Clinical trials: Helicobacter Pylori
Helicobacter Pylori Infection
Genotypic Resistance-guided Versus Empirical Therapy for H. Pylori Eradication.
This study aims to investigate the efficacy of a 7-day genotypic resistance-guided triple therapy, compared with empirical concomitant therapy, for first-line eradication of H. pylori.
- Trial name
- NCT04090021
- Testing
- Esomeprazole 40mg, Clarithromycin 500mg, Metronidazole 500 mg
- Where
- Greece
- Volunteers
- 304 people
- Sponsor
- Konstantopoulio-Patission General Hospital of Nea Ionia
Helicobacter Pylori Infection
Efficacy and Safety of Dual Therapy for Helicobacter Pylori Eradication
The purpose of this study was to evaluate the Efficacy and Safety of Vonoprazan- amoxicillin dual therapy for Helicobacter Pylori eradication
- Trial name
- NCT05469685
- Testing
- Vonoprazan, Amoxicillin
- Where
- 10 sites in China
- Volunteers
- 914 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Helicobacter Pylori
A Comparison of High-dose Dual Therapy and Half-dose Clarithromycin-containing Bismuth Quadruple Therapy for H.P Eradication in Elderly Patients
The purpose of this study is to assess and compare the effectiveness and safety of high-dose dual therapy and half-dose clarithromycin-containing bismuth quadruple therapy in elderly patients for eradicating H.pylori.
- Trial name
- NCT04101708
- Testing
- Lansoprazole, Amoxicillin, Lansoprazole, Amoxicillin,Clarithromycin and Bismuth subcitrate
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shandong University
Efficacy, Gastric Microbiota
The Effects Probiotic Has on Gastromicroecology and Combined With Quadruple Regimen for H Pylori Infection
This study assesses the efficacy and safety of treatment with two-week probiotics followed by a 10-day tetracycline- and furazolidone-containing quadruple regimen as rescue treatment for H. pylori infection.
- Conditions
- Efficacy, Gastric Microbiota, Safety
- Trial name
- NCT03377933
- Testing
- Compound Lactobacillus acidophilus
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yiqi Du
Oncology Epidemiology, Risk Factors
Prevalence of H. Pylori in Stomach Cancers in the West Indies
The incidence and mortality of stomach cancer are higher in the French West Indies than in mainland France. The prevalence of H. pylori infection associated with this cancer remains unknown in these populations.
- Trial name
- PyloCaGe (NCT07233447)
- Where
- 2 sites in Guadeloupe
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Helicobacter Pylori Infection
Helicobacter Pylori Rescue Treatment Containing Tetracycline in Patients Allergic to Penicillin
The purpose of this study is to assess and compare the effectiveness of furazolidone-tetracycline-containing and tinidazole-tetracycline-containing quadruple regimens for the rescue treatment of Helicobacter pylori infection in…
- Trial name
- NCT04264663
- Testing
- Furazolidone, Tinidazole
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shandong University
Helicobacter Pylori
Vonoprazan-Based Triple Therapy in Comparison With Extended Sequential Therapy
This study aims to compare the efficacy of the current standard first-line anti-helicobacter pylori regimen, extended proton pump inhibitor-based sequential therapy, with that of vonoprazan-based triple therapy, through a…
- Trial name
- NCT05371249
- Testing
- Vonoprazan-based triple therapy, Extended sequential therapy
- Where
- Taiwan
- Volunteers
- 628 people
- Sponsor
- Fu Jen Catholic University Hospital
HIV
The Study of the Prevalence of Helicobacter Pylori Infection Among HIV/AIDS Cohort
The purpose of the Study is to investigate the prevalence of Helicobacter Pylori infection among the HIV/AIDS group. The study will screen the patients who were confirmed HIV/AIDS in Kaohsiung Medical University Hospital and…
- Trial name
- NCT01261208
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Helicobacter Pylori Infection
Helicobacter Pylori Eradication According to DPO-PCR Methods (K-CREATE) Study)
Clarithromycin-containing triple therapy is still the primary therapy approved by the Korean government. However, studies of antibiotic resistance have shown that regional resistance patterns to antibiotics such as clarithromycin…
- Trial name
- NCT04147065
- Testing
- Duration of eradication regimen
- Where
- South Korea
- Volunteers
- 1,230 people, healthy volunteers welcome
- Sponsor
- Incheon St.Mary's Hospital
Helicobacter Infections
Long-term Follow up Helicobacter Pylori Reinfection Rate After Second-Line Treatment: Bismuth-Containing Quadruple Therapy Versus Moxifloxacin-Based Triple Therapy
patients who had failed previous H. pylori eradication on standard triple therapy were randomized into two regimens: 1, esomeprazole (20 mg b.i.d), tripotassium dicitrate bismuthate (300 mg q.i.d), metronidazole (500 mg t.i.d)…
- Trial name
- NCT01792700
- Testing
- esomeprazole, tripotassium dicitrate bismuthate, metronidazole
- Where
- South Korea
- Volunteers
- 648 people
- Sponsor
- Seoul National University Bundang Hospital
Gut Microbiota, Metabolic Profiles
Gut Microbiome-Metabolome Profiling in H. Pylori-SIBO Comorbidity
Patients with concurrent Helicobacter pylori infection and small intestinal bacterial overgrowth (SIBO) represent a clinically challenging subgroup, often experiencing refractory gastrointestinal symptoms and diminished treatment…
- Conditions
- Gut Microbiota, Metabolic Profiles, Helicobacter Pylori Infection, Small Intestinal Bacterial Overgrowth
- Trial name
- NCT07122284
- Testing
- 13C-Urea Breath Test, Hydrogen-Methane Breath Test
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Zhongshan Hospital (Xiamen), Fudan University
Helicobacter Pylori Infection
S0701, Trial of Three Antibiotic Regimens to Eradicate Helicobacter Pylori (H. Pylori)
The purpose of this study is to compare the effectiveness of three different antibiotic regimens against Helicobacter pylori (H. pylori).
- Trial name
- NCT01061437
- Testing
- PACx14, PACMx5, PAx5/PCMx5
- Where
- 7 sites in Chile, Colombia and 4 more
- Volunteers
- 1,859 people
- Sponsor
- SWOG Cancer Research Network
Helicobacter Pylori Infection
Evaluation of Saccharomyces Boulardii Combined With Standard Quadruple Therapy for Eradication of Helicobacter Pylori
The eradication rate of standard quadruple therapy has become less successful due to low compliance and high resistance to the antibiotics.
- Trial name
- NCT03688828
- Testing
- Saccharomyces boulardii, Esomeprazole, Amoxicillin
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Huazhong University of Science and Technology
Gastric Cancer, Intestinal Metaplasia of Gastric Mucosa
The GAstric Precancerous Conditions Study
Gastric cancer afflicts 27,000 Americans annually and carries a dismal prognosis. One reason for poor outcomes is late diagnosis, as the majority of gastric cancers in the United States are diagnosed at a relatively advanced…
- Conditions
- Gastric Cancer, Intestinal Metaplasia of Gastric Mucosa, Helicobacter Pylori Infection, Atrophic Gastritis
- Trial name
- GAPS (NCT04191551)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Stanford University
Helicobacter Pylori Infection
Efficacy and Safety of Lacidofil® STRONG as an Adjuvant for Helicobacter Pylori Treatment in Non-ulcer Dyspepsia
Treatment for H. pylori eradication includes antibiotics. The treatment has decreased its efficiency (lower capability to eradicate the infection) due to increasing antibiotic resistance in the population.
- Trial name
- NCT04473079
- Testing
- Lacidofil
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Lallemand Health Solutions
Helicobacter Pylori 23S rRNA Clarithromycin Resistance Mutation, Helicobacter Pylori Infection
Empirical vs Tailored Therapy for H. Pylori Infection
We aimed to compare the efficacy of genotypic resistance-guided tailored therapy vs empirical therapy for eradication of Helicobacter pylori (H. pylori) infection in randomized controlled trials.
- Trial name
- NCT04006340
- Testing
- triple therapy, quadruple therapy, dual-priming oligonucleotide-based multiplex (DPO)-PCR test
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Seoul National University Hospital
Helicobacter Pylori Infection
Doxycycline- and Furazolidone-containing Quadruple Regimen is Superior of Tailored Therapy
Doxycycline- and Furazolidone-containing Quadruple Regimen can be a successful rescue treatment for Helicobacter pylori Infection patients after Failure of several therapy.
- Trial name
- NCT02894268
- Testing
- Doxycycline, Furazolidone, Esomeprazole
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sir Run Run Shaw Hospital
Helicobacter Pylori Eradication
Optimal Recheck Time for Helicobacter Pylori Eradication: A Prospective Randomized Trial
Although Urea breath test has been commonly used to recheck the efficiency of Helicobacter pylori eradication, there has been no randomized trials comparing the accuracy of Urea breath test results at different times after…
- Trial name
- NCT05870397
- Testing
- HY-IREXB plus carbon 13 breath detector do the breath urea test after eradication at different times
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine