Clinical trials: Helminth Infection
Chronic Strongyloidiasis
Ivermectin Versus Albendazole for Chronic Strongyloidiasis
A prospective controlled trial to compare the efficacy and safety of 7-day albendazole, single dose ivermectin, and 2-single dose ivermectin in 72 patients with chronic strongyloidiasis will be conducted at Siriraj Hospital…
- Trial name
- NCT00765024
- Testing
- Ivermectin, Albendazole
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Mahidol University
Hookworm Infections
Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm
The rational of this study is to provide evidence on the safety and efficacy of a new chewable tablet of mebendazole compared to the standard tablet in preschool- and school-aged children infected with hookworm.
- Trial name
- CHEW_MEB_PEMBA (NCT03995680)
- Testing
- Mebendazole
- Where
- Tanzania
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Cystic Echinococcosis
Surgical Treatment of Hepatic Hydatidosis in Elderly Patients
Cystic echinococcosis is a clinically complex chronic parasitic disease and a major socioeconomic problem in endemic areas. The safety of liver resection in elderly patients is often debated among medical professionals.
- Trial name
- ELDHIDA (NCT05113550)
- Testing
- Surgical remove
- Where
- 2 sites in Spain
- Volunteers
- 279 people
- Sponsor
- Universidad de Extremadura
Trichuris Trichiura; Infection, Hookworm Infection
Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections
This study aims to assess the efficacy and safety of emodepside compared to mebendazole in adults and adolescents infected with T. trichiura, either as single infection or co-infections with hookworm and/or A. lumbricoides.
- Conditions
- Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection
- Trial name
- TREMO-Pemba (NCT06736691)
- Testing
- emodepside (BAY 44-4400), Mebendazole
- Where
- Tanzania
- Volunteers
- 315 people
- Sponsor
- Swiss Tropical & Public Health Institute
Schistosomiasis
Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis
Background: Schistosomiasis is a chronic infection. It is caused by parasitic worms called Schistosoma haematobium (Sh) that are spread by snails that live in rivers. It can lead to liver problems or bladder cancer.
- Trial name
- NCT02734186
- Testing
- Praziquantel
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Schistosomiasis, Schistosoma Mansoni
Repeated Controlled Human Schistosoma Mansoni Infection
A group of 24 healthy volunteers are challenged one or three times with 20 male Schistosoma mansoni cercariae to investigate whether this leads to protection and to identify potential correlates of protection
- Trial name
- NCT05085470
- Testing
- Schistosoma mansoni infection
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Schistosomiasis
Anti-Schistosomiasis Vaccine: Sm14 Phase 2b-Sn in School Children
The clinical trial phase 2b is designed to assess the safety and the specific immune response of the active ingredient (protein + adjuvant) in healthy and then in infected school children from 8 to 11 years of age with intestinal…
- Trial name
- NCT03799510
- Testing
- Sm14, GLA-SE solution
- Where
- Senegal
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Onchocerciasis (River Blindness), Schistosomiasis
Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations
Neglected Tropical Diseases (NTDs) are among the most common groups of diseases affecting over one billion people globally and are disproportionately concentrated in remote, underserved, and marginalized communities.
- Conditions
- Onchocerciasis (River Blindness), Schistosomiasis, Soil Transmitted Helminth (STH) Infections, Lymphatic Filariasis
- Trial name
- MISSION (NCT07707817)
- Testing
- Modified Mass Administration of Medicines Strategy, Albendazole 400 mg, Praziquantel 40 mg/kg
- Where
- Nigeria
- Volunteers
- 5,760 people, healthy volunteers welcome
- Sponsor
- Uwemedimo Friday Ekpo
Trachoma, Yaws
Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs )
This is a cluster randomised trial evaluating the safety of co-administering Azithromycin alongside the new IDA (Ivermectin, Diethylcarbamazine, Albendazole) combination treatment for LF.
- Conditions
- Trachoma, Yaws, Lymphatic Filariases, Scabies
- Trial name
- NCT03676140
- Testing
- Albendazole on Day 1, Ivermectin on Day 1, Diethylcarbamazine on day 1
- Where
- Papua New Guinea
- Volunteers
- 20,000 people
- Sponsor
- Lihir Medical Centre
Lymphatic Filariases, Onchocerciasis
Prevalence of LF Infection in Districts Not Included in LF Control Activities
Lymphatic filariasis is a neglected tropical disease earmarked for elimination as a public health problem by the year 2020. Since the year 2000, the Global Program for the Elimination of LF has together with endemic countries…
- Trial name
- NCT03131401
- Testing
- Diagnosis of lymphatic filariasis, Diagnosis of lymphatic Filariasis and onchocerciasis, DEC Patch
- Where
- Ghana
- Volunteers
- 3,736 people
- Sponsor
- Noguchi Memorial Institute for Medical Research
Filariasis, Helminthiasis
Host Response to Infection and Treatment in Filarial Diseases
This study will evaluate and treat patients with filarial infections to explore in depth the immunology of the disease, including susceptibility to infection, disease development, and response to treatment.
- Conditions
- Filariasis, Helminthiasis, Parasitic Infection, Mansonelliasis
- Trial name
- NCT00001230
- Testing
- Diethylcarbamazine
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cystic Echinococcosis
IM Bands in Inactive Hepatic CE
Comparison of immunoblotting bands pattern in patients with treated versus untreated echinococcal cysts of the liver
- Trial name
- NCT07333612
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Trichuriasis, Ascariasis
Efficacy and Safety of MOX/ALB vs. IVM/ALB Co-administration
The aim of this randomized controlled trial is to provide evidence on the efficacy and safety of co-administered moxidectin and albendazole compared to co-administered ivermectin and albendazole, and to assess the efficacy of the…
- Conditions
- Trichuriasis, Ascariasis, Hookworm Infections, Helminthes; Infestation, Intestinal
- Trial name
- NCT04700423
- Testing
- moxidectin (8 mg) / albendazole (400 mg), ivermectin (200 µg/kg) / albendazole (400 mg), ALBENDAZOLE 400 Mg ORAL TABLET [ZENTEL]
- Where
- Tanzania
- Volunteers
- 536 people
- Sponsor
- Jennifer Keiser
Malaria,Falciparum, Neglected Tropical Diseases
Adjunctive Ivermectin Mass Drug Administration for Malaria Control
This is a cluster-randomized placebo-controlled clinical trial to evaluate the additive benefit of Ivermectin (IVM) (or Placebo) mass drug administration (MDA) to dihydroartemisinin-piperaquine (DP) MDA for malaria control in a…
- Conditions
- Malaria,Falciparum, Neglected Tropical Diseases, Strongyloidiasis, Lymphatic Filariasis
- Trial name
- MATAMAL (NCT04844905)
- Testing
- Ivermectin, Dihydroartemisinin-piperaquine
- Where
- Guinea-Bissau
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Trichuriasis, Strongyloidiasis
Combination Therapies for Trichuris Trichiura Infection in Schoolchildren in Honduras
The goal of this Phase III clinical trial is to evaluate the efficacy, safety, and acceptability of different treatment regimens for Trichuris trichiura infection in schoolchildren aged 6 to 15 years living in La Moskitia…
- Conditions
- Trichuriasis, Strongyloidiasis, Ascariasis, Hookworm Infection
- Trial name
- AIM-T (NCT07661316)
- Testing
- Albendazole 400 mg, Albendazole Plus Ivermectin, Fixed-Dose Combination Albendazole/Ivermectin (FDC)
- Where
- Honduras
- Volunteers
- 368 people
- Sponsor
- Mundo Sano Foundation
Intestinal Diseases, Parasitic
Postpartum Deworming: Improving Breastfeeding and Optimizing Infant Growth
Women of reproductive age are considered a high-risk group for worm infections by the World Health Organization. Maternal infection and anemia contribute to infant malnutrition by affecting milk quality and quantity, and duration…
- Trial name
- NCT01748929
- Testing
- Albendazole
- Where
- Peru
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Helminthiasis
Bioavailability and Safety of Two Oral Fixed Dose Preparations Containing 18 mg Ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) Versus Reference Dosing (Weight Based) Containing 6 mg Ivermectin (REVECTINA®, Abbott Laboratórios do Brasil Ltda, Brazil)
Evaluation of the bioavailability and safety of one oral preparation containing fixed dose 18 mg ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) or two oral preparations containing fixed dose 18 mg ivermectin (IVM 36 MG…
- Trial name
- NCT03173742
- Testing
- T1, T2, T3, T1,T3,T2, T2,T1,T3
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
Schistosoma Mansoni
Clinical Evaluation of Ujiplus® Against Schistosoma Mansoni
Schistosomiasis is classified as among the world's neglected tropical diseases (NTD). Morbidity due to Schistosoma mansoni (S. mansoni) is greatest among school-age children who typically have the highest burden of infection.
- Trial name
- NCT04679831
- Testing
- Ujiplus®, Praziquantel 400mg
- Where
- Kenya
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Kenya Medical Research Institute
Cysticercosis
EFECAB: Improving Pig Management to Prevent Epilepsy in Burkina Faso
This is a pre-post randomized community-based controlled trial aimed at estimating the effectiveness of an educational package developed using PRECEDE PROCEED to reduce the cumulative incidence of Taenia solium cysticercosis in…
- Trial name
- EFECAB (NCT03095339)
- Testing
- Educational package
- Where
- Burkina Faso
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Neurocysticercosis
Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchymal Neurocysticercosis
The goal of this clinical trial is to compare the combination albendazole and praziquantel versus albendazole alone in patients affected by neurocysticercosis.
- Trial name
- NeuroSolve (NCT06376396)
- Testing
- albendazole and praziquantel, Albendazole
- Volunteers
- 300 people
- Sponsor
- R-Evolution Worldwide S.r.l. Impresa Sociale