Clinical trials: Helicobacter Infections
Helicobacter Pylori Infection
Primary Antimicrobial Resistance Patterns of Austrian Helicobacter Pylori Clinical Isolates
Helicobacter pylori infects ~ 50% of the world's population and a quarter of the European population. H. pylori is responsible for a large proportion of gastric and duodenal ulcers and gastritis. Chronic infection with H.
- Trial name
- NCT02925091
- Volunteers
- 2,000 people
- Sponsor
- Medical University of Vienna
H. Pylori Infection
Effect of Vitamin D on Drug Resistant Helicobacter Pylori (HP) Eradication Study
Background: Helicobacter pylori infection, which affects over 50% of the global population, is one of the most prevalent infectious diseases in the world. H.
- Trial name
- vDHp (NCT03142620)
- Testing
- Esomeprazole, Amoxicillin-Potassium Clavulanate Combination, Clarithromycin
- Where
- Hong Kong
- Volunteers
- 96 people
- Sponsor
- Chinese University of Hong Kong
Helicobacter Pylori Infection
Clarithromycin, Amoxicillin, and Metronidazole Based Regimens to Treat Helicobacter Pylori Infections in Colombia
More than half of the world's population is infected with Helicobacter pylori, a bacterium that colonizes the human stomach. Although most infected subjects live free of symptoms and disease outcomes (except superficial…
- Trial name
- NCT00719420
- Testing
- Clarithromycin, Metronidazole, Amoxicillin (+Omeprazole), Clarithromycin, Amoxicillin, Omeprazole
- Where
- Colombia
- Volunteers
- 151 people
- Sponsor
- University of North Texas Health Science Center
Gastritis
A Multi-center Study for Eradication of Refractory Helicobacter Pylori
Recently studies showed that the eradication rate of H. pylori fail to exceed 80% and even falls into an unacceptable range. A major cause of treatment failure is associated with antibiotic resistance and poor patient compliance.
- Trial name
- NCT02741414
- Testing
- The result of H pylori culture based on gram staining and enzyme activity testing, The result of 13C-urea breath test after treatment based on the selection of clarithromycin, levofloxacin, metronidazole, amoxicillin，tetracycline，furazolidone and the dose of esomeprazole, The result of Amoxicillin resistance in vitro based on antibiotic susceptibility testing
- Where
- China
- Volunteers
- 4,428 people
- Sponsor
- Taizhou Hospital
Helicobacter Pylori Infection
Tegoprazan-Amoxicillin Dual Therapy vs. Bismuth Quadruple Therapy for H. Pylori Infection (TATH-1)
Standard eradication therapies using proton pump inhibitors (PPIs) require double doses to achieve sufficient acid suppression, yet failure rates remain high due to antibiotic resistance.
- Trial name
- TATH-1 (NCT05647278)
- Testing
- Tegoprazan 50 mg, tablets, orally, qd, Esomeprazole 20mg BID, Tegoprazan 50 mg, tablets, orally, bid
- Where
- China
- Volunteers
- 370 people
- Sponsor
- Zhang Xiaofeng,MD
Helicobacter Pylori Infection
Optimized Bismuth Quadruple Therapy vs Triple Standard Therapy for Helicobacter Pylori Eradication
This study have as primary aim "To compare the H. pylori eradication rate between the quadruple bismuth therapy versus the standard triple therapy recommended by the AUGE Clinical Guidelines for Helicobacter pylori eradication…
- Trial name
- NCT05664685
- Testing
- Optimized bismuth quadruple therapy, Control
- Where
- 2 sites in Chile
- Volunteers
- 127 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Helicobacter Pylori Infection
Comparison of 12-day Reverse Hybrid Therapy and 12-day Standard Triple Therapy for Helicobacter Pylori Infection
Reverse hybrid therapy is a one-step two-phase treatment for Helicobacter pylori infection with less cost than standard triple therapy.
- Trial name
- REHYTRI (NCT02359435)
- Testing
- Reverse hybrid therapy, Standard triple therapy
- Where
- Taiwan
- Volunteers
- 440 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Gastritis, H Pylori Infection
Helicobacter Pylori Eradication With Clostridum Butyricum Capsule and Bacillus Coagulans Tablets
This study aims at evaluating efficacy Clostridum Butyricum Capsule and Bacillus Coagulans Tablets in H. pylori eradication. It is hypothesized that Clostridum Butyricum Capsule , Bacillus Coagulans Tablets monotherapy or…
- Conditions
- Gastritis, H Pylori Infection, Dyspepsia
- Trial name
- NCT03857425
- Testing
- Clostridum Butyricum Capsule, Bacillus Coagulans Tablets, Clostridum Butyricum Capsule plus Bacillus Coagulans Tablets
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection
Low Dose Bismuth Versus Lactobacillus Reuteri for H. Pylori Eradication
This study investigates the efficacy of a b.i.d. quadruple therapy containing Pylera® or L. reuteri for H. pylori infection.
- Trial name
- LactoBismu (NCT03925818)
- Testing
- Bismuth Subcitrate Potassium, Gastrus
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- Università degli Studi di Sassari
HELICOBACTER PYLORI INFECTIONS
Efficacy and Safety of Second-Line Helicobacter Pylori Eradication
Subjects with persistent H. pylori infection after first-line treatment failure receives either a 14-day PPI-based moxifloxacin triple regimen (esomeprazole, amoxicillin, and moxifloxacin) or a 14-day P-CAB-bismuth-containing…
- Trial name
- NCT07855497
- Testing
- P-CAB-BM quadruple regimen, Moxifloxacin triple regimen
- Where
- South Korea
- Volunteers
- 141 people
- Sponsor
- Seoul National University Bundang Hospital
Helicobacter Pylori Infection
Comparison of Different Helicobacter Pylori Detection Methods in Patients With Chronic Atrophic Gastritis
As we know，Helicobacter pylori is closely related to many gastrointestinal diseases such as chronic gastritis, peptic ulcer disease,gastric carcinoma and gastric mucosa-associated lymphoid tissue lymphoma，as well as…
- Trial name
- NCT04923113
- Testing
- Histology，13C urea breath test，Stool antigen test，Serological antibody test for H.pylori and Serologic test with a current infection marker of H.pylori, Rabeprazole，Minocycline，Amoxicillin and Colloidal bismuth pectin
- Where
- 2 sites in China
- Volunteers
- 281 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori Infection
Bismuth Quadruple Therapy in Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.
The researchers collect H.pylori-positive patients who need rescue therapy from the outpatient clinic. The subjects were randomized to receive a dose and frequency of tetracycline 500mg tid or qid of bismuth quadruple eradication…
- Trial name
- NCT05802888
- Testing
- Tetracycline 500mg tid, Tetracycline 500mg qid
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Helicobacter Pylori
H. Pylori Eradication With Argon Plasma During Endoscopy
The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori, Helicobacter Pylori Gastrointestinal Tract Infection, H. Pylori Infection
- Trial name
- HEAPE (NCT06529159)
- Testing
- HEAPE, Pre-HEAPE
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Dyspepsia Abdominal Burning Pain Diarrhea Dysentery
Concomitant Infection of Intestinal Parasites and Helicobacter Pylori
Intestinal parasitic infections such as Giardia lamblia, Entamoeba histolyica and Enterobius Vermicularis are among the most common infections worldwide.So parasitic infections are considered one of the major health problems in…
- Trial name
- NCT05360940
- Testing
- H.pylori stool antigen rapid test and stool parasitological examination
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Helicobacter Pylori Infection
Assesment of the Efficiency and Safety Helicobacter Pylori Therapy With or Without Saccharomyces Boulardii
This study assesses the effect of quadruple therapy for H. pylori, with the addition of probiotics Saccharomyces boulardii. In addition, he assesses whether this combination reduces the frequency of adverse effects of eradication…
- Trial name
- NCT03997279
- Testing
- Saccharomyces boulardii
- Volunteers
- 200 people
- Sponsor
- Clinical Centre of Serbia
Helicobacter Pylori Infection
Rifabutin-containing Triple Therapy for Treatment of Helicobacter Pylori
Rifabutin has good chemical stability and low drug resistance rate in acidic gastric environment. Therefore, it is often used in combination with amoxicillin proton pump inhibitor for the rescue treatment of Helicobacter pylori.
- Trial name
- NCT04879992
- Testing
- Esomeprazole, Bismuth Potassium Citrate, Tetracycline,Metronidazole
- Where
- China
- Volunteers
- 413 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection
Rescue Therapy for Helicobacter Pylori Infection
Dual therapy containing vonoprazan and amoxicillin had showed excellent eradication results with Helicobacter pylori first-line treatment. However, no study has examined its efficacy for H. pylori rescue treatment.
- Trial name
- NCT05874544
- Testing
- Vonoprazan, Bismuth Potassium Citrate, Tetracycline
- Where
- 3 sites in China
- Volunteers
- 360 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection
The Effect of Vitamin D Supplement as Adjuvant Therapy in Eradication of Helicobacter Pylori Infection
Helicobacter pylori (H. pylori) is one of the most common chronic infections worldwide. The mode of transmission of H. pylori is through the fecal-oral or oral-oral routes.
- Trial name
- NCT06964334
- Testing
- Lansoprazole, amoxicillin, clarithromycin
- Volunteers
- 70 people
- Sponsor
- Assiut University
Helicobacter-associated Gastritis
Detection of Helicobacter Pylori Infection by High Resolution Endoscopy
Although endoscopic findings of H. pylori have been reported in the literature, there is still some debate over whether H. pylori-related gastritis can be diagnosed via endoscopic features alone.
- Trial name
- NCT01434992
- Where
- South Korea
- Volunteers
- 585 people
- Sponsor
- Kyunghee University Medical Center
Iron Deficiency
Helicobacter Pylori Eradication Trial to Reduce Iron Deficiency in Children
The investigators hypothesize that the Helicobacter pylori bacterium decreases iron from the stomach and that this effect of the infection can be identified among persons with iron deficiency as well as among persons with normal…
- Trial name
- HEIDC (NCT00364104)
- Testing
- Quadruple sequential Helicobacter pylori eradication + iron sulfate, Quadruple sequential Helicobacter pylori eradication therapy, Ferrous sulfate
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston