Clinical trials: Hemorrhage Brain
Intracerebral Hemorrhage, Ischemic Stroke
Field Administration of Stroke Therapy-Blood Pressure Lowering
This is an open, pilot, dose-escalation study of glyceryl trinitrate (GTN, Nitroglycerin) administered by paramedics in the field within 2 hours of symptom onset to 45 severely hypertensive stroke patients.
- Trial name
- FAST-BP (NCT01811693)
- Testing
- Glycerly Trinitrate
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of California, Los Angeles
Aneurysmal Subarachnoid Hemorrhage
Effect of Antiplatelet Therapy on Cognition After Aneurysmal Subarachnoid Hemorrhage
Deficits in memory, executive function, and language are common cognitive sequelae of aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- NCT04548401
- Testing
- Antiplatelet Drug
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Stroke, Stiffness of Right Hand, Not Elsewhere Classified
Relationship Between Upper Extremity' Viscoelastic Properties and Functionality in Subacute Stroke
In stroke patients, the shoulder-upper extremity complex is affected and reduces independence and quality in activities of daily living.
- Conditions
- Stroke, Stiffness of Right Hand, Not Elsewhere Classified, Muscle Tone Abnormalities, Functional; Bleeding
- Trial name
- NCT05920837
- Testing
- MyotonPRO, Box and Block Test
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- University of Gaziantep
Subarachnoid Haemorrhage (SAH)
Evaluation of Transcutaneous Trigeminal Nerve Stimulation for Prevention of Cerebral Vasospasm After Subarachnoid Haemorrhage
Subarachnoid haemorrhage (SAH) secondary to ruptured aneurysm represents 5 to 15% of all cases of stroke. The mortality rate of SAH is 40% and the risk of serious neurological sequelae among survivors is 10 to 20%.The causes of…
- Trial name
- TRIVASOSTIM (NCT02482883)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Prematurity; Extreme, Cerebral Circulatory Failure
Sonographic QUantification of Venous Circulation In the Preterm Brain
The aim of the study is to develop an accessible, reproducible ultrasound tool for objective clinical measurement of brain circulation in preterm infants in order to identify infants being at risk for preterm brain injury at an…
- Conditions
- Prematurity; Extreme, Cerebral Circulatory Failure, Intraventricular Hemorrhage, Periventricular Leukomalacia
- Trial name
- SQUIB (NCT04535375)
- Testing
- Doppler Ultrasound of venous cerebral circulation
- Where
- Belgium
- Volunteers
- 47 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cerebral Hemorrhage, Intracranial Arteriovenous Malformations
MRI for the Early Evaluation of Acute Intracerebral Hemorrhage
What happens in the borderzone of a cerebral hemorrhage remains widely onknown and furhter the best timing for doing MR to look for vascular pathology in cerebral hemorrhage has not yet been determined.
- Conditions
- Cerebral Hemorrhage, Intracranial Arteriovenous Malformations, Intracranial Hemorrhage, Hypertensive, Brain Neoplasms
- Trial name
- NCT01689402
- Testing
- MRI Scan with the specified sequences below:
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Bispebjerg Hospital
Chronic Subdural Hematoma
Bedside Versus Operating Room Burr-Hole Drainage of Chronic Subdural Hematoma (DECIDE)
DECIDE (Bedside versus Operating Room Burr-Hole DrainagE of ChronIc SubDural HEmatoma) CSDH is an abnormal collection of blood between the layers of the brain causing brain tissue compression leading to neurological…
- Trial name
- DECIDE (NCT03053895)
- Testing
- CSDH - Bedside twist drill technique, CSDH - Operating Room Burr-hole technique
- Volunteers
- 486 people
- Sponsor
- Hamilton Health Sciences Corporation
Chronic Subdural Hematoma
Postoperative Balloninflation After Evacuation of cSDH
In this prospective, randomized, multicenter trial shall patients with chronic subdural hematoma (cSDH) recruited, who were surgically treated.
- Trial name
- BANISH (NCT04060186)
- Testing
- Balloninflation
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Chronic Subdural Hematoma
Effect and Safety Study of Atorvastatin to Treat Chronic Subdural Hematoma
To evaluate the clinic effects and security of oral administration of Atorvastatin on chronic subdural hematoma (CSDH).
- Trial name
- NCT02024373
- Testing
- Atorvastatin
- Where
- 31 sites in China
- Volunteers
- 200 people
- Sponsor
- Oriental Neurosurgery Evidence-Based-Study Team
Subarachnoid Hemorrhage, Aneurysmal
Molar Sodium Lactate Filling in Severe Meningeal Hemorrhage
Subarachnoid hemorrhage by aneurysmal rupture is a serious condition associated with a high mortality rate. Among the complications presented by these patients, vasospasm is one of the main causes of secondary aggravation, in…
- Trial name
- NCT04141371
- Testing
- Molar Sodium Lactate, physiological serum
- Where
- 3 sites in France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Intracerebral Hemorrhage
Amyloid Imaging and Cognitive Impairment After Intracerebral Hemorrhage
To evaluate Pet AV-45 Amyloid imaging in the etiological diagnosis of primary non traumatic intracerebral hemorrhage (Cerebral Amyloid Angiopathy and hypertension related hemorrhage).We hypothesize that patients with lobar…
- Trial name
- COGHIC-AV45 (NCT01619709)
- Testing
- Pet AV-45
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Toulouse
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
Endovascular middle meningeal artery (MMA) embolization is an emerging treatment for chronic subdural hematoma (cSDH). There is preliminary data to suggest that this minimally invasive therapy may be more efficacious and equally…
- Trial name
- NCT04065113
- Testing
- Middle Meningeal Artery Embolization with polyvinyl alcohol particles (PVA), Drainage of Subdural Hematoma
- Where
- United States
- Sponsor
- Washington University School of Medicine
Subarachnoid Hemorrhage, Aneurysmal
Pronostic Factors in Elderly Patients Admitted to the Intensive Care Unit for Aneurysmal Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) represents a significant proportion of hemorrhagic strokes. Severe SAH in elderly patients is associated with poorer outcomes compared to younger cohorts.
- Trial name
- FAPPAR-HSA (NCT07508683)
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Central Hospital, Nancy, France
Subarachnoid Hemorrhage, Aneurysmal, Poor Grade Subarachnoid Hemorrhage
Poor Grade Aneurysmal Subarachnoid Hemorrhage Study Group
Multicentric registry study in order to define outcome, predictors, treatment effects and their modifiers in poor grade aneurysmal subarachnoid haemorrhage patients.
- Trial name
- POGASH (NCT04945603)
- Testing
- Standard management according to international/national guidelines
- Where
- 10 sites in Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS San Raffaele
Intracerebral Hemorrhage Lobar
Evacuation of Lobar Intracranial Hemorrhage Using Microsurgical Technique (ELIMINATE)
ELIMINATE is a cohort study, phase 2A, designed to determine whether a standardized microsurgical procedure to evacuate spontaneous lobar intracranial hemorrhage (ICH) is feasible, safe and surgically efficacious in achieving a…
- Trial name
- ELIMINATE (NCT07697742)
- Testing
- Microsurgical hematoma evacuation
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Dr. Michael D Hill
Aneurysmal Subarachnoid Hemorrhage, Hyperchloremia
Impact of Multiple Electrolytes Injection Ⅱ and Saline on Hyperchloremia in Patients With Aneurysmal Subarachnoid Hemorrhage:a Pilot Study
The goal of this pilot randomized trial is to compare the effect of Multiple Electrolytes Injection Ⅱand saline on the occurrence of hyperchloremia within 72h of randomization in patients with aneurysmal subarachnoid…
- Trial name
- NCT06076590
- Testing
- maintenance fluid
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Ruptured Cerebral Aneurysm, Ruptured Berry Aneurysm
Safety and Tolerability Study of EG-1962 in Aneurysmal Subarachnoid Hemorrhage
Phase 1/2a Multicenter, Controlled, Randomized, Open Label, Dose Escalation, Safety, Tolerability, and Pharmacokinetic Study Comparing EG-1962 and Nimodipine in Patients with Aneurysmal Subarachnoid Hemorrhage
- Trial name
- NEWTON (NCT01893190)
- Testing
- Nimodipine, Nimodipine Microparticles
- Where
- 23 sites in United States, Canada and 2 more
- Volunteers
- 73 people
- Sponsor
- Edge Therapeutics Inc
Cerebral Palsy, Hip Surgery Corrective
Tranexamic Acid to Reduce Blood Loss After Varus Derotation Osteotomy
TABLO (Tranexamic Acid to reduce Blood Loss after varus derotation Osteotomy) is a clinical trial of postoperative tranexamic acid vs placebo in non-ambulatory children with cerebral palsy (CP) undergoing reconstructive hip…
- Conditions
- Cerebral Palsy, Hip Surgery Corrective, Tranexamic Acid Use, Blood Loss, Surgical
- Trial name
- TABLO (NCT07672158)
- Testing
- Tranexamic Acid (IV)
- Where
- Australia
- Volunteers
- 52 people
- Sponsor
- Murdoch Childrens Research Institute
Coronary Artery Disease
The Dual Antiplatelet Therapy Study (DAPT Study)
The DAPT Study is a double blind randomized controlled trial intended to determine the appropriate duration for dual antiplatelet therapy (the combination of aspirin and a second anti-clotting medication) as well as the safety…
- Trial name
- NCT00977938
- Testing
- Clopidogrel & Aspirin, Prasugrel & Aspirin
- Where
- 256 sites in United States, Australia and 8 more
- Volunteers
- 25,682 people
- Sponsor
- Baim Institute for Clinical Research
Aneurysmal Subarachnoid Hemorrhage
Cerebrospinal Fluid (CSF) Drainage Study
When patients suffer a subarachnoid hemorrhage (bleeding around the brain), they often develop hydrocephalus. This is an enlargement of the fluid-filled spaces (ventricles) in the brain.
- Trial name
- NCT01420978
- Testing
- CSF Diversion
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
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