrial Fibrillation, HFpEF - Heart Failure With Preserved Ejection Fraction
Catheter Ablation in Atrial Fibrillation Patients With HFpEF (STABLE-SR IV Trial)
To investigate whether RFCA is superior to AADs in AF patients with HFpEF on the basis of optimized anti-heart-failure drug therapy regarding their longterm clinical outcomes.
- Trial name
- NCT06125925
- Testing
- Radiofrequency catheter ablation (RFCA), Medical Therapy
- Where
- China
- Volunteers
- 436 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Healthy Volunteers
Multiple-ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD9977 in Healthy Male Subjects
This is a randomized, single-blind, placebo-controlled study conducted on healthy male subjects at a single study center to assess the safety, tolerability and the pharmacokinetics of AZD9977 following multiple-ascending oral…
- Trial name
- NCT03435276
- Testing
- AZD9977
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Heart Failure With Preserved Ejection Fraction
Finerenone and Cardiac Remodeling in HFpEF
This prospective randomized study aims to evaluate the efficacy of Finerenone as add-on therapy to standard of care compared to standard of care alone in preventing heart failure worsening and preserving cardiac function assessed…
- Trial name
- NCT07830940
- Testing
- Finerenone, Standard of care for HFpEF Description:
- Volunteers
- 194 people
- Sponsor
- Assiut University
Heart Failure With Preserved Ejection Fraction (HFpEF
Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF
The purpose of this clinical study is to evaluate the safety and early effectiveness of a catheter-based procedure that treats a nerve called the right greater splanchnic nerve.
- Trial name
- Rebalance-HF (NCT04592445)
- Testing
- Greater Splanchnic Nerve Ablation
- Where
- 26 sites in United States, Georgia
- Volunteers
- 150 people
- Sponsor
- Axon Therapies, Inc.
Heart Failure With Preserved Ejection Fraction
The Efficacy and Safety of Zhigancao Tang Granule for HFpEF of Qi-Yin Dificiency
This study was designed as a randomized, double blinded and placebo-controlled clinical trial. The aim of the study is to evaluate the efficacy and safety of Zhigancao Tang granule in patients with HFpEF of Qi-Yin dificiency.
- Trial name
- HFpEF (NCT04317339)
- Testing
- Zhigancao Tang granule
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Heart Failure, Heart Failure, Diastolic
MyoMobile Study: App-based Activity Coaching in Patients with Heart Failure and Preserved Ejection Fraction
The MyoMobile study is a single-center, randomized, controlled three-armed cohort study with prospective data collection to investigate the effect of a personalized mobile health intervention compared to usual care on the…
- Trial name
- MyoMobile (NCT04940312)
- Testing
- App-based physical activity coaching, No Intervention: Observational Cohort, Intervention Group 1
- Where
- Germany
- Volunteers
- 193 people
- Sponsor
- Johannes Gutenberg University Mainz
Heart Failure With Preserved Ejection Fraction
Clinical Characteristics and Predictors of Adverse Outcomes in HFpEF
Heart failure with preserved ejection fraction (HFpEF) is a prevalent form of heart failure characterized by impaired left ventricle pressures and diastolic dysfunction.
- Trial name
- NCT06228807
- Testing
- The study involved a comparison of clinical characteristics, medical history, laboratory biomarkers, echocardiographic measurements, angiographic findings, and clinical outcomes between two groups.
- Volunteers
- 584 people
- Sponsor
- Ya-Wei Xu
Heart Failure, Heart Failure Preserved Ejection Fraction
Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)
The purpose of this study is to evaluate the safety and effectiveness of tovinontrine compared to placebo to lower NT-proBNP in patients with chronic heart failure with preserved ejection fraction
- Conditions
- Heart Failure, Heart Failure Preserved Ejection Fraction, Cardiovascular Diseases, Heart Diseases
- Trial name
- Cycle-2-PEF (NCT06215586)
- Testing
- Tovinontrine (CRD-750)
- Where
- 84 sites in United States, Australia and 13 more
- Volunteers
- 303 people
- Sponsor
- Cardurion Pharmaceuticals, Inc.
Heart Failure With Preserved Ejection Fraction (HFpEF)
UK Heart Failure With Preserved Ejection Fraction
Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness.
- Trial name
- UK HFpEF (NCT05441839)
- Where
- 26 sites in United Kingdom
- Volunteers
- 10,000 people
- Sponsor
- Manchester University NHS Foundation Trust
HFpEF - Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation
AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure
The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF).
- Trial name
- AlEX-DHF (NCT06650995)
- Testing
- Exercise training
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
Heart Failure With Preserved Ejection Fraction
Endovascular GSN Ablation in Subjects With HFpEF
The purpose of this study is to evaluate the safety and potential benefits of single-side block of a nerve that connects to the intestines, liver and spleen called the "greater splanchnic nerve" for the treatments of patients…
- Trial name
- NCT04287946
- Testing
- Ablation
- Where
- 3 sites in Czechia, Georgia
- Volunteers
- 30 people
- Sponsor
- Axon Therapies, Inc.