Clinical trials: Hemorrhage Brain
Intracerebral Hemorrhage, CAA - Cerebral Amyloid Angiopathy
MRI-markers to Monitor Small Vessel Disease Dynamics in the Prognosis of Small Vessel Disease-associated, Cerebrovascular Events
This is a nested cohort study in the PRO-SVD cohort. Small vessel disease is a chronic disease and is thought to progress over time.
- Conditions
- Intracerebral Hemorrhage, CAA - Cerebral Amyloid Angiopathy, Cerebral Small Vessel Diseases
- Trial name
- MRI-PRO-SVD (NCT05773235)
- Testing
- Combined 3- and 7 Tesla-MRI
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Subarachnoid Hemorrhage, Aneurysmal
Shuxuening Injection for the Prevention of CVS in Patients With aSAH(SXN-CVS)
Aneurysmal subarachnoid hemorrhage (SAH) is a frequent worldwide cause for stroke with a mortality of around 30%. Worldwide, almost 500 000 patients have aneurysmal SAH annually.An incidence of 2-16 cases of spontaneous SAH per…
- Trial name
- SXN-CVS (NCT06138353)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xiaolin Chen, MD
Infant, Newborn, Infant, Small for Gestational Age
Vitamin E for Extremely Preterm Infants
The purpose of this pilot trial is to test the safety and efficacy of administering one dose of vitamin E, via a tube into the stomach, to extremely preterm infants (less than 27 weeks gestation and less than 1000 grams birth…
- Conditions
- Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature
- Trial name
- NCT01193270
- Testing
- Vitamin E
- Where
- 16 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Subarachnoid Hemorrhage, Aneurysmal
Angiotensin Metabolite Profile After Subarachnoid Hemorrhage
The outcome of subarchnoid hemorrhage depends on the severity of the bleeding and the development of secondary neurologic deficits caused by cerebral vasospasm.
- Trial name
- NCT05222542
- Testing
- Sampling of plasma and cerebrospinal fluid at specified time points
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Dr. Roman Ullrich
Chronic Subdural Hematoma
GET-UP Trial: Impact of an Early Out-of-bed Paradigm in Postoperative Outcomes of Chronic Subdural Hematomas
Compare rates of medical complications, recurrence and outcome in 2 randomized groups of patients with surgical chronic subdural hematomas.
- Trial name
- GET-UP (NCT03788005)
- Testing
- Early mobilization
- Where
- Portugal
- Volunteers
- 208 people
- Sponsor
- Centro Hospitalar do Porto
Subarachnoid Hemorrhage
French Validation of the SAHOT Outcome Scale After Subarachnoid Haemorrhage
Survivors of subarachnoid haemorrhage (SAH) frequently experience cognitive, psychological, physical and social sequelae, but no French-language instrument covers all these dimensions.
- Trial name
- SAHOT-FR (NCT07894666)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Intraventricular Hemorrhage, Premature Birth
Intranasal Fresh Mother's Own Milk to Prevent Intraventricular Hemorrhage in Extremely Preterm Infants
Babies born very prematurely are at risk of intraventricular hemorrhage (IVH), which is bleeding in or around the fluid-filled spaces of the brain. Most IVH occurs during the first week after birth.
- Trial name
- iF-MOM-IVH (NCT07812922)
- Testing
- Intranasal Fresh Mother's Own Milk (iF-MOM)
- Volunteers
- 67 people
- Sponsor
- University of Manitoba
Intraventricular Hemorrhage, Cerebral Hemorrhage
Early Lumbar Drainage for Intraventricular Hemorrhage
This is a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial in Chinese patients with intraventricular hemorrhage (IVH), comparing early lumbar drainage added to standard care with standard care…
- Trial name
- LD-IVH (NCT07625449)
- Testing
- Control treatment plus lumbar drainage, Control treatment schedule
- Where
- 31 sites in China
- Volunteers
- 392 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Stroke
ACT-GLOBAL Adaptive Platform Trial for Stroke
Stroke is causing 6.6 million deaths and is a major cause of disability worldwide in 2019. There remains an urgent need for interventions that improve outcomes which can be implemented with wide applicability for stroke.
- Trial name
- NCT06352632
- Testing
- Standard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase
- Where
- 2 sites in Australia, Canada
- Volunteers
- 20,000 people
- Sponsor
- The George Institute
Cerebral Infarction
Study on Yangxue Nao Granules Reducing the Risk of Stroke
Objective: To explore the effectiveness of raising serum nao granules in reducing the risk of bleeding in patients with acute ischemic stroke treated with intravenous thrombolysis in the real world
- Trial name
- NCT04949906
- Testing
- Raise serum brain granules, No nourishing serum brain granules are used
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Third Hospital
Subarachnoid Hemorrhage, Aneurysm
Dexmedetomidine and Subarachnoid Haemorrhage
The purpose of this study is to investigate how dexmedetomidine affects static and dynamic autoregulation, intracranial pressure (ICP) and cerebral oxygenation in aneurysmal subarachnoid haemorrhage (SAH) patients.
- Trial name
- NCT01664520
- Testing
- Dexmedetomidine infusion
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Turku University Hospital
Aneurysm, Intracranial Aneurysm
Appraising the Embolization of Aneurysms Using Balt Optima™ Coil System (APPLY Study)
In recent years, many developments have been made to the tools and techniques used to treat IAs via endovascular intervention. Specifically, to the detachable coils themselves.
- Conditions
- Aneurysm, Intracranial Aneurysm, Ruptured Aneurysm, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- APPLY (NCT04499508)
- Testing
- Optima Coil System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vascular Neurology of Southern California Inc.
Brain Injuries, Traumatic, Coagulopathy
The Influence of Noradrenaline on Coagulation and Fibrinolysis in Severe Isolated Brain Injury
Aim of the study The investigators aim to establish: Whether noradrenaline (NA) infusion has a significant effect on coagulation and fibrinolysis in patients with severe traumatic brain injury (TBI).
- Conditions
- Brain Injuries, Traumatic, Coagulopathy, Coagulation Defect; Acquired, Coagulation Defect; Bleeding
- Trial name
- NCT04515420
- Testing
- noradrenaline
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Perinatal Death, Respiratory Distress Syndrome, Newborn
Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities
Hyperoxygenation for resuscitation of abnormal fetal heart rate tracings has been routine obstetric practice. However, there have not been any studies to support this practice.
- Conditions
- Perinatal Death, Respiratory Distress Syndrome, Newborn, Hypoxic-Ischemic Encephalopathy, Neonatal Seizure
- Trial name
- NCT03996317
- Testing
- Room air
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Subarachnoid Hemorrhage, Spontaneous
Multicenter Registry of Patients With Subarachnoid Hemorrhage
The purpose of this registry is to collect detailed information on the characteristics, treatment, and outcomes of patients with a subarachnoid hemorrhage.
- Trial name
- MEASURE (NCT07482124)
- Testing
- None, observational study
- Where
- 9 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
SAH, Dementia
Ferritin and Iron Burden in SAH sIRB
Ruptured cerebral aneurysms lead to subarachnoid hemorrhage (SAH),that has a high morbidity and mortality rate, the severity of which is predicted by the "Hunt-Hess grade" (HHG).
- Trial name
- NCT03754725
- Testing
- Deferiprone pill, Montreal Cognitive Assessment
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- Duke University
Intracerebral Haemorrhage
Surgical Trial in Lobar Intracerebral Haemorrhage
To establish whether a policy of earlier surgical evacuation of the haematoma in selected patients with spontaneous lobar ICH will improve outcome compared to a policy of initial conservative treatment.
- Trial name
- NCT01320423
- Testing
- Surgical Trial
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- Taipei Medical University WanFang Hospital
Communicating Hydrocephalus, Cerebral Intraventricular Hemorrhage
The Safety and Efficacy of Rapamycin on Communicating Hydrocephalus Secondary to Intraventricular Hemorrhage
This prospective, multicenter, open-label clinical trial is designed to evaluate the safety and efficacy of rapamycin in the treatment of communicating hydrocephalus secondary to intraventricular hemorrhage.
- Conditions
- Communicating Hydrocephalus, Cerebral Intraventricular Hemorrhage, Secondary Normal Pressure Hydrocephalus, Post Hemorrhagic Hydrocephalus
- Trial name
- Saturn (NCT06563817)
- Testing
- Rapamycin
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Beijing Tiantan Hospital
Within 12 Hrs of Head Injury
An Evaluation of Near-Infrared Spectroscopy for Intracranial Hematoma Detection of Head Trauma Patients in the Emergency Department.
The purpose of this study is to evaluate Near-Infrared Spectroscopy for intracranial hematoma detection of head trauma patients
- Trial name
- NCT02222597
- Testing
- infrascanner
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Chronic Subdural Hematoma
The Swedish Study of Irrigation Fluid Temperature in the Evacuation of Chronic Subdural Hematoma
The study will be a multicenter randomised controlled trial of the use of irrigation fluid of body temperature versus irrigation fluid of room temperature during burr hole evacuation of chronic subdural hematoma.
- Trial name
- SIC! (NCT02757235)
- Testing
- Irrigation fluid of body temperature, Irrigation fluid of room temperature
- Where
- 3 sites in Sweden
- Volunteers
- 588 people
- Sponsor
- Sahlgrenska University Hospital
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