Clinical trials: Heart Infarction
Acute Myocardial Infarction
FFR Versus Angiography-Guided Strategy for Management of AMI With Multivessel Disease
The aim of the study is to compare clinical outcomes following fractional flow reserve (FFR)-guided versus angiography only guided strategy in treatment of non-infarction related artery (non-IRA) stenosis in patients with acute…
- Trial name
- FRAME-AMI (NCT02715518)
- Testing
- PCI using 2nd generation drug-eluting stent
- Where
- South Korea
- Volunteers
- 1,292 people
- Sponsor
- Samsung Medical Center
Acute Coronary Syndrome, Depression
MBCT Delivered Via Group Videoconferencing for ACS Patients With Elevated Depression Symptoms
The objective of this study is to identify Acute Coronary Syndromes (ACS) patients' specific needs and preferences for depression treatment via in-person or virtual individual interviews to (a) guide MBCT adaptation; and identify…
- Conditions
- Acute Coronary Syndrome, Depression, Myocardial Infarction, Unstable Angina
- Trial name
- NCT03878160
- Testing
- Individual Interview
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Acute Myocardial Infarction
Dissecting the Role of Distal Embolization of Athero-thrombotic Material in Primary PCI: the ThrombOticBurden and mIcrovAscularobStruction (TOBIAS) Study.
demonstrate that FD-OCT guidance is feasible and possibly results in reduction of frequency-domain Optical Coherence Tomography-defined residual thrombus burden after thrombus-aspiration.
- Trial name
- TOBIAS (NCT01914055)
- Testing
- angio-guided thrombus aspiration (Eliminate catheter, Terumo, Tokyo, Japan), OCT-guided thrombus aspiration (Eliminate catheter, Terumo, Tokyo, Japan)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Ospedale San Donato
Cardiac Rupture
Clinical Risk Score Predicting the Cardiac Rupture in Patients With ST-elevation Myocardial Infarction
The purpose of this study is to validate a practical risk score to predict the mechanical complication of ST-elevation myocardial infarction (STEMI).
- Trial name
- NCT02484326
- Testing
- Grouping by different risk stratification
- Where
- China
- Volunteers
- 3,779 people
- Sponsor
- Chinese PLA General Hospital
Cardiogenic Shock
Early Left Ventricular unLoading by Impella vs Intra-aortic Balloon Pump
Over the past decade, VA-ECMO has become the main mechanical support for cardiogenic shock (CS) unresponsive to medical therapy.
- Trial name
- ELLIPSE1 (NCT06645990)
- Testing
- Impella, IABP
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Myocardial Infarction
AngioJET Thrombectomy and STENTing for Treatment of Acute Myocardial Infarction
The purpose of this study is to determine whether prompt removal of thrombus (blood clot) from a blocked coronary artery using the AngioJet rheolytic thrombectomy device will result in improved blood flow within the heart and a…
- Trial name
- NCT00275990
- Testing
- rheolytic thrombectomy with direct stenting, direct stenting
- Where
- Italy
- Volunteers
- 501 people
- Sponsor
- Boston Scientific Corporation
Coronary Artery Disease, Acute Coronary Syndrome
BIOSTEMI Extended Survival
The objective of the BIOSTEMI ES study is to assess the long-term clinical outcomes with the Orsiro ultrathin-strut biodegradable polymer sirolimus-eluting stent compared to the Xience thin-strut durable polymer…
- Trial name
- BIOSTEMI ES (NCT05484310)
- Where
- 10 sites in Switzerland
- Volunteers
- 1,300 people
- Sponsor
- University Hospital, Geneva
Acute Myocardial Infarction (AMI)
Prospective Cohort Study of Aging in Patients With Acute Myocardial Infarction
This is a single-center, prospective, observational cohort study designed to investigate the association between aging-related characteristics and long-term outcomes in patients with acute myocardial infarction (AMI).
- Trial name
- NCT07705997
- Where
- China
- Volunteers
- 600 people
- Sponsor
- The Affiliated Hospital of Hangzhou Normal University
Acute Coronary Syndrome
Clinical Study to Validate the Use of a New Point of Care Troponin I Test
This trial is designed as a prospective, multi-center, observational study of "all-comers" eligible adult subjects presenting to participating emergency departments with symptoms suggestive of acute coronary syndrome (ACS)
- Trial name
- NCT02620397
- Where
- 14 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Trinity Biotech
Myocardial Infarction
Post- Myocardial Infarction Arterial Wall Improvement by Low-dose Fluvastatin and Valsartan
The concept of improving arterial wall characteristics by treatment with a very low-dose combination of fluvastatin and valsartan (low-flu/val) in stable, post-myocardial infarction (MI) patients was tested.
- Trial name
- NCT03309618
- Testing
- low-dose combination of fluvastatin (10 mg) and valsartan (20 mg) (low-flu/val)
- Where
- Slovenia
- Volunteers
- 36 people
- Sponsor
- University Medical Centre Ljubljana
Silent Myocardial Infarction, Stable Angina
Comparative Phase IV Study: Efficacy And Safety of TiTAN2 Versus COBALT-CHROME Stents- EVIDENCEII
The purpose of this study is to compare the effectiveness and safety, at 24 months, of the TITAN2 stent to any bare-metal stent (BMS) in Cobalt-Chromium in a population presenting an indication for these stents among 40% of which…
- Conditions
- Silent Myocardial Infarction, Stable Angina, Acute Coronary Syndrome
- Trial name
- EVIDENCE II (NCT01918150)
- Testing
- Titan 2 stents, Cobalt-Chromium Bare Metal Stents
- Where
- 42 sites in France
- Volunteers
- 1,350 people
- Sponsor
- Hexacath, France
HIV Infection, Cardiovascular Disease
HIV Treatment and CVD Events
Cardiovascular disease (CVD) has been associated with HIV infection. However, it is uncertain whether increased CVD rates are associated with HIV-related factors (e.g., HIV-infection or highly active antiretroviral therapy…
- Conditions
- HIV Infection, Cardiovascular Disease, Infection, Human Immunodeficiency Virus, Acute Myocardial Infarction
- Trial name
- NCT01054638
- Testing
- HAART Treatment
- Sponsor
- ViiV Healthcare
Acute Coronary Syndromes
PRemature Acute Myocardial Infarction Register of Serbia
This observational multicentric national study aims to understand better acute myocardial infarction (heart attack) in young adults aged 45 years or younger in Serbia.
- Trial name
- PRAMIRS (NCT06753591)
- Where
- 11 sites in Serbia
- Volunteers
- 1,000 people
- Sponsor
- Cardiology Society of Serbia
Myocardial Infarction, Coronary Artery Disease
Routine Ultrasound Guidance for Vascular Access for Cardiac Procedures
A randomized, controlled trial to determine whether the use of ultrasound guidance for vascular access during coronary angiography or percutaneous coronary intervention (PCI) will reduce the rates of major vascular complications.
- Conditions
- Myocardial Infarction, Coronary Artery Disease, Myocardial Ischemia
- Trial name
- UNIVERSAL (NCT03537118)
- Testing
- Fluoroscopic + Ultrasound Guidance
- Where
- Canada
- Volunteers
- 621 people
- Sponsor
- Population Health Research Institute
ST Elevation Myocardial Infarction, Arrhythmia Ventricular
Different Reperfusion Timing and Ventricular Arrhythmias in STEMI Patients
The aim of this study was to investigate the association between different reperfusion timing and ventricular arrhythmias (VAs) to provide evidence for clinical decision-making for patients with ST-segment elevation myocardial…
- Trial name
- NCT04660474
- Where
- China
- Volunteers
- 517 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
ST-elevation Myocardial Infarction
Cost-effectiveness of Remote Ischemic Conditioning as an Adjunct to Primary Percutaneous Coronary Intervention
The aim of this study is to investigate the cost-effectiveness of remote ischemic conditioning as an adjunct to primary percutaneous coronary intervention from the perspective of a Danish healthcare system.
- Trial name
- NCT02431338
- Testing
- Remote ischemic conditioning
- Where
- Denmark
- Volunteers
- 333 people
- Sponsor
- University of Aarhus
Sleep Quality, Anxiety
The Effect of Music on Anxiety Levels and Sleep Quality in Patients Who Have a Myocardial Infarction
Music therapy is a non-invasive method with no side effects and can be administered independently by a nurse. Nevertheless, it should be noted that music therapy can be discontinued if any adverse effects are experienced by…
- Trial name
- Anxiety Sleep (NCT07454434)
- Testing
- Music intervention
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mersin University
Acute Myocardial Infarction
Intervention of Suxiao Jiuxin Pill on Instability of Vulnerable Plaque in Acute Myocardial Infarction
The incidence of cardiovascular disease is still high in China under the condition of non-standard treatment of Western medicine.
- Trial name
- NCT05466968
- Testing
- Suxiao Jiuxin Pills
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Xiaolu Li
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
ACS - Acute Coronary Syndrome
European Unified Registries for Heart Care Evaluation and Randomised Trials Italy
Major advances in cardiovascular medicine have been driven by innovations in basic research in biological and technical sciences.
- Trial name
- EuroHeart ITA (NCT07283809)
- Testing
- Adherence to European Society of Cardiology (ESC) quality indicators
- Where
- 57 sites in Italy
- Volunteers
- 5,000 people
- Sponsor
- Heart Care Foundation
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