Clinical trials: Helicobacter
HELICOBACTER PYLORI INFECTIONS, Intestinal Metaplasia
Endoscopic Screening of Asymptomatic Patients for Helicobacter Pylori, Intestinal Metaplasia, and Barrett's Mucosa During Screening Colonoscopy
The goal of this observational study is to learn how common Helicobacter pylori (H. pylori) infection is in adults without stomach or upper gastrointestinal symptoms who are having a preventive screening colonoscopy.
- Conditions
- HELICOBACTER PYLORI INFECTIONS, Intestinal Metaplasia, Barett's Esophagus
- Trial name
- G-SCOGE (NCT07346521)
- Where
- Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sigmund Freud PrivatUniversitat
Helicobacter Pylori Infection
A "Screen and Treat" Helicobacter Pylori Eradication Trial in Adolescents in Three Regions of Chile
Gastric cancer remains a global health problem, and Chile has one of the highest GC mortality rates in the region. Helicobacter pylori (H.
- Trial name
- NCT05926804
- Testing
- Lansoprazole, Amoxicillin, Clarithromycin
- Where
- 3 sites in Chile
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Miguel O'Ryan Gallardo
Helicobacter Pylori Infection, Helicobacter Pylori Infection, Susceptibility to
Eradication of H. Pylori Infection With Moxifloxacin
The main objective of the study is to compare the effectiveness of moxifloxacin triple therapy with levofloxacin-based sequential therapy in terms of eradication rate, safety, and patient compliance.
- Trial name
- RCT (NCT05863858)
- Testing
- Sequential Regimen: Levofloxacin 500 mg BID, Amoxicillin 1 gm BID, omeprazole 20 mg BID for first five days followed by Levofloxacin 500 mgBID, Tinidazole 500 mg BID, Omeprazole 20 mg BID, Triple Regimen: Moxifloxacin 400mg OD, Amoxicillin 1 gm BID, Omeprazole 20mgBID
- Where
- Pakistan
- Volunteers
- 162 people
- Sponsor
- Iyad Naeem Muhammad, PhD
Helicobacter Pylori Infection
Helicobacter Pylori First-line Treatment in Patients Allergic to Penicillin
The purpose of this study is to assess and compare the effectiveness of levofloxacin-tetracycline -containing and tinidazole-tetracycline-containing quadruple regimens for the primary treatment of Helicobacter pylori infection in…
- Trial name
- NCT04122287
- Testing
- Levofloxacin, tinidazole
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shandong University
H. Pylori Infection
H. Pylori Eradication Using Pyklear in Adults in El Paso, Texas: a Pilot Study
The proposed open-label one arm before-after clinical trial will assess the efficacy of a 14-day quadruple therapy containing 420mg of bismuth subcitrate potassium, 375mg of metronidazole, 375mg of tetracycline hydrochloride…
- Trial name
- NCT01335334
- Testing
- bismuth subcitrate potassium, metronidazole,tetracycline hydrochloride and omeprazole
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Pulmonary Disease, Oropharyngeal Disease
Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases
This study will examine bacteria and toxins in the mouth, lung and digestive system that may be the cause of various diseases or symptoms. H.
- Conditions
- Pulmonary Disease, Oropharyngeal Disease, Lymphangioleiomyomatosis, Pulmonary Fibrosis
- Trial name
- NCT00366509
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Helicobacter Pylori
Keverprazan Combined With Amoxicillin for the Treatment of Helicobacter Pylori
The objective of this clinical trial is to determine whether the interventional behavioral drug Keverprazan in combined with amoxicillin, is effective in treating initial Helicobacter pylori infections in adults and to assess the…
- Trial name
- NCT06851468
- Testing
- Keverprazan, Esomeprazole, Amoxicillin
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Key Laboratory for Gastrointestinal Diseases of Gansu Province
Helicobacter Pylori Infection
VA Dual Sequential Therapy
Sequential therapy for Hp was first introduced by Zullo et al. in 2000 and consists of two phases: the first phase involves proton pump inhibitors with one antibiotic, and the second phase involves proton pump inhibitors with two…
- Trial name
- JSHERO3 (NCT06929962)
- Testing
- Vonoprazan and Amoxicillin for the first 7 days, Vonoprazan and Amoxicillin for the first 5 days, Vonoprazan and Amoxicillin for the second 7 days
- Where
- China
- Volunteers
- 600 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Stomach Neoplasms
Serological Screening of Gastric Cancer in Wuxi Region
The purpose of this study is to determine whether detection of pepsinogen Ⅰand Ⅱ combined with Helicobacter pylori antibody, so-called ABC method , is fit on gastric cancer screening in community of Wuxi City.
- Trial name
- NCT02663427
- Testing
- serological examination and gastroscope
- Volunteers
- 5,000 people
- Sponsor
- Wuxi People's Hospital
H. Pylori Infection
Immediate Detection of Helicobacter Infection With a New Electrochemical System.
Helicobacter pylori-infection (H. pylori) affects about fifty percent of the general population and is associated with peptic ulcer disease, non-cardia gastric adenocarcinoma and gastric lymphoma.
