Clinical trials: Hematopoietic
Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Blasts 5 Percent or More of Bone Marrow Nucleated Cells
Inotuzumab Ozogamicin and Vincristine Sulfate Liposome in Treating Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia
This phase Ib/II trial studies side effects and best dose of inotuzumab ozogamicin and how well it works when given together with vincristine sulfate liposome in treating patients with CD22 positive (+) B-cell acute lymphoblastic…
- Conditions
- Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Blasts 5 Percent or More of Bone Marrow Nucleated Cells, Blasts 5 Percent or More of Peripheral Blood White Cells, CD22 Positive
- Trial name
- NCT03851081
- Testing
- Inotuzumab Ozogamicin, Quality-of-Life Assessment, Vincristine Sulfate Liposome
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Oral Mucositis, Stomatitis
Amimestrocel Injection for Preventing Severe Oral Mucositis in HSCT Patients
This study aims to see if a single intravenous infusion of a cell therapy called Amimestrocel injection can help prevent severe mouth sores (oral mucositis) in patients receiving a stem cell transplant.
- Conditions
- Oral Mucositis, Stomatitis, Gastrointestinal Mucositis, Hematopoietic Stem Cell Transplantation
- Trial name
- NCT07400328
- Testing
- Amimestrocel injection
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Graft Versus Host Disease
Visilizumab for the Prevention of Graft-versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation
The purpose of this study was to test whether a new drug named visilizumab would decrease the severity of graft-versus-host disease in patients treated with a mismatched donor.
- Trial name
- NCT00720629
- Testing
- Visilizumab, Tacrolimus, Methotrexate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Collection of Outcomes Data for Pregnant Patients With Cancer
This study collects treatment and outcomes information on pregnant patients who are or were pregnant with cancer. Gathering and storing health information on pregnant patients with cancer, may provide data for future research…
- Trial name
- NCT00507572
- Testing
- Medical Chart Review
- Where
- United States
- Volunteers
- 313 people
- Sponsor
- M.D. Anderson Cancer Center
Lower Respiratory Tract Infections
Pathogen Identification in Pediatric Hematopoietic Stem Cell Transplant Patients With Suspected Lower Respiratory Tract Infection
This is a multicenter prospective collection of leftover respiratory tract secretions, paired blood and NP swabs, and clinical circumstances from pediatric HCT patients, followed by next generation genomic sequencing…
- Trial name
- NCT02926612
- Testing
- Next Generation Genomic Sequencing
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Pediatric Blood and Marrow Transplant Foundation, Inc.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
De-escalated Treatment Approach for Adult Ph-negative Acute Lymphoblastic Leukemia (ALL)
No high-dose methotrexate (MTX) and high-dose cytarabine (ARA-C) consolidation blocks, L-asparaginaseis scheduled for 1 year of treatment, 21 intrathecal injections through the whole treament, T-ALL patients in complete remossion…
- Trial name
- NCT03462095
- Testing
- Autologous HSCT
- Where
- Russia
- Volunteers
- 350 people
- Sponsor
- National Research Center for Hematology, Russia
Advanced MDS Without Identical Sibling Donor
Haplo-identical/Mismatched Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome
Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment for myelodysplastic syndrome (MDS), especially for advanced MDS (blast >5%).
- Trial name
- NCT01793675
- Testing
- transplant with haploidentical donor
- Where
- 8 sites in China
- Volunteers
- 116 people
- Sponsor
- Peking University People's Hospital
Lymphoma
Clinical Study on PEG-rhG-CSF in Mobilizing Autologous Hematopoietic Stem Cells
This study is a randomized controlled, open and multi-center clinical study. Patients who meet the selection criteria and do not meet the exclusion criteria are randomly given PEG-rhG-CSF with a fixed dose of 12mg when white…
- Trial name
- NCT06026995
- Testing
- PEG-rhG-CSF, RhG-CSF
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Chongqing University Cancer Hospital
Hematologic Malignancies, Other Diagnoses, Comorbidities, and Complications
Associations Between Pre-transplant Comorbidities and Post-transplant Toxicities and Quality of Life
We are interested in studying whether and how medical problems other than primary cancer before hematopoietic cell transplantation would impact the profiles of quality of life and toxicities post-transplantation for patients with…
- Trial name
- NCT01930981
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Fred Hutchinson Cancer Center
Thrombocytopenia
Eltrombopag for Post Transplant Thrombocytopenia
The goal of this clinical research study is to learn if eltrombopag can help to improve platelet counts in patients with low platelets after they have had a stem cell transplant. The safety of this drug will also be studied.
- Trial name
- NCT01000051
- Testing
- Eltrombopag
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- M.D. Anderson Cancer Center
BK Virus Infection
Role of Neutralizing Antibodies in the Prediction and Treatment of BK Virus Infection in Hematopoietic Stem Cell Allograft Patients at the Pediatric Oncology-hematology Department of the HUS
The BK virus (BKV) belongs to the Polyomaviridae family. The primary infection, generally asymptomatic, occurs during childhood.
- Trial name
- BKV-Allograf (NCT05618275)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant for Hematologic Cancer
This phase II trial is studying how well rituximab works in preventing acute graft-versus-host disease (GVHD) in patients undergoing a donor stem cell transplant for hematologic cancer.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Nasal Type Extranodal NK/T-cell Lymphoma
- Trial name
- NCT01044745
- Testing
- rituximab, mycophenolate mofetil, tacrolimus
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Oral Mucositis, Bone Marrow Transplant Complications
Assessment of Efficacy of LightWalker (Nd:Yag, Er:Yag) Laser Therapy on Incidence, Severity and Duration of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation (HSCT). Prospective Randomized Open-label Study
Oral mucositis (OM) is a common and debilitating adverse effect of conditioning regimens in patients undergoing hematopoietic cell transplantation (HCT). It is treated symptomatically with pain relief medications.
- Trial name
- NCT05175222
- Testing
- Laser therapy
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Gdansk
Acute Myeloid Leukemia
Venetoclax in Combination With Azacitidine (VEN/AZA) Followed by Donor Lymphocyte Infusion (DLI) for Patients With Very High-Risk Acute Myeloid Leukemia (AML) Undergoing Allogeneic Hematopoietic Cell Transplant (HCT)
The purpose of this study is to see the effects of an investigational combination treatment of venetoclax, azacitidine, and donor lymphocyte infusion (DLI) in patients with high-risk AML receiving allogeneic hematopoietic cell…
- Trial name
- NCT06158100
- Testing
- Venetoclax, Azacitidine, Donor Lymphocyte Infusion
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Antonio M Jimenez Jimenez
Autologous Hematopoietic Stem Cell Transplant
Evaluation of the Safety of Cytokine-Induced-Killer Cells During Early Transplant Period of Autologous Hematopoietic Stem Cell Transplant Recipients.
The goal of this clinical study is to evaluate the safety of cytokine-induced-killer (CIK) cells during early transplant period of autologous hematopoietic stem cell transplant.
- Trial name
- NCT07692607
- Testing
- CIK cells
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- LucasBio
Hematologic Neoplasm, Hematopoietic Stem Cell Transplantation
HematoCare: Feasibility of a Survivorship Care Plan for Hematologic Cancer Patients Undergoing HSCT
This is a feasibility study to implement a Survivorship Care (SC) Plan for patients with hematologic cancer undergoing hematopoietic stem cell transplantation (HSCT).
- Conditions
- Hematologic Neoplasm, Hematopoietic Stem Cell Transplantation, Survivorship, Cancer Survivorship
- Trial name
- HematoCare (NCT07579065)
- Testing
- Survivorship Care (SC) Plan
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Type and Grade of Toxicities, Demographic and Background Characteristics, Advanced, Metastatic, Recurrent Adenocarcinoma and Malignant Solid Neoplasm
Labyrinthin Vaccination in Veterans With Lung Adenocarcinoma
This phase 2 trial tests the safety and effectiveness of a cancer vaccine called LabVax 3(22)-23 and GM-CSF in combination with pembrolizumab in treating adenocarcinoma that has spread to other places in the body (advanced…
- Trial name
- NCT07859592
- Testing
- LabVax 3(22)-23 and GM-CSF (adjuvant) in combination with pembrolizumab
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Hematopoietic Stem Cell Transplantation
Physical Fitness of Allogeneic Stem Cell Transplant
Hematopoietic stem cell transplantation is a treatment used to restore blood cell function in diseases of myeloid and lymphoid origin, which can be malignant or non-malignant.
- Trial name
- NCT07049536
- Testing
- Assessment Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Istinye University
Kidney Cancer
Fludarabine and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Metastatic Kidney Cancer That Cannot Be Removed By Surgery
RATIONALE: Giving low doses of chemotherapy, such as fludarabine, and radiation therapy before a donor stem cell transplant helps stop the growth of cancer cells.
- Trial name
- NCT00243009
- Testing
- cyclosporine, fludarabine phosphate, mycophenolate mofetil
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- OHSU Knight Cancer Institute
Hematopoietic Stem Cell Transplantation, Transplant Complication
Cardiovascular Outcomes and Risk Evaluation Among Recipients of Hematopoietic Stem Cell Transplantation
This is a prospective, multicenter observational study for recipients of hematopoietic stem cell transplantation. Patients who underwent hematopoietic stem cell transplantation at the participating centers will be entrolled in…
- Conditions
- Hematopoietic Stem Cell Transplantation, Transplant Complication, Cardiovascular Events
- Trial name
- CORE-HCT (NCT07349498)
- Where
- 16 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Peking University People's Hospital
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