Clinical trials: Hemorrhage Brain
Intracerebral Hemorrhage
Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage
This is a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial. It aims to evaluate the efficacy and safety of oral minocycline in patients with acute spontaneous intracerebral hemorrhage within…
- Trial name
- MISTICH (NCT07338175)
- Testing
- Minocycline hydrochloride capsules
- Where
- 41 sites in China
- Volunteers
- 1,192 people
- Sponsor
- Beijing Tiantan Hospital
Aneurysmal Subarachnoid Hemorrhage, Vasospasm
Treatment of Vasospasm of Aneurysmal Subarachnoid Hemorrhage With Intrathecal Nicardipine - FAST-IT Trial
To investigate whether patients with cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage have a better prognosis with intrathecal nicardipine injection via extraventricular drainage or lumbar drainage.
- Trial name
- NCT06329635
- Testing
- Intrathecal Nicardipine, No intervention
- Where
- 28 sites in China
- Volunteers
- 396 people
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University
Stroke Patients With Constipation
A Study on the Effect of Electronic Moxibustion Based on Ziwu Liuzhu in Treating Constipation in Stroke Patients
This study aims to explore the application effect of Ziwu Liuzhu electronic moxibustion combined with auricular points on constipation in stroke patients through clinical controlled trials, as well as the advantages over using…
- Trial name
- NCT07372326
- Testing
- Electronic moxibustion instrument, An electronic moxibustion device under the guidance of the Yuziuyouluo theory
- Where
- China
- Volunteers
- 105 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Delirium, Cognitive Impairment
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Cognitive skills are essential to live independently, manage finances, maintain employment, and function in society. Loss of these cognitive skills puts a tremendous burden on society as seen with dementias, Alzheimer's disease…
- Conditions
- Delirium, Cognitive Impairment, Alzheimer; Early Onset, Trauma
- Trial name
- INSIGHT-ICU (NCT03098459)
- Testing
- Non-interventional observational prospective cohort study
- Where
- United States
- Volunteers
- 432 people
- Sponsor
- Vanderbilt University Medical Center
Intracerebral Haemorrhage
Ischaemic Lesions in Acute Intracerebral Haemorrhage
The aim of this observational study is to determine how and why inadequate brain blood flow occurs after bleeding in patients with intracerebral haemorrhage (ICH).
- Trial name
- CHALLENGE-ICH (NCT06410274)
- Testing
- Transcranial Doppler ultrasonography (TCD)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Leicester
Subarachnoid Hemorrhage, Aneurysmal
Continuous Assessment of Brain Blood Perfusion in Subarachnoid Hemorrhage Patients Using Near-Infrared Spectroscopy (NIRS)
The goal of this observational study is to continuously assess cerebral autoregulation in patients with subarachnoid hemorrhage (SAH) using cerebral oximetry index (COx) and hemoglobin volume reactivity index (HVx).
- Trial name
- NCT06932640
- Testing
- - Non-Invasive Near-infrared Spectroscopy (NIRS) device (HEM1 with Foresight Elite Sensor)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Intracerebral Hemorrhage
Remote Ischemic Conditioning for Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) results from the rupture of small vessels damaged by chronic hypertension, amyloid angiopathy or other disease.
- Trial name
- RICH (NCT03930940)
- Testing
- remote ischemic conditioning, Regular treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Capital Medical University
Coma, Traumatic Brain Injury
Continuous Quantified EEG in NeuroIntensive Care
To evaluate the ability of NICU (NeuroIntensive Care Unit) staff to interpret, before and after a training period, symmetry, sedation level, seizures activities and artefact on continuous cEEG/qEEG (continuous…
- Conditions
- Coma, Traumatic Brain Injury, Subarachnoid Hemorrhage, Ischemic Stroke
- Trial name
- CrazyEEG (NCT02901262)
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Intracerebral Hemorrhage
Clinical Diagnosis and Treatment of Intracerebral Hemorrhage Based on Artificial Intelligence
The purpose of this study is to test the reliability and validity of an artificial intelligence system and a related 5-score scale to predict hematoma expansion, and conduct a study cohort of intracerebral hemorrhage to screen…
- Trial name
- CATCH-AI (NCT04951570)
- Where
- China
- Volunteers
- 1,374 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
Multinational Survey of Epidemiology, Morbidity, and Outcomes in Intracerebral Hemorrhage
The aim of this project is development of a comprehensive, prospective, multinational, multicenter, hospital-based, data repository for patients with intracerebral hemorrhage.
- Trial name
- MNEMONICH (NCT02567162)
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Intracerebral Hemorrhage
The Spot Sign for Predicting and Treating ICH Growth Study
The purpose of this study is to determine if computed tomography angiography can predict which individuals with intracerebral hemorrhage will experience significant growth in the size of the hemorrhage.
- Trial name
- STOP-IT (NCT00810888)
- Testing
- recombinant activated factor VII
- Where
- 10 sites in United States, Canada
- Volunteers
- 92 people
- Sponsor
- University of Cincinnati
Stroke
The Clinical Trial Research of Stem Cell Transplantation Treats Cerebral
All experimental group patients of 100 patients accept a treatment course stem cell transplantation, including one time stem cell transplantation through intravenous injection way at the 10-21th day of cerebral hemorrhage, and…
- Trial name
- NCT01389453
- Testing
- stem cell transplantation
- Where
- China
- Sponsor
- General Hospital of Chinese Armed Police Forces
Subarachnoid Hemorrhage, Subdural Hematoma
Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury
The purpose of this study is to evaluate the antipyretic effect of bromocriptine in critically-ill patients with acute neurologic injury and fever from infectious and non-infectious etiologies.
- Conditions
- Subarachnoid Hemorrhage, Subdural Hematoma, Traumatic Brain Injury, Ischemic Stroke
- Trial name
- BFF (NCT03496545)
- Testing
- Bromocriptine 5 MG, Acetaminophen 650 MG
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of California, San Francisco
Aneurysmal Subarachnoid Hemorrhage
Gabapentin for Headache in Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to see how much gabapentin will reduce headaches associated with subarachnoid hemorrhage (SAH) and to reduce the amount of narcotic pain medication prescribed.
- Trial name
- NCT02330094
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Mayo Clinic
Intraventricular Hemorrhage, Periventricular Leukomalacia
Prediction of Brain Injury in Premature Infants
Extremely low birth weight (ELBW), birth weight less than or equal to 1000 g, infants are at high risk for developing brain injury in the first week of life.
- Conditions
- Intraventricular Hemorrhage, Periventricular Leukomalacia, Brain Injury, Extreme Prematurity
- Trial name
- NCT02814383
- Testing
- Brain Monitoring Platform
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Baylor College of Medicine
Brain Aneurysms
Remote Ischemic Pre-conditioning in Subarachnoid Hemorrhage
The purpose of the study is to investigate if briefly stopping blood flow to the patient's leg will lead to the patient's body being better able to tolerate possible decreased blood flow to regions of the brain which otherwise…
- Trial name
- RIPC-SAH (NCT02381522)
- Testing
- Remote Ischemic Pre-conditioning
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Loma Linda University
Hematoma, Subdural, Chronic
Chronic Subdural Hematoma - Reduction of Recurrence by Treatment With Angiotensin Converting Enzyme Inhibitors
The project aims at investigating if treatment with the Angiotensin Converting Enzyme inhibitor Coversyl (perindopril) for 3 months after surgery for chronic subdural hematoma will decrease the risc of recurrence.
- Trial name
- KSDH (NCT00915928)
- Testing
- Perindopril
- Volunteers
- 47 people
- Sponsor
- Odense University Hospital
Spontaneous Subarachnoid Hemorrhage
A New Minimal-invasive Brain Tissue Probe Applying Near Infrared Spectroscopy
To assess the feasibility of a new brain tissue probe for multi-parameter neuromonitoring (NeMo Probe) and the accuracy of measurement values.
- Trial name
- NCT01801306
- Testing
- NeMo Probe
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- NeMoDevices AG
Intracerebral Hemorrhage
Use of Minocycline in Intracerebral Hemorrhage
To date, no neuroprotective drugs have demonstrated clinical efficacy in intracerebral hemorrhage (ICH). This study will use intravenous (IV) minocycline in ICH to evaluate for (1) safety/ tolerability and (2) evaluate for…
- Trial name
- NCT03040128
- Testing
- Minocycline, normal saline infusion
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Acute Ischemic Stroke, Intracranial Hemorrhage
Hemodynamic in Postreperfusion Period and Functional Recovery in Acute Ischemic Stroke Patients
The investigators are suggtesting that lower goals of systolic blood pressure after intravenous thrombolysis may reduce the risk of hemorrhagic complications and improve functional outcomes after acute ischemic stroke.
- Trial name
- NCT05517109
- Testing
- Hemodynamic goal including lower goal of systolic blood pressure
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Northern State Medical University
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