Clinical trials: Helicobacter Pylori Eradication
Helicobacter Pylori Infection
Efficacy and Safety of a Triple Eradication Scheme for Helicobacter Pylori Based on Tegoprazan vs Esomeprazole
In Mexico, quadruple therapy is used to treat Helicobacter pylori (H.P.) at the expense of greater adverse effects, costs, and lower adherence to treatment.
- Trial name
- NCT06318104
- Testing
- Tegoprazan, Esomeprazole 40mg
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Helicobacter Pylori Infection
Helicobacter Pylori Eradication Study
The purpose of this study was to evaluate the efficacy and compliance of tailored therapy which using the polymerase chain reaction for point mutation of clarithromycin, compared to concomitant therapy, in patients without…
- Trial name
- NCT03130452
- Testing
- Lansoprazole 30mg, Amoxicillin 1.0g Tab, Clarithromycin 500mg
- Where
- South Korea
- Volunteers
- 423 people
- Sponsor
- Inje University
Helicobacter Pylori Infection
Vonoprazan in Helicobacter Pylori Treatment an RCT
RCT for comparison of Standard Triple therapy (Omeprazole+Amoxil+Clarithromycin) for H Pylori erradication with Vonoprazan+Amoxil dual therapy.
- Trial name
- NCT04901663
- Testing
- Omeprazole 20 MG Capsule; Amoxicillin 1000 MG; Clarithromycin 500 MG, Vonoprazan 20 MG; Amoxicillin 1000 MG
- Where
- Pakistan
- Volunteers
- 179 people
- Sponsor
- Dow University of Health Sciences
Helicobacter Pylori Infection
Efficacies of Two Bismuth Quadruple Therapies in the Second-line Treatment of H Pylori Infection
From the profiles of antibiotic susceptibility data following eradication therapy, tetracycline, amoxicillin and levofloxacin are all good candidates of antibiotics used in the rescue treatment.
- Trial name
- NCT03779087
- Testing
- 10d TL quadruple therapy, 10d AL quadruple therapy
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Ping-I (William) Hsu, M.D.
Helicobacter Pylori Infection
Standardize Communication With General Practitioner & Patient for Improved Eradication of Helicobacter Pylori
Patients who test Helicobacter pylori positive, are treated with antibiotics. However, due to a number of factors (such as unknown treatment compliance, no standardized follow-up, ...), a relative low eradication-percentage was…
- Trial name
- Helipro (NCT02873247)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Helicobacter Infections, Stomach Neoplasms
Helicobacter Pylori Eradication to Prevent Gastric Cancer
Gastric cancer is the fourth most common type of cancer and the second leading cause of cancer-related death in the world. In China, more than 390,000 new patients are diagnosed with gastric cancer and more than 300,000 patients…
- Trial name
- NCT01133951
- Testing
- OAC triple therapy
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Jie-Jun Wang
Gastritis Associated With Helicobacter Pylori
Comparison of Vonoprazan-based Dual and Triple Therapies for H. Pylori Eradication
Patients infected with H. pylori were randomly assigned to the dual therapy with vonoprazan 20 mg bid and amoxicillin 500 mg tid for 1 week or the triple therapy with vonoprazan 20 mg bid, amoxicillin 750 mg bid and…
- Trial name
- NCT02827942
- Testing
- vonoprazan 20 mg bid, Amoxicillin 500 mg tid, Amoxicillin 750 mg bid
- Where
- Japan
- Volunteers
- 112 people
- Sponsor
- Hamamatsu University
Gastric Cancer, H Pylori Infection
H. Pylori Screen-and-treat Study in a Population of Young Adults
Gastric cancer remains a major challenge to public health on a global scale. H. pylori related cancer burden contributes to the largest proportion of cancer cases attributable to infections in Europe.
- Conditions
- Gastric Cancer, H Pylori Infection, H Pylori Eradication, H-pylori
- Trial name
- NCT06275204
- Testing
- Bismuth-based quadruple therapy, Levofloxacin-based quadruple therapy, Standard triple therapy
- Where
- 7 sites in Croatia, Ireland and 4 more
- Volunteers
- 6,800 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Chemotherapy Effect
Perioperative Oxaliplatin With S-1 Combined H. Pylori Eradication in the Management of Locally Advanced Gastric Cancer
This study focuses on patients with H. pylori-positive resectable locally advanced adenocarcinoma of the gastric and oesophagogastric junction. It evaluates the perioperative oxaliplatin with S-1 (SOX) combined H.
- Trial name
- NCT06510010
- Testing
- Oxaliplatin With S-1 (SOX) Combined H. Pylori Eradication (Amoxicillin + clarithromycin + omeprazole + colloidal bismuth subcitrate), Oxaliplatin With S-1 （SOX）
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
HELICOBACTER PYLORI INFECTIONS
Efficacy and Safety of Linarazen Gluconate Capsules Combined With Amoxicillin (Dual-Drug Therapy) Versus Bismuth-Containing Quadruple Therapy for First-Line Eradication of Helicobacter Pylori Infection
This clinical trial aims to compare the efficacy of the dual therapy regimen of linralase glutarate capsules and amoxicillin versus the quadruple therapy regimen containing bismuth for the first-line eradication of Helicobacter…
- Trial name
- NCT07897994
- Testing
- Linalarose Glutarate, Bismuth Quadruple Test
- Where
- 24 sites in China
- Volunteers
- 448 people
- Sponsor
- Yongquan Shi
Helicobacter Pylori, the Operative Link on Gastric Intestinal Metaplasia
The Influence of Helicobacter Pylori Eradication on Gastric Pathology: a Long-term, Prospective Cohort Study
Helicobacter pylori (H. pylori) infection, affecting an estimated 50% of the global population, is a main cause of chronic gastritis, peptic ulcers and gastric cancer.
- Conditions
- Helicobacter Pylori, the Operative Link on Gastric Intestinal Metaplasia, Operative Link on Gastric Intestinal Assessment
- Trial name
- NCT02933229
- Testing
- biopsy, H. pylori eradication
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University
Gastric (Stomach) Cancer
Eradication of Helicobacter Pylori Subtypes at High Gastric Cancer Risk: a Cluster-randomized Controlled Trial
This study is a prospective, multicenter cluster randomized controlled trial. Additional fecal screening for high-risk SNP subtypes, in conjunction with routine Hp testing, may improve the identification of individuals at high…
- Trial name
- NCT06943794
- Testing
- recommendations for Hp eradication treatment
- Where
- China
- Volunteers
- 4,824 people, healthy volunteers welcome
- Sponsor
- Fudan University
Helicobacter Pylori Infection, Helicobacter Pylori
H. Pylori Eradication With Argon Plasma During Endoscopy
The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori, Helicobacter Pylori Gastrointestinal Tract Infection, H. Pylori Infection
- Trial name
- HEAPE (NCT06529159)
- Testing
- HEAPE, Pre-HEAPE
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Helicobacter Pylori Eradication
Effect of Probiotics on Helicobacter Pylori Eradication
The purpose of this clinical trial is to evaluate the clinical efficacy of Bifidobacterium quadruple live bacteria tablets (Si Lian Kang) on reducing the incidence rate of adverse reactions of Helicobacter pylori quadruple…
- Trial name
- NCT04034641
- Testing
- Bifidobacterium tetrad live bacteria tablet plus Helicobacter pylori quadruple eradication therapy
- Where
- 2 sites in China
- Volunteers
- 238 people
- Sponsor
- Hangzhou Grand Biologic Pharmaceutical, Inc.
Helicobacter Pylori Infection, Dyspepsia
Pylori Duo for Adjunctive Treatment and Prevention of Recurrence of Helicobacter Pylori Infection
This randomized, double-blind, placebo-controlled, single-center clinical trial will evaluate the efficacy and safety of Pylori Duo as an adjunctive treatment in adult patients with confirmed Helicobacter pylori infection.
- Conditions
- Helicobacter Pylori Infection, Dyspepsia, Gastrointestinal Adverse Effects
- Trial name
- NCT07729293
- Testing
- Omeprazole, Pylera (Bismuth subcitrate potassium, metronidazole, tetracycline) given in combination with omeprazole, Pylori Duo
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Gala Servicios Clinicos S.L.
Self Efficacy
Genotypic Resistance Guided Therapy in Helicobacter Pylori Eradication
We aimed to compare the efficacy of genotypic resistance guided sequential therapy vs. empiric therapy in the third line therapy.
- Trial name
- NCT01725906
- Testing
- empirical therapy, Genotypic resistance guided therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Gastric Ulcer, Chronic Gastritis
Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy
This study aims at evaluating efficacy and safety of berberine- amoxicillin containing quadruple therapy(berberine, amoxicillin, esomeprazole and bismuth) versus tetracycline-furazolidone quadruple therapy (tetracycline…
- Conditions
- Gastric Ulcer, Chronic Gastritis, Gastric Cancer, Helicobacter Pylori Infection
- Trial name
- NCT03609892
- Testing
- Berberine, Amoxicillin, Esomeprazole
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Non-alcoholic Fatty Liver Disease
Helicobacter Pylori Eradication in Subjects With Non-alcoholic Fatty Liver Disease
The aim of study was to evaluate the effect of helicobacter pylori eradication on liver function tests, lipid profile, homeostasis model assessment-IR (HOMA-IR) index, and anthropometric measurements (body mass index and waist…
- Trial name
- NCT01759628
- Testing
- H.pylori eradication
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Tehran University of Medical Sciences
GERD
Effect of Helicobacter Pylori Eradication on Gastroesophageal RefIux Disease (GERD)
Evaluate the effect of H.pylori eradication on Gastroesophageal-reflux disease and symptoms improvement
- Trial name
- NCT06457334
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Gastritis
A Multi-center Study for Eradication of Refractory Helicobacter Pylori
Recently studies showed that the eradication rate of H. pylori fail to exceed 80% and even falls into an unacceptable range. A major cause of treatment failure is associated with antibiotic resistance and poor patient compliance.
- Trial name
- NCT02741414
- Testing
- The result of H pylori culture based on gram staining and enzyme activity testing, The result of 13C-urea breath test after treatment based on the selection of clarithromycin, levofloxacin, metronidazole, amoxicillin，tetracycline，furazolidone and the dose of esomeprazole, The result of Amoxicillin resistance in vitro based on antibiotic susceptibility testing
- Where
- China
- Volunteers
- 4,428 people
- Sponsor
- Taizhou Hospital