Clinical trials: Helicobacter Pylori Eradication, open to volunteers
Helicobacter
7-day High-Dose Vonoprazan-amoxicillin Dual Therapy Versus 14-day Vonoprazan-amoxicillin Dual Therapy for H. Pylori
Helicobacter pylori infection is a prevalent global gastrointestinal condition linked to chronic gastritis, peptic ulcer disease, and gastric cancer. Potent and sustained acid suppression improves eradication efficacy.
- Trial name
- NCT07352098
- Testing
- 7-day high-dose vonoprazan-amoxicillin dual therapy group, 14-day vonoprazan-amoxicillin dual therapy group
- Where
- China
- Volunteers
- 290 people
- Sponsor
- Yueyue Li
H.Pylori Infection
Tegoprazan- Versus PPI-based H. Pylori Eradication
In 2015, vonoprazan, a potassium-competitive blocker (P-CAB), was launched in Japan and used as an alternative for proton pump inhibitors (PPIs) for eradicating Helicobacter pylori.
- Trial name
- NCT06682533
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Soonchunhyang University Hospital
Helicobacter Pylori Infection
Vonoprazan Evaluation Compared to Standard Triple Therapy in Helicobacter Pylori eRadication
Helicobacter pylori (H Pylori) infection is associated with functional dyspepsia, peptic ulcer disease, atrophy and gastric cancer. The bacterium has been classified as grade I carcinogen by the WHO in 1994(1).
- Trial name
- NCT06959368
- Testing
- Vonoprazan 20mg, Esomeprazole 40 mg, Amoxicillin 1 g, Clarithromycin 500 mg
- Where
- India
- Volunteers
- 484 people
- Sponsor
- Asian Institute of Gastroenterology, India
Helicobacter Infection
Keverprazan-Minocycline Dual Therapy of Different Durations Versus Bismuth Quadruple Therapy for Helicobacter Pylori Eradication.
This study aims to compare the efficacy and safety of keverprazan-minocycline dual therapy versus bismuth-based quadruple therapy for Helicobacter pylori eradication, focusing on eradication rates, patient adherence, and the…
- Trial name
- NCT07904429
- Testing
- Minocycline, Keverprazan, Amoxicillin
- Where
- China
- Volunteers
- 612 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Helicobacter Pylori Gastritis, Helicobacter Eradication
Clinical Evaluation of a 14day Modified Bismuth Quadruple Therapy for the Eradication of Helicobacter Pylori in a High Clarithromycin and Metronidazole Resistance Area Regarding Patients With Peptic Ulcer and Non Ulcer Dyspepsia
The goal of this clinical trial is to learn if a modified bismuth-containing therapy for the treatment of helicobacter pylori infection works to treat chronic helicobacter pylori related gastritis in adults treated either for…
- Trial name
- MBISQ4HP (NCT07146594)
- Testing
- Modified bismuth-containing eradication treatment
- Volunteers
- 150 people
- Sponsor
- Athens Medical Center
HELICOBACTER PYLORI INFECTIONS
Efficacy and Safety of 14-Day Vonoprazan-Minocycline Dual Therapy for Helicobacter Pylori Eradication
Investigators will enroll treatment-naïve H. pylori-positive patients according to the inclusion and exclusion criteria in the trial.
- Trial name
- NCT07757919
- Testing
- Vonoprazan-Amoxicillin Dual Therapy, Vonoprazan-Tetracycline Dual Therapy, Vonoprazan-Minocycline Dual Therapy
- Volunteers
- 492 people
- Sponsor
- Qilu Hospital of Shandong University
HELICOBACTER PYLORI INFECTIONS
Optimizing H. Pylori Eradication Regimen Under Intensified Acid Suppression
Background: Helicobacter pylori (H. pylori) infection affects approximately 50% of the global population and is closely associated with chronic gastritis, peptic ulcer disease, and gastric cancer. Eradication of H.
- Trial name
- NCT07750938
- Testing
- Keverprazan Hydrochloride 20 mg TID, Minocycline 100 mg (10-Day Regimen), Keverprazan Hydrochloride 20 mg BID
- Volunteers
- 316 people
- Sponsor
- Qilu Hospital of Shandong University
Helicobacter Pylori Infection, Dyspepsia
Epidemiological Investigation of Helicobacter Pylori-infected Patients and the Effect of Eradication Treatment on Dyspepsia Symptoms
The objectives of this multicenter, prospective, observational study were to investigate the incidence of dyspeptic symptoms in patients with Helicobacter pylori (H.
- Trial name
- NCT06422052
- Testing
- Epidemiological questionnaire and Functional Dyspepsia Symptom Diary（FDSD）
- Where
- 26 sites in China
- Volunteers
- 2,242 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection
Tailored Vs. Empirical Helicobacter Pylori Infection Treatment
Helicobacter pylori (Hp) is a gram-negative bacterium that colonizes human gastric mucosa and is associated with chronic gastritis that can progress to severe complications such as peptic ulcer disease, gastric adenocarcinoma and…
- Trial name
- NCT06200779
- Testing
- Clarithromycin (mutations in the 23S rRNA gene, A2134G, A2142G and A2142C mutations) and levofloxacin resistance (mutations in the gyrA gene) PCR test, Empirically H. pylori eradication treatment with bismuth quadruple therapy (Pylera®), PPI, amoxicillin 1 g and clarithromycin 500 mg, twice daily, for 10 days
- Where
- Portugal
- Volunteers
- 160 people
- Sponsor
- Manuel Coelho da Rocha
Helicobacter Infection
Clinical Trial to Evaluate the Efficacy of Probit-Based Triple Therapy for Helicobacter Pylori Eradication
This is a single-center, open-label, non-randomized, single-arm clinical study. Eligible participants who provide written informed consent will undergo screening based on inclusion/exclusion criteria.
- Trial name
- NCT07115173
- Testing
- This study aims to evaluate the efficacy and safety of a 14-day triple therapy regimen consisting of Zastaprazan 20 mg, clarithromycin, and amoxicillin for the eradication of Helicobacter pylori.
- Volunteers
- 103 people
- Sponsor
- Samsung Medical Center
HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection
Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori Infection
Helicobacter pylori is a Gram-negative, spiral-shaped bacterium that infects up to 50% of the world's population, residing in the gastric mucosa and using the mucus layer for protection from the stomach's high acidity.
- Conditions
- HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection, Helicobacter Pylori Gastrointestinal Tract Infection, Helicobacter Pylori Infected Patients
- Trial name
- NCT07293910
- Testing
- Vonoparazan, Vitamin D, Probiotic
- Where
- Egypt
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tanta University
Helicobacter Pylori Infection
VA Dual Sequential Therapy
Sequential therapy for Hp was first introduced by Zullo et al. in 2000 and consists of two phases: the first phase involves proton pump inhibitors with one antibiotic, and the second phase involves proton pump inhibitors with two…
- Trial name
- JSHERO3 (NCT06929962)
- Testing
- Vonoprazan and Amoxicillin for the first 7 days, Vonoprazan and Amoxicillin for the first 5 days, Vonoprazan and Amoxicillin for the second 7 days
- Where
- China
- Volunteers
- 600 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Helicobacter Pylori Eradication Rate
Optimization of Keverprazan-amoxicillin Dual Therapy for Eradicating Helicobacter Pylori Infection
Eradication of HP can significantly improve and reduce HP-related diseases. A 10-14 day quadruple regimen containing bismuth as first-line treatment, achieving an eradication rate of more than 85%.
- Trial name
- NCT06734260
- Testing
- Keverprazan Hydrochloride tablets + high dose amoxicillin, Keverprazan Hydrochloride tablets + low dose amoxicillin, Keverprazan Hydrochloride tablets + high dose amoxicillin（H-KA-10d）
- Where
- 4 sites in China
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University
HELICOBACTER PYLORI INFECTIONS
Effect of Bismuth Add-on to Dual Therapy for Helicobacter Pylori Eradication
This study aims to compare the efficacy and safety of a bismuth-supplemented 14-day vonoprazan-based dual therapy ( triple therapy) versus a 14-day vonoprazan-based dual therapy without bismuth for first-line H.
- Trial name
- NCT07576959
- Testing
- Bismuth Add-on to Vonoprazan Dual Therapy, Vonoprazan dual therapy
- Where
- Taiwan
- Volunteers
- 990 people
- Sponsor
- National Taiwan University Hospital
H Pylori Gastritis, H Pylori Infection
Efficacy of Carminal in Helicobacter Pylori Gastritis
Eighty patients will be included and randomized in two groups, one group (40 patients) will be administered 30 ml of the supplement Carminal, once a day, plus therapy for HP gastitis and the control group (40 patients) will be…
- Conditions
- H Pylori Gastritis, H Pylori Infection, H Pylori Eradication, Gastritis Associated With Helicobacter Pylori
- Trial name
- NCT07179237
- Testing
- Carminal Oral solution
- Where
- 2 sites in Serbia
- Volunteers
- 80 people
- Sponsor
- Catalysis SL
Helicobacter Pylori Infection
A "Screen and Treat" Helicobacter Pylori Eradication Trial in Adolescents in Three Regions of Chile
Gastric cancer remains a global health problem, and Chile has one of the highest GC mortality rates in the region. Helicobacter pylori (H.
- Trial name
- NCT05926804
- Testing
- Lansoprazole, Amoxicillin, Clarithromycin
- Where
- 3 sites in Chile
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Miguel O'Ryan Gallardo
Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer
Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial
This study aims to evaluate the efficacy of vonoprazan combined with different antibiotics in dual therapy for Helicobacter pylori eradication treatment.
- Trial name
- NCT07068607
- Testing
- Vonoprazan, Tetracycline 500mg tid, Minocycline
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yongquan Shi
Helicobacter Pylori Infection
The Effect of Vitamin D Supplement as Adjuvant Therapy in Eradication of Helicobacter Pylori Infection
Helicobacter pylori (H. pylori) is one of the most common chronic infections worldwide. The mode of transmission of H. pylori is through the fecal-oral or oral-oral routes.
- Trial name
- NCT06964334
- Testing
- Lansoprazole, amoxicillin, clarithromycin
- Volunteers
- 70 people
- Sponsor
- Assiut University
Helicobacter Pylori Infection, Peptic Ulcer Disease
Vonoprazan High-Dose Dual VS Levofloxacin Concomitant
This is a randomized controlled trial comparing the efficacy and safety of two vonoprazan-based regimens: high-dose dual therapy (vonoprazan plus a single antibiotic) versus triple therapy (vonoprazan plus two antibiotics) for…
- Conditions
- Helicobacter Pylori Infection, Peptic Ulcer Disease, Gastritis
- Trial name
- NCT07624422
- Testing
- Vonoprazan, Levofloxacin 500mg
- Where
- Syria
- Volunteers
- 150 people
- Sponsor
- Damascus Hospital
HELICOBACTER PYLORI INFECTIONS
Efficacy of Vonoprazan-based Rescue Therapy for H. Pylori Eradication
1. This study aims to compare the efficacy of empirical vonoprazan-based therapy versus susceptibility-guided vonoprazan-based therapy for third-line eradication of H. pylori. 2.
- Trial name
- NCT07130253
- Testing
- Vonoprazan based ET, Vonoprazan based SGT
- Where
- Taiwan
- Volunteers
- 220 people
- Sponsor
- National Taiwan University Hospital