Clinical trials: Helicobacter
Increase the Eradication Rate of Helicobacter Pylori
The Effect of Berry Extract on Helicobacter Pylori Eradication
Helicobacter pylori (HP) is the major risk factors of gastritis, gastric ulcers, duodenal ulcers, mucosa associated lymphoid tissue lymphoma and gastric cancer.
- Trial name
- NCT01045408
- Testing
- Berry extract
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Helicobacter Pylori Infection
Efficacy and Safety of an H.Pylori Vaccine in H.Pylori-Negative Adults
To study the safety, immunogenicity and efficacy of an investigational H. pylori vaccine, compared with placebo.
- Trial name
- NCT00736476
- Testing
- H.pylori vaccines
- Where
- Germany
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Helicobacter Pylori Infection
Efficacy of High-dose Dual Therapy vs Bismuth-containing Quadruple Therapy for First-line Treatment of Hp Infection
Up to now, there is few randomized, large scale study prospectively and simultaneously comparing the efficacy, adverse effects and patient adherence of high-dose dual therapy (HDDT) and bismuth-containing quadruple therapy (BQT)…
- Trial name
- NCT02483715
- Testing
- High-dose dual therapy (rabeprazole, amoxicillin), Bismuth-containing quadruple therapy (rabeprazole, tripotassium dicitrate bismuthate, metronidazole, tetracycline)
- Where
- Taiwan
- Volunteers
- 589 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Assessment of the Adjuvant Role of Dietary Supplementation of Antibiotic-tolerant Probiotics in Standard Therapy for the Eradication of Helicobacter Pylori Infection.
Randomized, double-blind, placebo-controlled clinical study to assess the adjuvant role of dietary supplementation of antibiotic-tolerant probiotics, derived from Lactobacillus acidophilus and Bifidobacterium animalis, in…
- Trial name
- NCT06499649
- Testing
- IBSA Probiotics
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- IBSA Farmaceutici Italia Srl
Helicobacter Pylori Infection
VA Dual Sequential Therapy
Sequential therapy for Hp was first introduced by Zullo et al. in 2000 and consists of two phases: the first phase involves proton pump inhibitors with one antibiotic, and the second phase involves proton pump inhibitors with two…
- Trial name
- JSHERO3 (NCT06929962)
- Testing
- Vonoprazan and Amoxicillin for the first 7 days, Vonoprazan and Amoxicillin for the first 5 days, Vonoprazan and Amoxicillin for the second 7 days
- Where
- China
- Volunteers
- 600 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
H. Pylori, SLE - Systemic Lupus Erythematosus
Associating Gastric Infection With Autoimmune Flare Severity in an Egyptians
A cross-sectional, observational study aims to evaluate the relationship between Helicobacter pylori infection and disease activity in patients diagnosed with systemic lupus erythematosus (SLE), using a combination of structured…
- Trial name
- NCT07157202
- Volunteers
- 115 people
- Sponsor
- Assiut University
Central Serous Chorioretinopathy
Effect of Helicobacter Pylori Treatment on Idiopathic Central Serous Chorioretinopathy (ICSCR)
Etiology of ICSCR is not known however recent studies regard the role of immunologic and infectious processes in the pathogenesis of ICSCR.one of these hypothesis is the role of helicobacter pylori in the pathogenesis of ICSCR so…
- Trial name
- ICSCR (NCT00817245)
- Testing
- omeprazole, Amoxicillin, metronidazole
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Tabriz University
Helicobacter Pylori Infection
Five Days Quadruple and Clarithromycin Containing Triple Therapy as Treatment for Helicobacter Pylori Eradication
The aim of this randomized trial is to compare the efficacy and tolerability of H. pylori eradication with a 5-day quadruple therapy versus a clarithromycin-containing triple therapy.
- Trial name
- NCT01306786
- Testing
- Quadruple therapy, Triple therapy
- Where
- Hong Kong
- Volunteers
- 800 people
- Sponsor
- The University of Hong Kong
Autoimmune Diseases, Helicobacter Pylori Gastritis
Pyloric or Pseudopyloric Metaplasia of the Corpus Mucosa in Autoimmune Gastritis
The study is aimed to investigate the different rates of pyloric/ pseudopyloric metaplasia or spasmolytic polypeptide-expressing metaplasia (SPEM) of corpus between autoimmune gastritis and H. pylori-infected non-ulcer dyspepsia.
- Conditions
- Autoimmune Diseases, Helicobacter Pylori Gastritis, Anemia, Pernicious, Metaplasia
- Trial name
- PM_in_AIG (NCT05238181)
- Testing
- Assess pyloric or pseudopyloric metaplasia of corpus by H&E stains, Assess pyloric or pseudopyloric metaplasia of corpus by TFF2 immunohistochemistry stains, The assessment of corpus-predominant gastritis index (CGI), Operative Link for Gastritis Assessment (OLGA), and Operative Link on Gastric Intestinal Metaplasia assessment (OLGIM)
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Functional Dyspepsia, Helicobacter Pylori Infection
Effect of Eradication of Helicobacter Pylori on the Dyspeptic Symptoms
Helicobacter pylori eradication and its impact on symptoms in patients with non-ulcer dyspepsia remain controversial . Many studies have examined the effect of H.
- Trial name
- EEHPDS (NCT00772837)
- Testing
- Omeprazole + Clarithromycin + Amoxycillin
- Where
- Pakistan
- Volunteers
- 370 people
- Sponsor
- Aga Khan University
Helicobacter Pylori Infection
Qingre Huashi Granules Combined the Modified Dual Therapy for Helicobacter Pylori Infection
This is an open-label, randomized controlled trial. The aim of the study is to evaluate the efficacy and safety of the Qingre Huashi Granules combined the modified dual therapy (or called high dose dual therapy) for Helicobacter…
- Trial name
- NCT05364619
- Testing
- Qingre Huashi Granules combined the modified dual therapy, Bismuth containing quadruple therapy
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Peking University First Hospital
Helicobacter Pylori Eradication
Effectiveness of Minocycline-Containing Bismuth Quadruple Therapy for Helicobacter Pylori Eradication
Although,bismuth-containing quadruple therapy has been highly recommended as first-line treatment regimen for H.pylori infection,it also has its problems and limitations in China.The primary resistance rates of…
- Trial name
- NCT04558502
- Testing
- Minocycline hydrochloride capsule, Clarithromycin, Amoxicillin
- Volunteers
- 339 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori, Atrophic Gastritis
Helicobacter Pylori, Atrophic Gastritis and Intestinal Metaplasia Registry and Prospective Study
Since much is unknown about factors that lead to progression of the pre-neoplastic lesions and cancer. In addition, there is ongoing debate on the optimal surveillance intervals and techniques.
- Conditions
- Helicobacter Pylori, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT05053945
- Testing
- Esophagogastroduodenoscopy
- Where
- 2 sites in Hong Kong
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
H. Pylori Eradication Failure
Mixed Strain H. Pylori Infection in Patients Who Have Problems With Eradication of H. Pylori
The purpose of this study is to determine whether mixed H. pylori strain infection is the reason for eradication failure during treatment of H. pylori infection.
- Trial name
- NCT01164969
- Testing
- Antibiotics to which H. pylori can not develope resistance
- Where
- Slovenia
- Volunteers
- 10 people
- Sponsor
- University Medical Centre Ljubljana
Helicobacter Pylori Infection, Antibiotic Resistant Strain
Tailored H. Pylori Eradication Based on Clarithromycin Resistance
The investigators investigated the point mutations in the 23S rRNA genes of patients infected with clarithromycin-resistant H. pylori and compared the H.
- Trial name
- NCT03884348
- Testing
- proton pump inhibitor, amoxicillin, clarithromycin, proton pump inhibitor, amoxicillin, metronidazole
- Volunteers
- 431 people
- Sponsor
- Kangdong Sacred Heart Hospital
HELICOBACTER PYLORI INFECTIONS
miRNA in Pediatric Gastritis
The goal of this clinical trial is to assess the differential expression of miR-155 and miRNA-204 in relation to gastritis, and assess their relation with the presence of H. pylori in children.
- Trial name
- microRNA (NCT07300787)
- Testing
- miRNA gene expression
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Benha University
Helicobacter Pylori Infection
Vonoprazan-containing Triple Therapy Versus Empiric Bismuth Quadruple Therapy for First-line Helicobacter Pylori Treatment: a Randomized Clinical Trial
Vonoprazan Amoxicillin and metronidazole based triple therapy had achieved a high cure rate in the rescue treatment of helicobacter pylori infection.
- Trial name
- NCT05726734
- Testing
- Vonoprazan, Amoxicillin, Metronidazole, Bismuth Potassium Citrate
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai East Hospital
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Changes Associated With H. Pylori and Gastric Carcinogenesis
This is a research study for patients who currently have or previously had an H. pylori infection or who have gastric or esophageal cancer and who plan to undergo an endoscopy as part of their care.
- Trial name
- IIT H pylori (NCT02164409)
- Testing
- Endoscopy tissue collection
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Gastritis
A Relevance Study Between the Result of Clinical Drug Intervention and Next-generation Sequencing Technology Focused on Refractory Helicobacter Pylori Infection
Approximately 50% of people in the world are infected with H. pylori, and its eradication rate fail to exceed 80% and even fails into an unacceptable range.Various risk factors for infection include lower socioeconomic status…
- Trial name
- NCT02806674
- Testing
- The eradication times of the patients, The result of 13C-urea breath test after treatment
- Where
- 4 sites in China
- Volunteers
- 1,845 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Helicobacter Pylori Infections, Atrophic Gastritis
Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality
Currently no ideal preventive modalities are available for reducing gastric-cancer caused mortality in organized population-based application.
- Conditions
- Helicobacter Pylori Infections, Atrophic Gastritis, Gastric Cancer
- Trial name
- GISTAR (NCT02047994)
- Testing
- Triple therapy
- Where
- Latvia
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer