Clinical trials: Hemodilution
Brain Infarct
Normal Saline Infusion for Stroke After Intravenous Thrombolysis
This study aims to explore the safety and efficacy of 0.9% normal saline （NS） infusion on stroke after intravenous thrombolysis (IVT), we decided to conduct this multi-centre randomized controlled trial for the first time.
- Trial name
- NS-STAR (NCT05993078)
- Testing
- 0.9% NaCl 2000ml, 0.9% NaCl 200-400ml
- Where
- 3 sites in China
- Volunteers
- 241 people
- Sponsor
- Tianjin Medical University General Hospital
Cardiac Valve Surgery
Application of Large Volume Acute Normovolemic Hemodilution in Cardiac Valve Surgery
The application of acute Normovolemic Hemodilution in cardiac surgery can effectively reduce perioperative blood transfusion, reduce postoperative complications and mortality, and is a low-cost, operable and effective blood…
- Trial name
- NCT03933917
- Testing
- Acute Normovolemic Hemodilution
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bleeding Reduction
Biomarker and Thrombogenicity Assessment in Cardiopulmonary Bypass Surgery Utilizing Acute Normovolemic Hemodilution
This study will help enhance current understanding of the impact of Acute Normovolemic Hemodilution (ANH) administration on transfusion requirements post cardiac surgery, the effect of this procedure on coagulation, and platelet…
- Trial name
- TARGET-ANH (NCT03326323)
- Testing
- Acute Normovolemic Hemodilution
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Inova Health Care Services
C.Surgical Procedure; Cardiac
Effects on Organ Damage and Surgical Outcome of a New Cardiopulmonary Pass System (EVADO)
The primary purpose of this study is to assess the effects of the use of EVADO with respect to a conventional cardio-pulmonary bypass (CBP) system on surgical morbidity and mortality.
- Trial name
- EVADO (NCT01805466)
- Testing
- EVADO, Conventional CPB
- Where
- 4 sites in Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele Roma
Adolescent Idiopathic Scoliosis
Intraoperative Cell Salvage and Hemodilution Technique in Scoliosis Surgery
Surgical correction of scoliosis with instrumentation carries significant blood loss and needs for blood transfusion with its inherent risk and cost.
- Trial name
- NCT02112409
- Testing
- cell salvage technique, acute normovolemic hemodilution
- Where
- Malaysia
- Volunteers
- 44 people
- Sponsor
- University of Malaya
Blood Transfusion, Blood Transfusion, Autologous
A Study to Determine the Effectiveness of Epoetin Alfa in Facilitating Self-donation of Blood Before Surgery in Non-anemic Patients Who Are Undergoing Orthopedic, Heart and Blood Vessel, or Breast Reduction Surgery; Performed in Combination With a Procedure to Reduce Blood Loss During Surgery.
The purpose of this study is to determine the safety and effectiveness of epoetin alfa and whether epoetin alfa will enable self-donation of blood during an 11-day period before surgery (which is shorter than the conventional…
- Conditions
- Blood Transfusion, Blood Transfusion, Autologous, Orthopedic Procedures, Orthopedic Surgery
- Trial name
- NCT00270023
- Testing
- epoetin alfa
- Volunteers
- 112 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
SID, Acid-Base Imbalance
Effect of Crystalloids With Different SID on pH, and Urinary Electrolytes During General Anesthesia
The present study will investigate variations in acid base equilibrium caused by the administration of four different crystalloids with increasing strong ion difference (0.9% saline, Ringer's lactate, Ringer's acetate…
- Trial name
- CRYSID (NCT03507062)
- Testing
- 0.9% saline administration, Ringer's lactate administration, Plasmalyte-like solution administration
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Mitral Regurgitation, Mitral Stenosis
Acute Normovolemic Hemodilution on Serum-creatinine Concentration in Cardiac Surgery
Serum-creatinine level (s-Cr) is an important factor for predicting perioperative patient's outcome regarding acute kidney injury.
- Conditions
- Mitral Regurgitation, Mitral Stenosis, Tricuspid Regurgitation
- Trial name
- NCT02831270
- Testing
- Acute normovolemic hemodilution (ANH), hydroxyethyl starch (HES 130/0.6)
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Konkuk University Medical Center
Platelet Dysfunction, Hemodilution
Effect of Aspirin, Hemodilution and Desmopressin on Platelet Dysfunction
Study hypothesis: Desmopressin (DDAVP) can improve platelet function under influence of aspirin, hemodilution and mild hypothermia Mild hypothermia (34-35oC) is known to cause platelet dysfunction.
