Clinical trials: Helicobacter
Helicobacter Pylori
A Study to Evaluate the Efficacy and Safety of Bismuth-Containing Quadruple Therapy With Oral Vonoprazan (TAK-438) 20 mg Compared to Esomeprazole 20 mg Twice Daily in Paticipants With Helicobacter Pylori Infection
The purpose of this study is to evaluate the efficacy of helicobacter pylori (HP) eradication with bismuth-containing quadruple therapy with vonoprazan versus esomeprazole in all HP-positive participants.
- Trial name
- NCT04198363
- Testing
- Vonoprazan, Amoxicillin, Clarithromycin
- Where
- 29 sites in China
- Volunteers
- 510 people
- Sponsor
- Takeda
Helicobacter Pylori Resistance
Helicobacter Pylori Resistance
The main goal of the study was to characterize the morbidity, immunological, microbiolical and clinical phenotypes of patients with treated- resistance to Helicobacter pylori (HP) infection, and the effect of triple therapy…
- Trial name
- CRIHEP (NCT05019586)
- Testing
- levofloxacin, amoxicillin, clarithromycin
- Volunteers
- 185 people
- Sponsor
- University Hospital of North Norway
Helicobacter Pylori
The Associations Between the Gastric Mucosal Pathology and the Eradication Rate of H.Pylori :A Multicenter Study
Use the two-categorical variable , eradicate success or failure ,as a dependent variable, and analyze the influential factors by logistic regression.And then the statistically significant influencing factors like gastric mucosal…
- Trial name
- NCT04030715
- Testing
- bismuth-containing quadral therapy based on antibiotic susceptibility
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Shandong University
Helicobacter Pylori Eradication Antibiotic
Efficacy and Safety of Ilaprazole Based Bismuth-containing Quadruple Regimen for the First-line Treatment of Helicobacter Pylori Infection
This study compared efficacy and safety of Ilaprazole based bismuth-containing quadruple regimen therapy including Ilaprazole 5mg, Bismuth Potassium Citrate 220mg, Clarithromycin 500mg and Amoxicillin Cap (Amoxicillin) 1000mg BID…
- Trial name
- NCT02835560
- Testing
- Ilaprazole antisecretory drug of each quadruple therapy the Ilaprazole -based quadruple therapy, Esoprazole antisecretory drug of each quadruple therapy Esoprazole-based quadruple therapy
- Volunteers
- 100 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Helicobacter Pylori Infection, Upper Endoscopy
Diagnosis of Helicobacter Pylori Based on Gastric Collecting Venules
Helicobacter pylori (Hp) is the major cause of gastritis and gastritis-associated diseases. Detection of a regular arrangement of collecting venules (RAC) pattern in the lesser gastric curvature correlates with negative Hp status…
- Conditions
- Helicobacter Pylori Infection, Upper Endoscopy, Regular Arrangement of Collecting Venules
- Trial name
- NCT04000243
- Testing
- Endoscopic diagnosis of Hp
- Where
- Spain
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Helicobacter Pylori Infection
Compare Sequential and Quadruple Therapy for the Eradication of Helicobacter Pylori in Korea
1. To compare 10-day sequential therapy and 14-day modified bismuth quadruple therapy and to establish more effective first-line regimen for the eradication of Helicobacter pylori in Korea. 2. To evaluate the effect of H.
- Trial name
- NCT02159976
- Testing
- Pantoprazole, Amoxicillin, Clarithromycin
- Where
- South Korea
- Volunteers
- 390 people
- Sponsor
- Seoul National University Bundang Hospital
Helicobacter Pylori Infection
Susceptibility-Guided Sequential Therapy for Helicobacter Pylori Infection
The main objective of this trial is to assess whether a sequential therapy strategy based on molecular antibiotic susceptibility testing (including clarithromycin and fluoroquinolone) for H.
- Trial name
- NCT05549115
- Testing
- clarithromycin-sensitive(first-line), clarithromycin-resistant(first-line), empirical therapy group first-line
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Liaocheng People's Hospital
Helicobacter Pylori, Atrophic Gastritis
Helicobacter Pylori, Atrophic Gastritis and Intestinal Metaplasia Registry and Prospective Study
Since much is unknown about factors that lead to progression of the pre-neoplastic lesions and cancer. In addition, there is ongoing debate on the optimal surveillance intervals and techniques.
- Conditions
- Helicobacter Pylori, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT05053945
- Testing
- Esophagogastroduodenoscopy
- Where
- 2 sites in Hong Kong
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Gastritis H Pylori
14-day Quadruple Therapy Versus Triple Therapy in HP Eradication
In this prospective randomized-controlled study, treatment-naive H. pylori-infected patients are randomized to receive either standard triple therapy or sequential therapy.
- Trial name
- HEPRA (NCT04769583)
- Testing
- metronidazole based quadriple therapy
- Where
- Tunisia
- Volunteers
- 121 people
- Sponsor
- mohamed bouchoucha
Helicobacter Pylori
Effect of Oral Helicobacter Pylori Infection on the Efficacy of Gastroluminal Helicobacter Pylori Eradication Therapy
The aim of this study is to assess the effect of oral Helicobacter pylori infection on the efficacy of gastric Helicobacter pylori infection eradication.
- Trial name
- NCT05790525
- Testing
- Standard bismuth quadruple
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infected Patients, Thyroid Cancer Patients
The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication
Because of the high iodine uptake in the stomach, radioactive iodine treatment for thyroid diseases (cancer or hyperthyroidism) or radioactive iodine administered for thyroid scan may be able to eradicate H.pylori infection from…
- Conditions
- Helicobacter Pylori Infected Patients, Thyroid Cancer Patients, Hyperthyroidism
- Trial name
- NCT00822289
- Volunteers
- 120 people
- Sponsor
- Rabin Medical Center
Microbial Colonization, Gastritis
Gastric and Duodenal Microbiota in Dyspeptic Subjects
The composition of gastric microbiota is determined by the status of Helicobacter pylori infection. In subjects who have never been infected by H.
- Trial name
- NCT02542579
- Testing
- 16S rRNA pyrosequencing analysis
- Where
- 2 sites in South Korea
- Volunteers
- 98 people
- Sponsor
- Konkuk University Medical Center
Gastric Cancer
The Efficacy of Serum Pepsinogen for Prediction of Metachronous Gastric Neoplasm
After endoscopic resection of early gastric cancer (EGC), there remained concerned about the development of the metachronous gastric neoplasm (MGN). The aim of this study was to evaluate the role of H.
- Trial name
- NCT02682446
- Testing
- H pylori eradication
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Kyungpook National University Hospital
H Pylori Infection
Antibiotyping and Prevalence of Virulent Genotypes Among Helicobacter Pylori and Their Impact on Response to Therapy
Detection of primary antimicrobial susceptibility and resistance of Helicobacter Pylori infection. Detection of resistance and virulence genes of Helicobacter Pylori infection. Assessment of H pylori carcinogenicity gene.
- Trial name
- NCT05444439
- Testing
- detection of vacuolating cytotoxin A (Vac A) and cytotoxin-associated gene A (Cag A) virulent H.Pylori genotypes by polymerase chain reaction amplification(PCR) in gastric biopsies :, Culture and sensitivity of endoscopic gastric biopsies:, Histopathological examination endoscopic gastric biopsies:
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Helicobacter Infections
The Effect of Probiotic Combination on Helicobacter Pylori Infection in Children
The combination of two Lactubacillus reuteri strains, ATC 55730 and ATCC PTA 6457 are marketed as GASTRUS® and has been proposed as better option in increasing Helicobacter pylori eradication rate compared to the single strain…
- Trial name
- Gastrus (NCT02645201)
- Testing
- Gastrus
- Where
- 5 sites in Belgium, Croatia and 3 more
- Sponsor
- University Medical Centre Ljubljana
Helicobacter Pylori Infection
A Study About the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure
The patients who accepted the quadruple eradication program of the helicobacter pylori but failed to eradicate helicobacter pylori will be assessed the most suitable re-eradication time of helicobacter pylori.
- Trial name
- NCT05493644
- Testing
- Remedial treatment within 3 months, Remedial treatment within 3 to 6 months, Remedial treatment within 6 to 12 months
- Volunteers
- 660 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Metabolic-associated Steatohepatitis
Huazhi Rougan Granule as an Add-On Therapy for H. Pylori Infection With Metabolic-associated Steatohepatitis
This study employed a double-blind, randomized, placebo-controlled design. Eligible treatment-naïve patients with Helicobacter pylori (Hp) infection complicated by metabolic-associated steatohepatitis (MASH) (dampness-heat…
- Conditions
- Helicobacter Pylori Infection, Metabolic-associated Steatohepatitis, High-dose Dual Therapy, Huazhi Rougan Granule
- Trial name
- NCT07159412
- Testing
- Vonoprazan-amoxicillin combined with Huazhi Rougan Granule
- Volunteers
- 286 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Helicobacter Pylori Infection
Rapid Urease Test for Diagnosis Helicobacter Pylori Infection
Nowadays, the gold standard examinations for diagnosing H. pylori infection are histopathology and culture examination. However, those examinations take long preparation so they are not suitable to be applied in daily practice.
- Trial name
- NCT03547544
- Where
- Indonesia
- Volunteers
- 97 people
- Sponsor
- Universitas Indonesia
H Pylori Infection Eradication, Antibiotics Therapeutic Strategies
Therapeutic Trial Comparing Triple Therapy Guided by the PCR Detection of Clarithromycin Resistance vs Empiric Concomitant Quadruple Therapy for Helicobacter Pylori Infection
The H pylori infection remains a public health problem. The eradication rate with the first line triple therapy (PPI-amoxicillin-clarithromycin) is insufficient (estimated at 70%) due to the frequency of resistance to…
- Conditions
- H Pylori Infection Eradication, Antibiotics Therapeutic Strategies, H Pylori Eradication
- Trial name
- Hepysé (NCT02576236)
- Testing
- Quadruple concomitant therapy treatment, Triple therapy guided by the result of the molecular resistance test
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Helicobacter Pylori Infection
Optimal Site for Rapid Urease Test in the Stomach
The accurate diagnosis of H. pylori infection is an important step for establishing the strategy for gastric cancer prevention. During endoscopy, rapid urease test (RUT) is the first of biopsy-based H. pylori tests.
- Trial name
- NCT02945137
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Soonchunhyang University Hospital