Clinical trials: Heat Stroke
Hot Weather; Adverse Effect, Heat Effect
Beat the Heat Boston
The goal of this stepped wedge trial is to assess the practical effects of air conditioners on hot weather impacts among older adults.
- Conditions
- Hot Weather; Adverse Effect, Heat Effect, Heat Stress, Heat Stroke, Heat Exhaustion
- Trial name
- NCT06982339
- Testing
- Air Conditioner, Electricity subsidy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Harvard School of Public Health (HSPH)
Heat Stroke, Healthy
The Development Of A Novel Biomarker For Early Identification Of The Individual's State Of Tolerance To Heat
Today, the level of tolerance to heat is based on physiological strain indices, with no correlates to any relevant biomarker. We hypothesize that oxidative stress (OS) and the formation of reactive oxygen and nitrogen species…
- Trial name
- NCT01290159
- Testing
- heat tolerance test (HTT)
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Fatigue, Overheating
Aspirin as a Pre-Treatment for Exercise in Multiple Sclerosis
Exercise has many benefits for people with multiple sclerosis (MS), such as improved physical symptoms, mood, fatigue, and cognition.
- Trial name
- NCT03051646
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Heat Stroke
Mechanism Study of G Protein-coupled Receptor 81 in Multiple Organ Dysfunction of Heat Stroke
Heat stroke is one of the common acute and critical conditions in the ICU, characterized by a high incidence and mortality rate, and there is still a lack of effective and precise treatment methods.
- Trial name
- NCT07346443
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Hyperthermia, Thermoregulation
Enhancing Heat Resiliency in Older Adults During Indoor Overheating Via Heat Acclimation by Warm Water Immersion
As overheating in buildings is expected to increase as global warming continues, proactive measures to increase heat resiliency in heat-vulnerable older people are needed, especially for those without access to home cooling or…
- Conditions
- Hyperthermia, Thermoregulation, Aging, Heat Acclimation and Thermotolerance
- Trial name
- NCT06670365
- Testing
- Heat acclimation by warm-water immersion
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Stroke
Study of Thermoregulation in Exercise Heat Stroke in the Military Environment
The EXPLO-MITO study is an ancillary study from the main EXPLO-CCE study (NCT04593316; IDRCB: 2020-A01967-32). The Heat Tolerance Test (HTT) is a physiological exploration that has several advantages for use in research and…
- Trial name
- EXPLO-MITO (NCT05847465)
- Testing
- Bike stress test, Heat Tolerance Test, Heat nociception test
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Cigarette Smoking
The Effect of Smoking on Thermoregulation
To the best of our knowledge, a possible relation between smoking and heat injuries or heat intolerance was never scientifically examined, although such a relation is logical according to the observations that smoking has a…
- Trial name
- NCT01596556
- Testing
- Nicotine, cigarette smoking
- Where
- Israel
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Heat Stroke, Heat Exhaustion
Chemical Ice Packs for Cooling Hyperthermic Patients
A common tool to cool people in the pre-hospital setting is the chemical ice pack. These are used by athletic trainers, EMS personnel, ER staff, and people in the prehosoital setting.
- Trial name
- NCT01694290
- Testing
- Chemical Cold Pack
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Stanford University
Heat Stress, Physiological Stress
Physiological Strain in Young Adults During a Simulated Heat Wave
The likelihood of exposure to overheated indoor environments is increasing as climate change is exacerbating the frequency and severity of hot weather and extreme heat events.
- Trial name
- NCT06618352
- Testing
- Simulated indoor overheating exposure
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Orthodontic Tooth Movement, Burn Injury
Comparison of the Effectiveness of Innovative Techniques to Prevent Tissue Overheating During Corticotomy Using Smartphone-Based Thermography: Reticulated Surgical Guide vs Dynamic Navigation.
Objectives: The aim of the present split-mouth randomized clinical trial was to compare the effectiveness of two innovative corticotomy techniques, using reticulated static computer-guided surgery and dynamic computer-guided…
- Trial name
- NCT06934161
- Testing
- dynamic computer-guided Corticotomy, static computer-guided Corticotomy, smartphone-based thermography
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- University of Roma La Sapienza
Heat Stress, Physiological Stress
Heat Stress in Individuals With Schizophrenia
Schizophrenia is a severe mental illness affecting approximately 24 million people worldwide and is associated with more than double the all cause mortality risk of the general population.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07383324
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Ottawa
Functional Neural Connectivity
Functional Neural Connectivity at Rest as a Diagnostic Tool for Intolerance to Heat
Functional neural connectivity at rest of 3 groups (heat tolerant, heat intolerant and healthy subjects) will be assessed using the anatomical and functional MRI scans and compared.
- Trial name
- fMRI (NCT02498158)
- Testing
- MRI scans
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Heat Stress, Physiological Stress
Influence of Indoor Humidity on Physiological Strain in Older Adults During a Simulated Heat Wave
Laboratory-based studies show that exposure to high humidity can worsen the effects of heat stress in young and older adults by impeding sweat evaporation - the main mechanism by which the human body cools itself.
- Trial name
- NCT06842953
- Testing
- Simulated indoor overheating
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation
Heat Shock Protein 47 in Thrombosis
The goal of this observational study is to learn if the novel biomarker Heat shock protein 47 (HSP47) can be used as a prognostic marker for vascular disease in people with acute venous thromboembolism (VTE), myocardial…
- Conditions
- Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation, Stroke (in Patients With Atrial Fibrillation)
- Trial name
- NCT06731673
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Heat Illness, Heat Stroke
Heat Emergency Awareness and Treatment (HEAT)
Investigators propose an intervention trial of a comprehensive education and treatment bundle designed to reduce morbidity and mortality associated with heat-related illness for low resource settings.
- Conditions
- Heat Illness, Heat Stroke, Heat Exhaustion, Heat Exposure
- Trial name
- HEAT (NCT03513315)
- Testing
- Implementation of Community-based Home Heat Bundle, Regular Community Healthcare provision
- Where
- 2 sites in Pakistan
- Volunteers
- 16,973 people
- Sponsor
- Johns Hopkins University
Exertional Heat Stroke
Study to Assess the Efficacy and Safety of Ryanodex as Adjuvant Treatment in Subjects With EHS
A double-blind, parallel study of Ryanodex for the adjuvant treatment of exertional heat stroke (EHS) compared to current Standard of Care (SOC) for EHS.
- Trial name
- NCT03600376
- Testing
- Ryanodex and Standard of Care, Standard of Care
- Where
- 4 sites in Saudi Arabia
- Volunteers
- 17 people
- Sponsor
- Eagle Pharmaceuticals, Inc.
Exertional Heat Illness, Hydration Status
Comparing Risk of Heat Illness Based on Peak Core Temps During Preseason Football Camp Across 3 Different Age Levels
To collect field data in professional, collegiate, and high school football players to determine how they respond physiologically to the rigors of preseason training environment.
- Trial name
- NCT01954537
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Ischemic Stroke
Heat-clearing and Blood-activating Chinese Medicinal Components in Acute Cerebral Infarction
The present study is designed to confirm the therapeutic effects of heat-clearing and blood-activating Chinese medicinal components in treatment of Acute Cerebral Infarction (ACI) and to investigate the therapeutic mechanisms of…
- Trial name
- NCT02544087
- Testing
- Ixeris of sonchifolia Hance, Panax notoginseng saponins, Ixeris of sonchifolia Hance combined with Panax notoginseng saponins
- Where
- 4 sites in China
- Volunteers
- 120 people
- Sponsor
- Yunling Zhang
Ischemic Stroke, Acute
Molecular Network Characteristics of Phlegm-heat Syndrome in Ischemic Stroke Based on Multi-omics Integrated Analysis
The molecular characteristics of ischemic stroke with phlegm-heat syndrome and candidate biomarkers were identified based on multi-omics data.
- Trial name
- NCT05626296
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Stroke, Upper Limb Paresis
Thermal Stimulation for Stroke Patients
Sensory and/or motor deficits in upper limb following stroke often have negative impacts on their daily living. Thermal stimulation with hot and cold pack alternatively incorporated into conventional rehabilitation has been…
- Trial name
- TSSP (NCT01658293)
- Testing
- thermal stimulation, control group ergometer exercises
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Buddhist Tzu Chi General Hospital