Clinical trials: Heart Rate Variability, open to volunteers
Acute Decompensated Heart Failure
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF) is a major cause of morbidity and mortality. It is associated with increased systemic inflammation.
- Trial name
- TREAT-HF (NCT02898181)
- Testing
- Neuromodulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Spinal Cord Injury
Cardiovascular Autonomic Function After Resistance Training
The purpose of this clinical trial is to evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic spinal cord injury (SCI).
- Trial name
- NCT07725952
- Testing
- Upper-Limb Resistance Training
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Pusan National University Yangsan Hospital
Peripheral Neuropathy With Type 2 Diabetes
A Physiologic Comparison of Two Approaches to Treating Peripheral Neuropathy
Diabetic peripheral neuropathy is one of the most common and costly microvascular complications of diabetes impacting more than 50% of patients and costing more than 10.1 billion dollars annually.
- Trial name
- NCT05577390
- Testing
- Intraneural Facilitation Therapy Treatment, Standard Physical Therapy Treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Loma Linda University
Prediabetes
Effects of Autonomic Nervous System Modulation by Heart Rate Variability Biofeedback Training With Resonant Frequency Breathing on Glucose Metabolism in Individuals With Prediabetes
Approximately 20% of adults have prediabetes in Germany. Prediabetes is defined as a condition with glucose levels outside the normal range but not yet meeting the criteria for type 2 diabetes.
- Trial name
- RwHRVBFinPD (NCT06739993)
- Testing
- Resonance frequency breathing with heart rate variability biofeedback training, Anti-Stress program
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Johannes Gutenberg University Mainz
Surgery--Complications
Variability of Heart Rate as a Marker of Complication of Colorectal Surgery
Heart rate variability reflects the autonomic nervous system on the intrinsic activity of sinus node cells. Sympathetic hyperactivity is an adaptation to stress, while parasympathetic hyperactivity is present at rest.
- Trial name
- VFC COLORECTAL (NCT04367987)
- Testing
- Heart Rate Variability
- Where
- France
- Volunteers
- 117 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Autonomic Nervous System (ANS) Functioning and Mood State, Heart Rate Variability (HRV)
taVNS During Multi-site HRV Measurement: Reliability & Agreement Study
This study examines the reliability and agreement of autonomic nervous system measurements obtained from different anatomical sites during transcutaneous auricular vagus nerve stimulation (taVNS).
- Conditions
- Autonomic Nervous System (ANS) Functioning and Mood State, Heart Rate Variability (HRV), Blood Pressure Monitoring, Transcutaneous Electric Nerve Stimulation
- Trial name
- taVNS-HRV (NCT07548723)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Fibromyalgia (FM) OR Fibromyalgia Syndrome, Manuel Therapy
Effects of Adding Vagal Neuromodulation to Manual Therapy in Women With Fibromyalgia
The aim of this study is to investigate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) added to manual therapy on pain, autonomic nervous system function, and illness perception in female patients…
- Conditions
- Fibromyalgia (FM) OR Fibromyalgia Syndrome, Manuel Therapy, Chronic Widespread Pain, Autonomic Nervous System Dysfunction
- Trial name
- NCT07894588
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Manual Therapy Program, Diaphragmatic Breathing and Stretching Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Hasan Kalyoncu University
Anxiety, Psychological Flexibility
Comparative Effects of Four Brief Breathwork and Mindfulness Interventions on Anxiety and Psychological Flexibility: A 4-Arm RCT
This four-arm, single-blind randomized controlled trial examines the effects of four brief daily 5-minute practices over 28 days on psychological flexibility and physiological variables in Spanish-speaking adults.
- Conditions
- Anxiety, Psychological Flexibility, Stress
- Trial name
- BREATH-4 (NCT07621042)
- Testing
- Box Breathing, Cyclic Sighing, Mindfulness AH Exhalation
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Valencian International University (VIU)
Insomnia, Health Adult Subjects
Does Style Matter: Comparison of Moderate- to Low-intensity Styles of Yoga
The goal of this clinical trial is to learn if yoga works to improve sleep and heart health in adults with and without insomnia disorder.
- Conditions
- Insomnia, Health Adult Subjects, Insomnia Disorder, Heart Health Markers
- Trial name
- NCT07638267
- Testing
- Vinyasa yoga, Gentle yoga, Non-active control
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Caitlin Cheruka
Stroke
COMPARISON OF BREATHING AND SUBOCCIPITAL RELEASE IN STROKE
The aim of this study is to investigate the positive effects of deep, slow breathing exercises and suboccipital relaxation, when added to a routine physiotherapy and rehabilitation program, on autonomic, motor, cognitive, and…
- Trial name
- NCT07725471
- Testing
- Breathing Exercise, Suboccipital Release, Standard treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Ankara Yildirim Beyazıt University
Heat Stress
Heat Stress Exposure Among Low-Income Residents in Bangladesh and Evaluation of Indoor Interventions
The goal of this clinical trial is to learn if infrastructure and equipment installed to cool homes reduce adverse health outcomes.
