Clinical trials: Hemangioma
Infantile Hemangioma
Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH)
The purpose of this study is to assess the safety and efficacy of Timolol 0.25% and 0.5% doses.
- Trial name
- TIM01 (NCT02913612)
- Testing
- 0.25% Timolol Maleate Gel Forming Solution, 0.5% Timolol Maleate Gel Forming Solution
- Where
- 12 sites in United States
- Volunteers
- 105 people
- Sponsor
- Kanecia Obie Zimmerman
Hemangioma
Immune Suppression Of Infants Treated With Steroids
The goal of this study is to clarify the degree of immune suppression in infants requiring therapy and to create guidelines for evaluation and prevention of infection in infants on oral steroids for hemangiomas.
- Trial name
- NCT00433940
- Testing
- Prednisolone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical College of Wisconsin
Hemangioblastoma, Hippel Lindau Disease
Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease
The purpose of this study is to learn more about the growth of brain and spinal cord tumors and cysts that develop in association with them in patients with von Hippel-Lindau disease.
- Trial name
- NCT00005902
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Kaposiform Hemangioendothelioma, Kasabach-Merritt Syndrome
Guided Discontinuation Versus Maintenance Treatment of Sirolimus in Pediatric Patients With Kaposiform Hemangioendothelioma
This randomized controlled trial aims to compare guided discontinuation with maintenance treatment of sirolimus in pediatric patients with KHE.
- Trial name
- NCT04448873
- Testing
- Sirolimus
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Fudan University
Vascular Diseases, Vascular Malformation
A New Approach in Laser Surgery Using the Regenerative Solution in Children Diagnosed With Vascular Pathology
Laser treatment (LT) is the first-line treatment for Vascular Pathology. However even when LT is based on the selective photothermolysis it causes the first-degree burns.
- Conditions
- Vascular Diseases, Vascular Malformation, Capillary Malformation-Arteriovenous Malformation, Port-Wine Stain
- Trial name
- DOUBLE-SKIN (NCT04999618)
- Testing
- Haemoblock
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Center for Vascular Pathology, Moscow
Liver Neoplasms, Sarcopenia
Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection
The investigators will investigate the impact of different biometric parameters (Body mass index, sarcopenia, lean muscle mass, hand-grip strength, gait speed, fat composition) on the postoperative outcomes of patients undergoing…
- Conditions
- Liver Neoplasms, Sarcopenia, Postoperative Complications
- Trial name
- NCT03630978
- Testing
- Liver resection
- Where
- Italy
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- San Camillo Hospital, Rome
Hippocampal Sclerosis, Dysembryoplastic Neuroepithelial Tumor
Exploration and Evaluation of Amygdalo-Hippocampectomy According to Prof. Coubes' Technique: An Anatomical, Clinical, and Educational Approach
The goal of this retrospective study is to evaluate the long-term clinical outcomes and complications associated with amygdalo-hippocampectomy using the surgical technique developed by Pr. Coubes (Montpellier, FRANCE).
- Conditions
- Hippocampal Sclerosis, Dysembryoplastic Neuroepithelial Tumor, Cortical Dysplasia, Ganglioglioma
- Trial name
- NCT06915649
- Testing
- Amygdalo-Hippocampectomy
- Where
- France
- Volunteers
- 3,504 people
- Sponsor
- University Hospital, Montpellier
Vascular Malformations, Vascular Anomaly
Vascular Anomaly Pathology and Genomics Biopsy Study
The purpose of this research is to gather information on the safety and effectiveness of core biopsy of vascular anomalies for clinical pathology and clinical genomics studies.
- Conditions
- Vascular Malformations, Vascular Anomaly, Hemangioma, Arteriovenous Malformations
- Trial name
- NCT04836884
- Testing
- Percutaneous Vascular Anomaly/Malformation Biopsy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Congenital Hemangioma, Hemangioendothelioma
A Study to Evaluate How Safe and Effective is the Mixture of Lipiodol® Ultra Fluid and Glue When Used for Embolization Procedures
This was a multicenter phase IV Post-Marketing Study. The study is designed to investigate the safety of Lipiodol® Ultra Fluid in association with surgical glues used according to each site medical practice of vascular…
- Conditions
- Congenital Hemangioma, Hemangioendothelioma, Angiosarcoma, Arteriovenous Malformations
- Trial name
- NCT02625389
- Testing
- Lipiodol Ultra Fluid with surgical glues
- Where
- 16 sites in India
- Volunteers
- 132 people
- Sponsor
- Guerbet
Malignant Melanoma, Merkel Cell Carcinoma
Optical Biopsy of Human Skin in Conjunction With Laser Treatment
This study is to compare the ability of optical biopsy. Research can use light enters the skin, collected, analyzed by the computer, and a picture created for the pathologist to conventional histologic examination compare with…
- Conditions
- Malignant Melanoma, Merkel Cell Carcinoma, Basal Cell Carcinoma, Squamous Cell Carcinoma
- Trial name
- NCT00540566
- Testing
- Optical Biopsy imaging
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Infantile Hemangioma
Timolol Maleate Gel for the Treatment of Infantile Hemangioma
The goal of this clinical trial is to evaluate the safety and efficacy of timolol maleate (TM) gel in subjects with superficial infantile hemangioma (IH) in the proliferative phase.
- Trial name
- NCT06677853
- Testing
- Timolol Maleate Gel
- Where
- 8 sites in China
- Volunteers
- 168 people
- Sponsor
- Auson Pharmaceuticals Inc.
Infantile Hemangioma
Assessing the Impact of Dosage Frequency of Propranolol on Sleep Patterns in Patients With Infantile Hemangiomas
The purpose of this study is to assess the baseline sleep pattern disruption for patients starting oral propranolol at the standard BID dosing regimen compared to the control (timolol) group and to determine if there is a…
- Trial name
- NCT05479123
- Testing
- Propranolol three times a day, Propranolol twice a day, Timolol
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- The University of Texas Health Science Center, Houston
Soft Tissue Sarcoma Adult, Undifferentiated Pleomorphic Sarcoma
Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients
This is a biology driven, monocentric study, designed to identify biomarkers of activity of trabectedin in patients with advanced non-L soft-tissue sarcoma.
- Conditions
- Soft Tissue Sarcoma Adult, Undifferentiated Pleomorphic Sarcoma, Epithelioid Sarcoma, Solitary Fibrous Tumors
- Trial name
- PIPER (NCT04008238)
- Testing
- Trabectedin
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Institut Bergonié
Hemangioma Liver
Efficacy Evaluation of Propranolol Treatment of Hepatic Hemangioma
Hepatic hemangioma is one of the most common benign tumor of the liver. Although the overall prognosis is good, active interventions are still needed in high-risk patients.
- Trial name
- NCT03633747
- Testing
- Propranolol Hydrochloride
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hemangioma
Clinical Trial of Vincristine vs. Prednisolone for Treatment of Complicated Hemangiomas
The goal of this study is to determine the safety and efficacy of Prednisolone and Vincristine for treatment of large, complicated infantile hemangiomas.
- Trial name
- NCT00555464
- Testing
- Vincristine, Prednisone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical College of Wisconsin
Cerebral Cavernous Malformation
Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial
This phase I/II randomized, placebo-controlled, double-blinded, single-site clinical trial is designed to investigate the effect of a prolonged course of atorvastatin versus placebo on CCM lesional iron deposition assessed by…
- Trial name
- AT CASH EPOC (NCT02603328)
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Hemangioma, Capillary
Infantile Hemangioma With Minimal or Arrested Growth : Epidemiology, Clinical Characteristics and Evolution
Infantile hemangioma (IH) is the most common vascular tumor of infancy, characterized by its clinical history. Absent at birth or present under the form of a premonitory mark, they display a rapid proliferative phase starting in…
- Trial name
- NCT05080868
- Where
- France
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Cavernous Malformation, Cerebral, Cavernous Angioma
Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy
Cerebral cavernous malformation (CCM)-related epilepsy (CRE) impairs the quality of life in patients with CCM. Patients could not always achieve seizure freedom after surgical resection of the lesion, suggesting an inadequate…
- Conditions
- Cavernous Malformation, Cerebral, Cavernous Angioma, Cavernous Hemangioma, Cavernous Hemangioma of Brain
- Trial name
- CRESS (NCT04076449)
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- yuanli Zhao
Hemangiomas
Pulse Steroids Versus Oral Steroids in Problematic Hemangiomas of Infancy
The purpose of the study is to determine if pulse steroids are more efficacious and safer than the standard treatment with oral corticosteroids.
- Trial name
- NCT00312520
- Testing
- prednisolone, methylprednisolone
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Hemangioma
Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma
There is no effective treatment for hemangioma regardless of immediate severity. That is in this respect a orphan disease. These hemangiomas, sometimes large, will have a phase of proliferation of several months (very scary for…
- Trial name
- NCT01743885
- Testing
- Acebutolol, Propanolol
- Where
- 4 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier