Clinical trials: Heat Stress Disorders
Heat Stroke
Early Body Temperature Targets and Relationship With Prognosis in Patients With Heat Stroke
The goal of this observational study is to explore the optimal target body temperature in first 24 hours and the relationship between body temperature and adverse outcomes of heat stroke.
- Trial name
- NCT05921682
- Testing
- observation
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Macromastia
A Study to Evaluate Cutaneous Scar Quality Following Bilateral Breast Reduction With the PEAK PlasmaBlade 4.0
The objective of this clinical study is to evaluate scar quality following incision with the PEAK PlasmaBlade 4.0 using the Patient and Observer Scar Assessment Scale (POSAS), and to compare these results to equivalently-aged…
- Trial name
- PRECISE (NCT01284491)
- Testing
- PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Medtronic Surgical Technologies
Heart Failure, Hyperthermia
IEEM-Heat and Heart Failure
We will test the hypothesis that increasing skin wetness, and thus evaporative cooling, will attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with…
- Trial name
- NCT06961929
- Testing
- Control Trial, Water-saturated T-shirt trial, Skin-Wetting Trial
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Ovarian Cysts
The Impact of Electrocoagulation on Ovarian Reserve After Laparoscopic Excision of Ovarian Cyst
The purpose of this study is to investigate the impact of electrocoagulation on ovarian reserve after laparoscopic excision of ovarian cyst and the possible mechanisms.
- Trial name
- NCT00713778
- Testing
- Ovarian cystectomy
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Shandong Provincial Hospital
Aging, Heat Stress
Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults
Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalizations and deaths are primarily due to cardiovascular events such as…
- Conditions
- Aging, Heat Stress, Hyperthermia, Heat Strain
- Trial name
- NCT06842784
- Testing
- Ambient heat stress
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Heat Stroke
Study of Thermoregulation in Exercise Heat Stroke in the Military Environment
The EXPLO-MITO study is an ancillary study from the main EXPLO-CCE study (NCT04593316; IDRCB: 2020-A01967-32). The Heat Tolerance Test (HTT) is a physiological exploration that has several advantages for use in research and…
- Trial name
- EXPLO-MITO (NCT05847465)
- Testing
- Bike stress test, Heat Tolerance Test, Heat nociception test
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Sepsis, Temperature
Temperature Optimization in Afebrile Septic PatienTs
The goal of this interventional study is to learn if external warming works to treat patients with a serious systemic infection (i.e. sepsis) that do not have fever.
- Trial name
- TOAST (NCT07831057)
- Testing
- External Warming
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Matt Harmon
Melanoma, Malignant Melanoma
Immunostimulating Interstitial Laser Thermotherapy in Malignant Melanoma
Thermotherapy is a technology aiming at destroying tissue, for example tumor tissue. Immunostimulating Interstitial Laser Thermotherpy (imILT) is a specific form of thermotherapy, which, in addition to destroying tumor tissue…
- Trial name
- NCT02650492
- Testing
- Immunostimulating Interstitial Laser Thermotherapy
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- Clinical Laserthermia Systems AB
Healthy Males, Neuromuscular Function
The Influence of Cerebral Blood Flow and PETCO2 on Neuromuscular Function During Passive Heat Stress
Increased core temperature (hyperthermia) has been associated with impaired neuromuscular performance; however, the mechanisms associated with these performance decrements and their potential synergies remain unclear.
- Trial name
- NCT01848665
- Testing
- Indomethacin
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Brock University
Long COVID
Heat thErapy And mobiLity in COVID-19 Survivors
Post-acute sequelae of SARS-CoV-2 infection (PASC) is becoming a major risk factor for chronic diseases, with older adults and those with underlying health conditions at risk of developing persistent mobility limitations and…
- Trial name
- HEAL (NCT06928116)
- Testing
- Heat therapy, Walking
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Nebraska
Heat Stress, Pregnancy
Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat
The purpose of this study is to learn whether a simple, traditional, and balanced meal made from local foods, eaten once a day during pregnancy, can help women in rural Pakistan stay healthier in hot weather and give birth to…
- Conditions
- Heat Stress, Pregnancy, Women of Reproductive Age, Nutrition Status
- Trial name
- INSPIRE (NCT07489664)
- Testing
- Indigenous Balanced Diet Arm
- Where
- Pakistan
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Heat Stress Disorders, Wounds and Injuries
Effects of Environmental Heat Exposure on Human Multiple Organ Function
This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of high temperature exposure and the underlying mechanisms.