- Trial name
- NCT06979258
- Testing
- Cooling intervention
- Where
- Bangladesh
- Volunteers
- 1,539 people
- Sponsor
- University of California, Berkeley
Hypertension, Autonomic Dysfunction
Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals
The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical…
- Conditions
- Hypertension, Autonomic Dysfunction, Orthostatic Hypotension
- Trial name
- NCT07482462
- Where
- Slovenia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Digital Health Intervention, Remote Consultation, Teleconsultation
Evaluation and Implementation of Digital Health Ecosystem in Academic Health Center
Mobile health technologies, such as smartwatches, wearable sensors, and digital applications, have the potential to support healthier lifestyles and improve the management of health conditions.
- Conditions
- Digital Health Intervention, Remote Consultation, Teleconsultation, Lifestyle Factors, Stress
- Trial name
- e-IDEA (NCT07831837)
- Testing
- Integrated Digital Health Ecosystem, Usual Primary Care
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Autonomic Nervous System Disease, Concussive Injury
Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms
Many combat veterans (c-Vs), service members (SMs) and civilians with mild traumatic brain injury (mTBI, also termed concussion) suffer from persistent post-concussion symptoms (PPCS) that degrade physical and cognitive…
- Conditions
- Autonomic Nervous System Disease, Concussive Injury, Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
- Trial name
- NCT07071350
- Testing
- HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Virginia Commonwealth University
Postpartum Depression, Heart Rate Variability
Vitamin B6 and Depression in Pregnant and Peri-partum Women
Perinatal depression is a highly prevalent and serious health issue during pregnancy. According to statistics, approximately one out of every ten postpartum women experiences this condition.
- Trial name
- NCT06445933
- Testing
- Vitamin B6
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Depression
Mediterranean Diet and the Microbiota Gut Brain Axis in Major Depression
The purpose of this study is to assess the efficacy of a Mediterranean diet on the function of the vagal nerve in patients with depression.
- Trial name
- MeDiVa (NCT04772651)
- Testing
- Mediterranean Diet, Normal hospital diet, dietary coaching
- Volunteers
- 108 people
- Sponsor
- Medical University of Graz
Restless Leg Syndrome
The Suggested Immobilization Test With Exploratory Heart Rate Variability Analysis for Diagnosis of Restless Legs Syndrome
Restless leg syndrome (RLS) is not uncommon and can also affect people's health and quality of life. Mainly, RLS is diagnosed based on clinical criteria subjectively.
- Trial name
- NCT07110961
- Testing
- A suggested immobilization test (SIT)
- Where
- Thailand
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Stress, Relaxation
Decreasing Stress Via Virtual Reality and Binaural Beats in Non-Clinical Adults
This study is a non-clinical substudy conducted within the DESTRESS research program (NCT05036538), which investigates the effects of relaxation interventions on physiological and psychological parameters.
- Conditions
- Stress, Relaxation, Virtual Reality, Binaural Beats
- Trial name
- DESTUD (NCT07387107)
- Testing
- Virtual Reality-Based Natural Environment, Binaural Auditory Stimulation, Control Condition (No Relaxation Intervention)
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Heart and Brain Research Group, Germany
Kinesiophobia (Fear of Movement), Musculoskeletal Injuries
Binaural Beats Stimulation on the Autonomic Nervous System (ANS), Kinesiophobia and Fitness Levels in Professional Athletes With Musculoskeletal (MSK) Injuries
The purpose of the current study is to investigate the effectiveness of binaural beat stimulation on the autonomic nervous system (ANS), taking into account kinesiophobia related to reinjury and fitness levels in professional…
- Trial name
- ANS MSK HRV (NCT07370636)
- Testing
- Auditory stimulation with binaural beats and guidance, Auditory stimulation without binaural beats, Auditory stimulation with background music
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of West Attica
Pediatric Anxiety
Non-Wearable Audiovisual Distraction for Children's Medical Anxiety in the ED
Pediatric emergency department (ED) visits often cause significant anxiety and stress for young patients due to unfamiliar environments and invasive medical procedures.
- Trial name
- NCT07761637
- Testing
- Non-Wearable Audiovisual Distraction, Routine ED Care
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital