Clinical trials: Hemorrhage, Surgical
Liver Resection
Post-Market Clinical Study to Confirm Safety and Performance of PuraStat Absorbable Haemostatic Material for the Management of Bleeding in Liver Surgery
The objective of this post-market clinical follow-up study is to collect medical information on patients implanted with PuraStat®, according to each participating institution's procedures and standards of care.
- Trial name
- NCT03600168
- Testing
- PuraStat®
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- 3-D Matrix Europe SAS
Bone Loss
Maxillary Vascular Canal Thickness and Sinus Augmentation Bleeding
This study aims to evaluate the relationship between the maxillary intra-osseous vascular canal thickness as measured by volumetric tomography and the amount of intra-operative bleeding during open sinus floor augmentation.
- Trial name
- NCT05710497
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Marmara University
Bleeding
Cardiac Surgery: In Vivo Titration of Protamine
Safe use of cardiopulmonary bypass (CPB) requires massive doses of intravenous unfractionated heparin. At end-CPB, residual heparin is neutralized with intravenous injection of protamine sulfate.
- Trial name
- Protamine (NCT00684450)
- Testing
- Titration protamine, Standard administration of protamine
- Where
- Canada
- Volunteers
- 138 people
- Sponsor
- Montreal Heart Institute
Blood Loss, Surgical
Delivering Transcutaneous Auricular Neurostimulation to Reduce Blood Loss During Dialysis AV Graft Placement Procedures
The objective of this study is to determine if tAN therapy can reduce the volume of blood lost during dialysis AV graft placement procedures.
- Trial name
- NCT06647017
- Testing
- Volta tAN System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University Surgical Vascular
Cardiac Surgical Procedures, Retained Blood Syndrome
CPPF After General Cardiac Surgery
In two randomized clinical trials the investigators have demonstrated that continuous postoperative pericardial flushing (CPPF) therapy can reduce postoperative blood loss and bleeding-related complications after cardiac surgery…
- Conditions
- Cardiac Surgical Procedures, Retained Blood Syndrome, Cardiac Tamponade, Postoperative Hemorrhage
- Trial name
- FLUID (NCT05308589)
- Testing
- CPPF
- Where
- 4 sites in Netherlands
- Volunteers
- 164 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Maxillofacial Abnormalities, Blood Pressure
Review of Anaesthetic Practice in Orthognathic Surgery
Orthognathic surgeries for maxillofacial deformities are commonly performed globally. However, they are associated with significant blood loss which can affect the surgical field and result in blood transfusion and its risks.
- Conditions
- Maxillofacial Abnormalities, Blood Pressure, Anesthesia
- Trial name
- NCT04813289
- Where
- Singapore
- Volunteers
- 269 people
- Sponsor
- Singapore General Hospital
Acquired Bleeding Disorder, Cardiac Surgery Requiring Cardiopulmonary Bypass
Activated Recombinant Human Factor VII Following Cardiac Bypass Surgery for Paediatric Congenital Heart Disease
This trial is conducted in Oceania. The aim of this trial is to investigate the efficacy of activated recombinant human factor VII and standard treatment compared with standard haemostatic replacement therapy in cardiopulmonary…
- Trial name
- NCT01562574
- Testing
- activated recombinant human factor VII
- Where
- Australia
- Volunteers
- 82 people
- Sponsor
- Novo Nordisk A/S
Cardiovascular, Neurologic (Spine), and General Surgery
A Study to Compare Human Thrombin Against Bovine Thrombin in Its Ability to Stop Bleeding After Surgery
The purpose of this study is to see if Human Thrombin is as effective as Bovine Thrombin in stopping surgical bleeding within 10 minutes of application.
- Trial name
- NCT00196534
- Testing
- Human Thrombin, Bovine Thrombin
- Where
- 17 sites in United States
- Volunteers
- 304 people
- Sponsor
- Ethicon, Inc.
Thyroid
Complications After Thyroid Surgeries: 10 Years' Experience
Thyroidectomy is one of the commonest elective surgeries in surgical practice nowadays. It is associated with wide range of complications, from unnoticed events up to lifelong problems and even life-threatening complications.
- Trial name
- NCT05699304
- Testing
- Thyroidectomy
- Where
- Egypt
- Volunteers
- 241 people
- Sponsor
- South Valley University
Lower Gastrointestinal Tract, Colorectal Surgery
Causes of Low Digestive Bleeding in Proctology
The various causes of bleeding Proctological are well known to gastroenterologists in clinical practice but their proportions have not, to our knowledge, been dedicated epidemiological studies.
- Conditions
- Lower Gastrointestinal Tract, Colorectal Surgery, Proctology
- Trial name
- CASPeR (NCT02846285)
- Testing
- No intervention
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Spinal Tumor, Spinal Injury
Study of Collagen-Based Thrombin Hemostat for the Control of Bleeding in Spinal Surgery
This clinical trial evaluates the effectiveness and safety of a collagen-based hemostatic agent containing thrombin in patients undergoing spinal surgery.
- Conditions
- Spinal Tumor, Spinal Injury, Hemostasis, Spinal Stenosis
- Trial name
- NCT07354178
- Testing
- CollaStat®, Floseal®
- Where
- 3 sites in South Korea
- Volunteers
- 130 people
- Sponsor
- DALIM TISSEN Co., Ltd.
Hip Fractures, Femoral Neck Fractures
Direct Anterior Approach Versus Mini Posterior Approach Versous Lateral Approach for Displaced Femoral Neck Fractures
In general, hip fractures in the elderly are associated with a high one year-mortality up to 36 %. Apart from choosing the proper treatment, optimizing the surgical technique itself offers options to improve the outcome.
- Trial name
- NCT04618549
- Testing
- Direct Anterior Approach Hemiarthroplasty, Mini Posterior Approach, Lateral approach
- Volunteers
- 90 people
- Sponsor
- National and Kapodistrian University of Athens
Hemorrhage, Cancer Surgery
AutoTransfusion Versus TRAnsfusion in Cancer Surgery
Acute bleeding is one of the most frequent intraoperative adverse events and is burdened with a significant morbidity and mortality rate.
- Conditions
- Hemorrhage, Cancer Surgery, Transfusion
- Trial name
- ATTRACS (NCT05452538)
- Testing
- Transfusion
- Where
- France
- Volunteers
- 5,808 people
- Sponsor
- Centre Leon Berard
Congenital Bleeding Disorder, Haemophilia A With Inhibitors
Safety and Efficacy of Activated Recombinant Human Factor VII in Haemophilia Patients With Inhibitors During and After Major Surgery
This trial is conducted in North America. The aim of this trial is to compare the safety and efficacy of activated recombinant human factor VII in patients with haemophilia A or B undergoing major surgical procedures.
- Conditions
- Congenital Bleeding Disorder, Haemophilia A With Inhibitors, Haemophilia B With Inhibitors
- Trial name
- NCT01561391
- Testing
- activated recombinant human factor VII, factor IX, factor VIII
- Where
- 14 sites in United States
- Volunteers
- 36 people
- Sponsor
- Novo Nordisk A/S
Acute Blood Loss
CHIlled Platelet Study "CHIPS"
A phase 3 randomized partial blind storage duration ranging study in patients undergoing complex cardiac surgery that will compare the transfusion of cold stored platelets to standard room temperature stored platelets.
- Trial name
- CHIPS (NCT04834414)
- Testing
- Cold Stored Platelets, Room Temperature Platelets
- Where
- 27 sites in United States, Australia
- Volunteers
- 1,000 people
- Sponsor
- Philip Spinella
Intracerebral Hemorrhage Basal Ganglia, Intracerebral Haemorrhage
Minimally Invasive Surgery For Patients With Spontaneous Deep Intracerebral Hemorrhage
This observational cohort study evaluates the safety and effectiveness of minimally invasive surgery (MIS) compared with standard medical management in adults with spontaneous deep intracerebral hemorrhage.
- Trial name
- MISDIH (NCT07234955)
- Where
- Vietnam
- Volunteers
- 300 people
- Sponsor
- Huynh Quoc Huy
Lumbar Spinal Stenosis, Thoracic Spinal Stenosis
Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery
Hypothesis: Topical application of Tranexamic acid into the surgical wound during spine surgery will decrease the overall blood loss post-operatively. This reduction in blood loss will reduce the need for transfusion.
- Trial name
- NCT02063035
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts General Hospital
Bleeding of the Staple Line
The Effect of Compression Time for Secure Stapling With a Linear Stapler in Laparoscopic Gastric Bypass Surgery
Bleeding from the staple line is a complication of linear stapling. After clamping, a short period after firing of the laparoscopic linear stapler is recommended.
- Trial name
- NCT02069626
- Testing
- compression time of the laparoscopic linear stapler
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Inonu University
Fibrinogen, Spine Deformity
Effect of Prophylactic Fibrinogen Concentrate In Scoliosis Surgery
EFISS is a prospective, randomized, placebo-controlled trial testing the feasibility, safety and efficacy of prophylactic administration of fibrinogen in paediatric spinal surgery.
- Conditions
- Fibrinogen, Spine Deformity, Coagulopathy, Consumption, Bleeding
- Trial name
- EFISS (NCT05391412)
- Testing
- Fibrinogen Concentrate Human
- Where
- Czechia
- Volunteers
- 32 people
- Sponsor
- Brno University Hospital
Infant ALL, Congenital Heart Disease
Determining the Effect of Two Different Methods in Children to Maintain Drain Patency After Cardiac Surgery
In this study, it was aimed to determine the effect of the use of milking and sucking methods on bleeding amount, vital signs and oxygen saturation in children with chest and mediastinal drains after cardiac surgery.
- Trial name
- NCT04454294
- Testing
- Control, Experimental Group (Absorption Group), Experimental Group (Milking Group)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Acibadem University