Clinical trials: Hematopoietic Stem Cell
Multiple Myeloma, Hematopoietic Stem Cell Mobilization
Comparison Study of EAP and CG Regimens for Mobilizing Hematopoietic Stem Cells in Multiple Myeloma Patients
This is a prospective, randomized, two-arm, multicenter, exploratory study aimed at evaluating the efficacy and safety of the combination of etoposide, cytarabine and Pegfilgrastim (EAP regimen) for mobilizing hematopoietic stem…
- Trial name
- NCT06520176
- Testing
- Etoposide, Cytarabine, Pegfilgrastim
- Where
- 16 sites in China
- Volunteers
- 99 people
- Sponsor
- The Affiliated People's Hospital of Ningbo University
Moxibustion, Hematopoietic Stem Cell Transplantation
Moxibustion in the Treatment of Hemorrhagic Cystitis After Allo-HSCT
This study was a prospective, multicenter, single-arm clinical study planned to enroll 60 patients who developed hemorrhagic cystitis after sexually allogeneic hematopoietic stem cell transplantation Patients with hemorrhagic…
- Conditions
- Moxibustion, Hematopoietic Stem Cell Transplantation, Hemorrhagic Cystitis, Treatment
- Trial name
- NCT06241274
- Testing
- Moxibustion, Symptomatic supportive treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cell Transplantation, Allogeneic
Belgian Cross-sectional Allogeneic Transplant Survivor Study
With the increasing successful use of allogeneic hematopoietic stem cell transplantation (HSCT) to cure advanced hematological disease, it becomes essential to evaluate the long-term effects of such a drastic treatment.
- Trial name
- BE-C@TS (NCT02312830)
- Volunteers
- 400 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Allogeneic Hematopoietic Stem Cell Recipients, Acute Respiratory Infection
Signature of the Host Response to a Respiratory Viral Infection, in the Prediction of Bronchiolitis Obliterans
Bronchiolitis obliterans (BO) is the well-known manifestation of the chronic pulmonary graft-versus-host disease(GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).
- Conditions
- Allogeneic Hematopoietic Stem Cell Recipients, Acute Respiratory Infection, Parainfluenza Virus (PIV)
- Trial name
- ALLOPIV (NCT04099082)
- Testing
- samples
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)
Reduced-Intensity Conditioning (RIC) and Myeloablative Conditioning (MAC) for HSCT in AML/MDS
The purpose of this study is to compare safety and efficacy of reduced-intensity conditioning and myeloablative conditioning regimens prior to HSCT in high-risk AML/MDS pediatric and young adult patients.
- Conditions
- Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Hematopoietic Stem Cell Transplant (HSCT)
- Trial name
- NCT02626715
- Testing
- Reduced-Intensity Conditioning Regimen, Myeloablative Conditioning Regimen
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Randy Windreich
Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Pharmacokinetics of Posaconazole in Allogeneic Transplant Patients With Mucositis
The goal of this study is to calculate pharmacokinetic parameters and to evaluate the trough levels of posaconazole reached in patients with different stages of mucositis, due to chemotherapy and total body irradiation.
- Trial name
- NCT01420562
- Testing
- blood sampling
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Graft-Versus-Host Disease, Hematopoietic Stem Cell Transplantation
Prospective Clinical Trial for Children With TCRαβ Depleted vs Traditional Haplo Identicle HSCT
This is a single-center prospective, non-randomized controlled clinical study in China using CliniMACS TCRα/β+ cell depleted stem cell haploidentical donors versus conventional Beijing protocol for haploidentical hematopoietic…
- Conditions
- Graft-Versus-Host Disease, Hematopoietic Stem Cell Transplantation, Child, Only, Haploidentical Hematopoietic Stem Cell Transplantation
- Trial name
- NCT06423131
- Testing
- TCRαβ Depleted haploidentical HCT
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Sijia Gu
Hematopoietic Stem Cell Transplant
Ultra-high Dose Vitamin D for HSCT
This is a pilot study to investigate the effects of achieving adequate vitamin D levels via ultra-high-dose vitamin D supplementation given prior to hematopoietic stem cell transplant on transplant-related complications and…
- Trial name
- NCT03759262
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Children's Hospital Los Angeles
Hematopoietic Stem Cell Transplantations
Remote Ischemic Conditioning in HSCT
This is a feasibility study at a single site, Cincinnati Children's Hospital Medical Center. The hypothesis will be tested using a prospective study design.
- Trial name
- RICH (NCT04808167)
- Testing
- autoRIC®
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute T Cell Lymphoblastic Leukemia, Haploidentical Hematopoietic Stem Cell Transplantation
Haplo-cord HCT vs. Haplo-HCT for T-ALL Patients
The goal of this clinical trial is to learn if haploidentical hematopoietic cell transplantation combined with an unrelated cord blood unit (haplo-cord HCT) works to treat acute T cell lymphoblastic leukemia (T-ALL).
- Conditions
- Acute T Cell Lymphoblastic Leukemia, Haploidentical Hematopoietic Stem Cell Transplantation, Cord Blood
- Trial name
- NCT06381817
- Testing
- Haplo-cord HCT, Haplo-HCT
- Where
- China
- Volunteers
- 146 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Relapse Leukemia, Refractory Acute Myeloid Leukemia
Efficacy and Safety of MTBF Conditioning Regimen for Salvageable Allo-HSCT in the Treatment of R/R AML
The primary objective of this study was to evaluate the efficacy of MTBF conditioning regimen of salvageable allo-HSCT in patients with relapsed or refractory acute myeloid leukemia.
- Conditions
- Relapse Leukemia, Refractory Acute Myeloid Leukemia, Conditioning, Hematopoietic Stem Cell Transplantation
- Trial name
- NCT06385808
- Testing
- MTBF regimen
- Volunteers
- 37 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hematologic Disorders and Bone Marrow Failure, Hematopoietic Stem Cell Transplantation (HSCT) or Cellular Therapy (CART)
Response to SARS-CoV-2 Vaccine in Stem Cell Transplant and Cellular Therapy Patients
For many patients with hematologic disorders and bone marrow failure, hematopoietic stem cell transplantation (HSCT) or cellular therapy (CART) offers a curative treatment option.
- Trial name
- NCT04723706
- Testing
- COVID-19 serology IgG
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Henry Ford Health System
Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Osteopenia
Denosumab in Treating Patients With Bone Loss Due to Donor Stem Cell Transplant
This Phase II trial studies the side effects of denosumab and to see how well it works in treating patients with bone loss who have received a donor stem cell transplant.
- Conditions
- Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Osteopenia, Osteoporosis
- Trial name
- NCT03925532
- Testing
- Denosumab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Roswell Park Cancer Institute
Graft Versus Host Disease, Hematopoietic Stem Cell Transplantation
Phase II Trial of Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft-Versus-Host Disease (GVHD) Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-002)
This is a multicenter prospective phase IIa dose escalation and phase IIa expansion cohort clinical trial designed to evaluate the safety and tolerability of efprezimod alfa for acute GVHD prophylaxis.
- Conditions
- Graft Versus Host Disease, Hematopoietic Stem Cell Transplantation, Leukemia
- Trial name
- NCT02663622
- Testing
- Efprezimod alfa, Methotrexate, Tacrolimus
- Where
- 4 sites in United States
- Volunteers
- 44 people
- Sponsor
- Oncoimmune, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
CMV Infection, Hematopoietic Stem Cell Transplantation
Immune Reconstitution to CMV After HSCT: Impact of Clinical Factors and Therapy Strategies
Cytomegalovirus (CMV) remains a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT05656599
- Testing
- Letermovir
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Chronic Graft-versus-Host-Disease, Allogeneic Hematopoietic Stem Cell Transplantation
Polyomic Biomarker Verification in Adult Chronic Graft-Versus-Host Disease (ABLE3.0/CTTC2201)
Chronic graft-versus-host disease (cGvHD) is one of the most serious complications following BMT (Bone Marrow Transplantation). cGvHD occurs when donor immune cells "attack" the tissues and organs of the person receiving the BMT.
- Conditions
- Chronic Graft-versus-Host-Disease, Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Blood Cancer
- Trial name
- NCT05692713
- Where
- 10 sites in United States, Canada
- Volunteers
- 320 people
- Sponsor
- University of British Columbia
Chronic Graft-versus-Host-Disease, Leukemia
Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study
This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults…
- Conditions
- Chronic Graft-versus-Host-Disease, Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation, Blood Cancer
- Trial name
- NCT04372524
- Where
- 16 sites in United States, Canada
- Volunteers
- 350 people
- Sponsor
- University of British Columbia
Leukemia, Myeloid, Acute, MDS
Venetoclax Plus RIC Regimen Allo-HSCT for Elderly Patients With High-risk Myeloid Malignancies
This study is a single center, single arm, prospective, phase II clinical study to evaluate the efficacy and safety of Venatoclax combined with reduced intensity conditioning regimen allo-HSCT in the treatment of high-risk…
- Conditions
- Leukemia, Myeloid, Acute, MDS, Hematopoietic Stem Cell Transplantation, Myeloid Malignancy
- Trial name
- NCT05583175
- Testing
- Venetoclax plus RIC
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xianmin Song, MD
Hematologic Diseases, Bone Marrow Transplantation
Evaluation of the Impact of the Use of NewSpringForMe on Transplanted Patients' Quality of Life and Support
Bone marrow transplantation is both a great treatment for patients with hematological diseases. It is also one of the only hopes of staying alive by "starting from scratch". It is a trying life experience, at all its stages.
- Conditions
- Hematologic Diseases, Bone Marrow Transplantation, Hematopoietic Stem Cell Transplantation
- Trial name
- NSFM (NCT06148610)
- Testing
- NewSpringForMe digital solution
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Fonds de Dotation HTC Project
Refractory Idiopathic Aplastic Anemia, Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation
Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation With Post-transplant Cyclophosphamide in Patients With Acquired Refractory Aplastic Anemia or in Relapse After Immunosuppression
Outcomes for patients with severe aplastic anemia (SAA) who are refractory to first-line immunosuppressive therapy (IST) and who lack a matched unrelated donor (MUD) remain poor.
- Trial name
- HAPLO-EMPTY (NCT05126849)
- Testing
- Allogenic transplantation
- Where
- 35 sites in France
- Volunteers
- 31 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris