Clinical trials: Hematopoietic
Bone Marrow Transplantation, Blood Disease
Blood and Marrow Transplant Clinical Research Network
The purpose of this network is to accelerate research in hematopoietic stem cell transplantation by comparing novel therapies to existing ones.
- Conditions
- Bone Marrow Transplantation, Blood Disease, Hematopoietic Stem Cell Transplantation, Leukemia
- Trial name
- NCT00023530
- Testing
- fluconazole, voriconazole, bone marrow transplant
- Where
- 16 sites in United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hematopoietic Stem Cell Transplant, GVHD
70% Ethanol for Decontamination of CVL Exposed to Calcineurine Inhibitors Version 1.0, 1/9/2014
This is for a study for patients that will be undergoing hematopoietic stem cell transplant (HSCT). For HSCT, patients will need a double lumen central venous line (CVL).
- Trial name
- 70% EtOH (NCT02441075)
- Testing
- 70% Ethanol
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Nationwide Children's Hospital
Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission
Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by CART19
RATIONALE: Placing a tumor antigen chimeric receptor that has been created in the laboratory into patient autologous or donor-derived T cells may make the body build immune response to kill cancer cells.
- Conditions
- Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission, B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia
- Trial name
- CART19 (NCT01864889)
- Testing
- anti-CD19-CAR vector-transduced T cells
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Chinese PLA General Hospital
Hematopoietic Stem Cell Transplantation
Dose Study of Antithymocyteglobulin in Haploidentical Allogeneic Stem Cell Transplantation
The purpose of this study is to compare the incidences of GVHD in haploidentical hematopoietic stem cell transplant recipients receiving different dose of antithymocyte globulin (ATG) for acute graft-versus-host disease(aGVHD)…
- Trial name
- NCT02643589
- Testing
- ATG
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hematopoietic/Lymphoid Cancer
Stress Management Intervention for Caregivers of Patients Undergoing Bone Marrow Transplant (BMT)
RATIONALE: A stress management intervention may be more effective than usual care in improving quality of life in caregivers of patients undergoing bone marrow transplant.
- Trial name
- NCT00833898
- Testing
- Paced respiration as part of PEPRR, PEPRR
- Where
- 2 sites in United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hematopoietic Stem Cell Transplantation
Immunomodulatory Effect of Vitamin D in Allogenic Post-transplant
The purpose of this study is to determine whether vitamin D is effective in the prevention of graft-versus-host-disease after completion of allogeneic transplant.
- Trial name
- Alovita-1 (NCT02600988)
- Testing
- 1000IU/day of Vitamine D, 5000IU/day of Vitamine D
- Where
- 7 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Stem Cell Transplantation, Hematopoietic
Evaluation of Cardiorespiratory Performance After Interval Exercise Training Prior to Hematopoietic Cell Transplantation
The primary objective of this study is to demonstrate the efficacy of a pre-transplant, interval exercise training (IET) intervention, in increasing peak oxygen uptake (VO2peak) scores on cycle ergometry.
- Trial name
- NCT02577939
- Testing
- Interval Exercise Training (IET)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Allogeneic Hematopoietic Stem Cell Transplantation, Myeloablative
Efficacy and Safety of rHuTPO on Platelet Engraftment After Allo-HSCT
Factors influencing platelet engraftment after allogeneic hematopoietic stem cell transplantation (Allo-HSCT) includes previous chemotherapy courses, conditioning regimen, HLA compatibility, source of stem cell, CD34+ cell count…
- Conditions
- Allogeneic Hematopoietic Stem Cell Transplantation, Myeloablative, Delayed Platelet Engraftment
- Trial name
- TPO (NCT01379391)
- Testing
- Recombinant Human Thrombopoietin (rHTPO)
- Where
- 9 sites in China
- Volunteers
- 80 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Adult Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm
Azacitidine and Oxaliplatin In Treating Patients With Advanced Cancers Relapsed or Refractory to Any Platinum Therapy
This phase I clinical trial studies the side effects and the best dose of azacitidine and oxaliplatin in treating patients with advanced cancers that do not respond to treatment or have returned after any platinum therapy.
- Trial name
- NCT01039155
- Testing
- Azacitidine, Laboratory Biomarker Analysis, Oxaliplatin
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- National Cancer Institute (NCI)
Bone Marrow Transplantation, Hematopoietic Stem Cell Transplantion
Glutamine Popsicles in Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients
Nutrition is an important part of the recovery process after having a head injury so that subjects can gain strength and fight off infection.
- Trial name
- NCT00204958
- Testing
- nutritional supplement, glutamine popsicle
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Wisconsin, Madison
Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission
Genetically Engineered Lymphocyte Therapy in Treating Patients With Lymphoma That is Resistant or Refractory to Chemotherapy
RATIONALE: Placing a gene that has been created in the laboratory into white blood cells may make the body build an immune response to kill cancer cells.
