Clinical trials: Helicobacter
Helicobacter Pylori Infection
Development of Treatment Algorithm for Eradication of Helicobacter Pylori Based on Antibiotic Susceptibility Test
Helicobacter pylori eradication (H. pylori) rates with clarithromycin-based triple therapy are declining, and an alternative strategy is needed urgently.
- Trial name
- NCT02759029
- Testing
- eradication of Helicobacter pylori
- Where
- South Korea
- Volunteers
- 123 people
- Sponsor
- Gangnam Severance Hospital
MALT Lymphoma of Stomach
Prospective Study of Frontline Antibiotics Therapy in the Treatment of Early-stage HP-negative Gastric MALT Lymphoma
We hypothesized that a proportion of patients with localized Helicobacter pylori-negative gastric MALT lymphoma may well respond to frontline Helicobacter pylori eradication therapy (HPE) and remain lymphoma-free for the long…
- Trial name
- GastricMALToma (NCT07144657)
- Testing
- Esomeprazole, Bismuth tripotassium dicitrate, Tetracycline, and Metronidazole
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Reflux Esophagitis, Hiatal Hernia
Immunologic Factors in Reflux Esophagitis and Barrett's Esophagus
By using combination of the expression of COX-2 and NOS and immunologic reaction in the esophagus with manometry of LES and cruel diaphragm and 24 hr esophageal pH monitoring to investigate the mechanisms and to make a new and…
- Trial name
- NCT00155805
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Study of Nitazoxanide (NTZ) for Helicobacter Pylori in Children
Study of Nitazoxanide (NTZ) based therapeutic regimens for Helicobacter pylori in children
- Trial name
- NCT04415983
- Testing
- Nitazoxanide, Clarithromycin, Metronidazole
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Helicobacter Pylori Infection
Head-to-head Study of Tegoprazan 50 mg BID Plus Amoxicillin 1 g TID vs. Vonoprazan 20 mg BID Plus Amoxicillin 1 g TID for H. Pylori Eradication
This study is a randomized, open-label, parallel-group clinical trial designed to compare two 14-day dual therapies for the eradication of Helicobacter pylori (H. pylori) infection.
- Trial name
- TV-HP (NCT07242456)
- Testing
- Tegoprazan, Amoxicillin, Vonoprazan
- Where
- China
- Volunteers
- 240 people
- Sponsor
- First People's Hospital of Hangzhou
Epilepsy, Generalized, Helicobacter Pylori Infection
Helicobacter Pylori Eradication Therapy for Epileptic Children
Helicobacter pylori (H. pylori) infection is associated with several health problems. The role of H. pylori infection in epilepsy has been investigated in a few studies.
- Trial name
- NCT05297695
- Testing
- Triple therapy for H. pylori infection
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Sohag University
Helicobacter Pylori Infection
Influence of Oral Hp Infection and Oral Related Factors on Gastric Hp Infection and Eradication Therapy
Helicobacter pylori (H. pylori) is closely related to the occurrence of gastric cancer and other diseases. The discovery and eradication of H. pylori is of great significance for the prevention and treatment of related diseases.
- Trial name
- Hp (NCT05455372)
- Testing
- PPI quadruple therapy
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Helicobacter Pylori Infection
Human Mass Balance and Biotransformation Study of [14C]TNP-2198
The purpose of the study is to analyze absorption, metabolism, excretion, mass balance and biotransformation after a single oral dose of [14C]TNP-2198 in healthy male participants
- Trial name
- NCT06137573
- Testing
- [14C]TNP-2198
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- TenNor Therapeutics (Suzhou) Limited
Helicobacter Pylori Infection
Efficacy of 10-day Concomitant Regimen Versus High Dose Dual Therapy in Anti-Helicobacter Pylori Rescue Therapy
Currently, a 10-day concomitant therapy has been reported to be equally effective and safe to the 10-day sequential therapy for 1st-line anti-Helicobacter pylori(H. pylori) therapy.
- Trial name
- NCT01265069
- Testing
- high dose dual therapy, concomitant therapy
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori, Gastric Antrum
Value of Additional Corpus Biopsy for Diagnosis of H Pylori in Atrophic Gastritis. Prospective Non-randomized Study
There are controversies about the best sites -biopsy based -tests for H pylori associated gastritis. The study is designed to evaluate the optimal site of gastric mucosal biopsy for identification of Helicobacter pylori…
- Conditions
- Helicobacter Pylori, Gastric Antrum, CORPUS BIOPSIES
- Trial name
- NCT02675010
- Testing
- ENDOSCOPIC GASTRIC BIOPSIES FROM ANTRUM AND BODY
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Helicobacter Pylori Infection
Levofloxacin-containing Therapies In Second Line Helicobacter Pylori Eradication
Asia Pacific Consensus states that levofloxacin-based triple therapy as an alternative second-line therapy after Helicobacter pylori (H. pylori) eradication failure when bismuth salts are not available.
- Trial name
- NCT02596620
- Testing
- Nexium, Amolin, Cravit
- Volunteers
- 164 people
- Sponsor
- Chang Gung Memorial Hospital
Helicobacter Pylori Infection
New Strategy for the Detection and Treatment of Helicobacter Pylori Infections in Primary Care Guided by a Non-invasive PCR in Stool
In France, every year 1 million people are explored for Helicobacter pylori infection and 200,000 receive eradication treatment.
- Trial name
- HEPYPRIM (NCT05495854)
- Testing
- PCR test in the stool, Hp serology and gastroscopy
- Where
- 13 sites in France
- Volunteers
- 245 people
- Sponsor
- Poitiers University Hospital
Helicobacter Pylori Infection
High Dose of Dual Therapy Plus Bismuth for Helicobacter Pylori Treatment
Dual therapy for Helicobacter Pylori including a proton pump inhibitor (PPI) and amoxicillin. Amoxicillin has low resistance rate as well as low percentage of side effects.
- Trial name
- NCT03405584
- Testing
- Esomeprazole, Amoxicillin, Bismuth Potassium Citrate
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection
The Effect of Time Intervals for Rescue Treatment on Eradication Effect of Helicobacter Pylori Infection
The researchers collect patients who accepted eradication program of the helicobacter pylori but failed to eradicate helicobacter pylor from the outpatient clinic.
- Trial name
- NCT05620602
- Testing
- Remedial treatment within 3 months, Remedial treatment within 3 to 6 months, Remedial treatment within 6 to 12 months
- Where
- China
- Volunteers
- 628 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
ADDITION OF BISMUTH TO THE STANDARD TRIPLE THERAPY FOR HELICOBACTER PYLORI ERADICATION
H pylori is an important cause of chronic gastritis and other complications. There is a decline in eradication rate for H pylori owing to multiple factors including drug resistance.
- Trial name
- NCT03968302
- Testing
- ARM A Triple therapy for helicobacter pylori, ARM B Quadruple therapy for helicobacter pylori
- Where
- Pakistan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Ziauddin University
Helicobacter Pylori, Gastritis
Safety and Immunogenicity of Chiron's Investigational H. Pylori Vaccine in Healthy Adults
This study was designed to investigate the safety and immunogenicity of Chiron's investigational H. pylori (HP3) vaccine
- Conditions
- Helicobacter Pylori, Gastritis, Gastric Cancer, Gastroduodenal Ulcers
- Trial name
- NCT00613665
- Testing
- helicobacter pylori vaccine
- Where
- Germany
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Helicobacter Pylori Infection
Intragastric pH and Bismuth Effect for H. Pylori Eradication
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. In Taiwan, there are around 3800 fresh cases annually, with about 5% of total cancers cases.
- Trial name
- NCT02894892
- Testing
- (A)Bismuth, (B)Bismuth, (C)Bismuth
- Where
- Taiwan
- Volunteers
- 21 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Effect of Dental Scaling on Helicobacter Pylori Eradication and Reinfection
Patients who had received H.pylori eradication treatment will be categorised as eradication and reinfection status and whether dental scaling has any influence on these results.
- Trial name
- Scaling and Hp (NCT01816269)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Goztepe Training and Research Hospital
Gastritis
A Multi-center Study for Eradication of Helicobacter Pylori With Triple Therapy Using Clarithromycin
As the resistant rate of the Helicobacter pylori to some common antibiotics was rising，the eradication rate of the Helicobacter pylori with the standard triple therapy failed to exceed 70% in China，and had to drop out of the…
- Trial name
- NCT02923856
- Testing
- The results of clarithromycin susceptibility test of H. pylori isolates, Computer generated random number, randomly assigned into groups, The result of 13C-urea breath test of patient in 7days/10days/14days treatment groups
- Where
- China
- Volunteers
- 672 people
- Sponsor
- Sanmen People's Hospital
Gastric Ulcer, Chronic Gastritis
Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy
This study aims at evaluating efficacy and safety of berberine- amoxicillin containing quadruple therapy(berberine, amoxicillin, esomeprazole and bismuth) versus tetracycline-furazolidone quadruple therapy (tetracycline…
- Conditions
- Gastric Ulcer, Chronic Gastritis, Gastric Cancer, Helicobacter Pylori Infection
- Trial name
- NCT03609892
- Testing
- Berberine, Amoxicillin, Esomeprazole
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Xijing Hospital of Digestive Diseases