Clinical trials: Hematopoietic Stem Cell
Hematopoietic Stem Cell Transplantation
NOX-A12 Multiple Ascending Dose Study in Healthy Volunteers
This is the second clinical study of NOX-A12. This study intends to provide information on the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of repeated intravenous doses of NOX-A12 (2.0 and 4.0 mg/kg/d)…
- Trial name
- SNOXA12C101 (NCT01194934)
- Testing
- NOX-A12, Filgrastim, NOX-A12 in combination with Filgrastim
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- TME Pharma AG
Febrile, Neutropenia
Piperacillin/Tazobactam for Empirical Therapy of Febrile Neutropenia
Neutropenia is very common in patients received hematopoietic stem cell transplantation, with median duration of about 14 days. In 2010 update, IDSA recommended Piperacillin/tazobactam as first-line mono-therapy for febrile…
- Conditions
- Febrile, Neutropenia, Hematopoietic Stem Cell Transplantation
- Trial name
- NCT01714570
- Testing
- Piperacillin-tazobactam combination product, Imipenem
- Where
- China
- Volunteers
- 123 people
- Sponsor
- Chinese PLA General Hospital
Stem Cell Transplantation, Hematopoietic, Poor Graft Function
Peripheral Blood Stem Cell Combined With Mesenchymal Stem Cells for Treatment of Poor Graft Function
The purpose of this study is to evaluate the utility of treating patients experiencing poor graft function after allogeneic hematopoietic stem cell transplantation with Granulocyte Colony-Stimulating Factor (G-CSF) mobilized…
- Conditions
- Stem Cell Transplantation, Hematopoietic, Poor Graft Function, Hematological Diseases
- Trial name
- NCT02083718
- Testing
- PBSC, MSCs
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation Based on Pharmacokinetic and Pharmacodynamic Modeling
In this study the investigators plan to develop a method to determine optimal busulfan dose through pharmacokinetic study.
- Trial name
- NCT01018446
- Testing
- Busulfan
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation With Targeted Busulfan and Fludarabine in Pediatric AML
In this study we plan to improve the outcome of hematopoietic stem cell transplantation by using optimal busulfan dose through pharmacokinetic study.
- Trial name
- NCT01274195
- Testing
- Busulfan
- Where
- South Korea
- Volunteers
- 27 people
- Sponsor
- Seoul National University Hospital
Acute Myeloid Leukemia, Precursor-cell Lymphoblastic Leukemia-Lymphoma
Prevention of Left Ventricular Dysfunction During Chemotherapy
The investigators' objective is to assess the efficacy of the combined treatment with enalapril and carvedilol in the prevention of left ventricular systolic dysfunction in patients with hematological malignancies submitted to…
- Conditions
- Acute Myeloid Leukemia, Precursor-cell Lymphoblastic Leukemia-Lymphoma, Lymphoid Neoplasm, Multiple Myeloma
- Trial name
- OVERCOME (NCT01110824)
- Testing
- Enalapril and carvedilol
- Where
- 2 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Hospital Clinic of Barcelona
Hematopoietic Stem Cell Transplant
International Travel Patterns and Health Preparations of Hematopoietic Stem Cell Transplant Recipients at Memorial Sloan-Kettering Cancer Center
The purpose of this study is to survey patients who underwent hematopoietic stem cell transplant (HSCT) to assess if they have traveled or not internationally after transplant.
- Trial name
- NCT01504152
- Testing
- questionnaire
- Where
- United States
- Volunteers
- 519 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hematopoietic Stem Cell Transplantation
Nutrition Support in Pediatric Stem Cell Transplantation
The purpose of this study is to determine which method of providing parenteral nutrition (complete intravenous nutrition) will provide the best nutritional and clinical results to children undergoing hematopoietic stem cell…
- Trial name
- NCT00115258
- Testing
- parenteral nutrition titrated to measured REE
- Volunteers
- 26 people
- Sponsor
- Boston Children's Hospital
Hematopoietic Stem Cell Transplantation, Obliterative Bronchiolitis
Respiratory Impedance and Obliterative Bronchiolitis
The aim of the present study will be to test the hypothesis that changes in within-breath total respiratory input impedance (Zrs) may provide an early evidence of obliterative bronchiolitis after allogeneic hematopoietic stem…
- Trial name
- FOT-BOS (NCT01255449)
- Testing
- albuterol
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Stem Cell Transplantation, Hematopoietic, Mesenchymal Stem Cells
Mesenchymal Stem Cells for Treatment of Poor Graft Function After Allogeneic Hematopoietic Stem Cell Transplant
The purpose of this study is to evaluate the utility of treating patients experiencing poor graft function after allogeneic hematopoietic stem cell transplantation with ex-vivo-expanded BM-drived mesenchymal stem cells from…
- Conditions
- Stem Cell Transplantation, Hematopoietic, Mesenchymal Stem Cells, Poor Graft Function, Hematological Diseases
- Trial name
- NCT01763086
- Testing
- Mesenchymal stem cells
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hematopoietic Stem Cell Transplantation, Mesenchymal Stem Cells
Mesenchymal Stem Cells Combined With Cord Blood for Treatment of Graft Failure
The purpose of this study is to evaluate the utility of treating patients experiencing graft failure after autologous hematopoietic stem cell transplantation with ex-vivo-expanded BM-drived mesenchymal stem cells from third-party…
- Conditions
- Hematopoietic Stem Cell Transplantation, Mesenchymal Stem Cells, Umbilical Cord Blood, Graft Failure
- Trial name
- NCT01763099
- Testing
- Mesenchymal stem cells, Mesenchymal stem cells and cord blood
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Neutropenia, Hematopoietic Stem Cell Transplantation
Prophylactic Piperacillin/Tazobactam in Hematopoietic Stem Cell Transplantation
Neutropenia is very common in patients received hematopoietic stem cell transplantation, with median duration of about 14 days. Almost all neutropenia will suffer from febrile without prophylactic antibiotics.
- Trial name
- NCT01714557
- Testing
- Piperacillin, Piperacillin-tazobactam combination product
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital
Mucositis, Hematopoietic Stem Cell Transplantation
Oral Selenium Therapy for the Prevention of Mucositis
Selenium as an antioxidant and anti-inflammatory agent could be effective in prevention of mucositis induced by chemotherapy and radiotherapy.
- Trial name
- NCT01432873
- Testing
- Oral selenium
- Where
- Iran
- Volunteers
- 76 people
- Sponsor
- Tehran University of Medical Sciences
Oral Mucositis, Hematopoietic Stem Cell Transplantation
Dose Escalation Study Of Palifermin in Pediatric Research Participants Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Mucositis is a well-known complication of both autologous and allogeneic hematopoietic stem cell transplantation (HSCT). Many who suffer this disorder require total parental nutrition and intravenous narcotics for pain control.
- Trial name
- NCT00701688
- Testing
- Palifermin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- St. Jude Children's Research Hospital
Hematological Neoplasms, Hematopoietic Stem Cell Transplantation
Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation for Malignant Hematological Diseases
To evaluate engraftment and toxicity of a reduced intensity preparative regimen for patients who receive a matched related or unrelated donor allogeneic stem cell transplant (ASCT) for malignant hematological diseases
- Trial name
- NCT00582894
- Testing
- Busulfex, Fludarabine, ALemtuzumab
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Oklahoma
Neutropenia, Hematopoietic Stem Cell Transplantation
Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation
This study is to evaluate safety and prophylaxis effect of micafungin after hematopoietic stem cell transplantation. Micafungin is administered until confirmation of neutrophil engraftment or treatment failure.
- Conditions
- Neutropenia, Hematopoietic Stem Cell Transplantation, Invasive Fungal Disease
- Trial name
- NCT01135589
- Testing
- Micafungin
- Where
- 7 sites in South Korea
- Volunteers
- 145 people
- Sponsor
- Asan Medical Center
Graft vs Host Disease, Hematopoietic Stem Cell Transplantation
Basiliximab for the Treatment of Acute Graft-versus-host Disease After Allogeneic Stem Cell Transplantation
Graft-versus-host disease (GVHD) contributes substantially to transplant-related morbidity and mortality. Steroids remains first line therapy for acute GVHD but there is currently no consensus on second line therapy for those in…
- Trial name
- NCT00563108
- Testing
- Basiliximab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hospital Authority, Hong Kong
Graft vs Host Disease, Hematopoietic Stem Cell Transplantation
Mycophenolate Mofetil for the Prophylaxis of Graft-versus-host Disease in High Risk Allogeneic Stem Cell Transplantation
There is a significant (50-80%) risk of acute graft-versus-host disease(GVHD) and early mortality (30%) associated with high risk stem cell transplantation (SCT) such as that from a matched unrelated donor or HLA-mismatch…
- Trial name
- NCT00563589
- Testing
- mycophenolate mofetil, methotrexate, cyclosporin, Methotrexate and cyclosporin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hospital Authority, Hong Kong
Cancer, Hematopoietic Stem Cell Transplantation
Spouses/Partners Expressing Their Thoughts After Transplant
This study seeks to test a brief psychological intervention for spousal caregivers of cancer patients (specifically, hematopoietic stem cell transplant patients), persons known to experience emotional distress.
- Trial name
- NCT01061801
- Testing
- Emotional expression
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Hematopoietic Stem Cell Transplantation
Ambulatory Physical Exercise Program in Hematopoietic Stem Cell Transplantation Recipients
The proposed study in an inception cohort of patients with hematological malignancies treated with PBSCT is designed to evaluate the effects of a physical exercise intervention on muscular-skeletal, physical activity and quality…
- Trial name
- NCT00402753
- Testing
- Ambulatory Physical Exercise Program
- Where
- 4 sites in Netherlands, Switzerland
- Volunteers
- 128 people
- Sponsor
- University of Zurich