Clinical trials: Hemoadsorption
Septic Shock
Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety Evaluation
Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety Evaluation. A Pilot Multicenter Randomized Controlled Trial. The goal of this clinical trial is the estimation of the efficacy and safety of hemoadsorption…
- Trial name
- HAdSS (NCT07661303)
- Testing
- Efferon LPS, Toramyxin PMX 20R, Jafron HA 330
- Where
- 7 sites in Russia
- Volunteers
- 76 people
- Sponsor
- Moscow Multidisciplinary Clinical Center "Kommunarka"
SIRS, Cytokine Storm
Cytokine Hemoadsorption in ECMO Patients
Cytokine hemoadsorption is a novel therapy used to improve outcome in critically ill patients with a dysregulated cytokine response and hemodynamic instability.
- Conditions
- SIRS, Cytokine Storm, Cardiogenic Shock, Cardiac Arrest
- Trial name
- NCT04901338
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Burns
Lipopolysaccharide Adsorption (Efferon LPS) in Patients With Thermal Burns
This observational pilot study aims to establish criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS device in adult patients with burn injury.
- Trial name
- NCT07259668
- Testing
- Efferon LPS
- Where
- Russia
- Sponsor
- Efferon JSC
Hemodialysis, Hemodiafiltration
Comparing Hemodiafiltration with and Without Hemoadsorption
Goals: The aim of the study is to assess the efficacy and safety of the combination of HDF + HA compared to HDF. To do this, we will evaluate the elimination of a wide range of molecular weight molecules, including small…
- Conditions
- Hemodialysis, Hemodiafiltration, Hemoadsorption
- Trial name
- NCT06710834
- Testing
- Hemoadsorption cartridge, Hemodiafiltration
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Clinic of Barcelona
Sepsis, Septic Shock
Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study
The aim of the study is to investigate the effect of CytoSorb® treatment within the first 48 hours of septic shock on organ dysfunction, microcirculation and on the cytokine storm as monitored by leukocyte activation and…
- Trial name
- NCT02288975
- Testing
- CytoSorb 300ml device (3804606CE01)
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Zsolt Molnár, MD, PhD, DEAA
ESRD (End-Stage Renal Disease), Maintenance Hemodialysis
Efficacy of pHA130 Hemoadsorption on Protein-Bound Uremic Toxins and Quality of Life in Kidney Failure
Patients on maintenance hemodialysis (MHD) face a high risk of cardiovascular mortality and reduced quality of life. Conventional high-flux hemodialysis (HD) is the standard of care but has limited efficacy in clearing…
- Trial name
- PHOENIX (NCT07656168)
- Testing
- pHA130 Hemoadsorption Cartridge, High-flux Hemodialyzer
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
End Stage Renal Disease on Dialysis
Effects of pHA Hemoperfusion Plus Hemodialysis on Protein-Bound Uremic Toxins
This single-center, prospective cohort Study evaluates whether adding the pHA130 hemoperfusion cartridge to conventional hemodialysis (HD) or hemodiafiltration (HDF) more effectively reduces protein-bound uremic…
- Trial name
- NCT07016841
- Testing
- pHA130 hemoperfusion device, HD/HDF, HA130 hemoperfusion device
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Chronic Kidney Diseases, Hemodialysis
Long-term, High Blood Flow Hemoadsorption Therapy in Patients Undergoing Maintenance Hemodialysis
Objective：The purpose of the study is to confirm that extending the duration of hemoadsorption (HA) and increasing blood flow during the HA+hemodialysis (HD) treatment process is safe and feasible, and to verify that extending…
- Trial name
- NCT06574425
- Testing
- long-term, high blood flow hemoadsorption therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Dongliang Zhang, MD
Sepsis
Quality of Life in Patients With Post-Sepsis Syndrome
The aim of the study is to assess health status and quality of life during the post-sepsis period using patient-reported outcome measures.
- Trial name
- NCT07889804
- Testing
- Efferon LPS
- Where
- 5 sites in Russia
- Volunteers
- 300 people
- Sponsor
- Efferon JSC
Myocardial Infarction, Cardiogenic Shock
Efferon CT Hemoadsorption for Cardiogenic Shock in Acute Myocardial Infarction
Cardiogenic shock is the most severe manifestation of acute heart failure and remains the leading cause of death in patients hospitalised with acute myocardial infarction.
- Trial name
- NCT06955936
- Testing
- Efferon CT
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Efferon JSC
Hemoadsorption, Vasopressor Therapy
Hemodynamic, Laboratory, and Clinical Outcomes of Hemoadsorption Therapy
This single-center retrospective observational cohort study aims to evaluate the clinical, hemodynamic, and laboratory effects of adjunctive hemoadsorption therapy in critically ill adult patients treated in the Intensive Care…
- Trial name
- HOPE-FUL (NCT07679555)
- Testing
- Hemoadsorption
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- Pest County Flór Ferenc Hospital
Cardiopulmonary Surgery, Endocarditis
Cytosorb Therapy in Cardiac Surgery
Cardiopulmonary surgery is associated with inflammatory responses that can lead to systemic inflammatory responses (SIRS), organ dysfunction (MOD) and death especially in patients with endocarditis.
- Conditions
- Cardiopulmonary Surgery, Endocarditis, Peri-operative Cytokines Levels
- Trial name
- NCT04309591
- Testing
- CytoSorb haemoadsorption (HA) device
- Where
- Switzerland
- Volunteers
- 249 people
- Sponsor
- University Hospital, Basel, Switzerland
Septic Shock
In Vivo Antibiotics Removal During Hemoadsorption Cartridges and Continuous Renal Replacement Therapy in the Intensive Care Unit
The purpose of this study is to measure the change in plasma concentrations of antibiotics used during passage through the CRRT filter and hemadsorption cartridge in patients with septic shock and renal failure requiring CRRT.
- Trial name
- ICARO (NCT07230041)
- Testing
- Liquid Chromatography - Tandem Mass Spectrometry
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Niguarda Hospital
Burns
Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Thermal Burns
This observational pilot study aims to identify criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS NEO device in pediatric burn injury.
- Trial name
- NCT07248930
- Testing
- Efferon LPS NEO
- Where
- 2 sites in Russia
- Sponsor
- Efferon JSC
Infective Endocarditis
Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective Endocarditis
Infective endocarditis (IE) is associated with high hospital mortality for various reasons; one of them is circulatory failure in patients who undergo cardiac surgery for IE.
- Trial name
- REMOVE (NCT03266302)
- Testing
- hemoadsorber for removal of cytokines
- Where
- 14 sites in Germany
- Volunteers
- 288 people
- Sponsor
- Jena University Hospital
Sepsis
Effects of Renal Replacement Therapy With Hemoadsoption in Patients With Sepsis
Hemoadsorption has been demonstrated to improve clinical and paraclinical results in critically ill patients with sepsis and septic shock.
- Trial name
- NCT04533256
- Testing
- CytoSorb
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Institutul Clinic Fundeni
Septic Shock
Effects of Hemoadsorption on Vascular Integrity in Septic Shock
This study aims to investigate the effects of adjunctive CytoSorb hemoadsorption therapy versus standard medical treatment on endothelial dysfunction in patients with refractory septic shock.
- Trial name
- ADSORP-VIP (NCT07711197)
- Testing
- CytoSorb hemoadsorption, Standard Medical Therapy (SMT)
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Cardiac Surgery Recovery, Inflammation
Jafron Cytokine Adsorber During Pediatric Open-Heart Surgeries
This prospective single-center randomized controlled trial aims at evaluating the safety and feasibility of an hemoadsorption protocol using Jafron HA-60 during cardio-pulmonary bypass in 20 pediatric patients undergoing…
- Conditions
- Cardiac Surgery Recovery, Inflammation, Complex Cardiovascular Surgery With Cardiopulmonary Bypass, Cytokine Storm
- Trial name
- JACKPOT (NCT07393087)
- Testing
- Hemoadsorption
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cardiac Arrest
Hemoadsorption With CytoSorb® in Post-Cardiac Arrest Syndrome
This prospective single-centre randomized control trial aims at evaluating the safety and efficacy of hemoadsorption with CytoSorb® in 40 patients with Post-Cardiac Arrest Syndrome admitted to the ICU.
- Trial name
- CATCH (NCT03523039)
- Testing
- CytoSorb® Hemoadsorption
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
COVID-19
Registry of CytoSorb Therapy in COVID-19 ICU Patients
The CTC Registry collects patient-level clinical data on CytoSorb hemoadsorption provided to COVID-19 ICU patients via integration of the CytoSorb device into ECMO, CRRT, or hemoperfusion extracorporeal circuits.
- Trial name
- CTC REGISTRY (NCT04391920)
- Testing
- CytoSorb 300 mL device
- Where
- 7 sites in United States
- Volunteers
- 138 people
- Sponsor
- CytoSorbents, Inc