Clinical trials: Hematopoiesis
Heart Failure With Preserved Ejection Fraction
CHIP in Endothelial Dysfunction Associated With HEpEF
This study aims at identifying processes that are deregulated in blood cells by Clonal Hematopoiesis of Indeterminate Potential (CHIP) which are involved in the development of heart failure with preserved ejection fraction…
- Trial name
- CHiEF (NCT05828888)
- Volunteers
- 80 people
- Sponsor
- University Hospital, Bordeaux
Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma
Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study
This study is being done to investigate clonal hematopoiesis and therapy-emergent myeloid neoplasms in patients with ovarian or other solid cancers.
- Conditions
- Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma, Recurrent Malignant Solid Neoplasm
- Trial name
- NCT06295965
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of Washington
HIV-1, SARS-CoV-2
Viral Infection of HSPC Impacts Hematopoiesis
We propose to demonstrate that HIV-1 and SARS-CoV-2 are capable of targeting long-lived HSPC with self-renewal capacities. These progenitors, thus transformed into host cells, can give rise to a durable source of infected cells…
- Trial name
- MEGAHOST (NCT06458504)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ST-elevation Myocardial Infarction (STEMI), Clonal Hematopoiesis of Indeterminate Potential (CHIP)
Clonal Hematopoiesis of Indeterminate Potential and Infarct Severity in ST-Elevation Myocardial Infarction
Clonal Hematopoiesis of Indeterminate Potential (CHIP) refers to the age-related expansion of hematopoietic stem cell clones carrying somatic mutations in leukemia-associated driver genes (e.g., DNMT3A, TET2, ASXL1) in the…
- Trial name
- CHIP in STEMI (NCT07615023)
- Testing
- Clonal hematopoiesis assessment and cardiac magnetic resonance imaging
- Where
- Austria
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Immunosuppresion, Thrombocytopenia
Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia
Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disorder characterized by pancytopenia and a hypocellular bone marrow.
- Conditions
- Immunosuppresion, Thrombocytopenia, Pancytopenia, Neutropenia
- Trial name
- NCT00260689
- Testing
- Anti-thymocyte globulin (rabbit), Anti-thymocyte globulin (horse), Cyclosporine
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Clonal Hematopoiesis
A Dietary Study for People With Clonal Hematopoiesis
The researchers are doing this study to find out whether a high-fiber plant-based diet (HFPBD) can improve quality of life for people with CH.
- Trial name
- NCT07590804
- Testing
- high-fiber plant-based meals, fermented foods, supplements
- Where
- 7 sites in United States
- Volunteers
- 36 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Vascular Inflammation, ASCVD
Effects of IL-1 Beta Inhibition on Vascular Inflammation in TET2 Clonal Hematopoiesis
The primary goal of this clinical trial is to test the hypothesis that the drug canakinumab (anti-IL-1B monoclonal antibody) decreases vascular inflammation when used by people with a history of coronary artery disease, including…
- Conditions
- Vascular Inflammation, ASCVD, ASCVD Management
- Trial name
- TECTONIC (NCT06691217)
- Testing
- CANAKINUMAB (ILARIS®)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Myelodysplastic Syndrome
The Role of Erythropoietin in Myelodysplastic Syndrome
The purpose of the study is to elucidate the causative molecular events responsible for the abnormal erythropoiesis in MDS.
- Trial name
- NCT00723112
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Utah
Leukemia, Myelogenous
Allogeneic Stem Cell Transplantation in Chronic Myeloid Leukemia Failing TKIs Therapy
Patients newly diagnosed with chronic phase chronic myeloid leukemia undergo treatment with TK inhibitors (TKI). A possible cause of TK failure is represented by the insufficient recovery of normal Ph- hematopoiesis during TKI…
- Conditions
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Trial name
- NCT02638467
- Testing
- Bosutinib, Bone Marrow Transplant, Bone Marrow cells
- Where
- 2 sites in Italy
- Volunteers
- 2 people
- Sponsor
- University of Milano Bicocca
Chronic Lymphocytic Leukemia, Monoclonal B-Cell Lymphocytosis
Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects
This study evaluates hematopoiesis to determine how MBL/CLL affected bone marrow responds to fight off infections in the body.
- Trial name
- NCT06536452
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lung Cancer (Diagnosis), Osteochondroma
Clonal Hematopoiesis Chemotherapy and Radiation Effects Study
The goal of the Clonal Hematopoiesis Chemotherapy and Radiation Effects (CH CARE) Study is to understand how the presence or absence of clonal hematopoiesis (CH) influences outcomes in people receiving chemotherapy and radiation…
- Conditions
- Lung Cancer (Diagnosis), Osteochondroma, Spitz Nevus, Solid Cancers
- Trial name
- CH CARE (NCT07675967)
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Dana-Farber Cancer Institute
Myelodysplastic Syndromes
Study Investigating the Interactions of Bone and Hematopoiesis in the Elderly
The prospective BoHemE study is designed to evaluate the correlation between bone marrow function and skeletal health in elderly patients (>= 60 years) with or without pre-existing myelodysplastic syndromes (MDS).
- Trial name
- NCT02867085
- Testing
- Observational
- Where
- 2 sites in Germany
- Volunteers
- 297 people
- Sponsor
- Technische Universität Dresden