Clinical trials: Hematological Neoplasm
Hematological Malignancy
Membrane Target Detection for Leukemia Treatment
Acute myeloid leukemia (AML) accounts for more than 40% of leukemia mortality in the United States. Each year around ten thousand people die from the disease, most within a few years of diagnosis.
- Trial name
- NCT04841447
- Testing
- Study sample collection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Missouri-Columbia
Allogeneic Hematopoietic Stem Cell Transplantation for Hematological Malignancies
Immunoregulatory T Lymphocytes Subtypes and Haematopoietic Stem Cell Transplantation (HSCT)
The purpose of this study is to confirm that invariant NKT lymphocytes (iNKT) reconstitution in recipient and in the graft content can predict the outcome of human allogeneic HSCT and to set up an algorithm for clinical practice…
- Trial name
- REG-Allo (NCT02194868)
- Testing
- Recipients, Donors
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Solid Tumors, Hematological Malignancies
Establish the PK of Belinostat in Patients With Wild-type, Heterozygous, and Homozygous UGT1A1*28 Genotypes
This is a Phase 1, open-label, nonrandomized study to determine the PK profiles of belinostat in patients with relapsed/refractory solid tumors or hematological malignancies who have heterozygous and homozygous UGT1A1*28…
- Trial name
- NCT02680795
- Testing
- Belinostat IV
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Acrotech Biopharma Inc.
Acute Leukemia, Immune Deficiency Disorder
Umbilical Cord Blood Transplantation From Unrelated Donors
This study is being done to determine how long it takes for the engraftment (recovery of blood cell counts) of umbilical cord stem cells and also how often engraftment of umbilical cord stem cells transplanted from an unrelated…
- Conditions
- Acute Leukemia, Immune Deficiency Disorder, Congenital Hematological Disorder, Metabolism Disorder
- Trial name
- NCT03016806
- Testing
- Total Body Irradiation 1200 cGy, Total Body Irradiation 200 cGy, Cyclophosphamide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Rochester
Hematological Malignancies
A Clinical Study of HMPL-506 in Patients With Hematological Malignancies
This is a Phase 1, multicenter, open-label clinical study of HMPL-506 administered orally in the treatment of hematological malignancies.
- Trial name
- NCT06387082
- Testing
- HMPL-506
- Where
- 16 sites in China
- Volunteers
- 132 people
- Sponsor
- Hutchmed
Invasive Fungal Disease, Chronic Disseminated Candidiasis
Hepatosplenic CANdidiasis : PETscan and Immune Response Analysis
The purpose of this study is to determine whether F18 fluorodeoxyglucose (18F-FDG) positron-emission tomography scan (PET scan) is useful for the therapy strategy of hepatosplenic candidiasis.
- Conditions
- Invasive Fungal Disease, Chronic Disseminated Candidiasis, Hematological Malignancies, Hematopoietic Stem Cell Transplantation
- Trial name
- CANHPARI (NCT01916057)
- Testing
- 18F-FDG PET Scan
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hematological Malignancies
The Study of ICP-248 in Patients With Mature B-cell Malignancies
A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of ICP-248 as Monotherapy or in Combination Therapy in Patients with Mature B-cell Malignancies.This study…
- Trial name
- NCT05728658
- Testing
- ICP-248, ICP-248+Orelabrutinib, ICP-248 +Rituximab
- Where
- 22 sites in China
- Volunteers
- 191 people
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Cancer and / or Hematological Malignancy, Hematopoetic Stem Cell Transplantation
Virtual Reality Intervention for Symptom Management in Stem Cell Transplantation
The goal of this clinical trial is to evaluate whether a virtual reality (VR) intervention based on the Symptom Management Model can reduce physical and psychosocial symptoms during hematopoietic stem cell transplantation (HSCT)…
- Conditions
- Cancer and / or Hematological Malignancy, Hematopoetic Stem Cell Transplantation, Nursing Interventions, Symptom Management
- Trial name
- NCT07145359
- Testing
- Virtual Reality Intervention
- Volunteers
- 30 people
- Sponsor
- Halic University
Hematological Malignancies
18F-Pentixafor PET in Hematologic Malignancies
The aim of this study is to evaluate the efficacy of 18F-Pentixafor PET imaging in the diagnosis, staging and response evaluation of hematological malignancies.
- Trial name
- NCT07122674
- Testing
- 18F-Pentixafor
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
CD20-positive Hematological Malignancies
Phase I Clinical Trial of TQB2825 Subcutaneous Injection in CD20-positive Hematological Malignancies
The aim of this study is to evaluate the pharmacokinetic characteristics, safety and efficacy of the TQB2825 injection (subcutaneous administration) in patients with CD20-positive hematological malignancies.
- Trial name
- NCT07110194
- Testing
- TQB2825 Injection (Subcutaneous Injection)
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.
Relapsed and Refractory Hematological Malignancies
A Clinical Study of CAR-T Cells in the Treatment of Relapsed and Refractory Hematological Malignancies
This project is intended to provide CAR-T cell therapy products for patients with severely life-threatening relapsed and refractory hematological malignancies.
- Trial name
- NCT04008524
- Testing
- CAR-T cells
- Where
- China
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Advanced Malignancies, Solid Tumor
Study Evaluating Food Effect and QTc in Patients With Advanced Malignancies
Phase 1 2-part study to evaluate the effect of food on pharmacokinetics of pelabresib (CPI-0610) and the effect of pelabresib on QTc in patients with advanced malignancies
- Conditions
- Advanced Malignancies, Solid Tumor, Hematological Malignancy
- Trial name
- NCT05391022
- Testing
- Pelabresib
- Where
- 10 sites in United States, Georgia and 1 more
- Volunteers
- 35 people
- Sponsor
- Constellation Pharmaceuticals
Pain Management, Anxiety
Distraction With Virtual Reality From Pain and Anxiety for Patients With Hematological Malignancies
The goal of this clinical trial] is to study the effectiveness of Virtual Reality (VR) in reducing pain and anxiety during painful procedures for patients with hematological malignancies The main question[s] it aims to answer…
- Conditions
- Pain Management, Anxiety, Procedures, Hematological Neoplasms
- Trial name
- NCT07085065
- Testing
- VR session
- Where
- Tunisia
- Volunteers
- 365 people
- Sponsor
- Yesmine Amara
Hematological Malignancy, Prehabilitation
Investigation of the Effects of Prehabilitation Education Delivered Through a Mobile Compatible Website on Quality of Life and Symptoms in Patients Undergoing Hematopoietic Stem Cell Transplantation
Aim of the Study: The aim of this study is to examine the effect of prehabilitation education delivered via a mobile-compatible website on the quality of life and symptom evaluation of patients undergoing hematopoietic stem cell…
- Conditions
- Hematological Malignancy, Prehabilitation, Patient Education
- Trial name
- NCT07066592
- Testing
- Prehabilitation education provided via mobile compatible website
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Saglik Bilimleri Universitesi
Graft Versus Host Disease, Hematological Malignancies
T Lymphocytes (LT) Expressing iCASP9 and ΔCD19 in Allogeneic Haematopoietic Transplantation.
This study evaluates the frequency of occurrence, severity, and response to treatment by a chemical agent, notably the dimerizer AP1903 (Bellicum Pharmaceuticals compagny), in the case of acute Graft versus Host Disease (aGvHD)…
- Trial name
- Side_by_Cide (NCT02849886)
- Testing
- T lymphocytes iCASP9 ΔCD19, Dimerizer drug AP1903
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Carbapenem-resistant Enterobacterales, Neutropenia
Prospective Study Evaluate the Timing of Empirical Treatment for Carbapenem-resistant Bacterials (CROEAT Study)
In this study, we will evaluate the feasibility and clinical outcomes of risk adaptive empirical therapy to cover carbapenem resistance gram negative bacteria (CRO) in patients with hematological malignancies colonized with CRO.
- Conditions
- Carbapenem-resistant Enterobacterales, Neutropenia, Hematological Malignancies
- Trial name
- NCT07047352
- Testing
- Empirical treatment
- Where
- China
- Volunteers
- 91 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
CXCR4, PET/CT
CXCR4-targeted PET/CT Imaging in Hematological Malignancies
Hematological malignancies continue to pose significant clinical challenges due to their high incidence, heterogeneous biology, and substantial mortality.
- Conditions
- CXCR4, PET/CT, Hematological Malignancy
- Trial name
- NCT05255926
- Testing
- 68Ga-pentixafor, PET/CT
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhongnan Hospital
Hematological Malignancy, Solid Tumor Malignancy
A Study for Participants Previously Treated With Century Therapeutics Cellular Therapy Product
This study is designed to collect long-term safety and survival data from participants previously treated in an eligible Century-sponsored index trial.
- Trial name
- NCT05768269
- Testing
- No Intervention
- Where
- 7 sites in United States
- Volunteers
- 375 people
- Sponsor
- Century Therapeutics, Inc.
Hematological Malignancies
National Longitudinal Cohort of Hematological Diseases (NICHE) - CART
This is a multicenter, ambispective, longitudinal, observational cohort study investigating CAR-T cell therapy in Chinese patients with hematological malignancies.
- Trial name
- NCT06607289
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
COVID-19 Infection in Hematological Malignancies Patients
Covid-19 in Hematological Malignancies
The overall purpose of this project is to better understand the epidemiology of COVID-19 in patients with hematological malignancies (including hematopoietic stem cell transplant recipients) in the different European Countries.
- Trial name
- EPICOVIDEHA (NCT04733729)
- Where
- 6 sites in Italy
- Volunteers
- 3,000 people
- Sponsor
- Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne