Clinical trials: Hemodilution
Coagulation Disorder, Bleeding
Coagulation Test Changes Associated With Acute Normovolemic Hemodilution in Cardiac Surgery
The researchers are trying to reduce the need for blood transfusions in subjects having surgery that will involve the use of cardiopulmonary bypass.
- Trial name
- NCT03647644
- Testing
- Coagulation Laboratory Testing
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Hypovolemia, Hypervolemia
Pilot Validation of a Hemodilution Technique to Estimate Blood Volume in Vivo
The objective of this study is to determine the accuracy of estimating patient blood volume using field-expedient point-of-care measurement of hematocrit before and after hemodilution with a standardized volume of intravenous…
- Trial name
- NCT03031600
- Testing
- Radiodilution via Daxor BVA-100, Hemodilution via hematocrit measurement
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Mitral Regurgitation, Mitral Stenosis
Mild ANH on Pre-bypass Coagulation Function During Cardiac Surgery
The impact of acute normovolemic hemodilution (ANH) using hydroxyethyl starch before initiating cardiopulmonary bypass (CPB) on whole blood viscoelastic profile after CPB has not been well established.
- Conditions
- Mitral Regurgitation, Mitral Stenosis, Tricuspid Regurgitation
- Trial name
- NCT06664320
- Testing
- Acute normovolemic hemodilution (ANH), hydroxyethyl starch (HES 130/0.6)
- Where
- 2 sites in South Korea
- Volunteers
- 70 people
- Sponsor
- Konkuk University Medical Center
Perioperative/Postoperative Complications, Fluid Overload
Influence of Perioperative Fluid Therapy on Hemoglobin and Methemoglobin Levels
The objective of the study is to evaluate influence of perioperative fluid therapy on Methemoglobin levels, and to changes in hemoglobin.
- Conditions
- Perioperative/Postoperative Complications, Fluid Overload, Hemoglobin H
- Trial name
- NCT03220620
- Testing
- GDT
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Rostock
Cardiac Defect
Safety and Efficacy of Acute Normovolemic Hemodilution in Pediatric Cardiac Surgery Patients
The investigators primary objective is to determine if acute normovolemic hemodilution (ANH) for pediatric cardiac surgical patients decreases the volume of blood products transfused during surgery and the immediate…
- Trial name
- NCT02751645
- Testing
- Acute Normovolemic hemodilution
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Acute Hypovolemia
Esophageal Echo Assessment of LV Function During Acute Normovolemic Hemodilution Using Crystalloid or Hypertonic Saline
The purpose of this study is to examine how the heart functions when a calculated amount of blood is removed and how two fluids, Lactated Ringer's (considered the standard replacement fluid) and Hypertonic Saline, re-expand the…
- Trial name
- NCT00683007
- Testing
- Volume resuscitation (Crystalloid), Volume resuscitation (Hypertonic Saline Solution)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of California, Davis
Cardiac Surgical Procedures
The Impact of Storage Techniques on Platelets Number and Function After Acute Normovolemic Hemodilution (ANH)
Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass.
- Trial name
- NCT02060838
- Testing
- Acute normovolemic hemodilution (ANH)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Aymen N Naguib
Liver Cancer
Controlled Trial Comparing Nomogram-based Versus Standard Allocation of Acute Normovolemic Hemodilution (ANH) During Hepatic Resection
The purpose of this study is to learn the best method of assigning patients to receive "acute normovolemic hemodilution" during liver surgery.
- Trial name
- NCT00902343
- Testing
- nomogram-based selection for acute normovolemic hemodilution, standard selection for ANH based on a planned resection of 3 or more segments
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ovarian Cancer, Fallopian Tube Carcinoma
Study of Acute Normovolemic Hemodilution (ANH) in People With Ovarian Cancer Who Are Having Cytoreductive Surgery
Participants will be scheduled for primary cytoreductive surgery as part of their standard care. Before surgery, participants will be assigned by chance to a study group.
- Conditions
- Ovarian Cancer, Fallopian Tube Carcinoma, Ovarian Carcinoma, Peritoneal Carcinoma
- Trial name
- NCT06290193
- Testing
- Acute Normovolemic Hemodilution/ANH
- Where
- 7 sites in United States
- Volunteers
- 86 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Brain Infarction
Normal Saline Infusion After Intravenous Thrombolysis in Stroke
The intravenous administration of abundant normal saline is an easy-to-use strategy commonly employed to expand the blood volume.
- Trial name
- NCT07497542
- Testing
- normal saline
- Where
- China
- Volunteers
- 752 people
- Sponsor
- Tianjin Medical University General Hospital
Surgery
Effect of Acute Normovolemic Haemodilution on Allogenic Transfusion Needs In Laparotomy
This study is aimed to determine if acute normovolemic hemodilution (ANH), an established blood conservation technique, reduces the requirement for allogeneic blood transfusion in operations with prediction of surgical bleeding…
- Trial name
- ANH (NCT02290964)
- Testing
- ANH
- Where
- Indonesia
- Volunteers
- 34 people
- Sponsor
- Universitas Padjadjaran
Hip Replacement Arthroplasty
Comparison Between Two Techniques of Volemic Expansion in Hip Replacement Arthroplasty
Currently the most use solution to volemic reposition in hip replacement arthroplasty is the crystalloid solution. This trial intends to compare two different volemic replacements: HES and Ringer's lactate.
- Trial name
- NCT00542516
- Testing
- Hydroxyethyl Starch, Ringer's lactate
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Other Functional Disturbances Following Cardiac Surgery
Study of Methemoglobin as a Biomarker of Tissue Hypoxia During Acute Hemodilution in Heart Surgery Patients
Acute and chronic anemia continue to be associated with increased mortality in a number of clinical settings, including cardiac and non-cardiac surgery.
- Trial name
- NCT01883713
- Testing
- Brain Oximetry
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Unity Health Toronto
Dehydration, Retinal Vascular Occlusion
Body-fluid Balance and Drinking Habits in Patients With Retinal Vascular Occlusion
The purpose of this study is to examine the body-fluid balance in patients with retinal vascular occlusion and the influence of drinking habits and hemodilution on the degree of body hydration.
- Trial name
- NCT01939119
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technische Universität Dresden
Endothelial Dysfunction, Hemolysis
Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part II
Acute microcirculatory perfusion disturbances is common in critical illness and associated with increased morbidity and mortality.
- Conditions
- Endothelial Dysfunction, Hemolysis, Fluid Overload
- Trial name
- PRIME part II (NCT05647200)
- Testing
- Treatment: additional albumin during cardiopulmonary bypass, control: additional ringers during cardiopulmonary bypass
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Amsterdam UMC, location VUmc
Surgery--Complications, Blood Transfusion Complication
Acute Normovolemic Hemodilution (ANH) in Patients Undergoing Cardiac Surgery
The purpose of this small randomized pilot study is to evaluate adherence to strict transfusion protocols in both the control and ANH group examining compliant and noncompliant transfusion rates and reasons for violation of the…
- Trial name
- NCT04127825
- Testing
- Acute Normovolemic Hemodilution (ANH)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Minnesota
Ischemic Heart Disease, Coronary Artery Disease
Impact of Acute Normovolemic Hemodilution on Blood Viscosity
Acute normovolemic hemodilution (ANH) has long been employed for reducing allogenic blood transfusion for cardiac surgery, and hydroxyethyl starch has been used as an intravenous replacement fluid during ANH procedure.
- Trial name
- NCT03366753
- Testing
- acute normovolemic hemodilution, In-vitro hemodilution
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Konkuk University Medical Center
Kidney Failure, Intraoperative Complications
Hemodilution and Outcome in Cardiac Surgery
An hematocrit of 21-25% is supposed to perform the best organ protection during cardiopulmonary bypass for cardiac surgery. The investigators want to establish the best timing for a transfusion (in patients with a predicted low…
- Trial name
- NCT00364494
- Testing
- Different timing of red blood cells transfusion (substudy 1); Acute hemodilution versus no hemodilution (substudy 2)
- Where
- Italy
- Sponsor
- Università Vita-Salute San Raffaele
Transfusion Related Complication, Hemodilution
Individualized ANH for Non-cardiac Surgery
In this trial, we proposed an individualized acute normovolemic hemodilution (ANH), and conduct a randomized controlled trial to testify the effect of individualized ANH on red cells requirement for non-cardiac surgeries with…
- Trial name
- NCT06399536
- Testing
- Individualized ANH
- Where
- China
- Volunteers
- 40 people
- Sponsor
- West China Hospital
Bone Tumor, Acute Normovolemic Hemodilution
A Substudy of the Effect of Acute Normovolemic Hemodilution in Bone Tumor Surgery
The prevention of perioperative anemia has the potential to reduce complications, hospital stays, and long-term prognosis in patients undergoing bone tumor surgery.
- Conditions
- Bone Tumor, Acute Normovolemic Hemodilution, Goal-Directed Fluid Therapy
- Trial name
- NCT06881498
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine