Clinical trials: Hematopoietic Cell Transplantation Recipient, open to volunteers
Cytomegalovirus Cell Mediated Immunity, Hematopoietic Cell Transplant
The Use of Cytomegalovirus Cell Mediated Immunity to Optimize the Duration of Letermovir Prophylaxis in Hematopoietic Cell Transplant Recipients
The goal of this laboratory research study is to learn if interrupting a patient's letermovir dosing based on their immune system response can help HSC transplant patients avoid post-treatment CMV infections better than taking…
- Trial name
- NCT06639854
- Testing
- Hematopoietic Cell Transplant, Letermovir
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- M.D. Anderson Cancer Center
Hematopoietic Cell Transplantation Recipient, Leukemia
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies
This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study.
- Conditions
- Hematopoietic Cell Transplantation Recipient, Leukemia, Solid Tumor
- Trial name
- NCT00736749
- Testing
- Assessment of Therapy Complications, Questionnaire Administration
- Where
- 164 sites in United States, Puerto Rico
- Volunteers
- 25,000 people
- Sponsor
- Children's Oncology Group
Pediatric Hematopoietic Stem Cell Transplantation, Malignant Disorders
Treosulfan Therapeutic Drug Monitoring in Pediatric Hematopoietic Stem Cell Transplant Recipients
One of the major challenges to improve the outcome of hematopoietic stem cell transplantation (HSCT) is the reduction of toxicity and non-relapse mortality caused by the pre-transplant conditioning regimen, while maintaining…
- Conditions
- Pediatric Hematopoietic Stem Cell Transplantation, Malignant Disorders, Non-malignant Disorders
- Trial name
- NCT06861257
- Where
- 10 sites in Italy
- Volunteers
- 70 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Shingles
Immunogenicity of Zoster Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients
This is a phase II study that will examine the immunogenicity of the Shingrix vaccine in patients following an allogeneic stem cell transplant.
- Trial name
- NCT05554068
- Testing
- Shingrix
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Loyola University
Bronchiolitis Obliterans Syndrome (BOS), HSCT
Efficacy of an Anti-TSLP Monoclonal Antibody in the Management of Chronic Bronchial Disease Induced by Bronchiolitis Obliterans Syndrome in Allogeneic Hematopoietic Stem Cells Transplantation Recipients
Allogeneic hematopoietic stem cell transplantation (HSCT) is burdened with a high morbidity and mortality rates. Graft versus host disease (GVHD) is the clinical manifestation of an immune conflict.
- Conditions
- Bronchiolitis Obliterans Syndrome (BOS), HSCT, Bronchial Disease
- Trial name
- IMMUNO-BOS (NCT07771855)
- Testing
- Tezepelumab
- Where
- 6 sites in France
- Volunteers
- 36 people
- Sponsor
- Hopital Foch
Bone Marrow Transplantation, AML
Model-Informed Precision Dosing on Cyclosporine Therapy in Hematopoietic Stem Cell Transplant Recipients
The purpose of this study is to develop a new tool that helps doctors choose the right cyclosporine dose for patients undergoing bone marrow transplantation.
- Trial name
- NCT07695571
- Volunteers
- 300 people
- Sponsor
- Yasmin medhat munir Mohamed
Allogeneic Hematopoietic Stem Cell Transplantation Recipient, CMV
VIROMARKERS GA n.101194735 - CMV and TTV Biomarkers Study Protocol
The study is one of the researches carried out in the VIROMARKERS Project. The project VIROMARKERS is supported by the Innovative Health Initiative Joint Undertaking (IHI JU) under grant agreement No 101194735.
- Trial name
- NCT07286461
- Testing
- letermovir prophylaxis
- Where
- Germany
- Volunteers
- 290 people
- Sponsor
- University of Rome Tor Vergata
Pulmonary, Pneumonia
Hyperpolarized 129-Xenon Imaging in Adult Hematopoietic Cell Transplant Recipients With Pulmonary Impairment
This study is designed to measure the correlation of hyperpolarized 129-Xe magnetic resonance imaging (129-XeMRI) in allogeneic hematopoietic cell transplant (allo-HCT) recipients at MD Anderson Cancer Center (MDACC) who develop…
- Conditions
- Pulmonary, Pneumonia, Hematopoietic System--Cancer
- Trial name
- NCT05041140
- Testing
- 29-XeMRI imaging
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Acute Myeloid Leukemia (AML)
VABu Conditioning in Elderly AML HSCT
This is an open-label, multi-center, single-arm clinical study evaluating the efficacy and safety of the VABu conditioning regimen in elderly patients (≥60 years) with acute myeloid leukemia (AML) undergoing allogeneic…
- Trial name
- NCT07583888
- Testing
- VaBU
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Hematopoietic Stem Cell Transplantation (HSCT), Pulmonary Rehabilitation
Effects of Different Inspiratory Muscle Training Protocols in Hematopoietic Stem Cell Transplant Recipients
Introduction: After haematopoietic stem cell transplantation (HSCT), patients often experience complications such as respiratory difficulties, fatigue and decreased quality of life.
- Conditions
- Hematopoietic Stem Cell Transplantation (HSCT), Pulmonary Rehabilitation, Inspiratory Muscle Training
- Trial name
- NCT07061444
- Testing
- Inspiratory Muscle Training, Functional Inspiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ceren Derya Gültekin
ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION, Carbapenem-resistant Enterobacterales
Perianal MBL-CRE Colonization and Infection in Allogeneic Hematopoietic Stem Cell Transplant Patients
The goal of this observational study is to characterize the clinical features of metallo-β-lactamase-producing carbapenem-resistant Enterobacterales (MBL-CRE) colonization and subsequent infection in patients after allogeneic…
- Trial name
- NCT07324291
- Volunteers
- 1,000 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Allogeneic Stem Cell Transplant Recipient
Fludarabine and Intermediate-dose TBI Followed by PTCy in Patients Undergoing Allo Transplant for Heme Malignancies
The Flu-TBI 800 trial is a prospective, single-arm, multicenter, interventional phase 2 study to evaluate whether fludarabine plus intermediate-dose total body irradiation (TBI 800 cGy) with post-transplant cyclophosphamide…
- Trial name
- NCT07214688
- Testing
- Fludarabine, Intermediate-dose Total Body Irradiation (TBI), Post-transplant Cyclophosphamide (PTCy)
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- Hackensack Meridian Health
Hematopoietic and Lymphatic System Neoplasm
Self-Amplifying mRNA COVID-19 Vaccine (LUNAR-COV19) Versus Comirnaty Vaccine in Adult Hematopoietic Cell Transplant Patients
This phase IIb trial compares the effect of LUNAR-COV19 vaccine to Comirnaty vaccine in treating adult patients who have received a hematopoietic cell transplant (HCT).
- Trial name
- NCT07390968
- Testing
- SARS-CoV-2 mRNA Vaccine ARCT-021, Tozinameran, Biospecimen Collection
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Fred Hutchinson Cancer Center
Clonal Hematopoiesis
Donor CHIP and Allogeneic HSCT Outcome
Current data on the impact of donor CHIP on long-term recipient outcome remain largely speculative. Data on the impact of donor CHIP including on allograft function, immunologic dysfunction, graft versus host disease (GVHD)…
- Trial name
- NCT04689750
- Testing
- Next generation sequencing
- Where
- Hong Kong
- Volunteers
- 850 people
- Sponsor
- The University of Hong Kong
Hematopoietic Cell Transplant, Solid Organ Transplant
Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients
The participants are being asked to take part in this clinical trial, a type of research study, because the participants are scheduled to receive or have recently received a hematopoietic cell transplant (HCT) or a solid organ…
- Conditions
- Hematopoietic Cell Transplant, Solid Organ Transplant, Respiratory Viral Infection
- Trial name
- NCT05550298
- Where
- 27 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Renal Transplantation
Combined Kidney and Hematopoietic Stem Cell Transplantation for Tolerance Induction
Combined transplantation of kidney and bone marrow between HLA-matched sibling donor-recipient pairs to induce immune tolerance in order to enable complete discontinuation of immunosuppressive therapy without kidney rejection.
- Trial name
- NCT05086003
- Testing
- Combined kidney and bone marrow transplantation
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rabin Medical Center
Allogeneic Hematopoietic Stem Cell Transplantation Recipient
Prehabilitation for Patients Diagnosed With Blood Cancer and Treated With Al-logeneic Hematopoietic Stem Cell Transplantation
Seventy-five percent of patients treated with hematopoietic stem cell transplants survive one-year post-transplantation. However, this intensive treatment is associated with prolonged hospitalizations and significant…
- Trial name
- PrepAllo (NCT07341698)
- Testing
- Resistance training, Nutritional Support, Usual care
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Solid Organ Transplant Complications, Solid Organ Transplant Recipients
Phase I Trial on the Safety of Delayed Infusion of a Naïve T Cell-Depleted Hematopoietic Graft With Memory T Cells in Solid Organ Transplant Recipients
The goal of this clinical trial is to evaluate the safety and feasibility of inducing hematopoietic mixed chimerism to promote immune tolerance and potentially reduce the need for lifelong immunosuppression in pediatric and adult…
- Conditions
- Solid Organ Transplant Complications, Solid Organ Transplant Recipients, Solid Organ Transplant Rejection
- Trial name
- DUALGRAFT (NCT06997471)
- Testing
- Investigational cellular therapy consisting on a HSCT using a graft enriched in CD34+, depleted of naïve T-lymphocytes and supplemented with memory lymphocytes
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Francisco Hernández Oliveros
Cytomegaloviral Infection, Hematopoietic Cell Transplant Recipient
Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Treating Pediatric Patients With Positive Cytomegalovirus Undergoing Donor Stem Cell Transplant
This phase I/II trial studies the side effects and best dose of multi-antigen cytomegalovirus (CMV)-modified vaccinia ankara vaccine and to see how well it works in treating pediatric patients with positive cytomegalovirus who…
- Trial name
- NCT03354728
- Testing
- Laboratory Biomarker Analysis, Multi-peptide CMV-Modified Vaccinia Ankara Vaccine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- City of Hope Medical Center
AML (Acute Myelogenous Leukemia), Allogeneic Hematopoietic Stem Cell Transplantation Recipient
Efficacy and Safety of the CloB2M (Clofarabine Combined With Busulfan and Melphalan) Conditioning Regimen in Allogeneic Hematopoietic Stem Cell Transplantation for Adult Patients With Acute Myeloid Leukemia in First Complete Remission
This is a single-center, prospective, exploratory clinical study. It plans to enroll 30 adult patients with acute myeloid leukemia (AML) who have achieved first complete remission (CR1) after induction therapy and meet the…
- Trial name
- NCT07644481
- Testing
- CloB2M (Clofarabine Combined With Busulfan and Melphalan) Conditioning Regimen
- Volunteers
- 30 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China