Clinical trials: Hemorrhage Brain
Aortic Valve Disease, Myocardial Infarction
Antiplatelet Therapy for Patients Undergoing Transcatheter Aortic Valve Implantation
At present, a variety of antithrombotic regimens are prescribed in the early postprocedure period after transcatheter aortic valve implantation (TAVI).
- Conditions
- Aortic Valve Disease, Myocardial Infarction, Stroke, Bleeding
- Trial name
- POPular-TAVI (NCT02247128)
- Testing
- Aspirin + clopidogrel, Aspirin monotherapy, OAC + clopicogrel
- Where
- 17 sites in Belgium, Czechia and 2 more
- Volunteers
- 1,016 people
- Sponsor
- St. Antonius Hospital
Subarachnoid Hemorrhage, Myocardial Stunning
Serial Echocardiography After Subarachnoid Hemorrhage
There is increasing interest in myocardial abnormalities following central nervous system events, such as subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Myocardial Stunning, Takotsubo Cardiomyopathy
- Trial name
- SEAS (NCT00123695)
- Where
- 6 sites in Netherlands
- Volunteers
- 350 people
- Sponsor
- Amsterdam UMC, location VUmc
Subarachnoid Hemorrhage
Constitution of Cerebrospinal Fluid and Blood Database/Specimen in Acute Stage of Subarachnoid Hemorrhage (aSAH) Patients
Neuropeptide Y (NPY) may play a major role in the pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH). To investigate the correlation of NPY in cerebrospinal fluid (CSF) and blood (serum) and the neurological outcome in…
- Trial name
- NCT01292278
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Regensburg
Severe Trauma (With or Without Traumatic Brain Injury)
Post Traumatic Critical Complications: a Prospective Cohort Study (ATLANREA)
The purpose of this observational epidemiological study is to investigate the management and the complications associated with severe trauma.
- Trial name
- NCT02426255
- Testing
- Collection of medical data from ICU patients
- Where
- 5 sites in France
- Volunteers
- 5,000 people
- Sponsor
- Nantes University Hospital
Subarachnoid Hemorrhage, Sleep Apnea
Effect of Sleep Apnea on Blood Pressure Control and Outcome Early After Subarachnoid Hemorrhage
In this observational study patients with subarachnoid hemorrhage (SAH) will be screened for sleep apnea (SA) to investigate if SA is associated with impaired blood pressure control and worse clinical outcome early after SAH.
- Trial name
- NCT02724215
- Testing
- Sleep Apnea Screening (Out of Center Polysomnography Device)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bonn
Intracerebral Hemorrhage
Intracerebral Hemorrhage Deferoxamine Trial - iDEF Ttrial
The investigators hypothesize that treatment with the iron chelator, Deferoxamine Mesylate, improves the outcome of patients with brain hemorrhage.
- Trial name
- NCT02175225
- Testing
- Deferoxamine Mesylate
- Where
- 28 sites in United States, Canada
- Volunteers
- 294 people
- Sponsor
- Beth Israel Deaconess Medical Center
Blood-Brain Barrier Permeability, Cerebral Small Vessel Disease
Blood-brain Barrier Quantification in Cerebral Small Vessel Disease
Cerebral small vessel disease (cSVD) encompasses all pathological processes that affect the small vessels of the brain. On brain-MRI cSVD is characterized by structural brain abnormalities such as white matter lesions (WMLs).
- Conditions
- Blood-Brain Barrier Permeability, Cerebral Small Vessel Disease, Cerebral Hemorrhage, Cortical Stroke
- Trial name
- NCT02033291
- Testing
- Dynamic contrast enhanced Brain MRI
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Maastricht University Medical Center
Intracerebral Hemorrhage
Deferoxamine and Xingnaojing Injection Treatment in Intracerebral Hemorrhage
The main purpose of this study is to determine whether deferoxamine and xingnaojing injection is effective and safe as a treatment for intracerebral hemorrhage.
- Trial name
- NCT02367248
- Testing
- deferoxamine, Xingnaojing injection, Normal saline
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Capital Medical University
Spontaneous Intracerebral Hemorrhage, Motor Function
Rehabilitation Paired with VNS for Motor Function Recovery
The goal of this clinical trial is to investigate the efficacy and safety of vagus nerve stimulation (VNS) combined with rehabilitation in improving upper extremity motor function after spontaneous intracerebral hemorrhage (ICH).
- Conditions
- Spontaneous Intracerebral Hemorrhage, Motor Function, Upper Extremity Injury, Rehabilitation
- Trial name
- NCT06892574
- Testing
- Active-VNS
- Volunteers
- 10 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Acetaminophen in aSAH to Inhibit Lipid Peroxidation and Cerebral Vasospasm
The objective of this study is to determine whether acetaminophen (APAP), N-acetylcysteine (NAC), and APAP in combination with NAC will inhibit lipid peroxidation in aneurysmal subarachnoid hemorrhage (aSAH), utilizing F2-IsoPs…
- Trial name
- NCT00585559
- Testing
- APAP 1 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly, APAP 1.5 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vanderbilt University Medical Center
Subarachnoid Hemorrhage, Aneurysmal, Headache
Neuroinflammatory Response and Headache Control in Patients After Subarachnoid Hemorrhage
The purpose of this study is to determine the relationship between the Neuroinflammatory response and headache pain after subarachnoid hemorrhage.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Headache, Subarachnoid Hemorrhage
- Trial name
- HASH4-CSF (NCT03604276)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- MaineHealth
Subarachnoid Hemorrhage, Aneurysmal
Glibenclamide in Aneurysmatic Subarachnoid Hemorrhage
A randomized, double-blind and prospective trial meant to evaluate the use of Glibenclamide on acute aneurysmatic subarachnoid hemorrhage.
- Trial name
- GASH (NCT03569540)
- Testing
- Glibenclamide
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Subarachnoid Hemorrhage
Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After aSAH
Our primary objective is to compare two treatment options for prevention of seizures following a subarachnoid hemorrhage and determine if a short-course regimen of levetiracetam is as efficacious in the prevention of in-hospital…
- Trial name
- DOPAST (NCT01137110)
- Testing
- Brief LEV, Extended LEV
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Washington University School of Medicine
Cerebral Hemorrhage, Hypertensive, Intracranial Hypertension
Bleeding Intracerebral Hemorrhage With Early Invasive Intracranial Pressure Monitoring Trial
Spontaneous cerebral hemorrhage (SICH) is a hemorrhage caused by the rupture of a blood vessel within the brain parenchyma that is non-traumatic.
- Conditions
- Cerebral Hemorrhage, Hypertensive, Intracranial Hypertension, Monitoring, Critical Care
- Trial name
- BIATICH (NCT05593380)
- Testing
- Parenchymal Intracranial pressure monitor, Treatment based on clinical and imaging observations
- Where
- 17 sites in China
- Volunteers
- 193 people
- Sponsor
- Xiangya Hospital of Central South University
Aneurysmal Subarachnoid Hemorrhage
SpareBrain - Mechanisms and Prevention of Secondary Brain Injury in Subarachnoid Haemorrhage
Subarachnoidal hemorrhage (SAH) is a cause of long-term disability and death. Annually about 1000 people in Finland suffer from SAH, their average age being under 50 years.
- Trial name
- NCT02026596
- Testing
- Magnetic resonance imaging, Cerebral microdialysis catheter insertion
- Where
- Finland
- Volunteers
- 61 people
- Sponsor
- Tampere University Hospital
Brain Edema, TBI (Traumatic Brain Injury)
Dynamic Decompressive Craniotomy
Prospective observational study on patients undergoing decompressive craniotomy
- Conditions
- Brain Edema, TBI (Traumatic Brain Injury), Stroke, Acute, Cerebral Hemorrhage
- Trial name
- NCT05051488
- Testing
- Dynamic craniotomy
- Volunteers
- 20 people
- Sponsor
- Rohit Khanna, MD
Extracorporeal Life Support, Extracorporeal Membrane Oxygenation
Quality Improvement to Reduce Mortality or Severe Intracranial Hemorrhage in Neonatal Extracorporeal Life Support
This is a three-year pre- and post- interventional study to assess the effectiveness of collaborative quality improvement interventions on reducing mortality and severe intracranial hemorrhage (ICH) for neonates receiving…
- Conditions
- Extracorporeal Life Support, Extracorporeal Membrane Oxygenation, Quality Improvement, Intracranial Hemorrhage
- Trial name
- NCT05075486
- Testing
- Collaborative quality improvement
- Sponsor
- Children's Hospital of Fudan University
Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage
Minimally Invasive Surgery for Spontaneous Deep Intracerebral Hemorrhage
This observational cohort study evaluates the real-world effectiveness and safety of minimally invasive surgery (MIS) versus standard medical management in adults with spontaneous deep intracerebral hemorrhage.
- Conditions
- Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage, Basal Ganglia Hemorrhage
- Trial name
- MIS-DEEP ICH (NCT07710313)
- Testing
- Minimally Invasive Surgery (MIS), Standard medical treatment (SMT)
- Volunteers
- 300 people
- Sponsor
- Tam Anh Research Institute
Aneurysmal Subarachnoid Hemorrhage
Astragalus Membranaceus on Aneurysmal Subarachnoid Hemorrhage
This research is trying to see if AM can enhance the clinical prognosis for spontaneous aneurysm ruptured subarachnoid hemorrhage patients.
- Trial name
- AMASH (NCT03271697)
- Testing
- Astragalus Membranaceus
- Volunteers
- 120 people
- Sponsor
- China Medical University Hospital
Intracerebral Hemorrhage
Multinational Survey of Epidemiology, Morbidity, and Outcomes in Intracerebral Hemorrhage
The aim of this project is development of a comprehensive, prospective, multinational, multicenter, hospital-based, data repository for patients with intracerebral hemorrhage.
- Trial name
- MNEMONICH (NCT02567162)
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
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