Clinical trials: Heat Stress Disorders
Hyperthermia
Work-To-Rest Ratios
The purpose of the study is to compare physiological responses to two hours of work adhering to two variations of a work-to-rest ratio in a hot environment.
- Trial name
- NCT05327764
- Testing
- Work to rest cycles of 40:20 minutes, Work to rest cycles of 20:10 minutes
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Hyperthermia, Hypothermia
Comparison of Bi-environmental Conditions During Occupational Related Activity
BHSAI is developing a computational system that provides early alerts of a rise and fall in core body temperature to help reduce the risk of thermal injury in the field and during training.
- Trial name
- COBRA (NCT05059730)
- Testing
- Zero Degrees Cold Environment, Eight Degrees Cold Environment, Ten Degrees Cold Environment
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Hyperthermia
Complementary and Alternative Medicine Sauna Detoxification Study: Phase I
The purpose of this study is to determine the impact of sauna use on polychlorinated biphenyls (PCB) in the blood of healthy human adults, as well as to assess safety, feasibility, and tolerability, and effects on quality of life…
- Trial name
- NCT01905098
- Testing
- Sauna Detoxification Protocol, Observation Sessions
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bastyr University
Body Temperature Changes, Heat Stress
Initial Stay Times and Heat Mitigation Controls for Uncompensable Occupational Heat Stress - Part III
Occupational heat stress directly threatens workers' ability to live healthy and productive lives. Heat exposed workers are at an elevated risk of experiencing impaired work performance and cognitive function leading to a greater…
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT06630832
- Testing
- Simulated work in the heat with no cooling during rest breaks, Simulated work in the heat with partial cooling during rest breaks, Simulated work in the heat with full cooling during rest breaks
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Exercise Intolerance, Aging
Heat Therapy and Muscle Function Study
Exercise tolerance decreases with age and a sedentary lifestyle. Muscle critical power (CP), is a sensitive measure of exercise tolerance that is more even more relevant to and predictive of endurance performance than VO2max.
- Conditions
- Exercise Intolerance, Aging, Heat Therapy, High Intensity Interval Training
- Trial name
- NCT04733287
- Testing
- High Intensity Interval Training of the Knee Extensors, Muscle Heat Therapy, Muscle Disuse
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Cutaneous Leishmaniasis
Efficacy of Radio-frequency Induced Heat (RFH)Therapy in Treatment of Cutaneous Leishmaniasis in India
Infections caused by the protozoan parasite Leishmania include cutaneous (CL), mucosal (ML) and visceral leishmaniasis (VL). Over 12 million people currently suffer from leishmaniasis, and approximately 2 million new cases occur…
- Trial name
- NCT01661296
- Testing
- RFH therapy, Sodium stibogluconate
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Sarder Patel Medical College
Hyperthermia, Fatigue; Heat
Work Design Interventions for Heat Resilience
The goal of this project is to compare different ways to schedule a workday to see if older workers should follow a specific work protocol to reduce strain on the heart and muscles.
- Conditions
- Hyperthermia, Fatigue; Heat, Work-Related Condition
- Trial name
- NCT06599788
- Testing
- Standard work pace, Reduced-pace work, Increased-pace work
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Skin Cancer, Heat Tolerance
Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals
The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans.
- Conditions
- Skin Cancer, Heat Tolerance, Heat-related Illness, Hyperthermia
- Trial name
- ICARUS (NCT07510061)
- Testing
- Controlled Heat and Ultraviolet Radiation Exposure Protocol
- Where
- 2 sites in Denmark, Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Methylphenidate
Methylphenidate (Ritalin®) Effect During Exposure to Exercise and Heat Stress in ADD/ADHD Treated Patients
The purpose of this study is to explore the possible effects of MPH use on physiological functions among ADHD\ADD patients, by performing a set of physical trials to assess aerobic and anaerobic capacity, to characterize the…
- Trial name
- NCT02704546
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Heat Stress, Aging
Aging, Beta Blockers, and Thermoregulatory Responses
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.
- Trial name
- NCT06582680
- Testing
- Ambient Heat
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Heat Stress, Exertional
Influences of Female Sex and Reproductive Hormones on Physiological Aspects of Heat Acclimation
Women are often understudied in thermal physiology research, leaving recommendations for Soldier safety and performance in hot conditions based largely on data collected in men.
- Trial name
- NCT05292170
- Testing
- Heat acclimation
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Recurrent Head and Neck Cancer
Combination of Hyperthermia and Concurrent Chemoradiotherapy (CCRT) for Recurrent Head and Neck Cancer
Clinical experience of with hyperthermia combined with radiotherapy and chemotherapy for recurrent head and neck cancer is limited.
- Trial name
- NCT02567383
- Testing
- Radiation, Hyperthermia; Thermotron RF-8, Cisplatin
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Body Temperature Changes, Heat Stress
Progressive Heat Exposure and Physiological Strain
Occupational heat-stress guidelines are commonly based on the level of environmental heat exposure and are largely derived from studies conducted under constant environmental conditions.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07847437
- Testing
- Constant Heat Exposure, Progressively Increasing Heat Exposure
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Stroke
Application of an Early In-Hospital Temperature Management Protocol for Heat Stroke Patients
Heat stroke is a life-threatening clinical syndrome characterized by an imbalance between heat production and heat dissipation in the body, resulting from exposure to hot and humid environments and/or strenuous exercise.
- Trial name
- NCT06537557
- Testing
- the early in-hospital temperature management protocol for heat stroke patients
- Where
- 7 sites in China
- Volunteers
- 188 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alcohol Consumption, Heat Stress
Ethanol Consumption in the Heat
Climate change has significantly increased the earth's average surface temperature and heat waves have been predicted to increase in frequency, intensity and duration.
- Conditions
- Alcohol Consumption, Heat Stress, Age
- Trial name
- NCT06935045
- Testing
- Alcohol (Ethanol)
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Lakehead University
Thermoregulation, Sleep Disturbance
Acute Sleep Deprivation on Whole-body Heat Exchange During Exercise-heat Stress in Young and Older Men
Sleep deprivation has long been thought to modulate thermoregulatory function. Seminal work on sleep deprivation and thermoregulation has demonstrated that sleep-deprived individuals experience greater elevations in core…
- Conditions
- Thermoregulation, Sleep Disturbance, Heat Exchange, Aging
- Trial name
- NCT05838014
- Testing
- Sleep deprivation, Normal sleep
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Liver Neoplasms, Neoplasm Metastasis
A Phase I Study of Isolated Hepatic Portal and Arterial Perfusion (IHP) With Escalating Dose Melphalan for Primary or Metastatic Unresectable Cancers of the Liver
Patients with unresectable primary or metastatic cancer confined to the liver will undergo a 1 hour hyperthermic isolated hepatic perfusion (IHP) via the portal vein and hepatic artery with escalating dose melphalan.
- Trial name
- NCT00001587
- Testing
- Isolated hepatic portal and arterial perfusion, Melphalan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Neoplasms Pancreatic
Percutaneous Immunostimulating Interstitial Laser Thermotherapy in Pancreatic Cancer
Thermotherapy is a technology aiming at destroying tissue, for example tumor tissue. Immunostimulating Interstitial Laser Thermotherapy (imILT) is a specific form of thermotherapy, which, in addition to destroying tumor tissue…
- Trial name
- NCT03187587
- Testing
- imILT, Standard chemotherapy treatment
- Where
- Portugal
- Volunteers
- 8 people
- Sponsor
- Clinical Laserthermia Systems AB
Gynaecologic Cancer
More Representative Vaginal Temperature Measurements With a Hyperthermia Pelotte During Hyperthermia Treatments for Gynaecological Cancer.
The goal of this comparative, cross over single centre study is to to determine whether the average measured vaginal temperature during hyperthermia treatment is (clinically) significant different with the use of a pelotte than…
- Trial name
- ORIENTATE (NCT07235540)
- Testing
- Pelotte
- Where
- Netherlands
- Volunteers
- 27 people
- Sponsor
- Dr. G.H. (Henrike) Westerveld
Osteoarthritis, Knee
The Effect of Cryotherapy in Pain Control, Function and Quality of Life in Individuals With Knee Osteoarthritis
The purpose of this study is to verify the effect of cryotherapy in pain control, function and quality of life in individuals with knee osteoarthritis.
- Trial name
- NCT02725047
- Testing
- Cryotherapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Federal de Sao Carlos