Clinical trials: Heat Stress Disorders
Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation
Heat Shock Protein 47 in Thrombosis
The goal of this observational study is to learn if the novel biomarker Heat shock protein 47 (HSP47) can be used as a prognostic marker for vascular disease in people with acute venous thromboembolism (VTE), myocardial…
- Conditions
- Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation, Stroke (in Patients With Atrial Fibrillation)
- Trial name
- NCT06731673
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Low Back Pain, Chronic Low-back Pain
Effects of Posterior-anterior Vertebral Mobilization Followed by Prone Press-up Exercise in Nonspecific Low Back Pain
Despite advances in intervention, many patients presenting with nonspecific low back pain (NSLBP) fail to have recovery from symptoms and activity limitation.
- Trial name
- NCT05997069
- Testing
- Posterior-anterior vertebral mobilizations followed by Prone press-up exercise, Conventional physiotherapy
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Dr. Aftab Ahmed Mirza Baig
Heat Illness
Examination of a New Non Invasive Sensor "Lifebeam" During HTT in Protective Clothing
CB (Chemical Biological)protective clothing provides a thermal resistance between the human body and its environment. CB protective clothing will be essential for combat soldiers in case of non conventional attacks.
- Trial name
- lifebeam (NCT01789931)
- Testing
- "Lifebeam"
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Heat Stroke
Efficacy and Safety of Ryanodex® (EGL-4104) as Adjuvant Treatment in Subjects With Exertional Heat Stroke (EHS)
Study EGL-4104-C-1502 is a phase 2, single-site, open-label, randomized, 2-arm parallel study of Ryanodex for the adjuvant treatment of exertional heat stroke (EHS) administered intravenously (IV), to current standard of care…
- Trial name
- NCT02513095
- Testing
- Dantrolene sodium for injectable suspension
- Where
- Saudi Arabia
- Volunteers
- 34 people
- Sponsor
- Eagle Pharmaceuticals, Inc.
Heat Stress, Exertional, Heat Acclimation and Thermotolerance
Acute Exercise With Overdressing
The purpose of this study is to determine if exercise with extra clothing in a gym-like environment can increase body temperatures appropriately to help people adapt to the heat.
- Trial name
- Acute-XO (NCT07080853)
- Testing
- Exercise with Overdressing, Control Exercise
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Diphenhydramine Causing Adverse Effects in Therapeutic Use, Hyperthermia
Diphenhydramine and Sweating
In 2012, it was estimated that nearly 1 in 4 Canadians suffer from allergic rhinitis. To add, 78% of individuals working in predisposing environments are predicted to develop occupational rhinitis.
- Conditions
- Diphenhydramine Causing Adverse Effects in Therapeutic Use, Hyperthermia, Allergic Rhinitis, Sweating
- Trial name
- BENEXE2022 (NCT05586477)
- Testing
- Diphenhydramine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lakehead University
Melanoma, Sarcoma
Pilot Study of a Double Isolation Perfusion Schedule Using Melphalan Alone for Intransit Melanoma or Unresectable Sarcoma of the Extremity
Hyperthermic isolated limb perfusion with melphalan alone is administered as a double perfusion schedule. These two isolates limb perfusions with melphalan are treated 3-6 weeks apart.
- Trial name
- NCT00001577
- Testing
- double isolated limb perfusion with melphalan alone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Ischemic Heart Disease
Cardiac-CT in the Treatment of Acute Chest Pain
Objectives The CATCH trial (CArdiac cT in the treatment of acute CHest pain) is a prospective randomized controlled trial designed to evaluate the clinical value of cardiac multidetector computed tomography (MDCT) as a first-line…
- Trial name
- CATCH (NCT01534000)
- Testing
- Cardiac computed tomographic angiography (CCTA)
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Hvidovre University Hospital
Neoplasms Pancreatic
Immunostimulating Interstitial Laser Thermotherapy in Pancreatic Cancer
Thermotherapy is a technology aiming at destroying tissue, for example tumor tissue. Immunostimulating Interstitial Laser Thermotherapy (imILT) is a specific form of thermotherapy, which, in addition to destroying tumor tissue…
- Trial name
- NCT02973217
- Testing
- Immunostimulating Interstitial Laser Thermotherapy
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Clinical Laserthermia Systems AB
Cutaneous Metastatic Melanoma
Intratumoral Targeted Hyperthermia Therapy (THT) for Cutaneous Metastatic Melanoma
This device phase I/II, first in human, early feasibility study (EFS), open-label, single-arm trial aims to evaluate the safety, tolerability, and preliminary efficacy of Gold Nanorod (GNR)-enabled sub-ablative targeted…
- Trial name
- NCT06870994
- Testing
- Targeted Hyperthermia Therapy
- Volunteers
- 10 people
- Sponsor
- Sona Nanotech Inc
Exertional Heat Illness, Hydration Status
Comparing Risk of Heat Illness Based on Peak Core Temps During Preseason Football Camp Across 3 Different Age Levels
To collect field data in professional, collegiate, and high school football players to determine how they respond physiologically to the rigors of preseason training environment.
- Trial name
- NCT01954537
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Heat Stress, Physiological Stress
Suitability of a 26 °C Indoor Environment for Mitigating Heat Strain in Young Adults
While an indoor upper temperature limit of 26 °C has been shown to protect heat-vulnerable older adults (DOI: 10.1289/EHP11651), this guideline has not been verified in young, habitually active adults.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07267598
- Testing
- Simulated indoor temperature upper limit
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Ottawa
Hyperthermia
Sauna Detoxification Study: Pilot Feasibility
The goal of this study is to assess the feasibility of the approach, conduct a dose-finding investigation, and obtain pilot data on hyperthermia via sauna to apply in follow-up trials in the assessment of human chemical body…
- Trial name
- NCT01576822
- Testing
- This protocol will utilize a sauna as the primary method of detoxification.
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bastyr University
Gingival Overgrowth
Assessment of Growth Factors Levels Associated with Wound Healing After Soft Tissue Crown Lengthening
Clinicians often encounter the need for crown lengthening in the practice of dentistry and have to make treatment decisions taking into consideration how to best address the biological, functional, and esthetic requirements of…
- Trial name
- NCT06806319
- Testing
- single intervention by Sirolase ® lower power diode laser 970 ± 15 nm (0.5 watts) continuous emission, power =3 watts, fiber 320 μm, single intervention by electrosurgical unit which was kept 38 watts rms ± 5%. The working frequency was adjusted to 1.5 MHz ± 5%.
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Body Temperature Changes, Heat Stress
Consecutive Occupational Heat Exposure With and Without Overnight Cooling
Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers exposed to hot environments.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07656519
- Testing
- Simulated occupational heat exposure with recovery at recommended indoor temperature limit, Simulated occupational heat exposure with recovery in an overheated indoor environment
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Lung Cancer, Lung Cancer Metastatic
ANET Electrosurgery Applicator Pilot Evaluation Study
Evaluate the preliminary safety and performance of the Electrosurgery Applicator (ANET device) during and after bronchoscopic ablation of a target pulmonary nodule/tumor.
- Trial name
- NCT03400748
- Testing
- RF Ablation
- Where
- 4 sites in United States, Canada
- Volunteers
- 6 people
- Sponsor
- Olympus Corporation of the Americas
Hyperthermia, Cocaine Use
Intranasal Cocaine and Temperature Regulation During Exercise
Assess the effects of intranasal cocaine on temperature regulation and whole-body sweat rate during exercise in warm environmental conditions.
- Conditions
- Hyperthermia, Cocaine Use, Exercise
- Trial name
- NCT05809453
- Testing
- Cocaine, Lidocaine
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Occupational Injuries, Heat Stress
Effect of Rapid Heat Stress on Firefighters Musculoskeletal Injury Risk
This study will examine the effect of heat stress on factors that influence musculoskeletal injury risk in firefighters. Participants will attend 4 data collection sessions. 1: informed consent, screening, and familiarization.
- Conditions
- Occupational Injuries, Heat Stress, Leg Injury, Back Injuries
- Trial name
- NCT06442956
- Testing
- Rapid Heat Condition, Gradual Heat Condition
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Hepatocellular Carcinoma, Liver Neoplasms
A Study of ThermoDox™ in Combination With Radiofrequency Ablation (RFA) in Primary and Metastatic Tumors of the Liver
The purpose of this study is to determine the maximum tolerated dose (MTD) of ThermoDox when used in combination with radiofrequency ablation (RFA) in the treatment of primary and metastatic tumors of the liver.
- Trial name
- NCT00441376
- Testing
- ThermoDox
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Imunon
Heat Cramps, Heat Rash
Testing Interventions to Mitigate the Health Impact of Heatwaves on Primary School Children in Climate-vulnerable Districts of Bangladesh.
The goal of this clinical trial is to assess the impact of implementing a combination of heat education and school-based physical infrastructure interventions in reducing heat related illnesses and improving educational outcomes…
- Conditions
- Heat Cramps, Heat Rash, Heat Exhaustion, Heat Stress
- Trial name
- NCT07877935
- Testing
- Solar reflective paint, Bamboo ceiling with polyethylene foam, Heat education toolkit
- Where
- 2 sites in Bangladesh
- Volunteers
- 2,875 people, healthy volunteers welcome
- Sponsor
- BRAC University