Clinical trials: Hematologic and Lymphocytic Disorder
Acute Myeloid Leukemia
Mismatched Donor Cells to Treat Acute Myeloid Leukemia
The purpose of this study is to assess the safety and efficacy of infusing immune cells from a donor as treatment for patients with acute myeloid leukemia that is resistant to chemotherapy or who have experienced relapse.
- Trial name
- ATAC-AML-01 (NCT01793025)
- Testing
- ATAC Therapy
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Multiple Myeloma
GMMG-HD10 / DSMM-XX / 64007957MMY2003, MajesTEC-5
A Phase 2 Study to Evaluate Safety and Efficacy of Teclistamab-, Talquetamab-, and JNJ-79635322-based Combination Regimens in Participants with Newly Diagnosed Transplant Eligible Multiple Myeloma OBJECTIVES: To evaluate the…
- Trial name
- HD10/DSMMXX (NCT05695508)
- Testing
- Teclistamab (Tec), Daratumumab, Dexamethasone
- Where
- 11 sites in Germany
- Volunteers
- 160 people
- Sponsor
- University of Heidelberg Medical Center
Leukemia, Lymphoma
Effect of Tight Control of Blood Glucose During Hyper-CVAD Chemotherapy For Acute Lymphocytic Leukemia (ALL)
The goal of this clinical research study is to learn if intense management and control of blood sugar levels during treatment for acute lymphocytic leukemia, Burkitts lymphoma, or lymphoblastic lymphoma will result in decreased…
- Trial name
- NCT00500240
- Testing
- Insulin Glargine, Insulin Aspart
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- M.D. Anderson Cancer Center
Paroxysmal Nocturnal Hemoglobinuria
NIS PDC the Efficacy and Safety of Iptacopan in Adults in Routine Clinical Practice
This is a prospective, non-interventional, multicenter study to evaluate the efficacy and safety of iptacopan in patients with PNH in real-world settings in Russia.
- Trial name
- PRIORITY- PNH (NCT07036718)
- Where
- 5 sites in Russia
- Volunteers
- 6 people
- Sponsor
- Novartis Pharmaceuticals
Leukemia, Solid Tumours
A Phase I Study of SB939 in Pediatric Patients With Refractory Solid Tumours and Leukemia
This research is being done because SB939 has been shown to shrink tumours in animals and in some people and seems promising, but we are not sure if it can offer better results than standard treatment.
- Trial name
- NCT01184274
- Testing
- SB939
- Where
- 8 sites in Canada
- Volunteers
- 12 people
- Sponsor
- NCIC Clinical Trials Group
Hypereosinophilic Syndrome
A Study to Determine the Safety and Efficacy of Imatinib Mesylate in Patients With Idiopathic Hypereosinophilic Syndrome
The objectives of the study are: 1. Evaluation of the safety profile of imatinib mesylate in patients with idiopathic hypereosinophilic syndrome resistant or refractory to, or intolerant of, prednisone, hydroxyurea or…
- Trial name
- NCT00171860
- Testing
- imatinib mesylate
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals
Blood Disease, Anemia, Aplastic
Aplastic Anemia Epidemiology: Incidence and Case-control
To conduct incidence and case-control studies of aplastic anemia in metropolitan Bangkok, Thailand
- Trial name
- NCT00005682
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Multiple Myeloma, Multiple Myeloma in Relapse
Pembrolizumab for the Treatment of Relapsed or Refractory Multiple Myeloma After Anti-BCMA CAR-T Therapies
This phase II trial tests whether pembrolizumab works to shrink tumors in patients with multiple myeloma whose cancer has come back (relapsed) or did not respond to previous treatment (refractory) with anti-BCMA CAR-T therapies.
- Conditions
- Multiple Myeloma, Multiple Myeloma in Relapse, Multiple Myeloma, Refractory, Recurrent Plasma Cell Myeloma
- Trial name
- NCT05191472
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Alfred Chung, MD
Sickle Cell Disease, Chronic Pain
MUSic Therapy to Improve Quality Of Life in Sickle Cell Disease (MUSIQOLS)
The purpose of this pilot study is to investigate the effects of a 6-session music therapy protocol on the pain, mood, quality of life, coping skills, and self-efficacy of adult patients with sickle cell disease (SCD) as compared…
- Trial name
- NCT03556657
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University Hospitals Cleveland Medical Center
Postpartum Anemia Nos, Iron-deficiency
Intravenous Iron Carboxymaltose, Isomaltoside and Oral Iron Sulphate for Postpartum Anemia
Anemia affects between 20 and 50 % of women in the postpartum period. It is associated with several adverse health consequences, such as impaired physical work capacity, deficits in cognitive function and mood, reduced immune…
- Trial name
- NCT03957057
- Testing
- Iron Carboxymaltose, Iron Isomaltoside, Ferrous sulphate
- Where
- Slovenia
- Volunteers
- 300 people
- Sponsor
- University Medical Centre Ljubljana
Acute Lymphoblastic Leukemia (ALL) in Complete Remission, Acute Myeloid Leukemia (AML) in Remission
Comparing Post-Transplant Cyclophosphamide As GVHD Prophylaxis to Standard of Care for Acute Leukemia Patients
This randomized clinical trial will evaluate two approaches of GvHD prophylaxis; the standard of care GVHD prophylaxis regimen (methotrexate/calcineurin inhibitors) and post-transplant cyclophosphamide with calcineurin inhibitors…
- Trial name
- PTCy-PMAT (NCT04314219)
- Testing
- Cyclophosphamide 50mg, Methotrexate
- Where
- Saudi Arabia
- Volunteers
- 264 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary
Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors
RATIONALE: Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary, Leukemia, Lymphoma
- Trial name
- NCT00112619
- Testing
- topotecan hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 19 people
- Sponsor
- Pediatric Brain Tumor Consortium
Leukemia, Myelodysplastic Syndromes
Comparing Two Diets in Patients Undergoing HSCT or Remission Induction Chemo for Acute Leukemia and MDS (UF-BMT-LDND-101)
This is an open-label, two-arm, phase III non-inferiority trial to evaluate the safety of a liberalized hospital diet inclusive of fresh fruits and vegetables to a neutropenic diet in patients with prolonged neutropenia.
- Trial name
- NCT03016130
- Testing
- Diet
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- University of Florida
Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ
Treating Patients With Recurrent PCNSL With Carboplatin/BBBD and Adding Rituxan To The Treatment Regimen
RATIONALE: Monoclonal antibodies, such as rituximab, can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Conditions
- Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ, Lymphoma, Thrombocytopenia
- Trial name
- NCT00074165
- Testing
- Rituxan, Cyclophosphamide, Etoposide
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- OHSU Knight Cancer Institute
Leukemia, Myeloid, Chronic-Phase
Imatinib Response in Patients With Chronic Myeloid Leukemia (CML) in Function of Abl Polymorphisms
The main objective of this study is to evaluate the existence of a relationship between the presence of certain abl polymorphisms (or haplotypes) upon CML diagnosis and the occurrence of primary resistance to the treatment of CML…
- Trial name
- abl LMC (NCT01650467)
- Where
- 3 sites in France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Myeloid Leukemia, Adult
Effect of a Hyperproteic Hyperenergetic Enteral Formula on Body Composition and VEGF in AML During Hospital Stay
A randomized controlled clinical trial in two groups of supplementation with high protein enteral formula and a normocaloric enteral formula in two groups of 37 patients .
- Trial name
- HEMVEF (NCT04240600)
- Testing
- Experimental group, Control group
- Where
- 2 sites in Mexico
- Volunteers
- 74 people
- Sponsor
- Hospital General de Mexico
Multiple Myeloma
Short Course Daratumumab in Patients With Multiple Myeloma
The purpose of this study is to test the safety of short course Daratumumab in combination with lenalidomide and to find out what effects, if any, short course Daratumumab in combination with lenalidomide has on people and their…
- Trial name
- NCT03490344
- Testing
- Daratumumab, Lenalidomide
- Where
- 7 sites in United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Recurrent Plasma Cell Myeloma
Gossypol Acetic Acid With Lenalidomide and Dexamethasone in Treating Patients With Relapsed Symptomatic Multiple Myeloma
This phase I trial studies the side effects and best dose of R-(-)-gossypol acetic acid when given together with lenalidomide and dexamethasone and to see how well it works in treating patients with multiple myeloma, also known…
- Trial name
- NCT02697344
- Testing
- Dexamethasone, Laboratory Biomarker Analysis, Lenalidomide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Multiple Myeloma
Tandem High Dose Melphalan Versus Triple Intermediate Dose Melphalan and Stem Cell Transplantation in Induction Phase and Prednisolone/IFN Versus IFN in Maintenance Therapy
This is an international,multicenter, prospective, open, double randomised and controlled phase III study to compare the therapeutic efficacy of tandem high dose Melphalan versus triple intermediate dose Melpahaln in…
- Trial name
- NCT00205764
- Testing
- Melphalan
- Where
- Austria
- Volunteers
- 212 people
- Sponsor
- Austrian Forum Against Cancer
Anemia, Iron-Deficiency
Epidemiological Study of Iron Deficiency and Iron Deficiency Anemia in Chinese Pregnant Women
The purpose of this study is to know the prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) among pregnant women in Chinese urban district at present, and to analyze the epidemiological characteristics of ID/IDA…
- Trial name
- EIDACPW (NCT02887963)
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- West China Hospital
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