Clinical trials: Heat Effect
Pain, Pain, Labor
Pulsed Heat as a Drug-free Treatment for Pregnancy Related Pain
Studies indicate that up to 75% of women will experience pain sometime during their pregnancy. Recent recommendations by the FDA recommended that non-steroidal anti-inflammatory (NSAIDS) medications be avoided during pregnancy.
- Trial name
- NCT05628298
- Testing
- Soovu Pain Relief System
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Soovu Labs Inc.
Effects of Heat, Tolerability
Evaluation of Experimental and Commercial Air-Activated, Adhesive Backed Heat Patches
To assess the safety and tolerability for the extended wear of an experimental air-activated self adhesive patch.
- Conditions
- Effects of Heat, Tolerability, Adhesiveness, Dermal Irritation
- Trial name
- NCT01841801
- Testing
- Thermal Adhesive Patch, Marketed Thermal Adhesive Patch
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Chattem, Inc.
Lymphoma, Follicular, Lymphoma, Small Lymphocytic
A Safety and Effectiveness Study of Vaccine Therapy in Patients With Indolent Lymphoma
Primary Objectives: To document the efficacy of treatment with autologous lymphoma-derived HSPPC-96 of selected patients with indolent lymphoma.
- Trial name
- NCT00081809
- Testing
- autologous human tumor-derived HSPPC-96
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Agenus Inc.
Healthy
To Assess the Effect of the Special Condition on the Pharmacokinetics and Tolerability of the Esflurbiprofen Topical System (EFTS) in Healthy Volunteers.
This study is a single-center, open-label, single-dose trial performed in a randomized, four-way, change-over design in healthy volunteers.
- Trial name
- NCT06870422
- Testing
- Esflurbiprofen Topical System
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Teikoku Seiyaku Co., Ltd.
Pain
TENS and Heat for Reducing Back Pain in Humans
Lower back pain is one of the most common and most expensive impairments costing time and expense in the work force today. With the effects on cognitive skills and addictive side effects of opioids and other prescription pain…
- Trial name
- NCT03740750
- Testing
- Thermacare heat wraps, TENS
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Future Sciene Technology
Sexual Dysfunction, Physiological
Vaginal Heat Wash-out (HWO) in 4 Groups of Women (Pre- and Postmenopausal With and Without Female Sexual Arousal Disorder (FSAD)).
The Pfizer developed Heat Wash-Out (HWO) system is a software controlled electromechanical system designed to measure vaginal wall blood flow. A small vaginal probe is attached to a control unit.
- Trial name
- FSAD HWO VBF (NCT00443248)
- Testing
- Vaginal Heat Wash-Out Device
- Where
- 2 sites in Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Pfizer
Intermediate AMD
A Clinical Trial Evaluating the Safety and Efficacy of a New Light Combination Therapy Addressing Intermediate AMD
The proposed clinical investigation wants primary to validate the safety of the innovative light therapy approach and in second priority provide insight and confirmations on therapeutic effect.
- Trial name
- retinaSEES-PoC (NCT06557369)
- Testing
- reSEES
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Oculox Technologies SA
Glioma of Brain
A Large-scale Research for Immunotherapy of Glioblastoma With Autologous Heat Shock Protein gp96
This trial is to further study the safety and effectiveness of autologous gp96 treatment of glioblastoma on the basis of preliminary work.
- Trial name
- NCT03650257
- Testing
- gp96, Temozolomide, radiotherapy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Cure&Sure Biotech Co., LTD
Healthy
Pharmacokinetics and Adhesion of Lidocaine Topical System 1.8% Under Conditions of Heat and Exercise
The objectives of this study are to evaluate the pharmacokinetic and adhesion performance of ZTlido (lidocaine topical system) 1.8% during physical exercise, application of heat, and under normal conditions.
- Trial name
- NCT04150536
- Testing
- Lidocaine topical system 1.8%
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Scilex Pharmaceuticals, Inc.
Neoplasms
Immunostimulating Interstitial Laser Thermotherapy in Solid Cancers
Thermotherapy is a technology aiming at destroying tissue, for example tumor tissue. Immunostimulating Interstitial Laser Thermotherapy (imILT) is a specific form of thermotherapy, which, in addition to destroying tumor tissue…
- Trial name
- NCT02690428
- Testing
- Immunostimulating Interstitial Laser Thermotherapy
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- Clinical Laserthermia Systems AB
Alzheimer's Disease
A Study to Evaluate the Effect of Heat Application on the Delivery Profile of Corplex™ Donepezil Transdermal Delivery System (TDS)
A study to assess the effect of heat application on the delivery profile of Corplex™ Donepezil Transdermal Delivery System (TDS)
- Trial name
- NCT03438604
- Testing
- Donepezil TDS
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Corium, Inc.
Pain Management, Osteoarthritis
The Effectiveness of Heat Treatment on Knee Pain in Patients With Osteoarthritis - an International, Multicenter Clinical Investigation
This post-market clinical follow-up, open-label, multicenter clinical investigation is designed to investigate the effectiveness, safety and tolerability of ThermaCare® Knee Heatwraps in the painful knee joint due to…
- Trial name
- NCT06650631
- Testing
- Knee Heatwraps
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Diarrhea, Upper Respiratory Infections
Children Immune Functions
The purpose of the planned study is to investigate the effect of heat-treated lactobacilli on diarrhea outcome in healthy children 1-4 years old in a randomized, double-blind, placebo-controlled study.
- Trial name
- NCT01717534
- Where
- 2 sites in Mexico
- Volunteers
- 374 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Cold
Efficacy and Safety of Regan Tangjiang for Treating the Common Cold With Wind-heat Syndrome
Efficacy and Safety of Regan Tangjiang for treating the common cold with wind-heat syndrome: A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo and Active-Controlled Phase 2b Study
- Trial name
- NCT03089138
- Testing
- Regan Tangjiang
- Volunteers
- 120 people
- Sponsor
- Beijing Da-an Bio-technology Co., Ltd.
Type2 Diabetes, Diabetic Retinopathy
Tangningtongluo Tablet in the Treatment of Non-proliferative Diabetic Retinopathy
This trial is planned to collect relevant clinical data to evaluate the prevention efficacy and safety of Tangningtongluo tablets on the non-proliferation period of diabetic retinopathy.
- Trial name
- NCT05007262
- Testing
- Tangningtongluo tablets, Calcium dobesilate capsules
- Where
- 13 sites in China
- Volunteers
- 240 people
- Sponsor
- Guizhou Bailing Group Pharmaceutical Co Ltd
Body Fat
Clinical Study to Evaluate the Body Fat Reducing Effects of Heat-Treated Green Tea Extract Complex
This clinical study was designed to evaluate the efficacy and safety of body fat reduction in obese adults by treatment of heat-treated green tea extract complex
- Trial name
- NCT06609603
- Testing
- HTGT compound
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amorepacific Corporation
Efficacy and Safety
A Phase IV Study of Huazhi Rougan Granule in the Treatment of Non-alcoholic Simple Fatty Liver
An open Label, Single-arm, Multicenter phase IV study; There was a 2-week screening period and a 12-week / 24-week treatment period
- Trial name
- NCT06202456
- Testing
- Huazhi Rougan granule
- Where
- China
- Volunteers
- 2,007 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Breast Cancer
PEAK PlasmaBlade™ 4.0 Versus Traditional Electrosurgery in Lumpectomy
The purpose of this clinical study is to quantify the difference in thermal injury depth at the surgical margin in breast lumpectomy specimens excised with the PlasmaBlade; to subjectively assess histopathologic sample quality…
- Trial name
- PRECISE (NCT00960154)
- Testing
- PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medtronic Surgical Technologies
Heat Stroke
Efficacy and Safety of Ryanodex® (EGL-4104) as Adjuvant Treatment in Subjects With Exertional Heat Stroke (EHS)
Study EGL-4104-C-1502 is a phase 2, single-site, open-label, randomized, 2-arm parallel study of Ryanodex for the adjuvant treatment of exertional heat stroke (EHS) administered intravenously (IV), to current standard of care…
- Trial name
- NCT02513095
- Testing
- Dantrolene sodium for injectable suspension
- Where
- Saudi Arabia
- Volunteers
- 34 people
- Sponsor
- Eagle Pharmaceuticals, Inc.
Healthy
Investigational Air-Activated Adhesive-Backed Heat Patch (3-Cell)
This is an open-label study. A total of approximately 60 subjects will be randomly assigned to receive either the heat patch (30 subjects) with a temperature probe/skin reference probe or a heat patch (30 subjects) alone.
- Trial name
- NCT02241057
- Testing
- Investigational Air-Activated Adhesive-Backed Heat Patch (3-Cell), Temperature Probe
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chattem, Inc.