Clinical trials: Hematopoietic
Hematological Neoplasms, Hematopoietic Stem Cell Transplantation
Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation for Malignant Hematological Diseases
To evaluate engraftment and toxicity of a reduced intensity preparative regimen for patients who receive a matched related or unrelated donor allogeneic stem cell transplant (ASCT) for malignant hematological diseases
- Trial name
- NCT00582894
- Testing
- Busulfex, Fludarabine, ALemtuzumab
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Oklahoma
Menin Inhibitors, Acute Leukemia
A Real-world Study on the Efficacy and Safety of Menin Inhibitors as Maintenance After Allo-HSCT
The objective of this observational study is to evaluate the efficacy and safety of menin inhibitor maintenance therapy in patients with acute leukemia who have undergone allogeneic hematopoietic stem cell transplantation…
- Conditions
- Menin Inhibitors, Acute Leukemia, Post Hematopoietic Stem Cell Transplantation, Maintenance Therapy
- Trial name
- NCT07559695
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Non-Hodgkin's Lymphoma
Assessment of Hematopoietic Recovery Following Chemotherapy for Non-Hodgkin's Lymphoma
A study to determine the accuracy of FLT-PET in quantifying tumor cell proliferation at the initial staging of patients with Non-Hodgkin's Lymphoma in comparison wit the "gold standard" FDG-PET.
- Trial name
- NCT00775957
- Testing
- FLT-PET scan, FDG-PET scan
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Oklahoma
Allogeneic Hematopoietic Stem Cell Transplantation
Allogeneic Hematopoietic Stem Cell Transplantation Cohort Study
Clinical observational studies using epidemiologic theories and methods. Through the collection of various clinically relevant data, specific outcomes are evaluated in hematologic transplant patients, providing high quality…
- Trial name
- NCT06708130
- Where
- 3 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Ruijin Hospital
Invasive Fungal Infection, Aspergillosis
Evaluate Three Methods for Diagnosis of Invasive Fungal Infection in Chinese Patients After HSCT
The purpose of this study is to assess the cut-off value of GM/G test in Chinese patients after hematopoietic stem cell transplantation, and evaluate GM/G test and real-time PCR for diagnosis of IFI in Chinese patients.
- Conditions
- Invasive Fungal Infection, Aspergillosis, Fungemia, Hematopoietic Stem Cell Transplantation
- Trial name
- NCT00460330
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University
Hematopoietic/Lymphoid Cancer
Donor Umbilical Cord Blood Transplant After Cyclophosphamide, Fludarabine Phosphate, and Total-Body Irradiation in Treating Patients With Hematologic Disease
RATIONALE: Giving low doses of chemotherapy and total-body irradiation before a donor umbilical cord blood transplant helps stop the growth of abnormal cells.
- Trial name
- NCT00959231
- Testing
- cyclophosphamide, cyclosporine, fludarabine phosphate
- Where
- 6 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cancer Research UK
Graft-Versus-Host Disease, Hematopoietic Stem Cell Transplantation
Prospective Clinical Trial for Children With TCRαβ Depleted vs Traditional Haplo Identicle HSCT
This is a single-center prospective, non-randomized controlled clinical study in China using CliniMACS TCRα/β+ cell depleted stem cell haploidentical donors versus conventional Beijing protocol for haploidentical hematopoietic…
- Conditions
- Graft-Versus-Host Disease, Hematopoietic Stem Cell Transplantation, Child, Only, Haploidentical Hematopoietic Stem Cell Transplantation
- Trial name
- NCT06423131
- Testing
- TCRαβ Depleted haploidentical HCT
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Sijia Gu
Systemic Aspergillosis, Systemic Candidiasis
Antimycotic Prophylaxis in Pediatric Patients Following Allogeneic Stem Cell Transplantation
Pediatric patients are at high risk to acquire mycotic infections following allogeneic bone marrow transplantation. In the present retrospective analysis we assess the safety and efficacy of different regimens in antimycotic…
- Trial name
- NCT01040156
- Where
- Germany
- Sponsor
- University Children's Hospital Tuebingen
Hemoglobin, Stem Cell Transplant
Fertility Preservation in Women Who Will Have Gonadotoxic Therapy or Hematopoetic Stem Cell Transplantation, and in Women With Sickle Cell Disease
Background: Some treatments for cancer or other diseases can lead to infertility in women. These treatments include chemotherapy, some stem cell transplants, and pelvic radiotherapy. They are called gonadotoxic therapies.
- Conditions
- Hemoglobin, Stem Cell Transplant, Aplastic Anemia
- Trial name
- NCT02225145
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Comparing the Impact of Four Types of Meditation Practices for Relaxation in Cancer Survivors
This clinical trial compares the impact of four types of meditation practices, breathing only, focused attention only, mindfulness only, and breathing, focused attention and mindfulness combined, for relaxation in cancer…
- Trial name
- NCT06500377
- Testing
- Biospecimen Collection, Meditation Therapy, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- City of Hope Medical Center
Advanced Solid Tumor, Advanced Solid Malignancies
A Phase I Study, Evaluating the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors
This is a Phase I, multicenter, open-label, 3+3 dose escalation study to determine the safety and preliminary efficacy of PRJ1-3024 in subjects with relapsed/refractory solid tumors.
- Trial name
- NCT05159700
- Testing
- PRJ1-3024
- Where
- 6 sites in United States
- Volunteers
- 39 people
- Sponsor
- Zhuhai Yufan Biotechnologies Co., Ltd
Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphatic System Neoplasm
A Virtually Delivered Diet Intervention (LASO-3) for the Improvement of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors Post-treatment
This clinical trial studies whether a virtually delivered diet intervention focused on lower added sugar, higher fiber, and higher omega 3 fatty acid (LASO-3) can be used to improve chemotherapy-induced peripheral neuropathy…
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT07365007
- Testing
- Biospecimen Collection, Educational Intervention, Electronic Health Record Review
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan Rogel Cancer Center
Acute Myeloid Leukemia Myelodysplastic Syndromes
Total Body Irradiation and Cladribine Before Allogeneic Hematopoietic Cell Transplantation in Patients With AML (Acute Myeloid Leukemia) and Myelodysplastic Syndromes
A single center, prospective, one arm clinical study to assess the tolerance and effectiveness of total body irradiation and cladribine in adult patients diagnosed with AML( acute myeloid leukemia) and myelodysplastic syndromes.
- Trial name
- CLARA (NCT04861207)
- Testing
- Cladribine
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome
This phase I/II trial studies the side effects and best dose of a radioactive agent linked to an antibody (211At-BC8-B10) followed by donor stem cell transplant in treating patients with high-risk acute leukemia or…
- Conditions
- Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Acute Myeloid Leukemia in Remission, Chronic Myelomonocytic Leukemia
- Trial name
- NCT03670966
- Testing
- Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10, Cyclophosphamide, Total-Body Irradiation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Fred Hutchinson Cancer Center
CMV, AdV Infection
Phase 3 Randomized Trial for Refractory ADV or CMV Infection With Family Matched CTLs and Standard of Care (SOC) vs SOC Alone
Patients with refractory ADV or CMV infection post allogeneic stem cell transplant will be randomized to either Family donor-derived viral specific cytotoxic T lymphocytes (CTLs) plus standard of care (SOC) vs SOC alone.
- Conditions
- CMV, AdV Infection, AdV Reactivation, Adenovirus
- Trial name
- NCT07225972
- Testing
- Standard of Care Antiviral medications, Viral CTLs
- Where
- 2 sites in United States
- Volunteers
- 138 people
- Sponsor
- New York Medical College
Myeloid Leukemia, Acute, Chronic Myeloid Leukemia
Post-transplantation Benadamustine and Cyclophosphamide in Patients With Refractory Myeloid Malignancies
Prognosis of patients undergoing salvage allogeneic stem cell transplantation for refractory leukemia or other refractory myeloid malignanies is poor.
- Conditions
- Myeloid Leukemia, Acute, Chronic Myeloid Leukemia, Myelodysplastic Syndromes, Myeloproliferative Neoplasm
- Trial name
- PTBCy (NCT04943757)
- Testing
- Bendamustine Hydrochloride, Cyclophosphamid
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Beta-Thalassemia
Evaluating the Safety and Effectiveness of Mozobil Mobilization in Adults With Beta-Thalassemia Major
Thalassemia is considered the most common genetic disorder worldwide, occurring with high frequency in Mediterranean areas, the Middle East, Southeast Asia, and the Pacific Islands.
- Trial name
- NCT01206075
- Testing
- Mozobil
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- University of Washington
Cytomegalovirus Cell Mediated Immunity, Stem Cell Transplantation, Hematopoietic
Impact of CMV-Specific Immune Reconstitution at the End of Letermovir Prophylaxis on the Development of Late Cytomegalovirus Infection in Hematopoietic Stem Cell Transplant Recipients (INMUNOEND)
Cytomegalovirus (CMV) infection is a common complication in patients undergoing hematopoietic stem cell transplantation (SCT). Fixed-duration letermovir (LTV) prophylaxis during the first 100 days post-SCT is effective and safe…
- Trial name
- INMUNOEND (NCT06814301)
- Testing
- Periodic immunological monitoring of CMV-specific immune reconstitution will be performed using QTF-CMV
- Where
- Spain
- Volunteers
- 123 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Hematologic Disease
Human Leukocyte Antigen (HLA) Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation
This study is a single center, prospective, single arm exploratory clinical trial that includes patients with hematological malignancies who are indicated for allogeneic hematopoietic stem cell transplantation (allo HSCT) but…
- Trial name
- MIGHT (NCT06809712)
- Testing
- Busulfan (Busulfex), Cyclophosphamide (CTX), Fludarabine (Fludara)
- Where
- China
- Volunteers
- 29 people
- Sponsor
- He Huang
Renal Disease, Renal Insufficiency
Two-Point Measurement of Glomerular Filtration Rate by Iohexol Plasma Disappearance
The purpose of this study is to measure glomerular filtration rate (GFR) by iohexol plasma disappearance (gold standard) and measure serum Cystatin C levels (surrogate marker) in patients enrolled in our prospective study at…
- Trial name
- NCT01545531
- Testing
- Iohexol
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Washington
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