Clinical trials: Helicobacter Pylori Eradication
Iron Deficiency
Helicobacter Pylori Eradication Trial to Reduce Iron Deficiency in Children
The investigators hypothesize that the Helicobacter pylori bacterium decreases iron from the stomach and that this effect of the infection can be identified among persons with iron deficiency as well as among persons with normal…
- Trial name
- HEIDC (NCT00364104)
- Testing
- Quadruple sequential Helicobacter pylori eradication + iron sulfate, Quadruple sequential Helicobacter pylori eradication therapy, Ferrous sulfate
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Helicobacter Pylori Infection
Simplified Dual Regimen Guided by Fecal Clarithromycin Resistance Gene Detection for First-line H. Pylori Eradication
To investigate the efficacy, safety, and compliance of a simplified strategy using vonoprazan plus clarithromycin for first-line treatment in patients with Helicobacter pylori infection, among those infected with strains without…
- Trial name
- NCT07439445
- Testing
- Vonoprazan 20 mg twice daily + clarithromycin 500 mg twice daily for 14 days
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University First Hospital
Gastric Cancer, Helicobacter Pylori Infection
A Real World Study of Bismuth Colloidal Pectin Granules Quadruple Therapy for H. Pylori Eradication
To observe the eradication rate of H. pylori infection, symptom improvement and the incidence of adverse effects in patients using a bismuth colloidal pectin granules quadruple therapy.
- Conditions
- Gastric Cancer, Helicobacter Pylori Infection, Bismuth
- Trial name
- NCT04660123
- Testing
- Bismuth Colloidal Pectin Granules Quadruple Therapy for H. Pylori Eradication
- Where
- China
- Volunteers
- 959 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection, Antimicrobial Susceptibility Testing
Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the First-line Helicobacter Pylori Eradication.
The purpose of this study is to assess efficacy of 10-day antimicrobial susceptibility test guided triple therapy for the first-line treatment of Helicobacter pylori infection, then comparing it with 14-day empirical tailored…
- Trial name
- NCT03571230
- Testing
- two sensitive antibiotics(amoxicillin, clarithromycin, metronidazole, tinidazole, levofloxacin, furazolidone and tetracycline), two antibiotics based on personal medication history(amoxicillin,clarithromycin,furazolidone), one proton pump inhibitor(PPI)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Evaluation of Saccharomyces Boulardii Combined With Standard Quadruple Therapy for Eradication of Helicobacter Pylori
The eradication rate of standard quadruple therapy has become less successful due to low compliance and high resistance to the antibiotics.
- Trial name
- NCT03688828
- Testing
- Saccharomyces boulardii, Esomeprazole, Amoxicillin
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Huazhong University of Science and Technology
Epilepsy, Generalized, Helicobacter Pylori Infection
Helicobacter Pylori Eradication Therapy for Epileptic Children
Helicobacter pylori (H. pylori) infection is associated with several health problems. The role of H. pylori infection in epilepsy has been investigated in a few studies.
- Trial name
- NCT05297695
- Testing
- Triple therapy for H. pylori infection
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Sohag University
H. Pylori Infection
Bismuth for PCAB-based H. Pylori Eradication
Tegoprazan is a new potassium-competitive acid blocker (PCAB) that has been clinically available since 2018 in South Korea. P-CAB is highly active drugs targeting H+, K+ -ATPase in the gastric acid secretion of parietal cells.
- Trial name
- NCT05453994
- Testing
- H. pylori eradication
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Soonchunhyang University Hospital
Gastritis Associated With Helicobacter Pylori
Comparison of Vonoprazan-based Dual and Triple Therapies for H. Pylori Eradication
Patients infected with H. pylori were randomly assigned to the dual therapy with vonoprazan 20 mg bid and amoxicillin 500 mg tid for 1 week or the triple therapy with vonoprazan 20 mg bid, amoxicillin 750 mg bid and…
- Trial name
- NCT02827942
- Testing
- vonoprazan 20 mg bid, Amoxicillin 500 mg tid, Amoxicillin 750 mg bid
- Where
- Japan
- Volunteers
- 112 people
- Sponsor
- Hamamatsu University
Helicobacter Pylori Infection
Genotypic Resistance Guided Versus Susceptibility Testing Guided Therapy for the First-line Eradication of H. Pylori
We aimed to (1) compare the efficacy of genotypic resistance guided sequential therapy vs. susceptibility testing guided therapy in the first-line therapy (2) assess the long term impact of eradication therapy on the antibiotic…
- Trial name
- NCT03556254
- Testing
- GGT, SGT
- Where
- Taiwan
- Volunteers
- 560 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Tailored Vs. Empirical Helicobacter Pylori Infection Treatment
Helicobacter pylori (Hp) is a gram-negative bacterium that colonizes human gastric mucosa and is associated with chronic gastritis that can progress to severe complications such as peptic ulcer disease, gastric adenocarcinoma and…
- Trial name
- NCT06200779
- Testing
- Clarithromycin (mutations in the 23S rRNA gene, A2134G, A2142G and A2142C mutations) and levofloxacin resistance (mutations in the gyrA gene) PCR test, Empirically H. pylori eradication treatment with bismuth quadruple therapy (Pylera®), PPI, amoxicillin 1 g and clarithromycin 500 mg, twice daily, for 10 days
- Where
- Portugal
- Volunteers
- 160 people
- Sponsor
- Manuel Coelho da Rocha
H. Pylori Infection
Eradication Efficacy and Safety of Two Rescue Treatments for Helicobacter Pylori Infection
The aim of this study was to evaluate the efficacy and safety of high-dose dual therapy compared with furazolidone-based quadruple therapy as a rescue treatment for helicobacter pylori infection.
- Trial name
- NCT05176821
- Testing
- esomeprazole plus amoxicillin, amoxicillin, furazolidone, bismuth potassium citrate , esomeprazole
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Shanghai Zhongshan Hospital
Gastritis, Dyspepsia
Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology
This study was conducted to investigate the effects of high-dose diphtherapy and bismuth quadruple therapy on H. pylori eradication on intestinal microecology, to clarify the changes in intestinal microbiota diversity and…
- Conditions
- Gastritis, Dyspepsia, Helicobacter Pylori Infection, Gastric Cancer
- Trial name
- NCT05742568
- Testing
- Esomeprazole, Amoxicillin, Bismuth
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori
The Influence of FP-10 on the Eradication Rates of H. Pylori by a Triple Therapy
FP-10 is a food ingredient derived from milk casein. FP-10 can inhibit H. pylori to attach to the gastric epithelium. FP-10 has been made clear to decrease the intragastric urease activity (which is assumed to be produced by H.
- Trial name
- NCT00281047
- Testing
- FP-10
- Where
- 7 sites in Japan
- Volunteers
- 138 people
- Sponsor
- Hamamatsu University
Gastroesophageal Reflux Disease
Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication
Background: Rebound acid hypersecretion and acid-related symptoms after discontinuation of proton-pump inhibitor has been reported in previous studies.
- Trial name
- NCT02934152
- Testing
- H pylori eradication, H pylori eradication timing
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori
A Comparison of Clarithromycin-based and Furazolidone-based Bismuth-containing Regimens for H. Pylori Eradication
We aim to assess and compare the effectiveness of clarithromycin- and furazolidone-based regimens as primary therapies in eradicating H. pylori.
- Trial name
- NCT03716622
- Testing
- Furazolidone, Clarithromycin
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Bismuth Quadruple Therapy With Cefuroxime for Helicobacter Pylori Eradication Treatment
To observe the efficacy of cefuroxime-containing bismuth quadruple regimen in the eradication treatment of Helicobacter pylori, and to evaluate whether it can be used as a remedial treatment for Helicobacter pylori after initial…
- Trial name
- NCT04723472
- Testing
- Cefuroxime containing bismuth quadruple treatment, Classic bismuth quadruple treatment
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Shanghai East Hospital
Helicobacter Pylori Infection
Lactobacillus Reuteri in Management of Helicobacter Pylori Infection in Dyspeptic Patients
Addition of L. reuteri to the standard triple therapy improves H. Pylori treatment outcomes.
- Trial name
- NCT01593592
- Testing
- Lactobacillus reuteri, Omeprazole, Amoxicillin
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Zagazig University
Peptic Ulcer Hemorrhage
Helicobacter Pylori Empiric Treatment in Ulcer Bleeding
The goal of the study is to compare the effectiveness of empirical Helicobacter pylori treatment compared with treatment depending on diagnostic tests for Helicobacter pylori in patients with Upper gastrointestinal bleeding due…
- Trial name
- HETUB (NCT00687336)
- Testing
- Empirical Hp eradication, Eradication treatment guided by a positive test
- Where
- Spain
- Volunteers
- 178 people
- Sponsor
- Hospital de Sabadell
Helicobacter Pylori Infection
Influencing Factors of Helicobacter Pylori Infection and Eradication Failure
Helicobacter pylori (H. pylori) is closely related to the occurrence of gastric cancer and other diseases, the discovery and eradication of H.
- Trial name
- NCT05226819
- Testing
- PPI quadruple therapy
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Peptic Ulcer, Dyspepsia
Aizthromycin or Clarithromycin in H-pylori Eradication Regimen
The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.
- Conditions
- Peptic Ulcer, Dyspepsia, H-pylori
- Trial name
- H-pylori (NCT01667692)
- Testing
- azithromycin, clarithmycin
- Where
- Iran
- Volunteers
- 78 people
- Sponsor
- Shahid Sadoughi University of Medical Sciences and Health Services