- Trial name
- NCT01234389
- Testing
- Electrochemical H. pylori detection method, IHC, C13-urea breath test
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Helicobacter Pylori Infection
A Phase 3 Study to Evaluate the Efficacy and Safety of Triple Therapy With CJ-12420 in H. Pylori Positive Patients
The current study is designed to demonstrate the non-inferiority of CJ-12420-based triple therapy (CJ-12420, amoxicillin and clarithromycin) versus lansoprazole-based triple therapy (lansoprazole, amoxicillin and clarithromycin)…
- Trial name
- NCT03317223
- Testing
- CJ-12420/Clarithromycin/Amoxicillin
- Where
- South Korea
- Volunteers
- 350 people
- Sponsor
- HK inno.N Corporation
Helicobacter Pylori Infection
Efficacy of High-dose Dual Therapy vs Bismuth-containing Quadruple Therapy for First-line Treatment of Hp Infection
Up to now, there is few randomized, large scale study prospectively and simultaneously comparing the efficacy, adverse effects and patient adherence of high-dose dual therapy (HDDT) and bismuth-containing quadruple therapy (BQT)…
- Trial name
- NCT02483715
- Testing
- High-dose dual therapy (rabeprazole, amoxicillin), Bismuth-containing quadruple therapy (rabeprazole, tripotassium dicitrate bismuthate, metronidazole, tetracycline)
- Where
- Taiwan
- Volunteers
- 589 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Community-based Helicobacter Pylori Eradication
Based on a universal eradication of H. pylori in an offshore island (Matsu) with a high prevalence of gastric cancer as well as premalignant gastric lesion, we first examined the infection rate of H. pylori.
- Trial name
- NCT00155389
- Testing
- Helicobacter pylori eradication
- Where
- 2 sites in Taiwan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori
Vonoprazan Hp Dual or Triple Eradication Regimes
To evaluate the efficacy and safety of dual or triple regimes for Helicobacter Pylori eradication using Vonoprazan as the antiacid agent.
- Trial name
- NCT05345210
- Testing
- Vonoprazan Fumarate+Amoxycillin+Clarithromycin 14days (VAC14), Vonoprazan Fumarate+Amoxycillin 14days (VA14), Vonoprazan Fumarate+Amoxycillin 7days (VA7)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Functional Dyspepsia, Irritable Bowel Syndrome
Psychoemotional Status and Functional Gastrointestinal Disorders
This prospective cohort study will evaluate the influence of psychoemotional status on the clinical course and quality of life of adult patients with functional dyspepsia and/or irritable bowel syndrome diagnosed according to…
- Trial name
- NCT07539051
- Testing
- Questionnaire and Symptom Assessment, Helicobacter pylori Status Assessment
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Center of New Medical Technologies
Helicobacter Pylori Infection
Efficacy of Acetylcysteine-containing Triple Therapy in the First Line of Helicobacter Pylori Infection
Helicobacter pylori infection has been shown to be associated with the development of gastric cancer and peptic ulcer diseases. Eradication of H. pylori infection could reduce the occurence or recurrence of these diseases.
- Trial name
- NCT02249546
- Testing
- N-acetylcysteine + PPI-amoxicillin-clarithromycin, PPI-amoxicillin-clarithromycin
- Where
- 2 sites in Taiwan
- Volunteers
- 654 people
- Sponsor
- National Taiwan University Hospital
Functional Dyspepsia, Scarred Peptic Ulcer
Empirical Rescue Therapies of Helicobacter Pylori Infection
The increase of antibiotic resistance to H. pylori causes failure of treatment. Furazolidone, amoxicillin and tetracycline are good candidates for rescue therapy since resistance to these three antimicrobials was rare.
- Trial name
- NCT01668927
- Testing
- Proton Pump Inhibitor, Bismuth, Metronidazole
- Where
- China
- Volunteers
- 424 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
HELICOBACTER PYLORI INFECTIONS
Feasibility and Performance of FFPE qPCR for Detection of Clarithromycin Resistance in Helicobacter Pylori
This prospective observational study aims to evaluate the feasibility and performance of real-time PCR (qPCR) performed on formalin-fixed, paraffin-embedded (FFPE) gastric biopsies to detect Helicobacter pylori infection and…
- Trial name
- HED-2T (NCT07821294)
- Testing
- q-PCR on FFPE gastric biopsies
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Clinique Bizet
Helicobacter Pylori Infection Chronic Gastrit
Efficacy and Safety of Tegoprazan and Minocycline Dual Therapy for Helicobacter Pylori Initial Treatment
The purpose of this study was to evaluate the efficacy and safety of tegoprazan and minocycline dual therapy for Helicobacter pylori initial treatment.
- Trial name
- NCT06523764
- Testing
- tegoprazan, Minocycline, bismuth potassium citrate
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection
Vonoprazan-based Therapy Versus Standard Regimen for Helicobacter Pylori Infection Management
Appropriately, half of the global population is infected with H. pylori, and it is now recognized that it causes at least 95% of all gastric cancers. Currently, the main challenge in the field of H.
- Trial name
- NCT05614934
- Testing
- standard Clarithromycin triple therapy, Vonoprazan triple therapy, Vonoprazan dual therapy
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Alexandria University