- Conditions
- Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission, B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia
- Trial name
- NCT01735604
- Testing
- anti-CD20-CAR vector-transduced autologous T cells, genetically engineered lymphocyte therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese PLA General Hospital
Mobilization of Hematopoietic Stem Cells (HSC) to Peripheral Blood (PB)
A Phase I Study Evaluating Safety, Tolerability, PK and PD of BL-8040 for Stem Cell Mobilization in Healthy Volunteers
The purpose of this study is to determine whether BL-8040 is safe, tolerable and effective in the mobilization of Hematopoietic Stem Cells (HSC) in healthy volunteers
- Trial name
- NCT02073019
- Testing
- BL-8040
- Where
- Israel
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- BioLineRx, Ltd.
Graft vs Host Disease, Allogeneic Hematopoietic Cell Transplantation
The Effect of Folinic Acid Rescue Following MTX GVHD Prophylaxis on Regimen Related Toxicity and Transplantation Outcome
The purpose of this study is to assess the impact of folinic acid (FA) -rescue following methotrexate (MTX) graft-versus-host disease (GVHD) prophylaxis on regimen related toxicity and transplantation outcomes after allogeneic…
- Conditions
- Graft vs Host Disease, Allogeneic Hematopoietic Cell Transplantation, Mucositis
- Trial name
- NCT02506231
- Testing
- Folinic acid
- Volunteers
- 160 people
- Sponsor
- Rabin Medical Center
Hematopoietic/Lymphoid Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Molecular Markers and Genetic Markers in Patients Undergoing Radiation Therapy for Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Conditions
- Hematopoietic/Lymphoid Cancer, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00899808
- Where
- United States
- Sponsor
- Rutgers, The State University of New Jersey
Hematopoietic Stem Cell Transplantation
Cyclosporine (CSA) Level in Blood Samples Collected From Different Lines
The purpose of this study is to verify whether differences exist in cyclosporine levels between the samples collected through peripheral venous access, the catheter line used to infuse the drug and the line not used for infusion…
- Trial name
- NCT01598688
- Testing
- Blood collection immediately after interrupting CSA infusion, Blood collection five minutes after interrupting CSA infusion
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- University of Sao Paulo
Hematopoietic Stem Cell Transplant
Studies of the Immune Response to Vaccination After Hematopoietic Stem Cell Transplantation
The purpose of this research study is to perform a serial analysis of immune function using blood cells and sera obtained from patients after vaccination following hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT01581164
- Testing
- Influenza vaccine, Varicella vaccine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Graft Versus Host Disease, Hematopoietic/Lymphoid Cancer
Lymphocyte Profiles and Activation Status in Patients With Graft-Versus-Host Disease
This research trial studies lymphocyte profiles and activation status in patients with graft-versus-host disease. Studying samples of blood in the laboratory from patients with cancer may help doctors identify and learn more…
- Trial name
- NCT01988701
- Testing
- Ancillary-Correlative
- Sponsor
- Ohio State University Comprehensive Cancer Center
Refractory Cytopenia of Childhood, Reduced Intensity Conditioning (RIC)
Serial Analysis of Chimerism in Patients With Refractory Cytopenia (RC) Transplanted With Reduced Intensity Conditioning (RIC)
This is a prospective, non-randomized multi-center multi-national study to evaluate the chimerism measured by STR and SNP in patients with hypoplastic RC and normal karyotype transplanted with a preparative regimen of reduced…
- Conditions
- Refractory Cytopenia of Childhood, Reduced Intensity Conditioning (RIC), Myelodysplastic Syndrome (MDS), Hematopoietic Stem Cell Transplantation (SCT)
- Trial name
- NCT00682799
- Where
- Germany
- Volunteers
- 112 people
- Sponsor
- Charlotte Niemeyer, MD
Stem Cell Transplantation, Hematopoietic, CMV Infection
MSC for Treatment of CMV Infection
The purpose of this study is to evaluate the efficacy of mesenchymal stem cells (MSC) in the treatment of refractory cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Conditions
- Stem Cell Transplantation, Hematopoietic, CMV Infection, Hematological Diseases
- Trial name
- NCT02083731
- Testing
- MSCs
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Allogeneic Hematopoietic Stem Cell Transplantation
Inspiratory Muscle Training in Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) causes various toxic effects in many body tissues, organs and systems such as immune, cardiovascular, pulmonary, gastrointestinal, neuroendocrine and musculoskeletal…
- Trial name
- NCT02270346
- Testing
- Inspiratory muscle training
- Volunteers
- 40 people
- Sponsor
- Gazi University