Clinical trials: Hemodynamic Stability
Hypotension on Induction
CirQPOD Shoulder Study
Intrathoracic pressure regulation (IPR) therapy, delivered by impedance threshold devices (ITDs) or intrathoracic pressure regulators (ITPRs), increases venous return, preload, cardiac output, blood pressure, and cerebral…
- Trial name
- NCT04299776
- Testing
- CirQPOD, Standard airway management
- Where
- United States
- Sponsor
- Zoll Medical Corporation
Heart Failure
Study to Evaluate the Effects of TRV120027 in Patients With Heart Failure
In this study, TRV120027 (or a placebo) intravenous infusion will be given to people with heart failure to learn about the effects of TRV120027.
- Trial name
- NCT01187836
- Testing
- TRV120027
- Where
- 9 sites in United States, Czechia and 1 more
- Volunteers
- 33 people
- Sponsor
- Trevena Inc.
Hypertension, Pulmonary
Interaction Study in Patients With Pulmonary Hypertension and Stable Treatment of Sildenafil 20 mg TID
This study is to demonstrate the safety, tolerability, pharmakokinetic and pharmacodynamic effect of BAY63-2521 in patients with pulmonary hypertension and stable treatment of sildenafil 20 mg.
- Trial name
- NCT00680654
- Testing
- Riociguat (Adempas, BAY63-2521)
- Where
- 5 sites in Germany
- Volunteers
- 7 people
- Sponsor
- Bayer
Coronary Artery Disease, Unstable Angina
Restore EF Observational Study
A multi-center, prospective, observational, non-interventional single arm, study of the intermediate-term clinical outcomes collected from electronic health records of high-risk patients which have previously undergone standard…
- Conditions
- Coronary Artery Disease, Unstable Angina, Angina, Stable, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- NCT04648306
- Testing
- Prophylactic Impella support for a non-emergent PCI
- Where
- 21 sites in United States
- Volunteers
- 406 people
- Sponsor
- Abiomed Inc.
Systemic Inflammatory Response Syndrome, Kidney Failure, Acute
High Cut-Off Continuous Veno-venous Hemodialysis (CVVHD) in Patients Treated for Acute Renal Failure After Systemic Inflammatory Response Syndrome (SIRS)/Septic Shock
This study will assess the influence of the High Cut-Off (HCO) CVVHD treatment on the disease progression in septic patients. The primary aim of the study is to evaluate whether HCO CVVHD leads to a significant improvement of the…
- Trial name
- HICOSS (NCT00875888)
- Testing
- continuous venovenous hemodialysis
- Where
- 4 sites in Austria, Germany
- Volunteers
- 80 people
- Sponsor
- Vantive Health LLC
Liver Cirrhosis
A Study to Assess the Safety and Effects of Intravenous (IV) Conivaptan on the Hepatic Hemodynamic Response in Cirrhotic Patients
To evaluate the safety of IV conivaptan in stable euvolemic or hypervolemic cirrhotic patients, and to characterize the effects of IV conivaptan on the hepatic hemodynamic response in patients with cirrhosis.
- Trial name
- NCT00592475
- Testing
- conivaptan
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Cumberland Pharmaceuticals
Heart Failure
Safety and Hemodynamic Effects and Pharmacokinetics of CXL-1020 in Patients With Stable Heart Failure
A Phase 1-2a Study of CXL-1020-01 in Patients with Stable Heart Failure
- Trial name
- NCT01092325
- Testing
- CXL-1020, CXL-1020 Dose for Echo Cohort A, CXL-1020 Doses for Echo Cohort B
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Bristol-Myers Squibb
Diabetes Mellitus, Type 2, Hypertension
A Phase 2 Trial of IW-1973, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Stable Type 2 Diabetes and Hypertension
To evaluate the impact of escalating doses of IW-1973 on endothelial function [using EndoPAT to measure fingertip small vessel pulse volume], blood pressure (BP), and heart rate.
- Trial name
- NCT02906579
- Testing
- IW-1973
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cyclerion Therapeutics
Stable Angina
Effectiveness of a Combination of Trimetazidine With One Hemodynamic Agent in Patients Recently Diagnosed With Stable Angina and Still Symptomatic Despite First Line Hemodynamic Therapy
The purpose of this study is to assess in recently diagnosed stable Angina patients symptomatic despite first line hemodynamic therapy, the effect of a combination of this hemodynamic agent with a metabolic one (trimetazidine).
- Trial name
- NCT06298045
- Where
- Romania
- Volunteers
- 600 people
- Sponsor
- Servier Affaires Médicales
Spinal Cord Injury, Orthostatic Hypotension
ARC Therapy to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury
The goal of this interventional study is to evaluate the safety and preliminary effectiveness of the ARC-IM Therapy to improve hemodynamic management in people with sub-acute or chronic spinal cord injury.
- Trial name
- HemON-NL (NCT05941819)
- Testing
- ARC-IM Thoracic System implantation
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- ONWARD Medical, Inc.
Hemodynamic Stability
Hemodynamic Stability During Carotid Endarterectomy.Comparison of LENOXe™ (Xenon 100% v/v) Versus Sevoflurane
The purpose of this study is to compare the hemodynamics effects of two usual hypnotic agents (LENOXe ™ (xenon 100 % v/v) and sevoflurane) during a general anesthesia for carotid endarterectomy in elderly patients.
- Trial name
- NCT00937807
- Testing
- xenon, sévoflurane
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Air Liquide Santé International
Chronic Kidney Disease
Repeated Dosing Study to Assess Safety and Tolerability in CKD-3 Patients on Stable ACE-I Treatment
Primary Objective: To assess the tolerability and safety of repeated oral ascending doses of SAR407899A in patients with moderate chronic kidney disease (CKD) on stable angiotensin converting enzyme-inhibitor (ACE-I) Secondary…
- Trial name
- NCT01485900
- Testing
- SAR407899A
- Where
- 2 sites in Moldova, Romania
- Volunteers
- 20 people
- Sponsor
- Sanofi