- Conditions
- Platelet Dysfunction, Hemodilution, Mild Hypothermia, NSAID
- Trial name
- NCT01382134
- Testing
- Aspirin, desmopressin
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Coronary Artery Bypass Grafting, Acute Normovolemic Hemodilution
Hemodynamic Management in Autologous Blood Collection for CABG Surgery
In this study, investigated the hemodynamic differences between patients who underwent acute normovolemic hemodilution during the Autologous Blood Collection procedure in coronary artery bypass graft surgery and those who did…
- Trial name
- NCT06835257
- Testing
- Acute normovolemic hemodilutions, Vasopressor infusion
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ataturk University
Hemodilution, Coronary Artery Disease
Retrograde Autologous Priming and Mannitol for Reducing Hemodilution in Cardiac Surgery
Hemodilution reduces concentrations of blood constituents: concentration of hemoglobin, red blood cells (hematocrit), physiological ions and coagulation factors that can contribute to impaired hemostasis and increasing the risk…
- Conditions
- Hemodilution, Coronary Artery Disease, Fluid Overload
- Trial name
- RAPPER-MAN (NCT04870073)
- Testing
- Retrograde autologous priming, Mannitol, Conventional Priming
- Where
- Canada
- Sponsor
- Hamilton Health Sciences Corporation
Cardiac Surgical Procedures
Masimo CO-Oximeter Study
This is a study to evaluate the accuracy of the Masimo Rainbow SET Pulse CO-Oximeter in monitoring the hemoglobin levels of patients undergoing isovolemic hemodilution.
- Trial name
- NCT01184521
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Nationwide Children's Hospital
Acute Normovolemic Hemodilution
Clinical Study on the Effectiveness and Safety of Succinylated Gelatin Injection
The succinylated gelatin injection (specification: 500 mL: 20 g) developed and produced by Nanjing Chia-tai Tianqing Pharmaceutical..
- Trial name
- NCT06977763
- Testing
- succinylated gelatin injection 1, succinylated gelatin injection
- Volunteers
- 104 people
- Sponsor
- Nanjing Chia-tai Tianqing Pharmaceutical
C.Surgical Procedure; Cardiac
Acute Normovolemic Hemodilution in High Risk Cardiac Surgery Patients.
Transfusions are one of the most overused treatments in modern medicine, and saving blood is one important issue all around the world.
- Trial name
- ANH (NCT03913481)
- Testing
- Acute normovolemic hemodilution, Standard care
- Where
- 32 sites in United States, Bahrain and 9 more
- Volunteers
- 2,000 people
- Sponsor
- Università Vita-Salute San Raffaele
Pancreaticoduodenectomy, Hepatectomy
Acute Normovolemic Hemodilution Versus Standard Intraoperative Management in Patients Having Hepatic Resection and Pancreaticoduodenectomy
With a major liver or pancreas operation, there is a chance that one will require a transfusion of blood products (either red blood cells or plasma). This may be necessary during the operation or a few days after surgery.
- Trial name
- NCT00200148
- Testing
- Normovolemic Hemodilution (ANH), Standard of care
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Fluid Therapy, Microcirculation
The Impact of Intra-operative Fluid Infusion Rate on Microcirculation
Intraoperative fluid therapy (IFT) is an integral part of anesthesia care during surgery. Its main indication is the optimization of oxygen supply to the tissues.
- Conditions
- Fluid Therapy, Microcirculation, Hemodilution
- Trial name
- NCT05606536
- Testing
- Crystalloid Solutions
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- University Hospital Hradec Kralove
Dilutional Coagulopathy
Hemodilution and Coagulopathy With 3 Colloids
Aim of this in vitro trial is to assess the effect on blood coagulation after 60 % dilution with different colloids (HES 130/0.42, Gelatin and Gelatin balanced) and investigate reversibility by replacement of fibrinogen (FBG)…
- Trial name
- NCT01727830
- Testing
- Induced Coagulopathy by HES (Tetraspan), Gelatin (Physiogel), Gelatin balanced (Physiogel balanced)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Blood Coagulation Disorder
Dilutional Coagulopathy in Patients Undergoing Elective Surgery
The purpose of the present study is to perform a comprehensive description of haemostasis parameters before and after haemodilution with Hydroxyethyl starch (HES) following acute bleeding during elective surgery.
- Trial name
- NCT00493272
- Testing
- Fibrinogen
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Christian Fenger-Eriksen
Acute Kidney Injury
Acute Normovolemic Hemodilution on Urine Neutrophil Gelatinase-associated Lipocalin Levels
Acute normovolemic hemodilution (ANH) is performed as a blood conservation technique during surgical procedures with high risk for significant blood loss.
- Trial name
- NCT05349292
- Testing
- ANH
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Mitral Regurgitation, Mitral Stenosis
Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery
Impact of acute normovolemic hemodilution (ANH) using hydroxyethyl starch before initiating cardiopulmonary bypass (CPB) on whole blood viscoelastic profile after CPB has not been well established.
- Conditions
- Mitral Regurgitation, Mitral Stenosis, Tricuspid Regurgitation
- Trial name
- NCT02502448
- Testing
- Acute normovolemic hemodilution (ANH), hydroxyethyl starch (HES 130/0.6)
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Konkuk University Medical Center