Clinical trials: Hemangioma, Capillary
Port-Wine Stain
Pilot Study to Evaluate the Effect of Multiple Passes on Port Wine Stain Treatments With the Cutera Excel V™ Laser.
Two limitations of single pulse, laser treatment of port-wine stains (PWS) are: (i) hemorrhage and purpura which may lead to post-treatment pigmentation and (ii) the necessity for repeated treatment sessions.
- Trial name
- NCT04103164
- Testing
- Cutera excel V™ Laser
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hemangiomas of Infancy
Hemangioma Growth During the First 6 Months of Life
One of the most important and unique characteristics of infantile hemangiomas is their dramatic growth during early infancy. Most hemangiomas are either absent at birth or barely evident as a small scratch or bruise-like area.
- Trial name
- NCT00911781
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infantile Hemangioma
Hemangiol, Post Marketing Surveillance Study
Infantile hemangioma is a benign tumor belonging to the group of vascular tumors in the ISSVA classification (International Society for the Study of Vascular Anomalies). The diagnosis is clinical and radiological.
- Trial name
- postHemangiol (NCT04105517)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Deafness, Kidney Diseases
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors
The von Hippel Lindau (VHL) gene has recently been identified as the genetic defect resulting in a syndrome of multiple neoplasias.
- Conditions
- Deafness, Kidney Diseases, Kidney Neoplasms, Neoplasms
- Trial name
- NCT00001668
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Port Wine Stain
A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.
The purpose of this study is to improve port wine stain therapeutic outcome in response to laser therapy. The researchers want to determine whether the combined use of pulsed dye laser therapy and rapamycin will improve PWS…
- Trial name
- NCT00800722
- Testing
- Rapamycin Treatment of Port Wine Stain
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of California, Irvine
Infantile Hemangioma
Nadolol for Proliferating Infantile Hemangiomas
The purpose of this study is to explore the efficacy and safety of Nadolol in hemangiomas of infancy. The secondary objective is to assess the feasibility of conducting a randomized controlled trial comparing nadolol with…
- Trial name
- NCT01010308
- Testing
- Nadolol
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Hemangioma
Randomized Study of Hormonal Regulation of Infantile Hemangioma
OBJECTIVES: I. Evaluate the clinical efficacy of leuprolide, a gonadotropin-releasing hormone agonist (GnRHa), in treating infants with vision-endangering or large, disfiguring hemangiomas. II.
- Trial name
- NCT00004436
- Testing
- leuprolide, prednisone
- Volunteers
- 30 people
- Sponsor
- FDA Office of Orphan Products Development
CNS Tumors, Meningioma
68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors.
The study population consists of patients who undergo resection for somatostatin receptor-positive (SSTR-positive) CNS tumors, focusing on meningioma, and including esthesioneuroblastoma, hemangioblastoma, medulloblastoma…
- Conditions
- CNS Tumors, Meningioma, Esthesioneuroblastoma, Hemangioblastoma
- Trial name
- DOMINO-START (NCT04081701)
- Testing
- Ga68-DOTATATE-PET/MRI
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Capillary Malformations
Onreltea (Brimonidine) Gel In Pediatric Patients With Capillary Malformations
Capillary Malformations (CM) affect a significant proportion of otherwise healthy children and may lead to psychological discomfort if left untreated.
- Trial name
- NCT02764411
- Testing
- Brimonidine 0.33% gel
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- The Hospital for Sick Children
Port-Wine Stains (Capillary Malformations)
Comparative of Sequential Application of Pulsed Dye Laser and Potassium-titanyl-phosphate Laser Treatment for Capillary Malformations Versus Single Application
This prospective, non-randomized study aims to evaluate the efficacy and tolerability of treating port-wine stains (capillary malformations) using pulsed dye laser (PDL), potassium titanyl phosphate (KTP) laser, or a sequential…
- Trial name
- NCT07015073
- Testing
- Pulsed dye laser (PDL), Potassium titanyl phosphate (KTP) laser, Sequential KTP + PDL laser treatment
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Infantile Hemangioma
Evaluation of the Efficacy of Captopril Versus Propranolol and Timolol as a Treatment of Infantile Capillary Hemangioma
Is to compare and evaluate the efficacy of oral captopril with oral propranolol, intralesional propranolol injection, and topical Timolol in the treatment of infantile hemangioma and their effect on vascular endothelial growth…
- Trial name
- NCT04288700
- Testing
- oral propranolol, Oral Captopril, intralesional propranolol injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Hemangioma, Infant
Topical Timolol 0.5% Solution for Proliferating Infantile Hemangiomas
The purpose of this study is to learn about a new potential use for topical timolol 0.5% aqueous solution that may help treat small uncomplicated infantile hemangiomas.
- Trial name
- NCT01147601
- Testing
- topical 0.5% Timolol
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Oregon Health and Science University
Port-Wine Stain
Pathogenic Mechanisms of Port Wine Stain and Repository of Port Wine Stain Biopsy Samples
The purpose of this study is to investigate the pathogenic mechanisms of Port Wine Stain, collect biopsy samples and blood samples to characterize exosomes and metabolites from Port Wine Stain.
- Trial name
- NCT02051101
- Testing
- Biopsy sample from Port Wine Stain Birthmark
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Infantile Hemangioma
Optical Tomographic Imaging of Infantile Hemangiomas
The investigators hypothesize that there are differences between infantile hemangiomas (IH) during the proliferating and involuting phases and in response to medical treatment that can be detected by optical tomography of these…
- Trial name
- NCT01673971
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Columbia University
Hemangioma
Topical Timolol for Superficial Infantile Hemangioma
Infantile hemangioma (IH) is the most common benign vascular tumor in pediatric population. The characteristic natural history of this tumor is rapid growth in the first year of life and follows by spontaneous involution.
- Trial name
- NCT01685398
- Testing
- 0.5% timolol maleate eye drop, Normal saline
- Where
- Thailand
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Infantile Hemangioma
Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo
There is an unsatisfied medical need for a first-line treatment of localized uncomplicated proliferating Infantile Hemangioma with a good benefit/risk profile.
- Trial name
- NCT01512173
- Testing
- propranolol gel
- Where
- 17 sites in France, Poland and 1 more
- Volunteers
- 82 people
- Sponsor
- Pierre Fabre Dermatology
Hemangioblastoma of CNS, Von Hippel-Lindau Disease
Propranolol and Von Hippel-Lindau Disease
Propranolol (beta-blocker), is successfully used for the treatment of infantile hemangiomas, the most common vascular tumor of newborns. The mechanism is related to its anti-angiogenetic and pro-apoptotic effects.
- Trial name
- PRO-HEB (NCT05424016)
- Testing
- Propranolol, follow-up
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemangioma, Capillary
A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy
Hemangiomas of infancy, the most common benign tumors of infancy, are congenital or early infancy lesions characterized by a rapid postnatal growth, with high expression of angiogenic stimulators for 9-18 months, followed by slow…
- Trial name
- NCT00601016
- Testing
- Imiquimod 5% cream
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- St. Justine's Hospital
Kaposiform Hemangioendotheliomas, Tufted Angioma
Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies
The purpose of this study is to determine if the use of sirolimus in the treatment of children and young adults with complicated vascular anomalies will prove to be safe and provide objective response resulting in improved…
- Conditions
- Kaposiform Hemangioendotheliomas, Tufted Angioma, Capillary Venous Lymphatic Malformation, Venous Lymphatic Malformation
- Trial name
- NCT00975819
- Testing
- sirolimus
- Where
- 2 sites in United States
- Volunteers
- 61 people
- Sponsor
- Denise Martin Adams