- Conditions
- Heat Stress Disorders, Wounds and Injuries, Body Temperature Changes, Multiple Organ Dysfunction
- Trial name
- NCT06938932
- Testing
- High temperature exposure, Moderate temperature exposure
- Where
- China
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Yinan Qu
Body Temperature Changes, Heat Exposure
Preparing for Heat Waves - Enhancing Human Thermophysiological Resilience
As the ongoing progression of climate change exposes individuals to elevated temperatures and an escalating frequency of extreme heat events, the risk of more intense and prolonged heat waves raises significant concerns for…
- Conditions
- Body Temperature Changes, Heat Exposure, Heat Stress, Hyperthermia
- Trial name
- Prep4heat (NCT06389604)
- Testing
- Heat acclimation
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Locoregional Recurrence, Breast Cancer
Postoperative Re-irradiaTion With and Without HYPERthermia, or Surgery Only: Toxicity, Quality of Life and Survival in Patients With Locoregional Recurrent Breast Cancer
In the Netherlands, breast cancer patients with locoregional recurrence (LRR) and intermediate- and high-risk factors are treated with surgery with or without postoperative re-irradiation with or without hyperthermia.
- Conditions
- Locoregional Recurrence, Breast Cancer, Re-irradiation, Hyperthermia
- Trial name
- RT-HYPE (NCT06452485)
- Testing
- No interventions, patient-reported outcomes (PROMs) and toxicity will be collected in both groups.
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Amsterdam UMC, location VUmc
SCI - Spinal Cord Injury
Home-Based Heat Therapy in Spinal Cord Injury to Improve Cardiovascular Health
The study is designed to investigate the effects of passive heat therapy on blood vessel health in 40 people (48 enrolled with attrition rate of 20%).
- Trial name
- IIS_SCIDoD (NCT07317843)
- Testing
- HEAT - Passive Heat Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cardiovascular Risk Factor, Heat Stress
Exercise and Sauna on Blood Pressure and Cardiovascular Health
The study aims to investigate the effects of including regular heat therapy when included to exercise. Specifically, participants in the sauna intervention group will undergo 15 minutes of sauna exposure immediately after a…
- Conditions
- Cardiovascular Risk Factor, Heat Stress, Sedentary Behavior
- Trial name
- ES2019 (NCT04540718)
- Testing
- Exercise, Sauna
- Where
- Finland
- Volunteers
- 47 people
- Sponsor
- University of Jyvaskyla
Hyperthermia, Weather; Heat
Efficacy of Electric Fans for Mitigating Thermal Strain in Older Adults During Heat Waves
With the increasing regularity and intensity of hot weather and heat waves, there is an urgent need to develop heat-alleviation strategies able to provide targeted protection for heat-vulnerable older adults.
- Conditions
- Hyperthermia, Weather; Heat, Heat Stress, Aging
- Trial name
- NCT05695079
- Testing
- No cooling (control), Electric fan (low airflow), Electric fan (high airflow)
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
HER2-negative Breast Cancer
Neoadjuvant Concomitant Modulated Electro-hyperthermia in HER2-negative Breast Cancer
The aim of this study is to investigate whether the application of concomitant modulated electro-hyperthermia in a neoadjuvant chemotherapeutic setting is beneficial for patients with HER2-negative, stage II-III breast cancer.
- Trial name
- NeoHTerMa (NCT05889390)
- Testing
- Oncotherm EHY-2030, Paclitaxel, Carboplatin
- Where
- Hungary
- Volunteers
- 71 people
- Sponsor
- Semmelweis University
Urinary Bladder Diseases, Urinary Bladder Neoplasms
Hyperthermia Treatment in Conjunction With Mitomycin C Versus Bacillus Calmette-Guérin Immunotherapy (BCG) for Superficial Bladder Cancer
The study is designed to compare the efficacy and safety of 2 treatment types for the prevention of tumor recurrence of superficial bladder cancer: 1. A combination of bladder wall heating and local chemotherapy (Synergo) 2.
- Conditions
- Urinary Bladder Diseases, Urinary Bladder Neoplasms, Urinary Bladder Cancer, Malignant Tumor of Urinary Bladder
- Trial name
- NCT00384891
- Testing
- Synergo + MMC, Bacillus Calmette-Guérin
- Where
- 8 sites in Austria, Israel and 2 more
- Volunteers
- 190 people
- Sponsor
- Medical Enterprises Europe B.V.
Obesity, Lung Functions
The Effect of CLA on Obesity, Lung Functions, Lipid Profile and Inflammation in Women With BMI≥25
Conjugated linoleic acid or CLA, is one of the food supplements that could be found in meat, fats, and dairy products of ruminants which has been fed grass not on grains.
- Conditions
- Obesity, Lung Functions, Inflammation, Lipid Disorder
- Trial name
- NCT04641494
- Testing
- Conjugated linoleic acid, High oleic acid safflower oil capsules
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Chester