Clinical trials: Helicobacter
Helicobacter Pylori Infection
Probiotics in the Reduction of Adverse Effects and Dysbiosis of H. Pylori Eradication
The investigators aimed to assess the effect of probiotic supplementation with Vigiis 101-LAB during H. pylori eradication therapy with 14-day sequential therapy in the reduction of adverse effects and the restoration of the…
- Trial name
- NCT03722433
- Testing
- Vigiis 101-LAB and sequential therapy
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection, Helicobacter Pylori Infection, Susceptibility to
Eradication of H. Pylori Infection With Moxifloxacin
The main objective of the study is to compare the effectiveness of moxifloxacin triple therapy with levofloxacin-based sequential therapy in terms of eradication rate, safety, and patient compliance.
- Trial name
- RCT (NCT05863858)
- Testing
- Sequential Regimen: Levofloxacin 500 mg BID, Amoxicillin 1 gm BID, omeprazole 20 mg BID for first five days followed by Levofloxacin 500 mgBID, Tinidazole 500 mg BID, Omeprazole 20 mg BID, Triple Regimen: Moxifloxacin 400mg OD, Amoxicillin 1 gm BID, Omeprazole 20mgBID
- Where
- Pakistan
- Volunteers
- 162 people
- Sponsor
- Iyad Naeem Muhammad, PhD
Helicobacter Pylori Infection
Tegoprazan-Amoxicillin Dual Therapy vs. Bismuth Quadruple Therapy for H. Pylori Infection (TATH-1)
Standard eradication therapies using proton pump inhibitors (PPIs) require double doses to achieve sufficient acid suppression, yet failure rates remain high due to antibiotic resistance.
- Trial name
- TATH-1 (NCT05647278)
- Testing
- Tegoprazan 50 mg, tablets, orally, qd, Esomeprazole 20mg BID, Tegoprazan 50 mg, tablets, orally, bid
- Where
- China
- Volunteers
- 370 people
- Sponsor
- Zhang Xiaofeng,MD
Helicobacter Pylori Infection
Intraluminal Mono-antibiotic Therapy for Helicobacter Pylori Infection - A Comparison of Levofloxacin Powder and Levofloxacin Solution
Helicobacter pylori (H. pylori) is an important causal factor of chronic gastritis, peptic ulcer disease, gastric cancer and gastric lymphoma. The World Health Organization classified H. pylori as a Group 1 carcinogen in 1994.
- Trial name
- NCT03832465
- Testing
- Levofloxacin film-coated tablet, Levofloxacin intravenous solution
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Mackay Memorial Hospital
Peptic Ulcer
PPI vs H2RA in Patients With Helicobacter Pylori-Negative Idiopathic Bleeding Ulcers
The aim of this study is to compare the efficacy of a proton pump inhibitor (lansoprazole) and a histamine-2 receptor antagonist (famotidine) in preventing recurrent ulcer bleeding in patients with a history of H.
- Trial name
- NCT01180179
- Testing
- Lansoprazole, Famotidine
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Chinese University of Hong Kong
Gut Microbiota, Metabolic Disturbance
The Effects of High-dose Dual Therapy With Probiotics on Gut Microbiota for Helicobacter Pylori Rescue Treatment
The aim of this study was to evaluate the effects of High-dose Dual therapy combined with probiotics on the gut microbiota for Helicobacter pylori rescue treatment.
- Conditions
- Gut Microbiota, Metabolic Disturbance, Helicobacter Pylori Eradication
- Trial name
- NCT06292546
- Testing
- Vonoprazan, Amoxicillin, Bacillus subtilis enteric-coated capsules
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Zhongshan Hospital (Xiamen), Fudan University
Dyspepsia, Chronic Gastritis
Helicobacter Pylori Eradication With Berberine Plus Amoxicillin Triple Therapy Versus Bismuth-containing Quadruple Therapy
This study aims at evaluating efficacy and safety of berberine hydrochloride, amoxicillin and rabeprazole triple therapy versus bismuth-containing quadruple therapy(amoxicillin, clarithromycin, rabeprazole and bismuth) in the…
- Conditions
- Dyspepsia, Chronic Gastritis, Gastric Cancer, Helicobacter Pylori Infection
- Trial name
- NCT04697186
- Testing
- Berberine, Amoxicillin, Rabeprazole
- Where
- China
- Volunteers
- 524 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection
Effect of Propolis on Patients Infected With H. Pylori
This research aims to contribute to the literature by researching the effect of propolis as an add-on treatment and nutritional education on patients with H pylori and the alleviation of gastrointestinal symptoms.In order to…
- Trial name
- NCT05259007
- Testing
- propolis solved in lactic acid solvent, Amoxicillin-Clarithromycin-Lansoprazole, IV saline 0.9%
- Volunteers
- 96 people
- Sponsor
- Fatma Zehra Arvas
H Pylori Infection Eradication, Antibiotics Therapeutic Strategies
Therapeutic Trial Comparing Triple Therapy Guided by the PCR Detection of Clarithromycin Resistance vs Empiric Concomitant Quadruple Therapy for Helicobacter Pylori Infection
The H pylori infection remains a public health problem. The eradication rate with the first line triple therapy (PPI-amoxicillin-clarithromycin) is insufficient (estimated at 70%) due to the frequency of resistance to…
- Conditions
- H Pylori Infection Eradication, Antibiotics Therapeutic Strategies, H Pylori Eradication
- Trial name
- Hepysé (NCT02576236)
- Testing
- Quadruple concomitant therapy treatment, Triple therapy guided by the result of the molecular resistance test
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Gastritis
Evaluation of Immunohistochemical Expression of Heparanase in Helicobacter Pylori-Associated Chronic Gastritis
Treatment of H.pylori may not be achieved in many patients with chronic gastritis. Termination of the inflammatory respose produced by h.pylori may be useful in management of difficult cases.
- Trial name
- NCT05073614
- Testing
- immunohistochemical detection of Heparanase in chronic gastritis
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Sohag University
Gastric Cancer, Helicobacter Pylori Infection
Helicobacter Pylori Eradication for Gastric Cancer Prevention in the General Population
The aim of this study is to define the role of H. pylori eradication in the prevention of gastric cancer and its precursors in the context of a population-based endoscopic screening program.
- Trial name
- HELPER (NCT02112214)
- Testing
- 10-day bismuth-based quadruple therapy
- Where
- 11 sites in South Korea
- Volunteers
- 5,224 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Antibiotic-Associated Diarrhea
Effect of a Fresh Fermented Dairy Drink Product Consumption on Antibiotic Associated Diarrhea and Gastro-Intestinal Disorders
The purpose of this clinical study is to evaluate the effect of a four-week consumption of a fresh fermented dairy drink containing probiotic strains on Antibiotic-Associated Diarrhea and Gastro-Intestinal disorders in adult…
- Trial name
- NCT02900196
- Testing
- 1 - Fermented dairy drink, 2 - Acidified dairy drink
- Where
- Germany
- Volunteers
- 136 people
- Sponsor
- Danone Global Research & Innovation Center
Helicobacter Pylori Infection, Colorectal Cancer
European Implementation Study on Simultaneous Screening for Gastric and Colorectal Cancers
The EUGastScreen study is designed as a quality implementation study to explore gastric cancer screening strategies within organised cancer screening frameworks.
- Conditions
- Helicobacter Pylori Infection, Colorectal Cancer, Gastric Cancer
- Trial name
- EUGastScreen (NCT07873580)
- Testing
- Fecal sample acquisition for Helicobacter pylori stool antigen test, Upper endoscopy with biopsies, Colonoscopy with biopsies after bowel cleansing
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Gastrointestinal Ulcer Haemorrhage, Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Helicobacter Eradication Aspirin Trial
HEAT (Helicobacter Eradication Aspirin Trial) is a large simple double-blind placebo controlled outcomes study of Helicobacter pylori (H. pylori) eradication to prevent ulcer bleeding in aspirin users.
- Trial name
- HEAT (NCT01506986)
- Testing
- Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg
- Where
- 6 sites in United Kingdom
- Volunteers
- 30,024 people
- Sponsor
- University of Nottingham
Helicobacter Pylori Infection
Intraluminal Therapy for Helicobacter Pylori Infection
Helicobacter pylori (H. pylori) is the most common chronic bacterial infection in humans. The prevalence of H. pylori is about 30~50% in the Western adult population.
- Trial name
- NCT03124420
- Testing
- Lansoprazole, Amoxicillin, Clarithromycin
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Mackay Memorial Hospital
Dyspepsia
Antibiotic Resistant Helicobacter Pylori in Rajavithi Hospital
Peptic ulcer disease is the most common gastrointestinal disease. Antibiotic resistant Helicobacter pylori is a major problem worldwide.
- Trial name
- NCT00285688
- Testing
- gastroscopic examination
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Gastric, Peptic Ulcer
Ulcer Pomegranate Muffins
Pomegranate (Punica granatum L.) peel powder, known for its potent antioxidant, anti-inflammatory, and antimicrobial properties, has shown promise in the dietary management of gastrointestinal disorders.
- Trial name
- NCT07123259
- Testing
- WHOLE WHEAT MUFFIN, 1.5g enriched pomegranate muffins, 3g enriched pomegranate muffins
- Where
- Pakistan
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Non-variceal Upper Gastrointestinal Bleeding
Effects of Different Omeprazole Dosing on Gastric pH in Non-variceal Upper Gastrointestinal Bleeding
The aim of the study is to identify the best method of omeprazole (OME) application with respect to intragastric pH, cytochrome P450 2C19 (CYP2C19) genotype and phenotype.
- Trial name
- NCT03980496
- Testing
- Omeprazole
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Bialystok
Helicobacter Infections
Eradication Rates of Helicobacter Pylori and Its Affecting Factors
The purpose of this study is to investigate the trend of eradication rates of first-line triple therapy for Helicobacter pylori in recent ten years and clinical factors that affect the eradication in Korean.
- Trial name
- NCT01922505
- Testing
- PPI triple therapy
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Seoul National University Bundang Hospital
Helicobacter Pylori Infection, Comorbidities and Coexisting Conditions
Real-world Treatment of H. Pylori Eradication in Patients with Comorbidity
Most of the studies of H. pylori eradication were conducted in academic institutes and designed to enrolled patients who did not have comorbidities.
- Conditions
- Helicobacter Pylori Infection, Comorbidities and Coexisting Conditions, Real-world Outcome, Medication Adherence
- Trial name
- Real-world_Hp (NCT05475431)
- Testing
- The sequential therapy, The triple therapy, The hybrid therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 1,053 people
- Sponsor
- National Cheng-Kung University Hospital