Clinical trials: Helicobacter
Helicobacter Pylori Infection, Helicobacter Pylori Gastritis
Helicobacter Pylori Local Prevalence and Antibiotic Resistance
The clinical management of H. pylori infection depends essentially on two factors, prevalence and local resistance. In Germany, only limited data from rather small cohorts currently exist regarding both factors.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori Gastritis, Drug Resistant Bacterial Infection, Antibiotic Resistant Infection
- Trial name
- HelicoPTER (NCT05561504)
- Where
- Germany
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Helicobacter Pylori Infection
A Study to Evaluate Preliminary Helicobacter Pylori Eradication After Multiple Doses of TNP-2198 Capsules Combined With Rabeprazole Sodium Enteric-coated Tablets, or Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules
This phase Ⅰb/Ⅱa, single-center, randomized, open-label study was designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary Helicobacter Pylori eradication efficacy in asymptomatic subjects with…
- Trial name
- NCT06076681
- Testing
- TNP-2198, Rabeprazole Sodium, Amoxicillin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- TenNor Therapeutics (Suzhou) Limited
Helicobacter Pylori Infection
Bismuth Quadruple Therapy Versus Standard Triple Therapy
The goal of this clinical trial is to compare the standard triple therapy with Bismuth quadruple therapy in children infected with Helicobacter pylori.
- Trial name
- BismoHelP (NCT06143124)
- Testing
- Bismuth Subcitrate
- Where
- Slovenia
- Volunteers
- 216 people
- Sponsor
- University Medical Centre Ljubljana
Helicobacter Pylori Infection
Human Mass Balance and Biotransformation Study of [14C]TNP-2198
The purpose of the study is to analyze absorption, metabolism, excretion, mass balance and biotransformation after a single oral dose of [14C]TNP-2198 in healthy male participants
- Trial name
- NCT06137573
- Testing
- [14C]TNP-2198
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- TenNor Therapeutics (Suzhou) Limited
Gastric Cancer, Helicobacter Pylori Infection
Gastric Cancer Prevention in the Family Members by Helicobacter Pylori Eradication
This study evaluate whether treatment of Helicobacter pylori infection reduces the incidence of gastric cancer in subjects with family history of gastric cancer.
- Conditions
- Gastric Cancer, Helicobacter Pylori Infection, Family Members
- Trial name
- NCT01678027
- Testing
- LAC triple therapy
- Where
- South Korea
- Volunteers
- 1,838 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Helicobacter Pylori Infection, Early Gastric Cancer
Effects of H. Pylori Eradication on the Gastric Preneoplastic Lesion and Neoplasm After ESD
This study evaluates whether Helicobacter pylori eradication improves precancerous lesions including glandular atrophy and intestinal metaplasia as well as metachronous cancers or dysplasias after endoscopic mucosal resection for…
- Conditions
- Helicobacter Pylori Infection, Early Gastric Cancer, Endoscopic Resection
- Trial name
- NCT02407119
- Testing
- 7 day H.pylori eradication Omeprazole or Rabeprazole, Clarithromycin, Amoxicillin
- Where
- South Korea
- Volunteers
- 470 people
- Sponsor
- National Cancer Center, Korea
Helicobacter Pylori Infection in Patients With Chronic Tonsillits
Helicobacter Pylori in Patients With Chronic Tonsillits Prepared for Tonsillectomy
Tonsillar disorders are frequent In both pediatric and adult otolaryngological practice, . Numerous disorders that damage tonsillar tissue necessitate tonsillectomy. Tonsillectomy is typically required for recurrent tonsillitis.
- Trial name
- NCT06117956
- Testing
- Rapid urease test for h pylori
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Helicobacter Pylori Eradication Rate
Optimization of Vonoprazan--amoxicillin Dual Therapy for Eradicating Helicobacter Pyloriinfection
Helicobacter pylori infection is closely related to gastritis, peptic ulcer, mucosa-associated lymphoid tissue lymphoma and gastric cancer. Eradication of HP can significantly improve and reduce HP-related diseases.
- Trial name
- NCT05719831
- Testing
- vonoprazan fumarate + high dose amoxicillin（H-10d）, vonoprazan fumarate + low dose amoxicillin（L-10d), vonoprazan fumarate + amoxicillin（H-14d)
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Helicobacter Pylori Infection
Personalized Treatment for Refractory H Pylori Infection
In this study, the investigators develop a personalized treatment according to culture-guided antibiotics plus high-dose proton-pump inhibitor and bismuth to treat refractory H pylori infection.
- Trial name
- NCT02547025
- Testing
- rabeprazole+3 antibiotics, rabeprazole+bismuth+2 antibiotics, rabeprazole+amox+tetr+levo
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Helicobacter Pylori Infection
Comparing the Efficacy of Hybrid, High-dose Dual and Bismuth Quadruple Therapies
Both hybrid and high-dose dual therapies developed by the scholars from Taiwan can achieve a high eradication rate for clarithromycin-resistant strains, and have a great potential to replace bismuth quadruple therapy in the…
- Trial name
- NCT03779074
- Testing
- 10d bismuth quadruple therapy, 14d hybrid therapy, 14D high-dose dual therapy
- Where
- Taiwan
- Volunteers
- 918 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Helicobacter Pylori Infection
Efficacies of Two Bismuth Quadruple Therapies in the Second-line Treatment of H Pylori Infection
From the profiles of antibiotic susceptibility data following eradication therapy, tetracycline, amoxicillin and levofloxacin are all good candidates of antibiotics used in the rescue treatment.
