Clinical trials: Helicobacter
Helicobacter Pylori Infection
Performances of a Fast Test for the Detection of Helicobacter Pylori Antigens in Child Stool
The diagnostic tests used to detect Helicobacter pylori (H. pylori) infection are either direct and invasive, as in culture, histology and the rapid urease test (RUT) or noninvasive, such as serology, the 13C-Urea breathe test or…
- Trial name
- DISPOSE (NCT03324763)
- Testing
- stool sampling
- Where
- France
- Volunteers
- 158 people
- Sponsor
- Lille Catholic University
Helicobacter Pylori Infection
Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the Rescue Treatment of Helicobacter Pylori Infection
The purpose of this study is to assess efficacy of 14-day antimicrobial susceptibility test guided quadruple therapy for the rescue treatment of Helicobacter pylori infection, then comparing it with 14-day personal medication…
- Trial name
- NCT03565484
- Testing
- susceptibility guided therapy, personal medication history guided therapy, salvage treatment for failed eradication
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Dyspepsia
Epidemiological Investigation of Helicobacter Pylori-infected Patients and the Effect of Eradication Treatment on Dyspepsia Symptoms
The objectives of this multicenter, prospective, observational study were to investigate the incidence of dyspeptic symptoms in patients with Helicobacter pylori (H.
- Trial name
- NCT06422052
- Testing
- Epidemiological questionnaire and Functional Dyspepsia Symptom Diary（FDSD）
- Where
- 26 sites in China
- Volunteers
- 2,242 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection
New Strategy for the Detection and Treatment of Helicobacter Pylori Infections in Primary Care Guided by a Non-invasive PCR in Stool
In France, every year 1 million people are explored for Helicobacter pylori infection and 200,000 receive eradication treatment.
- Trial name
- HEPYPRIM (NCT05495854)
- Testing
- PCR test in the stool, Hp serology and gastroscopy
- Where
- 13 sites in France
- Volunteers
- 245 people
- Sponsor
- Poitiers University Hospital
Helicobacter Pylori Infection
Randomized Study on Efficacy of Gemifloxacin-based Regimen for Helicobacter Pylori Infection
New generations of fluoroquinolones, like levofloxacin and moxifloxacin, exhibit a broad-spectrum activity against Gram-positive and Gram-negative bacteria, and have been successfully introduced into the treatment of Helicobacter…
- Trial name
- NCT02368470
- Testing
- Gemifloxacin-based triple therapy, Standard triple therapy
- Where
- South Korea
- Volunteers
- 252 people
- Sponsor
- Samsung Medical Center
Gastritis
A Multi-center Study for Eradication of Helicobacter Pylori With Triple Therapy Using Clarithromycin
As the resistant rate of the Helicobacter pylori to some common antibiotics was rising，the eradication rate of the Helicobacter pylori with the standard triple therapy failed to exceed 70% in China，and had to drop out of the…
- Trial name
- NCT02923856
- Testing
- The results of clarithromycin susceptibility test of H. pylori isolates, Computer generated random number, randomly assigned into groups, The result of 13C-urea breath test of patient in 7days/10days/14days treatment groups
- Where
- China
- Volunteers
- 672 people
- Sponsor
- Sanmen People's Hospital
H Pylori
Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori Infection
Current studies have primarily focused on comparing the advantages and disadvantages of P-CAB and PPI drugs, with little comparison between different P-CAB drugs or between regimens with varying drug combinations and treatment…
- Trial name
- NCT07040839
- Testing
- Clarithromycin 500 mg, Amoxicillin 1 g, Omeprazole 40 mg
- Where
- Pakistan
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Helicobacter Pylori Infection
Efficacy of Clarithromycin and Flouroquinolones Based Regimens in H.Pylori Eradication in Covid-19 Era
Era of COVID-19 and the related panic lead to widely spread antibiotics misuse especially for azithromycin. Cross sensitivity between azithromycin and clarithromycin can impact success rates of H.
- Trial name
- NCT05035186
- Testing
- Amoxicillin
- Where
- Egypt
- Volunteers
- 233 people
- Sponsor
- Alexandria University
Helicobacter Infections
Dual Therapy With High Doses of Ilaprazole and Amoxicillin for Helicobacter Pylori Infection
This study assessed eradication rate of dual therapy with high doses of Ilaprazole 40mg BID and Amoxicillin 750mg QID for 14 days on Helicobacter pylori infection.
- Trial name
- NCT02401477
- Testing
- Ilaprazole + Amoxicillin
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Helicobacter Pylori Infection
Pilot Study of a 14-day Modified Sequential Therapy for Helicobacter Pylori Infection
The purpose of this study is to assess efficacy of a 14-day sequential therapy for the rescue treatment of refractory Helicobacter pylori infection, and whether it is safe while maintaining an ideal eradication rates.
- Trial name
- NCT03616405
- Testing
- rabeprazole, amoxicillin, tetracycline, furazolidone (only for the first 7 days), colloidal bismuth pectin (for the second 7 days)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong University
Gastric Ulcer Associated With Helicobacter Pylori
Additive Effect of Endonase on Eradication Rate of First Line Therapy for Helicobacter Pylori
Endonase, a kind of protease, is known to cause both extensive degradation of mucins and a reduction in mucus viscosity. As part of the search for more effective forms of therapy against H.
- Trial name
- NCT01645761
- Testing
- Endonase
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Helicobacter Pylori Infection
The Diagnostic Validity of the Urea Breath Test
1. To compare the diagnostic accuracy of the 13C-Urea breath test between using the citric acid as test meal and controlled group by endoscopic biopsy methods(histology, CLOtest and H. pylori culture). 2.
- Trial name
- NCT02359942
- Testing
- Citric acid
- Where
- South Korea
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Duodenal Ulcer, Gastric Ulcer
Lymphocytic Subsets and Cytokine Production With H. Pylori Infection
The aims of this study are 1) to determine the cytokines produced by both Th1 and Th2 subsets in gastric antral biopsy specimens from Taiwanese patients before and after anti H.
- Conditions
- Duodenal Ulcer, Gastric Ulcer, Dyspepsia
- Trial name
- NCT00173953
- Testing
- immune response
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Sequential and Hybrid Therapies for H Pylori Infection
Primary: To evaluate efficacy of 14 day 2-phase sequential therapy given in two forms. One in which the first component consists of a proton pump inhibitor and amoxicillin given for 7 days followed by the PPI, clarithromycin and…
- Trial name
- NCT01085786
- Testing
- 14-day sequential treatment, 14-day hybrid treatment
- Where
- 2 sites in Taiwan
- Volunteers
- 240 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Helicobacter Pylori Infection
Efficacy of Low-dose Vonoprazan for Helicobacter Pylori Eradication
The primary objective of this retrospective study was to assess the efficacy and safety of a bismuth quadruple regimen of a low-dose potassium-competitive acid blocker versus a standard-dose potassium-competitive acid blocker and…
- Trial name
- NCT06037122
- Volunteers
- 558 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori Infection, Susceptibility to
Helicobacter Pylori Infection Among Women With Recurrent Abortion of Unknown Cause
Helicobacter pylori (H. pylori) infection affects approximately one half of the world population and it is more prevalent in developing countries. This microorganism colonizes the stomach.
- Trial name
- NCT07293169
- Testing
- H pylori eradication
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
H. Pylori Infections, Non-communicable Diseases
Effects of Fermented Rye Bran Products on Helicobacter Pylori (HP) Infection and Metabolic Risk Factors
The investigators hypothesize that long-term fermented high-fibre rye intake may reduce the Helicobacter pylori infection through dampening inflammation and thereby leading to lower adherence of the bacteria to surfaces.The…
- Trial name
- RyeClaim (NCT03103386)
- Testing
- intake of food product with a patented fermented rye bran, intake of food product with common refined wheat
- Where
- China
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Fudan University
Helicobacter Pylori Infection
A Study on Eradication Rate of Triple Therapy According to Treatment Period and CYP2C19 Polymorphisms in H.Pylori Patients
This study compared efficacy and safety of basic triple therapy according to treatment period. This study evaluated Effect of CYP2C19 genetic polymorphisms on the efficacy
- Trial name
- NCT03099876
- Testing
- treatment period
- Where
- 4 sites in South Korea
- Volunteers
- 320 people
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Helicobacter Pylori Infection
14-day Double Therapy Versus Bismuth Quadruple Therapy in First-line Treatment of Helicobacter Pylori Infection
The researchers collected untreated H. pylori positive patients from outpatient clinics. Subjects were randomized to 14 days of dual therapy with Tegoprazan or 14 days of quadruple therapy with bismuth for eradication.
- Trial name
- NCT05438550
- Testing
- 14-day high-dose Tegoprazan Dual Therapy (HDDT)
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Shandong University
Infection, Achlorhydria
Clinical Experiment of Helicobacter Pylori Transmission
The study proposes to test whether chronic infection with Helicobacter pylori protects individuals from symptomatic infection with enteropathogenic E. coli.
- Trial name
- NCT00550368
- Testing
- Biological intervention: Enteropathogenic E. coli
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stanford University