Clinical trials: Hemodynamic
Aortic Stenosis
The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery
This study is looking at the effects of high spinal anesthesia (also known as total spinal anesthesia) combined with general anesthesia versus general anesthesia alone on the following: Stress response: Patients undergoing aortic…
- Trial name
- NCT00348920
- Testing
- High Spinal and General Anesthesia
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
Hemodynamics
Hemodynamic Monitoring of Newborn Infants With Impedance Cardiography Versus Echocardiography; a Validation Study
Background: Impedance cardiography (ICG) is a noninvasive method for continuous left cardiac output monitoring based on measurement of thoracic electrical bioimpedance.
- Trial name
- NCT03867825
- Testing
- Non-invasive hemodynamic monitoring
- Sponsor
- University Hospital of North Norway
Heart Failure
Cardiac MR (CMR) in Cardiac Resynchronization Therapy Non-responders
Cardiac MR (CMR) will be used to assess myocardial activation and hemodynamics in patients with CRT. Goals are to demonstrate that differences in Left ventricle (LV)- right ventricle (RV) pacing delays cause differences in…
- Trial name
- NCT01367691
- Testing
- CRT reprogramming (Medtronic CRT)
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- University Hospital, Bonn
Functional Magnetic Resonance Imaging
A Study of Two Methodologies for Measuring Blood Flow in the Brain in Response to Non-Drug Stimuli (P08085/MK-0000-180)
This study will identify a dose of ferumoxytol that can reliably detect changes in blood flow/volume in response to non-drug stimuli.
- Trial name
- NCT01244282
- Testing
- fMRI with sensory stimulation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Extracorporeal Membrane Oxygenation, Cardio/Pulm: Heart Failure
Real-time Pressure Volume Loop Monitoring as a Guide for Enhanced Understanding of Changes in Elemental Cardiovascular Physiology During Therapeutic Strategies Aiming for Hemodynamic Optimization. Cohort I: Veno-arterial Extracorporeal Membrane Oxygenation (PLUTO-I)
Invasive pressure-volume (PV) loop measurements have the potential to confirm or refute earlier computer simulations and animal studies regarding changes in cardiovascular physiology induced by (veno-arterial) ECMO.
- Trial name
- PLUTO-I (NCT05909280)
- Testing
- Pressure-volume loop measurements
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Coronary Disease, Echocardiography
Meta-Analysis of Stress Myocardial Perfusion Imaging
Background: Detection of coronary artery disease (CAD) is important due to its high prevalence and its medical and economic implications.
- Conditions
- Coronary Disease, Echocardiography, Fractional Flow Reserve, Myocardial, Hemodynamics
- Trial name
- NCT03180060
- Where
- Mexico
- Volunteers
- 23,051 people
- Sponsor
- American British Cowdray Medical Center
Mechanical Circulatory Support
BRAIN-HEART Ultrasound Study Normative Values for Transcranial Doppler Based Cerebral Blood Flow Assessment
There is a dire need to establish normative values for transcranial Doppler(TCD) derived cerebral blood flow parameters for each type of Mechanical circulatory support (MCS) device and explore the relationship between the MCS…
- Trial name
- MCS (NCT05924503)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Wake Forest University Health Sciences
Tachycardia, Hypertension
A Comparison of the Perioperative Hemodynamic Effects of Remifentanil and Esmolol in Intracranial Surgery
It was hypothesized that the use of esmolol as an alternative to remifentanil with sevoflurane inhalation anesthesia during intracranial surgery, could provide better hemodynamic conditions and cause lesser side effects in the…
- Conditions
- Tachycardia, Hypertension, Myocardial Ischemia
- Trial name
- NCT01628562
- Testing
- Esmolol, Remifentanil
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Diskapi Teaching and Research Hospital
High-risk Surgery
Association of Intraoperative Hemodynamic Characteristics to Postoperative Complications and Mortality
Worldwide, about 400 million major surgeries are performed annually. The scarce data available in the literature still suggest high postoperative morbidity and mortality, even in Europe.
- Trial name
- HeCoMo (NCT06355362)
- Volunteers
- 1,000 people
- Sponsor
- Kliniken Essen-Mitte
Carotid Endarterectomy, Percutaneous Transluminal Angioplasty
Study of Blood Flow Changes and Microemboli During Carotid Surgery
The purpose of this study is to determine the clinical and radiologic implications of the intraoperative microemboli during carotid revascularization.
- Conditions
- Carotid Endarterectomy, Percutaneous Transluminal Angioplasty, Cognitive Aspects, Diffusion Weighted MRI
- Trial name
- NCT01343615
- Testing
- carotid stenting, carotid endarterectomy
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Campinas, Brazil
Inadequate; Pulmonary Function, Newborn
Use of ICON™ to Detect Hemodynamic Variables During Dexmedetomidine Sedation in Children Undergoing Pulmonary Function Test
To collect and analyze the physiologic data of the ICON™ during dexmedetomidine (DEX) sedation for neonatal pulmonary function testing.
- Trial name
- NCT03205943
- Sponsor
- Boston Children's Hospital
Lower Limb Surgeries
Effect of Height Based vs Conventional Dose of Spinal Anesthesia in Lower Limb Surgeries
This study aim is to compare height based dose of spinal anesthesia vs conventional dose. Hypothesis is height based dose has less hemodynamics changes compared to conventional dosing.
- Trial name
- NCT07751835
- Testing
- Height based dose of hyperbaric bupivacaine 0.5%
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Liaquat National Hospital & Medical College
Cesarean Section, Hemodynamic Instability
Low-Doses Of Isobaric Bupivacaine On Intraoperative Hemodynamics In Spinal Anesthesia During Cesarean Section
The primary aim of this study was to compare the effects of two different low-dose bupivacaine used in spinal anesthesia on intraoperative hemodynamics in cesarean section operations.Investigators think that low-dose bupivacaine…
- Trial name
- NCT05136040
- Testing
- Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Type2diabetes
Finerenone and Renal Oxidative Stress
The main goal of this mechanistic, prospective, double-blind, placebo controlled, randomized study is to demonstrate the effect of finerenone on the oxidative stress of renal vasculature.
- Trial name
- NCT06244758
- Testing
- Finerenone 20 MG Oral Tablet
- Where
- Germany
- Volunteers
- 91 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hemodynamic Instability, General Anesthesia
End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE)
The purpose of the study is to evaluate the influence of different durations of the end-expiratory occlusion test to predict fluid responsiveness in mechanically ventilated patients in the operating room.
- Conditions
- Hemodynamic Instability, General Anesthesia, Surgery, Protective Mechanical Ventilation
- Trial name
- EXPIRE (NCT04399278)
- Testing
- Diagnostic Test: end-expiratory occlusion (EEO) test
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Shock
The CCUS Based Characteristic of Hemodynamic and Lung Pathology in Early Stage of Shock in ICU: The Epidemic and Prognostic Value
Shock is a common condition in critical care unit (ICU). It is extremely important that the patient accepts early goal-directed therapy (EGDT) treatment in the early stage of shock.
- Trial name
- NCT03082326
- Where
- China
- Volunteers
- 181 people
- Sponsor
- West China Hospital
Liver Transplantation, End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL) - Pilot
Hypothesis: A Canadian multicentre clinical trial is feasible. Study Design: Multicenter internal pilot parallel arm randomized controlled trial.
- Trial name
- REFIL-1 (NCT05647733)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Optimized cardiac output liberal fluid management strategy, Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 138 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Heart Failure With Preserved Ejection Fraction, Heart Diseases
Heart Failure With Preserved Ejection Fraction: Evaluation and Recognition by CMR
Heart failure with preserved ejection fraction (HFpEF) is a common and growing condition with a poor prognosis but the pathophysiology and management are still being investigated.
- Trial name
- PREFER-CMR (NCT05114785)
- Testing
- Multi Parametric Cardiac Magnetic Resonance
- Volunteers
- 100 people
- Sponsor
- University of East Anglia
Cardiac Arrest
The Haemodynamic Effects of Mechanical Standard and Active Chest Compression-decompression During Out-of-hospital CPR
The aim of this randomized out-of-hospital cardiopulmonary resuscitation study is to investigate haemodynamics generated by the standard mechanical external chest compression device (LUCAS™ 2) compared to a new version generating…
- Trial name
- NCT02479152
- Testing
- LUCAS2 AD
- Where
- Norway
- Volunteers
- 126 people
- Sponsor
- Physio-Control
Aortic Dissection
Hemodynamic Changes in the Aorta After Endovascular Treatment of the Aortic Dissection
Aortic dissection (AD) is a serious pathology affecting one person for 300 000 habitants per year. In case of complicated AD on the descending aorta, it is necessary to perform an endovascular surgery in association with medical…
- Trial name
- 4DAo (NCT03669055)
- Testing
- Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Hospices Civils de Lyon