- Trial name
- NCT03779087
- Testing
- 10d TL quadruple therapy, 10d AL quadruple therapy
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Ping-I (William) Hsu, M.D.
Helicobacter Pylori Eradication
Potassium Copetitive Acid Blockers Efficacy in H.Pylori Eradication
This trial assessed the efficacy of potassium competetor acid blocker (P-CAB) in the eradication of H.pylori
- Trial name
- P-CABs (NCT06101420)
- Testing
- Vonoprazan
- Where
- Egypt
- Volunteers
- 232 people
- Sponsor
- Ain Shams University
Helicobacter Pylori Infection, Helicobacter Pylori Eradication
Efficacy of Amoxicillin-Esomeprazole HDDT Compared to Levofloxacin Triple Therapy for H. Pylori Eradication: A RCT
The goal of this clinical trial is to compare the efficacy of two different therapeutic regimen for the treatment of Helicobacter pylori infected dyspeptic patients. The aim is - 1. To identify the percentage of H.
- Trial name
- NCT06088316
- Testing
- group A : Amoxicillin Esomeprazole HDDT, group-B : Levofloxacin triple therapy
- Where
- Bangladesh
- Volunteers
- 70 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Helicobacter Pylori Infection
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Food Effect of TNP-2198 Capsules After Single Oral Dose in Healthy Participants
This was a single-center, randomized, double-blind, placebo-controlled phase 1 study to evaluate the safety, tolerability, pharmacokinetics of single ascending dose and the food effect on the pharmacokinetics of TNP-2198 capsules…
- Trial name
- NCT06081699
- Testing
- TNP-2198
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- TenNor Therapeutics (Suzhou) Limited
Helicobacter Pylori Infection
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of TNP-2198 Capsules in Asymptomatic Participants With Helicobacter Pylori Infection
This study was a Phase 1, single-center, randomized, double-blind, placebo-controlled, multiple ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and preliminary Helicobacter Pylori eradication efficacy…
- Trial name
- NCT06081712
- Testing
- TNP-2198
- Where
- China
- Volunteers
- 48 people
- Sponsor
- TenNor Therapeutics (Suzhou) Limited
Helicobacter Infections, Stomach Neoplasms
Helicobacter Pylori Eradication to Prevent Gastric Cancer
Gastric cancer is the fourth most common type of cancer and the second leading cause of cancer-related death in the world. In China, more than 390,000 new patients are diagnosed with gastric cancer and more than 300,000 patients…
- Trial name
- NCT01133951
- Testing
- OAC triple therapy
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Jie-Jun Wang
Helicobacter Pylori Infection
Rapid Urease Test for Diagnosis Helicobacter Pylori Infection
Nowadays, the gold standard examinations for diagnosing H. pylori infection are histopathology and culture examination. However, those examinations take long preparation so they are not suitable to be applied in daily practice.
- Trial name
- NCT03547544
- Where
- Indonesia
- Volunteers
- 97 people
- Sponsor
- Universitas Indonesia
Autoimmune Diseases, Helicobacter Pylori Gastritis
Pyloric or Pseudopyloric Metaplasia of the Corpus Mucosa in Autoimmune Gastritis
The study is aimed to investigate the different rates of pyloric/ pseudopyloric metaplasia or spasmolytic polypeptide-expressing metaplasia (SPEM) of corpus between autoimmune gastritis and H. pylori-infected non-ulcer dyspepsia.
- Conditions
- Autoimmune Diseases, Helicobacter Pylori Gastritis, Anemia, Pernicious, Metaplasia
- Trial name
- PM_in_AIG (NCT05238181)
- Testing
- Assess pyloric or pseudopyloric metaplasia of corpus by H&E stains, Assess pyloric or pseudopyloric metaplasia of corpus by TFF2 immunohistochemistry stains, The assessment of corpus-predominant gastritis index (CGI), Operative Link for Gastritis Assessment (OLGA), and Operative Link on Gastric Intestinal Metaplasia assessment (OLGIM)
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Helicobacter Pylori Infection
Levofloxacin Concomitant Versus Levofloxacin Sequential
The goal of this trial is to determine the efficacy of levofloxacin based sequential treatment regimen or concomitant levofloxacin based regimens as empirical first-line therapy in the Syrian population
- Trial name
- NCT06065267
- Testing
- sequential, Levofloxacin 500Mg Oral Tablet
- Where
- Syria
- Volunteers
- 150 people
- Sponsor
- Damascus Hospital
Helicobacter Pylori
Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice
Helicobacter pylori is the main cause of chronic gastritis, peptic ulcer and gastric tumors (adenocarcinoma and lymphoma). The cure of the H.
- Trial name
- NCT01273441
- Testing
- PPI, amoxicillin, metronidazole and clarithromycin
- Where
- 11 sites in Spain
- Volunteers
- 338 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa