Clinical trials: Heat Stress
Heat Strain, Healthy Volunteer Study
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers.
- Conditions
- Heat Strain, Healthy Volunteer Study, Kidney Dysfunction
- Trial name
- NCT06983730
- Testing
- Vitamin B3
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Heat Stroke
The Relationship Between Normal Saline Infusion and Acute Kidney Injury in Heat Stroke
The goal of this clinical trial is to compare the effect of high chlorine solution such as normal saline and non-high chlorine solution such as sodium lactate ringer's solution on renal function in patients with heat stroke.
- Trial name
- NCT05921695
- Testing
- Normal Saline infusion and Ringer lactate infusion
- Where
- 7 sites in China
- Volunteers
- 104 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Subarachnoid Hemorrhage, Subdural Hematoma
Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury
The purpose of this study is to evaluate the antipyretic effect of bromocriptine in critically-ill patients with acute neurologic injury and fever from infectious and non-infectious etiologies.
- Conditions
- Subarachnoid Hemorrhage, Subdural Hematoma, Traumatic Brain Injury, Ischemic Stroke
- Trial name
- BFF (NCT03496545)
- Testing
- Bromocriptine 5 MG, Acetaminophen 650 MG
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of California, San Francisco
Dehydration (Physiology), Hyperthermia
Water Bolus Volumes During Continuous Exercise in Heat
Hydration is important to all individuals including occupational workers who complete physical activity in the heat. Current best practice guidelines suggest drinking a cup of water every 15-20 minutes during activity in a hot…
- Trial name
- NCT04613856
- Testing
- Hydration protocol - 237 mL water bolus, Hydration protocol - 500 mL water bolus
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Heat Tolerance
Heat Stress and Physiological Strain of Permeable vs. Impermeable CB Protective Garment
Current protective clothing of any kind, especially the nuclear-biological-chemical (NBC) protective garments, amplify thermal stress because of the inherent properties of the clothing material.
- Trial name
- NCT01221012
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Heart Rate, All-day Steps
Assessing the Effect of Cool Roofs on Health Using Smartwatches in Colima, Mexico
Ambient air temperatures in Mexico have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Heart Rate, All-day Steps, Distance Walked, Active Minutes
- Trial name
- REFLECT (NCT06831006)
- Testing
- Cool roof
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Inguinal Hernia
Electrocoagulation Employment During TAPP Inguinal Hernia Repair
Laparoscopic TAPP (transabdominal preperitoneal) hernia repair presents a minimally invasive surgical procedure, which tends to be a gold standard in a wide range of inguinal hernia operations.
- Trial name
- NCT03566784
- Testing
- Inguinal hernia repair
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Hyperthermia, Colorectal Neoplasms
Impact of an Optimised Monitored Anesthesia on the Patients' Recovery After Cytoreduction Surgery Plus HIPEC
The objective of our PILOT study is to evaluate the impact of a controlled (monitored) randomized anesthesia during cytoreductive surgery with HIPEC to oxaliplatin in order to treat adenocarcinomas of colorectal origin.
- Conditions
- Hyperthermia, Colorectal Neoplasms, Oxaliplatin
- Trial name
- CHIPNOL (NCT04104334)
- Testing
- Remifentanil infusion, desflurane titration and fluid infusion will be guided by NOL index, BIS index and Flotrac EV1000 system respectively, Remifentanil infusion and desflurane titration will be guided by anesthesia usual practices
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Knee Osteoarthritis
Deep Versus Superficial Heating in Patients With Knee Osteoarthritis
Heat therapy is frequently prescribed to patients with symptomatic knee osteoarthritis (OA). Deep hyperthermia via localized microwave diathermy is effective in several musculoskeletal painful conditions.
- Trial name
- NCT01343147
- Testing
- Microwave diathermy, Superficial hyperthermia
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Catholic University of the Sacred Heart
Melanoma
STA-9090(Ganetespib) in Patients With Unresectable Stage III or Stage IV Melanoma
STA9090 is a drug which inactivates or blocks the work of a protein called Heat Shock Protein 90 or HSP90. HSP90 is a protein that helps some molecules inside your cells to have the right shape.
- Trial name
- NCT01551693
- Testing
- STA-9090
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Dana-Farber Cancer Institute
Circumcision
Bipolar Electrosurgery Versus Thermocautery in Circumcision With Safe Anesthetic Techniques
Background: Circumcision is the most commonly performed surgical procedure done among the pediatric age group worldwide and is considered to be one of the oldest operations done.
- Trial name
- NCT05590052
- Testing
- Bipolar Electrosurgery, Thermocautery
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Damanhour Teaching Hospital
Total Abdominal Hysterectomy
Are Sutures Required in Total Abdominal Hysterectomy? A Randomised Control Trial
The Hypothesis of this study is that performing total abdominal hysterectomy using the newer electrocoagulation forceps, specifically, the gyrus open seal forceps, curved, compared to the traditional clamp \& suture technique…
- Trial name
- NCT00484835
- Testing
- Performing abdominal hysterectomy using gyrus electrocoagulation forceps
- Where
- 3 sites in Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Southern Health
Peripheral Arterial Disease, Cardiovascular Health
Heat Therapy and Peripheral Artery Disease
The purpose of the study is to assess the efficacy of a novel 8 week heat therapy intervention in intermittent claudication compared to usual care controls.
- Conditions
- Peripheral Arterial Disease, Cardiovascular Health, Vascular Function, Intermittent Claudication
- Trial name
- NCT06827691
- Testing
- Heat Therapy Intervention
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Manchester Metropolitan University
Heat Stress, Athletic Performance
Effectiveness of Topical Menthol as A Cooling Method During Exercise in A Recreational Runner Population
The goal of this clinical trial is to evaluate the effectiveness of topical menthol as a cooling method during exercise in a hot air environment in healthy adult recreational runners aged 18 to 45 years.
- Trial name
- NCT07482046
- Testing
- Light blue gel with the trademark Counterpain COOL® (License Number: POM QD. 111 709 501) containing the active substance Menthol 4%.
- Where
- Indonesia
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Taisho Pharmaceutical Indonesia
Elastosis
PEAK PlasmaBlade™ vs. Traditional Electrosurgery in Abdominoplasty
The objective of this clinical study is to evaluate healing of incisions made with the PEAK PlasmaBlade 4.0 compared to scalpel and traditional electrosurgery (Bovie); to monitor and record key post-operative metrics following…
- Trial name
- PRECISE (NCT00943150)
- Testing
- PEAK PlasmaBlade, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medtronic Surgical Technologies