Clinical trials: Hemodynamic Stability
Hypertension, Pulmonary
Interaction Study in Patients With Pulmonary Hypertension and Stable Treatment of Sildenafil 20 mg TID
This study is to demonstrate the safety, tolerability, pharmakokinetic and pharmacodynamic effect of BAY63-2521 in patients with pulmonary hypertension and stable treatment of sildenafil 20 mg.
- Trial name
- NCT00680654
- Testing
- Riociguat (Adempas, BAY63-2521)
- Where
- 5 sites in Germany
- Volunteers
- 7 people
- Sponsor
- Bayer
Dexmedetomidine, Craniotomy
Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block vs Bupivacaine Alone for Hemodynamics Stability in Craniotomy
The investigator tested the effect of dexmedetomidine as an adjuvant to bupivacaine compared to bupivacaine alone in mean arterial pressure stability in adult patients undergoing craniotomy
- Conditions
- Dexmedetomidine, Craniotomy, Regional Anesthesia, Mean Arterial Pressure Stability
- Trial name
- NCT06951256
- Testing
- Scalp block with bupivacaine alone, Scalp block by adding dexmedetomidine as an adjuvant to bupivacaine
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Peripheral Edema
Sequential Compression Device in Distributive Peripheral Edema and Hemodynamic Stability Among Patients in Critical Care Units
Objectives of The Study: 1. Assess the effectiveness of sequential compression device on distributive peripheral edema and hemodynamic stability for patients in critical care units. 2.
- Trial name
- SCD (NCT07305870)
- Testing
- Sequential compression device
- Where
- Iraq
- Volunteers
- 56 people
- Sponsor
- Karbala University
Hemodynamically Stable, Critical Illness
Comparing USCOM and Echocardiographic Hemodynamic Measurements in Children (CUE Study)
The primary objective of this study is to evaluate the agreement between hemodynamic measurements obtained using the Ultrasound Cardiac Output Monitor (USCOM®; USCOM Ltd., Sydney, Australia), and reference standards as determined…
- Trial name
- NCT02083172
- Testing
- Ultrasound Cardiac Output Monitor and 2 D-Echo
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- McMaster University
Ear and Nose Surgeries With Hypotensive Anaesthesia e.g FESS , MLS , TURBINECTOMY
Dexmedetomidine Versus Dexmedetomidine and Ketamine (Ketodex) in Ear and Nose Surgeries
The study aims to compare the efficacy, safety and overall effectiveness of dexmedetomidine and dexmedtomidine and ketamine (ketodex) in achieving controlled hypotension during Ear and nose surgeries.
- Trial name
- NCT06981494
- Testing
- Dexmedetomidine, Dexmedetomidine and ketamine ( Ketodex )
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Sohag University
Intubation, Anesthesia
Comparative Efficacy of Intravenous Labetalol and Lignocaine in Mitigating Hemodynamic Responses to Laryngoscopy During Laparoscopic Cholecystectomy
Laryngoscopy and intubation during laparoscopic cholecystectomy often cause sudden increases in heart rate and blood pressure, which can be harmful in some patients.
- Conditions
- Intubation, Anesthesia, Laparoscopic Cholecystectomy, Hemodynamic Response to Laryngoscopy
- Trial name
- LAB-LIG RCT (NCT07192081)
- Testing
- Labetalol, Lignocaine
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Dr. Waseem Ullah
Hemodynamic Stability
Comparative Analytical Study of Intravenous Bolus Dose of Mephentermine and Phenylephrine for Hemodynamic Stability During Elective Cesarean Section Under Spinal Anesthesia at KIST Medical College and Teaching Hospital
Hemodynamics changes with spinal anesthesia is mainly due to sympathetic block which causes mainly hypotension \& bradycardia. Post spinal hypotension usually leads to various adverse maternal and fetal outcomes.
- Trial name
- NCT05706727
- Testing
- Intravenous bolus dose of Mephentermine and mephentermine, intravenous bolus dose of phenylephrine 50 mcg
- Where
- Nepal
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- KIST Medical and Teaching Hospital
Airway Stress Response
Dexmedetomidine vs Labetalol for Airway Stress in Hypertensive Craniotomy Patients
This randomized trial compares dexmedetomidine and labetalol in controlling airway and hemodynamic stress during extubation in hypertensive patients undergoing craniotomy.
- Trial name
- NCT07034898
- Testing
- Dexmedetomidine, Labetalol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Aortic Valve Stenosis, Remimazolam
Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVR
Anesthetic agents can cause hypotension, and be especially dangerous in patients with severe aortic stenosis, which can lead to even circulatory collapse. Remimazolam is known for its hemodynamic stability compared to propofol.
- Trial name
- NCT05864625
- Testing
- Remimazolam besylate, Propofol/ Sevoflurane
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Pusan National University Yangsan Hospital
Hemodynamic MAP Stability
Delta Variation to Guide Hemodynamic Optimization
intraoperative hemodynamic optimization will be based on the percentage of variation of the parameters
- Trial name
- DELTA (NCT06932484)
- Testing
- parameters
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Diabetic Foot Ulcer, Lower Extremity Amputation
Comparison of Anesthetic Modalities on Hemodynamic Stability and Postoperative Pain in Diabetic Foot Patients Undergoing Minor Lower Extremity Amputation
Diabetic foot ulcer is the most common cause of non traumatic lower extremity amputations (LEA) associated with diabetes. Traditionally general and spinal anesthesia were the preferred modality of anesthesia.
- Trial name
- NCT02440282
- Volunteers
- 86 people
- Sponsor
- Yonsei University
Complications; Cesarean Section
Spinal Aesthesia in Women With Placenta Previa Percreta
Placenta previa percreta is a dangerous complication during surgery. Due to the high risk of hemorrhage, most parturients with placenta previa have to accept cesarean section.
- Trial name
- SAW (NCT02686242)
- Testing
- spinal anesthesia, general anesthesia
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Air Force Military Medical University, China
Liver Disease
Portal Blood Flushes in the Peri-Reperfusion Stage of Liver Transplantation
By showing that increased levels of acidotic metabolites and electrolytes in the systemic blood of patients who do not receive portal blood flush prior to reperfusion compared to patients who do receive portal blood flush, and…
- Trial name
- NCT03563404
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Cesarean Section Complications, Spinal Anesthesia
Phenylephrine Versus Norepinephrine for Maintenance of Hemodynamic During Cesarean Section Under Spinal Anesthesia
Comparison between prophylactic continuous variable infusion of phenylephrine (starting dose 0,5mcg/kg/min) and norepinephrine tartrate (starting dose 0,1mcg/kg/min) to prevent hypotension and maintain cardiac output under spinal…
- Trial name
- PHENAD (NCT03849508)
- Testing
- Norepinephrine, Phenylephrine
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Cardiac Surgery
Effect of Topical Airway Block on Hemodynamic Stability Post Induction of Anaesthesia in Cardiac Surgeries
Opioids have always been the mainstay in management of patients during cardiac surgeries. Mega doses are often used to relieve stress of surgeries in highly labile patients with narrow hemodynamic threshold to keep the balance…
- Trial name
- hemodynamics (NCT06395727)
- Testing
- Fentanyl, Lidocain
- Where
- 2 sites in Egypt
- Volunteers
- 106 people
- Sponsor
- Ain Shams University
Colorectal Neoplasms
DEXDES Trial: Dexmedetomidine-Desflurane Combination in Laparoscopic Colectomy
This randomized double-blind controlled clinical trial aims to evaluate the efficacy and safety of combining Dexmedetomidine with Desflurane in patients undergoing elective laparoscopic colectomy.
- Trial name
- NCT07239479
- Testing
- Dexmedetomidine + Desflurane, Desflurane + Normal Saline
- Where
- Vietnam
- Volunteers
- 40 people
- Sponsor
- Tam Anh Research Institute
Hemodynamic Stability, Post Operative Pain
Comparative Efficacy & Safety of Dexmedetomidine vs Tramadol in Paeds Hernioraphy. A Caudal Anaesthesia Approach
Among the postoperative adverse effects, pain has significant importance. Caudal block is a common technique for pediatric analgesia for infraumbilical surgeries.
- Conditions
- Hemodynamic Stability, Post Operative Pain, Inguinal Hernia Repair
- Trial name
- NCT06735443
- Testing
- Bupivacaine with Dexmetedomidine, Bupivacaine with Tramadol
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sahiwal medical college sahiwal
Breast Cancer, Breast Surgery
Hemodynamic Effects of Intradermal Methylene Blue During Breast Surgery Under General Anesthesia
This prospective observational study aims to evaluate the effects of intradermal methylene blue injection on intraoperative hemodynamic stability in patients undergoing breast surgery under general anesthesia.
- Conditions
- Breast Cancer, Breast Surgery, Sentinel Lymph Node Biopsy, Methylene Blue
- Trial name
- NCT07040540
- Testing
- Methylene Blue, Standard Surgical Care Without Dye
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Heart Failure
Safety and Hemodynamic Effects and Pharmacokinetics of CXL-1020 in Patients With Stable Heart Failure
A Phase 1-2a Study of CXL-1020-01 in Patients with Stable Heart Failure
- Trial name
- NCT01092325
- Testing
- CXL-1020, CXL-1020 Dose for Echo Cohort A, CXL-1020 Doses for Echo Cohort B
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Bristol-Myers Squibb
The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability
The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability During Anesthesia Induction in Adults.
The aim of our study to compare two different doses of Dexmedetomidine added to anesthetic dose of ketamine in the induction of general anesthesia in adult patients regarding the hemodynamic profile, adequacy of hypnosis…
- Trial name
- NCT05948267
- Testing
- ketamine- dexmeditomidine admixure, Propofol, Lidocaine and fentanyl
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Kasr El Aini Hospital