Clinical trials: Helicobacter
Helicobacter Pylori Eradication Rate
Optimization of Keverprazan-amoxicillin Dual Therapy for Eradicating Helicobacter Pylori Infection
Eradication of HP can significantly improve and reduce HP-related diseases. A 10-14 day quadruple regimen containing bismuth as first-line treatment, achieving an eradication rate of more than 85%.
- Trial name
- NCT06734260
- Testing
- Keverprazan Hydrochloride tablets + high dose amoxicillin, Keverprazan Hydrochloride tablets + low dose amoxicillin, Keverprazan Hydrochloride tablets + high dose amoxicillin（H-KA-10d）
- Where
- 4 sites in China
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University
Helicobacter Pylori, Family
Family-based Screening and Treatment of Helicobacter Pylori：A Real World Study
The habit of family meals makes the infection rate of Helicobacter pylori high in China, which is also the main cause of reinfection of Helicobacter pylori.
- Trial name
- NCT04956679
- Testing
- carbon 13 breath test
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shandong University
Helicobacter Pylori Eradication Rate
Efficacy of Short-message-based Re-education (SMRE) on Helicobacter Pylori Eradication
Helicobacter pylori (H. pylori) is a pathogen that infects more than 50% of the human population, resulting in high healthcare costs worldwide. However, H.
- Trial name
- NCT02833623
- Testing
- Short-message-based Re-education, conventional education
- Where
- China
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Resistant Infection
One Sequencing Find All for Helicobacter Pylori Infection
The aim of this study is to Identify antibiotic resistance gene mutations in Helicobacter pylori (HP) and genetic diversity of drug metabolism for antibiotics and proton pump inhibitors (PPIs) in patients with HP infection using…
- Trial name
- NCT03837990
- Testing
- Helicobacter Pylori eradication therapy
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Antimicrobial Susceptibility Testing, Triple Therapy
Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment
Helicobacter pylori (H. pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer.
- Trial name
- NCT03139253
- Testing
- amoxicillin, clarithromycin, tinidazole
- Volunteers
- 120 people
- Sponsor
- Yanqing Li
HELICOBACTER PYLORI INFECTIONS
miRNA in Pediatric Gastritis
The goal of this clinical trial is to assess the differential expression of miR-155 and miRNA-204 in relation to gastritis, and assess their relation with the presence of H. pylori in children.
- Trial name
- microRNA (NCT07300787)
- Testing
- miRNA gene expression
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Benha University
Helicobacter Pylori Infection, Dyspepsia
Assessment and Management of Chronic Dyspepsia in Eastern Uganda
Chronic dyspepsia, or a sensation of indigestion, remains an underdiagnosed and often inappropriately managed cause of morbidity in countries with limited medical resources.
- Trial name
- NCT04525664
- Testing
- Clarithromycin 500mg, Amoxicillin 1000 MG, Omeprazole 40 MG
- Where
- United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Gastritis
A Multi-center Study for Eradication of Refractory Helicobacter Pylori
Recently studies showed that the eradication rate of H. pylori fail to exceed 80% and even falls into an unacceptable range. A major cause of treatment failure is associated with antibiotic resistance and poor patient compliance.
- Trial name
- NCT02741414
- Testing
- The result of H pylori culture based on gram staining and enzyme activity testing, The result of 13C-urea breath test after treatment based on the selection of clarithromycin, levofloxacin, metronidazole, amoxicillin，tetracycline，furazolidone and the dose of esomeprazole, The result of Amoxicillin resistance in vitro based on antibiotic susceptibility testing
- Where
- China
- Volunteers
- 4,428 people
- Sponsor
- Taizhou Hospital
Helicobacter Pylori Infection
High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection
This study is a multicentra, prospective study. The enrolled patients are HP positive. They are diagnosed as HP positive by rapid urease test and/or 13C urea breath test.
- Trial name
- NCT06561698
- Testing
- Vonoprazan, Amoxicillin, Bismuth Potassium Citrate
- Where
- 10 sites in China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection
Efficacy and Safety of a Triple Eradication Scheme for Helicobacter Pylori Based on Tegoprazan vs Esomeprazole
In Mexico, quadruple therapy is used to treat Helicobacter pylori (H.P.) at the expense of greater adverse effects, costs, and lower adherence to treatment.
- Trial name
- NCT06318104
- Testing
- Tegoprazan, Esomeprazole 40mg
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Helicobacter Pylori Infection
Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the Rescue Treatment of Helicobacter Pylori Infection
The purpose of this study is to assess efficacy of 14-day antimicrobial susceptibility test guided quadruple therapy for the rescue treatment of Helicobacter pylori infection, then comparing it with 14-day personal medication…
- Trial name
- NCT03565484
- Testing
- susceptibility guided therapy, personal medication history guided therapy, salvage treatment for failed eradication
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Standardize Communication With General Practitioner & Patient for Improved Eradication of Helicobacter Pylori
Patients who test Helicobacter pylori positive, are treated with antibiotics. However, due to a number of factors (such as unknown treatment compliance, no standardized follow-up, ...), a relative low eradication-percentage was…
- Trial name
- Helipro (NCT02873247)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
CYP2C19 Polymorphism, H.Pylori Infection
Effect of the CYP2C19 Polymorphism in Helicobacter Pylori Eradication
Background: Triple therapy efficacy against Helicobacter pylori is low worldwide, thus alternatives must be sought to improve eradication. Aim: To determine CYP2C19 genetic polymorphism effect on H. pylori eradication.
- Conditions
- CYP2C19 Polymorphism, H.Pylori Infection, Therapy
- Trial name
- NCT03650543
- Testing
- amoxicillin clarithromycin omeprazole 1, amoxicillin clarithromycin omeprazole 2
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Javeriana University
Helicobacter Pylori
Pilot Study of a Gastric String Test Combined With a Rapid Antigen Assay for Helicobacter Pylori Detection
This single-center, open-label, prospective pilot study aims to evaluate the feasibility, safety, and preliminary diagnostic performance of a minimally invasive gastric string sampling device combined with a rapid antigen assay…
- Trial name
- NCT07906938
- Testing
- HP String Test With Rapid Antigen Assay
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University Hospital
Helicobacter Pylori Infection
Telephone-Based Re-education for Hp Eradication
It was suggested that the patient compliance plans an important role in the Hp eradication. However, data on whether re-education could improve the eradication rate are lacking.
- Trial name
- NCT03193450
- Testing
- telephone-based re-education, First education at the clinic
- Where
- China
- Volunteers
- 162 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Helicobacter Pylori Infection
The Efficacy of 10-day or 14-day Course of Bismuth-containing Quadruple Therapy:A Randomized Clinical Trial
The researchers collect treatment-naive H.pylori-positive patients from the outpatient clinic. The subjects were randomized to receive a 10-day or 14-day course of Tegoprazan bismuth-containing quadruple eradication therapy at 6…
- Trial name
- NCT05586113
- Testing
- 10-day Tegoprazan bismuth-containing quadruple therapy
- Where
- China
- Volunteers
- 398 people
- Sponsor
- Shandong University
Advanced Colorectal Neoplasms, Throat Cancer
Fecal Screening Assay for Taiwanese Population
Fecal occult blood test (FOBT) is a convenient tool for the screening of asymptomatic gastrointestinal (GI) bleeding while 「guaiac-based fecal occult test (G-FOBT) 」 is increasingly replaced by the use of an 「immunochemical-based…
- Conditions
- Advanced Colorectal Neoplasms, Throat Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT01341197
- Testing
- Fecal immunochemical test, guaiac fecal occult-blood test, and Helicobacter pylori stool antigen test
- Where
- Taiwan
- Volunteers
- 3,172 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Tailored Vs. Empirical Helicobacter Pylori Infection Treatment
Helicobacter pylori (Hp) is a gram-negative bacterium that colonizes human gastric mucosa and is associated with chronic gastritis that can progress to severe complications such as peptic ulcer disease, gastric adenocarcinoma and…
- Trial name
- NCT06200779
- Testing
- Clarithromycin (mutations in the 23S rRNA gene, A2134G, A2142G and A2142C mutations) and levofloxacin resistance (mutations in the gyrA gene) PCR test, Empirically H. pylori eradication treatment with bismuth quadruple therapy (Pylera®), PPI, amoxicillin 1 g and clarithromycin 500 mg, twice daily, for 10 days
- Where
- Portugal
- Volunteers
- 160 people
- Sponsor
- Manuel Coelho da Rocha
Helicobacter Pylori Infection, Iron Deficiency Anemia
Potential Adverse Developmental and Nutritional Consequences of Helicobacter Pylori Infection in Israeli Children
The investigators believe that there is an association between H. pylori infection and nutritional status and between H. pylori infection and cognitive development.
- Conditions
- Helicobacter Pylori Infection, Iron Deficiency Anemia, Child Development
- Trial name
- NCT02654197
- Where
- Israel
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
GERD
Effect of Helicobacter Pylori Eradication on Gastroesophageal RefIux Disease (GERD)
Evaluate the effect of H.pylori eradication on Gastroesophageal-reflux disease and symptoms improvement
- Trial name
- NCT06457334
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University